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Ward G. Kirlin
Title Associate Professor
Faculty Rank
Degree Ph.D.
Institution Morehouse School of Medicine
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Morehouse School of Medicine
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Telephone (404) 752-1709
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1. Harmon T, Harbuzariu A, Lanier V, Lipsey CC, Kirlin W, Yang L, Gonzalez-Perez RR. Nanoparticle-linked antagonist for leptin signaling inhibition in breast cancer. World J Clin Oncol. 2017 Feb 10; 8(1):54-66.
2. Bayse GS, Hammonds-Odie LP, Jackson KM, Tucker DK, Kirlin WG. Permeation of roxarsone and its metabolites increases caco-2 cell proliferation. Adv Biol Chem. 2013 Aug; 3(4):389-396.
3. Odom RY, Dansby MY, Rollins-Hairston AM, Jackson KM, Kirlin WG. Phytochemical induction of cell cycle arrest by glutathione oxidation and reversal by N-acetylcysteine in human colon carcinoma cells. Nutr Cancer. 2009; 61(3):332-9.
4. Cai J, Kirlin WG, Chen Y, Yan X, Jones DP, Sartorelli AC. Overexpression of heat shock factor 1 inhibits butyrate-induced differentiation in colon cancer cells. Cell Stress Chaperones. 2006; 11(3):199-207.
5. Jones DP, Go YM, Anderson CL, Ziegler TR, Kinkade JM, Kirlin WG. Cysteine/cystine couple is a newly recognized node in the circuitry for biologic redox signaling and control. FASEB J. 2004 Aug; 18(11):1246-8.
6. Miller LT, Watson WH, Kirlin WG, Ziegler TR, Jones DP. Oxidation of the glutathione/glutathione disulfide redox state is induced by cysteine deficiency in human colon carcinoma HT29 cells. J Nutr. 2002 Aug; 132(8):2303-6.
7. Rodriguez JW, Kohan MJ, King LC, Kirlin WG. Detection of DNA adducts in developing CD4+ CD8+ thymocytes and splenocytes following in utero exposure to benzo[a]pyrene. Immunopharmacol Immunotoxicol. 2002 Aug; 24(3):365-81.
8. Kirlin WG, Cai J, Thompson SA, Diaz D, Kavanagh TJ, Jones DP. Glutathione redox potential in response to differentiation and enzyme inducers. Free Radic Biol Med. 1999 Dec; 27(11-12):1208-18.
9. Kirlin WG, Cai J, DeLong MJ, Patten EJ, Jones DP. Dietary compounds that induce cancer preventive phase 2 enzymes activate apoptosis at comparable doses in HT29 colon carcinoma cells. J Nutr. 1999 Oct; 129(10):1827-35.
10. Rodriguez JW, Kirlin WG, Wirsiy YG, Matheravidathu S, Hodge TW, Urso P. Maternal exposure to benzo[a]pyrene alters development of T lymphocytes in offspring. Immunopharmacol Immunotoxicol. 1999 May; 21(2):379-96.
11. Bradford LD, Kirlin WG. Polymorphism of CYP2D6 in Black populations: implications for psychopharmacology. Int J Neuropsychopharmacol. 1998 Dec; 1(2):173-185.
12. Lee M, Kirlin W, Sturrup M, Rodriguez J, Urso P. Variation in the response of T cells to concanavalin A after in vitro exposure to benzo[A]pyrene and 2-aminofluorene. Immunopharmacol Immunotoxicol. 1996 May; 18(2):309-21.
13. Rodriguez JW, Kirlin WG, Ferguson RJ, Doll MA, Gray K, Rustan TD, Lee ME, Kemp K, Urso P, Hein DW. Human acetylator genotype: relationship to colorectal cancer incidence and arylamine N-acetyltransferase expression in colon cytosol. Arch Toxicol. 1993; 67(7):445-52.
14. Flammang TJ, Yerokun T, Bryant MS, Couch LH, Kirlin WG, Lee KJ, Ogolla F, Ferguson RJ, Talaska G, Hein DW. Hemoglobin adduct and hepatic- and urinary bladder-DNA adduct levels in rapid and slow acetylator Syrian inbred hamsters administered 2-aminofluorene. J Pharmacol Exp Ther. 1992 Feb; 260(2):865-71.
15. Kirlin WG, Ogolla F, Andrews AF, Trinidad A, Ferguson RJ, Yerokun T, Mpezo M, Hein DW. Acetylator genotype-dependent expression of arylamine N-acetyltransferase in human colon cytosol from non-cancer and colorectal cancer patients. Cancer Res. 1991 Jan 15; 51(2):549-55.
16. Trinidad A, Hein DW, Rustan TD, Ferguson RJ, Miller LS, Bucher KD, Kirlin WG, Ogolla F, Andrews AF. Purification of hepatic polymorphic arylamine N-acetyltransferase from homozygous rapid acetylator inbred hamster: identity with polymorphic N-hydroxyarylamine-O-acetyltransferase. Cancer Res. 1990 Dec 15; 50(24):7942-9.
17. Ogolla F, Ferguson RJ, Kirlin WG, Trinidad A, Andrews AF, Mpezo M, Hein DW. Acetylator genotype-dependent expression of arylamine N-acetyltransferase and N-hydroxyarylamine O-acetyltransferase in Syrian inbred hamster intestine and colon. Identity with the hepatic acetylation polymorphism. Drug Metab Dispos. 1990 Sep-Oct; 18(5):680-5.
18. Yerokun T, Hein DW, Ferguson RJ, Ogolla F, Heflich RH, Minor TY, Trinidad A, Kirlin WG, Andrews AF. Relationship of Syrian inbred hamster acetylator genotype to the mutagenic activation of 2-aminofluorene. Mutagenesis. 1990 May; 5(3):233-9.
19. Hein DW, Trinidad A, Yerokun T, Kirlin WG, Ogolla F, Ferguson RJ, Andrews AF. Genetic regulation of acetyltransferases in the Syrian inbred hamster: a model for man. Prog Clin Biol Res. 1990; 340B:115-24.
20. Yerokun T, Kirlin WG, Trinidad A, Ferguson RJ, Ogolla F, Andrews AF, Brady PK, Hein DW. Identification and kinetic characterization of acetylator genotype-dependent and -independent arylamine carcinogen N-acetyltransferases in hamster bladder cytosol. Drug Metab Dispos. 1989 May-Jun; 17(3):231-7.
21. Trinidad A, Kirlin WG, Ogolla F, Andrews AF, Yerokun T, Ferguson RJ, Brady PK, Hein DW. Kinetic characterization of acetylator genotype-dependent and -independent N-acetyltransferase isozymes in homozygous rapid and slow acetylator inbred hamster liver cytosol. Drug Metab Dispos. 1989 May-Jun; 17(3):238-47.
22. Kirlin WG, Trinidad A, Yerokun T, Ogolla F, Ferguson RJ, Andrews AF, Brady PK, Hein DW. Polymorphic expression of acetyl coenzyme A-dependent arylamine N-acetyltransferase and acetyl coenzyme A-dependent O-acetyltransferase-mediated activation of N-hydroxyarylamines by human bladder cytosol. Cancer Res. 1989 May 01; 49(9):2448-54.
23. Hein DW, Trinidad A, Yerokun T, Ferguson RJ, Kirlin WG, Weber WW. Genetic control of acetyl coenzyme A-dependent arylamine N-acetyltransferase, hydrazine N-acetyltransferase, and N-hydroxy-arylamine O-acetyltransferase enzymes in C57BL/6J, A/J, AC57F1, and the rapid and slow acetylator A.B6 and B6.A congenic inbred mouse. Drug Metab Dispos. 1988 May-Jun; 16(3):341-7.
24. Hein DW, Flammang TJ, Kirlin WG, Trinidad A, Ogolla F. Acetylator genotype-dependent metabolic activation of carcinogenic N-hydroxyarylamines by S-acetyl coenzyme A-dependent enzymes of inbred hamster tissue cytosols: relationship to arylamine N-acetyltransferase. Carcinogenesis. 1987 Dec; 8(12):1767-74.
25. Hein DW, Kirlin WG, Yerokun T, Trinidad A, Ogolla F. Inheritance of acetylator genotype-dependent arylamine N-acetyltransferase in hamster bladder cytosol. Carcinogenesis. 1987 May; 8(5):647-52.
26. Hein DW, Kirlin WG, Ogolla F, Trinidad A. Extrahepatic expression of N-acetylator genotype in the inbred hamster. Drug Metab Dispos. 1987 Jan-Feb; 15(1):68-73.
27. Hein DW, Kirlin WG, Ferguson RJ, Thompson LK, Ogolla F. Identification and inheritance of inbred hamster N-acetyltransferase isozymes in peripheral blood. J Pharmacol Exp Ther. 1986 Dec; 239(3):823-8.
28. Hein DW, Kirlin WG, Ogolla F, Trinidad A, Thompson LK, Ferguson RJ. The role of acetylator genotype on hepatic and extrahepatic acetylation, deacetylation, and sulfation of 2-aminofluorene, 2-acetylaminofluorene, and N-hydroxy-2-acetylaminofluorene in the inbred hamster. Drug Metab Dispos. 1986 Sep-Oct; 14(5):566-73.
29. Hein DW, Kirlin WG, Ferguson RJ, Weber WW. Biochemical investigation of the basis for the genetic N-acetylation polymorphism in the inbred hamster. J Pharmacol Exp Ther. 1985 Aug; 234(2):358-64.
30. Hein DW, Kirlin WG, Ferguson RJ, Weber WW. Inheritance of liver N-acetyltransferase activity in the rapid and slow acetylator inbred hamster. J Pharmacol Exp Ther. 1985 Jun; 233(3):584-7.
31. Kandasamy SB, Kirlin WG, Kaul PN. Prostacyclin-induced hypothermia: involvement of central histamine H2-receptors. Life Sci. 1981 Jun 01; 28(22):2553-60.

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Glutathione
Oxidation-Reduction
Carcinogens
Arylamine N-Acetyltransferase
Plants
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