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Michelle M. Martinez-Montemayor
Title Assistant Professor
Faculty Rank Assistant Professor
Degree Ph.D.
Institution Universidad Central Del Caribe
Department Department of Biochemistry
Clusters Cancer
P.O. Box 60327
City Bayamon
State PR
Postal Code 00960-6032
Telephone 787-798-3001 ext 2153
Fax 787-740-4390
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Awards and Honors icon

Universidad Central del Caribe American Association for Cancer Research Minority Scholar in Cancer Research Award
Universidad Central del Caribe American Association for Cancer Research Minority-Serving Institution Faculty Scholar Award
Universidad Central del Caribe American Association for Cancer Research Minority-Serving Institution Faculty Scholar Award
Michigan State University Distinguished Jacob Hoefer Fellowship
Universidad Central del Caribe Scientific Research Development Unit Fellowship recipient
2000 Michigan State University Competitive Doctoral Enrichment Fellowship
2010 Universidad Central del Caribe Member of the American Association for Cancer Research Minority Scholar in Training Award Committee

Narrative icon

  Our lab focuses on molecular, cellular and cancer biology investigating natural therapeutics, breast cancer and diabetes. Currently, we investigate inflammatory breast cancer (IBC) biology and potential natural therapeutics for this intractable disease. My long-term goal is to lead independent research programs to identify molecular targets and develop effective strategies for the prevention and treatment of breast cancer. Currently, I stimulate the participation of minority students in cancer research both at the undergraduate and graduate level. I have three Ph.D. level students, one M.S. student, and three undergraduates in my laboratory. The Ph.D. students are in diverse stages within their training, where one of them is a NIH-F31 recipient. Our lab has two funded projects, which focus on training students in cutting edge techniques in cancer research, and investigating Reishi mushroom mechanistic effects against IBC in vitro and in vivo.

Publications icon

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1. Martínez-Montemayor MM, Ling T, Suárez-Arroyo IJ, Ortiz-Soto G, Santiago-Negrón CL, Lacourt-Ventura MY, Valentín-Acevedo A, Lang WH, Rivas F. Identification of Biologically Active Ganoderma lucidum Compounds and Synthesis of Improved Derivatives That Confer Anti-cancer Activities in vitro. Front Pharmacol. 2019; 10:115.
2. Rios-Fuller TJ, Ortiz-Soto G, Lacourt-Ventura M, Maldonado-Martinez G, Cubano LA, Schneider RJ, Martinez-Montemayor MM. Ganoderma lucidum extract (GLE) impairs breast cancer stem cells by targeting the STAT3 pathway. Oncotarget. 2018 Nov 13; 9(89):35907-35921.
3. Suárez-Arroyo IJ, Loperena-Alvarez Y, Rosario-Acevedo R, Martínez-Montemayor MM. Ganoderma spp.: A Promising Adjuvant Treatment for Breast Cancer. Medicines (Basel). 2017 Mar; 4(1).
4. Suárez-Arroyo IJ, Feliz-Mosquea YR, Pérez-Laspiur J, Arju R, Giashuddin S, Maldonado-Martínez G, Cubano LA, Schneider RJ, Martínez-Montemayor MM. The proteome signature of the inflammatory breast cancer plasma membrane identifies novel molecular markers of disease. Am J Cancer Res. 2016; 6(8):1720-40.
5. Suárez-Arroyo IJ, Rios-Fuller TJ, Feliz-Mosquea YR, Lacourt-Ventura M, Leal-Alviarez DJ, Maldonado-Martinez G, Cubano LA, Martínez-Montemayor MM. Ganoderma lucidum Combined with the EGFR Tyrosine Kinase Inhibitor, Erlotinib Synergize to Reduce Inflammatory Breast Cancer Progression. J Cancer. 2016; 7(5):500-11.
6. Satishkumar S, Vuram PK, Relangi SS, Gurram V, Zhou H, Kreitman RJ, Martínez Montemayor MM, Yang L, Kaliyaperumal M, Sharma S, Pottabathini N, Lakshman MK. Cladribine Analogues via O6-(Benzotriazolyl) Derivatives of Guanine Nucleosides. Molecules. 2015 Oct 09; 20(10):18437-63.
7. Gavillán-Suárez J, Aguilar-Perez A, Rivera-Ortiz N, Rodríguez-Tirado K, Figueroa-Cuilan W, Morales-Santiago L, Maldonado-Martínez G, Cubano LA, Martínez-Montemayor MM. Chemical profile and in vivo hypoglycemic effects of Syzygium jambos, Costus speciosus and Tapeinochilos ananassae plant extracts used as diabetes adjuvants in Puerto Rico. BMC Complement Altern Med. 2015 Jul 22; 15:244.
8. Suarez-Arroyo IJ, Rosario-Acevedo R, Aguilar-Perez A, Clemente PL, Cubano LA, Serrano J, Schneider RJ, Martínez-Montemayor MM. Anti-tumor effects of Ganoderma lucidum (reishi) in inflammatory breast cancer in in vivo and in vitro models. PLoS One. 2013; 8(2):e57431.
9. de la Parra C, Otero-Franqui E, Martinez-Montemayor M, Dharmawardhane S. The soy isoflavone equol may increase cancer malignancy via up-regulation of eukaryotic protein synthesis initiation factor eIF4G. J Biol Chem. 2012 Dec 07; 287(50):41640-50.
10. Martínez-Montemayor MM, Acevedo RR, Otero-Franqui E, Cubano LA, Dharmawardhane SF. Ganoderma lucidum (Reishi) inhibits cancer cell growth and expression of key molecules in inflammatory breast cancer. Nutr Cancer. 2011; 63(7):1085-94.
11. Martínez-Montemayor MM, Otero-Franqui E, Martinez J, De La Mota-Peynado A, Cubano LA, Dharmawardhane S. Individual and combined soy isoflavones exert differential effects on metastatic cancer progression. Clin Exp Metastasis. 2010 Oct; 27(7):465-80.
12. Castillo-Pichardo L, Martínez-Montemayor MM, Martínez JE, Wall KM, Cubano LA, Dharmawardhane S. Inhibition of mammary tumor growth and metastases to bone and liver by dietary grape polyphenols. Clin Exp Metastasis. 2009; 26(6):505-16.
13. Martínez-Montemayor MM, Hill GM, Raney NE, Rilington VD, Tempelman RJ, Link JE, Wilkinson CP, Ramos AM, Ernst CW. Gene expression profiling in hepatic tissue of newly weaned pigs fed pharmacological zinc and phytase supplemented diets. BMC Genomics. 2008 Sep 17; 9:421.
14. Colón-Cesario WI, Martínez-Montemayor MM, Morales S, Félix J, Cruz J, Adorno M, Pereira L, Colón N, Maldonado-Vlaar CS, Peña de Ortiz S. Knockdown of Nurr1 in the rat hippocampus: implications to spatial discrimination learning and memory. Learn Mem. 2006 Nov-Dec; 13(6):734-44.
15. Martínez MM, Link JE, Hill GM. Dietary pharmacological or excess zinc and phytase effects on tissue mineral concentrations, metallothionein, and apparent mineral retention in the newly weaned pig. Biol Trace Elem Res. 2005; 105(1-3):97-115.
16. Martínez MM, Hill GM, Link JE, Raney NE, Tempelman RJ, Ernst CW. Pharmacological zinc and phytase supplementation enhance metallothionein mRNA abundance and protein concentration in newly weaned pigs. J Nutr. 2004 Mar; 134(3):538-44.

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