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Frida Kleiman
Title Associate Professor of Chemistry
Faculty Rank
Degree Ph.D.
Institution Hunter College, CUNY
Department Chemistry
Clusters Cancer
Gene and Environmental Health/Toxicology
Address
Room 1307 HN, Hunter College, CUNY
695 Park Avenue
City New York
State NY
Postal Code 10065
Telephone (212) 772-5355
Fax
Email
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  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

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1.
2018Role of the mRNA 3? processing factor CstF-50 in regulating the BRCA1/BARD1 E3 ubiquitin ligase activity during the DNA damage response5R21CA204610-02
2.
2017Role of the mRNA 3? processing factor CstF-50 in regulating the BRCA1/BARD1 E3 ubiquitin ligase activity during the DNA damage response1R21CA204610-01A1
3.
2014Role of nucleolin in regulating mRNA stability during DNA damage response (DDR)5R21CA175794-02
4.
2013Role of nucleolin in regulating mRNA stability during DNA damage response (DDR)1R21CA175794-01
5.
2011Mechanisms of Response to DNA Damage Nuclear Factors5SC1GM083806-04
6.
2010Mechanisms of Response to DNA Damage Nuclear Factors5SC1GM083806-03
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2009Mechanisms of Response to DNA Damage Nuclear Factors5SC1GM083806-02
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2008Mechanisms of Response to DNA Damage Nuclear Factors1SC1GM083806-01
9.
1998PROTEIN/PROTEIN INTERACTIONS IN THE POLYADENYLATION COMP5F05TW005379-02
10.
1997PROTEIN/PROTEIN INTERACTIONS IN THE POLYADENYLATION COMP1F05TW005379-01

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1. Fonseca D, Baquero J, Murphy MR, Aruggoda G, Varriano S, Sapienza C, Mashadova O, Rahman S, Kleiman FE. mRNA Processing Factor CstF-50 and Ubiquitin Escort Factor p97 Are BRCA1/BARD1 Cofactors Involved in Chromatin Remodeling during the DNA Damage Response. Mol Cell Biol. 2018 Feb 15; 38(4).
2. Zhang X, Xiao S, Rameau RD, Devany E, Nadeem Z, Caglar E, Ng K, Kleiman FE, Saxena A. Nucleolin phosphorylation regulates PARN deadenylase activity during cellular stress response. RNA Biol. 2018 Feb 01; 15(2):251-260.
3. Devany E, Park JY, Murphy MR, Zakusilo G, Baquero J, Zhang X, Hoque M, Tian B, Kleiman FE. Intronic cleavage and polyadenylation regulates gene expression during DNA damage response through U1 snRNA. Cell Discov. 2016; 2:16013.
4. Zhang X, Devany E, Murphy MR, Glazman G, Persaud M, Kleiman FE. PARN deadenylase is involved in miRNA-dependent degradation of TP53 mRNA in mammalian cells. Nucleic Acids Res. 2015 Dec 15; 43(22):10925-38.
5. Zhang X, Kleiman FE, Devany E. Deadenylation and its regulation in eukaryotic cells. Methods Mol Biol. 2014; 1125:289-96.
6. Devany E, Zhang X, Park JY, Tian B, Kleiman FE. Positive and negative feedback loops in the p53 and mRNA 3' processing pathways. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3351-6.
7. Goss DJ, Kleiman FE. Poly(A) binding proteins: are they all created equal? Wiley Interdiscip Rev RNA. 2013 Mar-Apr; 4(2):167-79.
8. Nazeer FI, Devany E, Mohammed S, Fonseca D, Akukwe B, Taveras C, Kleiman FE. p53 inhibits mRNA 3' processing through its interaction with the CstF/BARD1 complex. Oncogene. 2011 Jul 07; 30(27):3073-83.
9. Zhang X, Virtanen A, Kleiman FE. To polyadenylate or to deadenylate: that is the question. Cell Cycle. 2010 Nov 15; 9(22):4437-49.
10. Cevher MA, Kleiman FE. Connections between 3'-end processing and DNA damage response. Wiley Interdiscip Rev RNA. 2010 Jul-Aug; 1(1):193-9.
11. Cevher MA, Zhang X, Fernandez S, Kim S, Baquero J, Nilsson P, Lee S, Virtanen A, Kleiman FE. Nuclear deadenylation/polyadenylation factors regulate 3' processing in response to DNA damage. EMBO J. 2010 May 19; 29(10):1674-87.
12. Edwards RA, Lee MS, Tsutakawa SE, Williams RS, Nazeer I, Kleiman FE, Tainer JA, Glover JN. The BARD1 C-terminal domain structure and interactions with polyadenylation factor CstF-50. Biochemistry. 2008 Nov 04; 47(44):11446-56.
13. Mirkin N, Fonseca D, Mohammed S, Cevher MA, Manley JL, Kleiman FE. The 3' processing factor CstF functions in the DNA repair response. Nucleic Acids Res. 2008 Apr; 36(6):1792-804.
14. Kim HS, Li H, Cevher M, Parmelee A, Fonseca D, Kleiman FE, Lee SB. DNA damage-induced BARD1 phosphorylation is critical for the inhibition of messenger RNA processing by BRCA1/BARD1 complex. Cancer Res. 2006 May 01; 66(9):4561-5.
15. Shin C, Kleiman FE, Manley JL. Multiple properties of the splicing repressor SRp38 distinguish it from typical SR proteins. Mol Cell Biol. 2005 Sep; 25(18):8334-43.
16. Kleiman FE, Wu-Baer F, Fonseca D, Kaneko S, Baer R, Manley JL. BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II. Genes Dev. 2005 May 15; 19(10):1227-37.
17. Chen A, Kleiman FE, Manley JL, Ouchi T, Pan ZQ. Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase. J Biol Chem. 2002 Jun 14; 277(24):22085-92.
18. Kleiman FE, Manley JL. The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression. Cell. 2001 Mar 09; 104(5):743-53.
19. Kleiman FE, Manley JL. Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50. Science. 1999 Sep 03; 285(5433):1576-9.
20. Kleiman FE, Ramírez AO, Dodelson de Kremer R, Gravel RA, Argaraña CE. A frequent TG deletion near the polyadenylation signal of the human HEXB gene: occurrence of an irregular DNA structure and conserved nucleotide sequence motif in the 3' untranslated region. Hum Mutat. 1998; 12(5):320-9.

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