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Zhongmao Guo
Title Professor
Faculty Rank Professor
Degree M.D., Ph.D.
Institution Meharry Medical College
Department Physiology
Clusters Cardiovascular and Related Diseases
1005 Dr. T.B. Todd Jr. Blvd
City Nashville
State TN
Postal Code 37208-3599
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Awards and Honors icon

2000 American Heart Association AHA 0030239N: Involvement of genomic instability in atherosclerosis
2002 American Federation for Aging Research AFAR research award: Effect of calorie restriction on atherosclerosis
2003 NIH NIH P20 RR011792 pilot project: Hypertension, oxidative stress and races
2003 NIH NIH R15 HL071525: The role of reactive oxygen species in atherogenesis
2003 NIH NIH S06 GM08037 sub-project: The role of oxidative stress in atherogenesis
2006 NIH NIH R01 ES014471: Effect of antioxidant enzymes on BaP-induced atherogenesis
2009 NIH NIH R01 HL089382: Endoplasmic reticulum stress and foam cell formation
2014 NIH NIH UL1 TR000445 subproject: Increase in plasma cholecystokinin is a cause of hypercholesterolemia
2015 NIH U54MD0007593 pilot project: Racial Differences in Hypercholesterolemic Activity of Cholecystokinin

Narrative icon

  My current research focuses on the signaling pathways that regulate cholesterol metabolism in endothelial cells, macrophages, and intestine epithelial cells.

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1. Ho MH, Guo ZM, Chunga J, Goodwin JS, Xie H. Characterization of Innate Immune Responses of Human Endothelial Cells Induced by Porphyromonas gingivalis and Their Derived Outer Membrane Vesicles. Front Cell Infect Microbiol. 2016; 6:139.
2. Yang F, Yang H, Ramesh A, Goodwin JS, Okoro EU, Guo Z. Overexpression of Catalase Enhances Benzo(a)pyrene Detoxification in Endothelial Microsomes. PLoS One. 2016; 11(9):e0162561.
3. Okoro EU, Guo Z, Yang H. Akt isoform-dependent regulation of ATP-Binding cassette A1 expression by apolipoprotein E. Biochem Biophys Res Commun. 2016 08 12; 477(1):123-8.
4. Harris KL, Pulliam SR, Okoro E, Guo Z, Washington MK, Adunyah SE, Amos-Landgraf JM, Ramesh A. Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a polyposis in rat coli (PIRC) rat model of colon cancer. Oncotarget. 2016 May 17; 7(20):28947-60.
5. Okoro EU, Zhang H, Guo Z, Yang F, Smith C, Yang H. A Subregion of Reelin Suppresses Lipoprotein-Induced Cholesterol Accumulation in Macrophages. PLoS One. 2015; 10(8):e0136895.
6. Miao L, Okoro EU, Cao Z, Yang H, Motley-Johnson E, Guo Z. High-density lipoprotein-mediated transcellular cholesterol transport in mouse aortic endothelial cells. Biochem Biophys Res Commun. 2015 Sep 18; 465(2):256-61.
7. Shan G, Yang F, Zhou L, Tang T, Okoro EU, Yang H, Guo Z. Increase in Blood Glutathione and Erythrocyte Proteins Related to Glutathione Generation, Reduction and Utilization in African-American Old Women with Diabetes. J Sci Technol Environ. 2015; 5(1).
8. Zhou L, Yang H, Okoro EU, Guo Z. Up-regulation of cholesterol absorption is a mechanism for cholecystokinin-induced hypercholesterolemia. J Biol Chem. 2014 May 09; 289(19):12989-99.
9. Zhou L, Yang D, Wu DF, Guo ZM, Okoro E, Yang H. Inhibition of endoplasmic reticulum stress and atherosclerosis by 2-aminopurine in apolipoprotein e-deficient mice. ISRN Pharmacol. 2013; 2013:847310.
10. Lin X, Yang H, Zhang H, Zhou L, Guo Z. A novel transcription mechanism activated by ethanol: induction of Slc7a11 gene expression via inhibition of the DNA-binding activity of transcriptional repressor octamer-binding transcription factor 1 (OCT-1). J Biol Chem. 2013 May 24; 288(21):14815-23.
11. Zhou L, Yang H, Lin X, Okoro EU, Guo Z. Cholecystokinin elevates mouse plasma lipids. PLoS One. 2012; 7(12):e51011.
12. Okoro EU, Zhao Y, Guo Z, Zhou L, Lin X, Yang H. Apolipoprotein E4 is deficient in inducing macrophage ABCA1 expression and stimulating the Sp1 signaling pathway. PLoS One. 2012; 7(9):e44430.
13. Zhang HF, Lin XH, Yang H, Zhou LC, Guo YL, Barnett JV, Guo ZM. Regulation of the activity and expression of aryl hydrocarbon receptor by ethanol in mouse hepatic stellate cells. Alcohol Clin Exp Res. 2012 Nov; 36(11):1873-81.
14. Prins PA, Perati PR, Kon V, Guo Z, Ramesh A, Linton MF, Fazio S, Sampson UK. Benzo[a]pyrene potentiates the pathogenesis of abdominal aortic aneurysms in apolipoprotein E knockout mice. Cell Physiol Biochem. 2012; 29(1-2):121-30.
15. Chen X, Guo Z, Okoro EU, Zhang H, Zhou L, Lin X, Rollins AT, Yang H. Up-regulation of ATP binding cassette transporter A1 expression by very low density lipoprotein receptor and apolipoprotein E receptor 2. J Biol Chem. 2012 Feb 03; 287(6):3751-9.
16. Lin X, Yang H, Zhou L, Guo Z. Nrf2-dependent induction of NQO1 in mouse aortic endothelial cells overexpressing catalase. Free Radic Biol Med. 2011 Jul 01; 51(1):97-106.
17. Chen X, Zhao Y, Guo Z, Zhou L, Okoro EU, Yang H. Transcriptional regulation of ATP-binding cassette transporter A1 expression by a novel signaling pathway. J Biol Chem. 2011 Mar 18; 286(11):8917-23.
18. Zhao Y, Guo Z, Lin X, Zhou L, Okoro EU, Fan G, Ramaswamy R, Yang H. Apolipoprotein E-Deficient Lipoproteins Induce Foam Cell Formation by Activation of PERK-EIF-2a Signaling Cascade. J Bioanal Biomed. 2010 Oct 06; 2:113-120.
19. Chen A, Guo Z, Zhou L, Yang H. Hepatic Endosome Protein Profiling in Apolipoprotein E Deficient Mice Expressing Apolipoprotein B48 but not B100. J Bioanal Biomed. 2010 Sep 23; 2(5):100-106.
20. Tang T, Lin X, Yang H, Zhou L, Wang Z, Shan G, Guo Z. Overexpression of antioxidant enzymes upregulates aryl hydrocarbon receptor expression via increased Sp1 DNA-binding activity. Free Radic Biol Med. 2010 Aug 01; 49(3):487-92.
21. Wang Z, Yang H, Ramesh A, Roberts LJ, Zhou L, Lin X, Zhao Y, Guo Z. Overexpression of Cu/Zn-superoxide dismutase and/or catalase accelerates benzo(a)pyrene detoxification by upregulation of the aryl hydrocarbon receptor in mouse endothelial cells. Free Radic Biol Med. 2009 Oct 15; 47(8):1221-9.
22. Yang H, Zhou L, Wang Z, Roberts LJ, Lin X, Zhao Y, Guo Z. Overexpression of antioxidant enzymes in ApoE-deficient mice suppresses benzo(a)pyrene-accelerated atherosclerosis. Atherosclerosis. 2009 Nov; 207(1):51-8.
23. Onumah OE, Jules GE, Zhao Y, Zhou L, Yang H, Guo Z. Overexpression of catalase delays G0/G1- to S-phase transition during cell cycle progression in mouse aortic endothelial cells. Free Radic Biol Med. 2009 Jun 15; 46(12):1658-67.
24. Wu D, Yang H, Zhao Y, Sharan C, Goodwin JS, Zhou L, Guo Y, Guo Z. 2-Aminopurine inhibits lipid accumulation induced by apolipoprotein E-deficient lipoprotein in macrophages: potential role of eukaryotic initiation factor-2alpha phosphorylation in foam cell formation. J Pharmacol Exp Ther. 2008 Aug; 326(2):395-405.
25. Guo Z, Ran Q, Roberts LJ, Zhou L, Richardson A, Sharan C, Wu D, Yang H. Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice. Free Radic Biol Med. 2008 Feb 01; 44(3):343-52.
26. Wu D, Sharan C, Yang H, Goodwin JS, Zhou L, Grabowski GA, Du H, Guo Z. Apolipoprotein E-deficient lipoproteins induce foam cell formation by downregulation of lysosomal hydrolases in macrophages. J Lipid Res. 2007 Dec; 48(12):2571-8.
27. Wang QS, Zheng YM, Dong L, Ho YS, Guo Z, Wang YX. Role of mitochondrial reactive oxygen species in hypoxia-dependent increase in intracellular calcium in pulmonary artery myocytes. Free Radic Biol Med. 2007 Mar 01; 42(5):642-53.
28. Zhou L, Xiang W, Potts J, Floyd M, Sharan C, Yang H, Ross J, Nyanda AM, Guo Z. Reduction in extracellular superoxide dismutase activity in African-American patients with hypertension. Free Radic Biol Med. 2006 Nov 01; 41(9):1384-91.
29. Zhou L, Shi M, Guo Z, Brisbon W, Hoover R, Yang H. Different cytotoxic injuries induced by lysophosphatidylcholine and 7-ketocholesterol in mouse endothelial cells. Endothelium. 2006 May-Jun; 13(3):213-26.
30. Wu D, Yang H, Xiang W, Zhou L, Shi M, Julies G, Laplante JM, Ballard BR, Guo Z. Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice. J Lipid Res. 2005 Jul; 46(7):1380-7.
31. Yang H, Roberts LJ, Shi MJ, Zhou LC, Ballard BR, Richardson A, Guo ZM. Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E. Circ Res. 2004 Nov 26; 95(11):1075-81.
32. Van Remmen H, Qi W, Sabia M, Freeman G, Estlack L, Yang H, Mao Guo Z, Huang TT, Strong R, Lee S, Epstein CJ, Richardson A. Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress. Free Radic Biol Med. 2004 Jun 15; 36(12):1625-34.
33. Shi M, Yang H, Motley ED, Guo Z. Overexpression of Cu/Zn-superoxide dismutase and/or catalase in mice inhibits aorta smooth muscle cell proliferation. Am J Hypertens. 2004 May; 17(5 Pt 1):450-6.
34. Yang H, Shi M, Story J, Richardson A, Guo Z. Food restriction attenuates age-related increase in the sensitivity of endothelial cells to oxidized lipids. J Gerontol A Biol Sci Med Sci. 2004 Apr; 59(4):316-23.
35. Cabelof DC, Guo Z, Raffoul JJ, Sobol RW, Wilson SH, Richardson A, Heydari AR. Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens. Cancer Res. 2003 Sep 15; 63(18):5799-807.
36. Yang H, Shi M, Richardson A, Vijg J, Guo Z. Attenuation of leukocyte-endothelium interaction by antioxidant enzymes. Free Radic Biol Med. 2003 Aug 01; 35(3):266-76.
37. Uddin M, Yang H, Shi M, Polley-Mandal M, Guo Z. Elevation of oxidative stress in the aorta of genetically hypertensive mice. Mech Ageing Dev. 2003 Jul; 124(7):811-7.
38. Cabelof DC, Yanamadala S, Raffoul JJ, Guo Z, Soofi A, Heydari AR. Caloric restriction promotes genomic stability by induction of base excision repair and reversal of its age-related decline. DNA Repair (Amst). 2003 Mar 01; 2(3):295-307.
39. Yang H, Shi M, VanRemmen H, Chen X, Vijg J, Richardson A, Guo Z. Reduction of pressor response to vasoconstrictor agents by overexpression of catalase in mice. Am J Hypertens. 2003 Jan; 16(1):1-5.
40. Cabelof DC, Raffoul JJ, Yanamadala S, Guo Z, Heydari AR. Induction of DNA polymerase beta-dependent base excision repair in response to oxidative stress in vivo. Carcinogenesis. 2002 Sep; 23(9):1419-25.
41. Dong LQ, Ramos FJ, Wick MJ, Lim MA, Guo Z, Strong R, Richardson A, Liu F. Cloning and characterization of a testis and brain-specific isoform of mouse 3'-phosphoinositide-dependent protein kinase-1, mPDK-1 beta. Biochem Biophys Res Commun. 2002 May 31; 294(1):136-44.
42. Guo Z, Mitchell-Raymundo F, Yang H, Ikeno Y, Nelson J, Diaz V, Richardson A, Reddick R. Dietary restriction reduces atherosclerosis and oxidative stress in the aorta of apolipoprotein E-deficient mice. Mech Ageing Dev. 2002 Apr 30; 123(8):1121-31.
43. Cabelof DC, Raffoul JJ, Yanamadala S, Ganir C, Guo Z, Heydari AR. Attenuation of DNA polymerase beta-dependent base excision repair and increased DMS-induced mutagenicity in aged mice. Mutat Res. 2002 Mar 20; 500(1-2):135-45.
44. Guo ZM, Yang H, Hamilton ML, VanRemmen H, Richardson A. Effects of age and food restriction on oxidative DNA damage and antioxidant enzyme activities in the mouse aorta. Mech Ageing Dev. 2001 Oct; 122(15):1771-86.
45. Van Remmen H, Williams MD, Guo Z, Estlack L, Yang H, Carlson EJ, Epstein CJ, Huang TT, Richardson A. Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis. Am J Physiol Heart Circ Physiol. 2001 Sep; 281(3):H1422-32.
46. Hamilton ML, Van Remmen H, Drake JA, Yang H, Guo ZM, Kewitt K, Walter CA, Richardson A. Does oxidative damage to DNA increase with age? Proc Natl Acad Sci U S A. 2001 Aug 28; 98(18):10469-74.
47. Guo Z, Van Remmen H, Yang H, Chen X, Mele J, Vijg J, Epstein CJ, Ho YS, Richardson A. Changes in expression of antioxidant enzymes affect cell-mediated LDL oxidation and oxidized LDL-induced apoptosis in mouse aortic cells. Arterioscler Thromb Vasc Biol. 2001 Jul; 21(7):1131-8.
48. Hamilton ML, Guo Z, Fuller CD, Van Remmen H, Ward WF, Austad SN, Troyer DA, Thompson I, Richardson A. A reliable assessment of 8-oxo-2-deoxyguanosine levels in nuclear and mitochondrial DNA using the sodium iodide method to isolate DNA. Nucleic Acids Res. 2001 May 15; 29(10):2117-26.
49. Pahlavani MA, Vargas DM, Guo Z, Richardson A. Normal immune function in young and old DNA polymerase-beta deficient mice. Immunol Lett. 2000 Apr 03; 72(1):17-21.
50. Raffoul JJ, Guo Z, Soofi A, Heydari AR. Caloric restriction and genomic stability. J Nutr Health Aging. 1999; 3(2):102-10.
51. Guo Z, Heydari A, Richardson A. Nucleotide excision repair of actively transcribed versus nontranscribed DNA in rat hepatocytes: effect of age and dietary restriction. Exp Cell Res. 1998 Nov 25; 245(1):228-38.
52. Guo ZM, Van Remmen H, Wu WT, Richardson A. Effect of cAMP-induced transcription on the repair of the phosphoenolpyruvate carboxykinase gene by hepatocytes isolated from young and old rats. Mutat Res. 1998 Oct 21; 409(1):37-48.
53. Guo Z, Heydari AR, Wu W, Yang H, Sabia MR, Richardson A. Characterization of gene-specific DNA repair by primary cultures of rat hepatocytes. J Cell Physiol. 1998 Aug; 176(2):314-22.
54. Guo ZM, Liu CT. Role of atrial natriuretic peptide in disturbed water and electrolyte metabolism of guinea pigs infected with Pichinde virus. Lab Anim Sci. 1995 Oct; 45(5):484-92.
55. Guo ZM, Qian C, Peters CJ, Liu CT. Changes in platelet-activating factor, catecholamine, and serotonin concentrations in brain, cerebrospinal fluid, and plasma of pichinde virus-infected guinea pigs. Lab Anim Sci. 1993 Dec; 43(6):569-74.
56. Qian C, Guo ZM, Peters CJ, Liu CT. Platelet-activating factor (PAF)-induced cardiopulmonary dysfunctions and their reversal with a PAF antagonist (BN 52021) in strain 13 guinea pigs. J Lipid Mediat. 1993 Jul; 7(3):223-37.
57. Guo ZM, Liu CT, Peters CJ. Possible involvement of endogenous beta-endorphin in the pathophysiological mechanisms of Pichinde virus-infected guinea pigs. Proc Soc Exp Biol Med. 1992 Jul; 200(3):343-8.
58. Guo ZM, Liu CT. Pulmonary responses of conscious strain 13 guinea pigs to Pichinde viral infection. Lab Anim Sci. 1991 Dec; 41(6):581-4.
59. Kass DA, Maughan WL, Guo ZM, Kono A, Sunagawa K, Sagawa K. Comparative influence of load versus inotropic states on indexes of ventricular contractility: experimental and theoretical analysis based on pressure-volume relationships. Circulation. 1987 Dec; 76(6):1422-36.

Original Articles icon


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1. Liu CT, Guo ZM, Jahrling PB, Peter CJ. Pressure changes in cardiac chambers: Possible mechanisms of Pichinde virus-induced pulmonary edema in strain 13 guinea pigs. Pathophysiol. 1998; 5:91-98.
2. Liu CT, Guo ZM. Cardiovascular responses to intracerebroventricular infusion of artificial cerebrospinal fluid in strain 13 guinea pigs. Lab Anim Sci. 1992; 42:275-279.
3. Liu CT, Guo ZM. Technique for repeated collection of cerebrospinal fluid from cisterna magna of anesthetized strain 13 guinea pigs. Proc Soc Exp Biol Med. 1991; 197:400-403.
4. Jiang ZY, Yang H, Guo ZM. Effects of Propafenone on physiologic properties of infant and adult rabbits. Pacemaker and Heart. 1990; 4:146-148.
5. Yang H, Guo ZM, Xu J. Non-invasive measurement of arterial pressure in the rabbit with a four post admittance measurement technique. Chinese Journal of Applied Physiology. 1989; 4:37-40.
6. Guo ZM, Yang H, Xu J. Evaluation of arterial elasticity with volumetric wave spread in human artery. Acta Academiae Hubei. 1989; 10:309-311.
7. Guo ZM, Xu J. Effects of verapamil on myocardial strength-duration relationship in juvenile and adult rabbits. Physiological News. 1988; 5:13-17.
8. Guo ZM, Yang H. Instantaneous acceleration of left ventricular pressure (d2p/dt2): A useful measurement for cardiac performance. Acta Physiologica Sinica. 1988; 41:102-110.
9. Yang H, Guo ZM, Zhang SZ. Experimental study of the therapeutic efficacy and adverse effects of drugs used to treat acute myocardial ischemia. Acta Academiae Hubei. 1986; 7:323-329.
10. Guo ZM, Zhang SZ. An application of the first and second derivative impedance cardiogram for evaluating myocardial ischemia. Journal of Chinese Physics in Medicine. 1985; 7:236-239.
11. Guo ZM, Zhang SZ. Analysis of the first and second derivative impedance cardiogram of human. Wuhan Medical Journal. 1984; 8:260-264.
12. Ren K, Guo ZM, Zhang GL. Effects of electroacupuncture on the efferent discharges of the splanchnic nerve in rabbits and its relation to central adrenergic receptors. Acupuncture Research. 1982; 3:209-215.
13. Guo ZM, Zhang GL. Effects of intracerebroventricular injection of naloxone on arterial pressure and the discharge of greater splanchnic nerves in hemorrhagic shock rabbits. Acta Academiae Hubei. 1981; 2:64-70.

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