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Waldemar Popik
Title Associate Professor
Faculty Rank
Degree Ph.D.
Institution Meharry Medical College
Department Internal Medicine Center for AIDS Health Disparities Research
Clusters HIV/AIDS
Meharry Medical College
1005 D. B. Todd Blvd
City Nashville
State TN
Postal Code 37208
Telephone 615-327-6734
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1. Popik W, Khatua A, Hildreth JEK, Lee B, Alcendor DJ. Phosphorodiamidate morpholino targeting the 5' untranslated region of the ZIKV RNA inhibits virus replication. Virology. 2018 Apr 18; 519:77-85.
2. Haque S, Patil G, Mishra A, Lan X, Popik W, Malhotra A, Skorecki K, Singhal PC. Effect of APOL1 disease risk variants on APOL1 gene product. Biosci Rep. 2017 04 30; 37(2).
3. Lan X, Wen H, Lederman R, Malhotra A, Mikulak J, Popik W, Skorecki K, Singhal PC. Protein domains of APOL1 and its risk variants. Exp Mol Pathol. 2015 Aug; 99(1):139-44.
4. Taylor HE, Simmons GE, Mathews TP, Khatua AK, Popik W, Lindsley CW, D'Aquila RT, Brown HA. Phospholipase D1 Couples CD4+ T Cell Activation to c-Myc-Dependent Deoxyribonucleotide Pool Expansion and HIV-1 Replication. PLoS Pathog. 2015 May; 11(5):e1004864.
5. Khatua AK, Cheatham AM, Kruzel ED, Singhal PC, Skorecki K, Popik W. Exon 4-encoded sequence is a major determinant of cytotoxicity of apolipoprotein L1. Am J Physiol Cell Physiol. 2015 Jul 01; 309(1):C22-37.
6. Rana T, Hasan RJ, Nowicki S, Venkatarajan MS, Singh R, Urvil PT, Popov V, Braun WA, Popik W, Goodwin JS, Nowicki BJ. Complement protective epitopes and CD55-microtubule complexes facilitate the invasion and intracellular persistence of uropathogenic Escherichia coli. J Infect Dis. 2014 Apr 01; 209(7):1066-76.
7. Taylor HE, Khatua AK, Popik W. The innate immune factor apolipoprotein L1 restricts HIV-1 infection. J Virol. 2014 Jan; 88(1):592-603.
8. Taylor HE, Linde ME, Khatua AK, Popik W, Hildreth JE. Sterol regulatory element-binding protein 2 couples HIV-1 transcription to cholesterol homeostasis and T cell activation. J Virol. 2011 Aug; 85(15):7699-709.
9. Khatua AK, Taylor HE, Hildreth JE, Popik W. Non-productive HIV-1 infection of human glomerular and urinary podocytes. Virology. 2010 Dec 05; 408(1):119-27.
10. Khatua AK, Taylor HE, Hildreth JE, Popik W. Inhibition of LINE-1 and Alu retrotransposition by exosomes encapsidating APOBEC3G and APOBEC3F. Virology. 2010 Apr 25; 400(1):68-75.
11. Khatua AK, Taylor HE, Hildreth JE, Popik W. Exosomes packaging APOBEC3G confer human immunodeficiency virus resistance to recipient cells. J Virol. 2009 Jan; 83(2):512-21.
12. Fiala M, Eshleman AJ, Cashman J, Lin J, Lossinsky AS, Suarez V, Yang W, Zhang J, Popik W, Singer E, Chiappelli F, Carro E, Weinand M, Witte M, Arthos J. Cocaine increases human immunodeficiency virus type 1 neuroinvasion through remodeling brain microvascular endothelial cells. J Neurovirol. 2005 Jul; 11(3):281-91.
13. Alce TM, Popik W. APOBEC3G is incorporated into virus-like particles by a direct interaction with HIV-1 Gag nucleocapsid protein. J Biol Chem. 2004 Aug 13; 279(33):34083-6.
14. Fiala M, Popik W, Qiao JH, Lossinsky AS, Alce T, Tran K, Yang W, Roos KP, Arthos J. HIV-1 induces cardiomyopathyby cardiomyocyte invasion and gp120, Tat, and cytokine apoptotic signaling. Cardiovasc Toxicol. 2004; 4(2):97-107.
15. Popik W, Alce TM. CD4 receptor localized to non-raft membrane microdomains supports HIV-1 entry. Identification of a novel raft localization marker in CD4. J Biol Chem. 2004 Jan 02; 279(1):704-12.
16. Twu C, Liu NQ, Popik W, Bukrinsky M, Sayre J, Roberts J, Rania S, Bramhandam V, Roos KP, MacLellan WR, Fiala M. Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathways. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14386-91.
17. Liu NQ, Lossinsky AS, Popik W, Li X, Gujuluva C, Kriederman B, Roberts J, Pushkarsky T, Bukrinsky M, Witte M, Weinand M, Fiala M. Human immunodeficiency virus type 1 enters brain microvascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway. J Virol. 2002 Jul; 76(13):6689-700.
18. Popik W, Alce TM, Au WC. Human immunodeficiency virus type 1 uses lipid raft-colocalized CD4 and chemokine receptors for productive entry into CD4(+) T cells. J Virol. 2002 May; 76(10):4709-22.
19. Gujuluva C, Burns AR, Pushkarsky T, Popik W, Berger O, Bukrinsky M, Graves MC, Fiala M. HIV-1 penetrates coronary artery endothelial cells by transcytosis. Mol Med. 2001 Mar; 7(3):169-76.
20. Popik W, Pitha PM. Exploitation of cellular signaling by HIV-1: unwelcome guests with master keys that signal their entry. Virology. 2000 Oct 10; 276(1):1-6.
21. Popik W, Pitha PM. Inhibition of CD3/CD28-mediated activation of the MEK/ERK signaling pathway represses replication of X4 but not R5 human immunodeficiency virus type 1 in peripheral blood CD4(+) T lymphocytes. J Virol. 2000 Mar; 74(6):2558-66.
22. Popik W, Pitha PM. Early activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, and c-Jun N-terminal kinase in response to binding of simian immunodeficiency virus to Jurkat T cells expressing CCR5 receptor. Virology. 1998 Dec 05; 252(1):210-7.
23. Popik W, Hesselgesser JE, Pitha PM. Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway. J Virol. 1998 Aug; 72(8):6406-13.
24. Popik W, Pitha PM. Binding of human immunodeficiency virus type 1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras-independent pathway. Mol Cell Biol. 1996 Nov; 16(11):6532-41.
25. Su Y, Popik W, Pitha PM. Inhibition of human immunodeficiency virus type 1 replication by a Tat-activated, transduced interferon gene: targeted expression to human immunodeficiency virus type 1-infected cells. J Virol. 1995 Jan; 69(1):110-21.
26. Shirazi Y, Popik W, Pitha PM. Modulation of interferon-mediated inhibition of human immunodeficiency virus type 1 by Tat. J Interferon Res. 1994 Oct; 14(5):259-63.
27. Zhong F, Swendeman SL, Popik W, Pitha PM, Sheffery M. Evidence that levels of the dimeric cellular transcription factor CP2 play little role in the activation of the HIV-1 long terminal repeat in vivo or following superinfection with herpes simplex virus type 1. J Biol Chem. 1994 Aug 19; 269(33):21269-76.
28. Popik W, Pitha PM. Differential effect of tumor necrosis factor-alpha and herpes simplex virus type 1 on the Tat-targeted inhibition of human immunodeficiency virus type 1 replication. Virology. 1994 Aug 01; 202(2):521-9.
29. Popik W, Pitha PM. The presence of tat protein or tumor necrosis factor alpha is critical for herpes simplex virus type 1-induced expression of human immunodeficiency virus type 1. J Virol. 1994 Mar; 68(3):1324-33.
30. Popik W, Pitha PM. Role of tumor necrosis factor alpha in activation and replication of the tat-defective human immunodeficiency virus type 1. J Virol. 1993 Feb; 67(2):1094-9.
31. Popik W, Pitha PM. Transcriptional activation of the tat-defective human immunodeficiency virus type-1 provirus: effect of interferon. Virology. 1992 Aug; 189(2):435-47.
32. Popik W, Pitha PM. Inhibition by interferon of herpes simplex virus type 1-activated transcription of tat-defective provirus. Proc Natl Acad Sci U S A. 1991 Nov 01; 88(21):9573-7.
33. Zielinska-Jenczylik J, Inglot AD, Inglot O, Popik W. Transforming growth factor-beta inhibits the antiviral action of interferons in human embryonic fibroblasts. J Interferon Res. 1991 Apr; 11(2):87-9.
34. Popik W, Inglot AD. Combined action of interferons and transforming growth factor beta on the proliferation of human fibroblasts. Arch Immunol Ther Exp (Warsz). 1991; 39(1-2):19-26.
35. Popik W, Inglot O. Bovine transforming growth factor beta. Purification and characterization. Arch Immunol Ther Exp (Warsz). 1989; 37(5-6):715-24.
36. Popik W. [Transforming growth factors--molecular structure and biological role]. Postepy Hig Med Dosw. 1988 Sep-Oct; 42(5):523-42.
37. Popik W, Inglot AD, Wilusz T, Polanowski A. Participation of polypeptide proteinase inhibitors in proliferation of fibroblasts. Arch Immunol Ther Exp (Warsz). 1988; 36(5):645-53.
38. Popik W, Inglot AD. Interactions of interferons and transforming growth factors during clonal growth of mouse or human cells in soft agar and in mice. Int J Cancer. 1987 Jul 15; 40(1):108-13.
39. Popik W. [Transforming growth factors]. Postepy Biochem. 1987; 33(2-3):165-81.
40. Popik W. Separation of transforming growth factors TGF alpha and TGF beta during chromatographic purification of extracts from mouse C-234 tumors. Arch Immunol Ther Exp (Warsz). 1987; 35(6):839-51.
41. Inglot AD, Popik W, Piasecki E, Czyrski J. A few distinct 'molecular sandwiches' are basis for structural and functional similarities of subspecies of interferon alpha and of families of growth-promoting hormones. Mol Biol Rep. 1986; 11(1):37-42.
42. Piasecki E, Popik W, Inglot AD, Konieczny M, Charytonowicz D. New derivatives of blue dextran binding and stabilizing human or mouse interferons. Arch Immunol Ther Exp (Warsz). 1984; 32(2):231-8.

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