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Hassan Ashktorab
Title Professor
Faculty Rank
Degree Ph.D
Institution Howard University
Department Medicine
Clusters Cancer
Address
Cancer Center Rm320
Howard University
2041 Georgia Ave
City Washington
State DC
Postal Code 20060
Telephone 202-806-6121
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Email
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Title Professor
Institution Howard University
Department Medicine
Division Cancer

Awards and Honors icon

2015 Jingsue University Jingsue University visiting professor

Narrative icon

  Gastroenterology cancer research group at HU Cancer Center

Dr. Hassan Ashktorab is Professor in the Departments of Medicine. He serves, or has served as the member of gastrointestinal working group in the Howard University Cancer Center, executive member of The Howard University Cancer Center, Adjunct Professor at The Department of Genetics and Human Genetics and the Director of Microarray facility at Howard University and former Chair of College of Medicine Research committee. He is a member of the Editorial boards of PLoS One, Digestive Diseases and Science, World Journal of Gastroenterology and Gouvaresh and former Editorial Board member of Gut. He has been awarded several NIH grants including RO3, RO1 and DOD grants. He received the HU-COM Outstanding Researcher Award in 2011. He has been a member of different NIH study sections since 2005. Dr. Ashktorab’s group focus is on epigenetics, genetics and epidemiology of gastrointestinal cancers especially colorectal cancer.

Gastroenterology Research:
Gastroenterology laboratory is investigating the molecular mechanisms governing cellular proliferation, including epigenetic and genetic influence during oncogenic transformation and tumorigenesis. The long term goals include the identification and characterization of epigenetic factors such as DNA methylation, miRNA and histone modifications that play a central and direct role in the initiation and/or progression of human cancers, specifically gastric and colon cancer. This includes research on chromatin modification through methylation or acetylation of genes/histones that may play critical roles in the regulation of transcription of many genes, leading to alteration of cell function and cell cycle. In addition, the detection of DNA methylation biomarkers for both early detection and prognosis is part of our interests using Next Generation Sequencing (NGS). We have recently detected several epigenetic biomarkers that are hypermethylated significantly in tumors from African Americans compared to Caucasians. Dr. Ashktorab’s translational/clinical research focuses on the African American population, investigating genomic instability and gene silencing in patients with adenoma and colorectal cancer. This is a critical step for the understanding of the onset of cancer progression in African Americans with the goal of tackling this health disparity in this population.

NGS is revolutionizing medicine and health care approaches. As it becomes cheaper and more accessible, more in-depth personalized genomic information will be available that dictates more appropriate and individualized approaches for both detection and treatment.
Dr. Ashktorab’s NGS research recently identified novel mutations in African Americans with colorectal cancer which were highlighted in the Journal Cancer. His group is working toward biomarkers identification in early to late colorectal carcinogenesis. One of the genes that is an early marker in colorectal carcinogenesis is APC. This gene is part of WNT pathway and his group found novel mutations in African Americans with colorectal cancer which is highlighted in Cancer and PNAS 2015.
The identification of these biomarkers will help in the detection, prognostic and treatment of the patients. The NGS research is followed by targeted exome sequencing for gene panels in detect colorectal cancer specifically in African Americans.
Much of the sporadic colorectal cancer’s underlying genetic mutations (driver genes) are unknown in patients from specific ethnic groups such as African Americans. We also reported the identification of distinct novel variants from adenoma and CRC patients in mismatch repair (MMR) genes MHS3 and MSH6, and in PIK3CA.

A new line of research was recently developed with Dr. Brim in the context of the role that the gut microbiota might play in the initiation and progression of colon neoplasia. Dr. Brim is a faculty at the Department of Pathology. Several publications have pointed to potential roles of specific bacteria in triggering genetic and epigenetic events such as those described in colon carcinogenesis. The primary goal of this line of research is to define specific bacteria that associate with higher risk of neoplasia. This will likely offer the opportunity to intervene at the gut microbiota’s level to reduce the risk of colon carcinogenesis.

We are also collaborating with Dr. Laiyemo, a gastroenterologist and Dr. Nouraie Faculty at the College of medicine, on several epidemiological studies that seek to assess factors at play in the adherence to colonoscopy and treatment in minority patients.

Along with our genetic, epigenetic, microbiomic and epidemiological studies that target colorectal cancer in African Americans, we are also investigating such a disease in other minorities such as Hispanics. We are also investigating other gastrointestinal diseases through several ongoing epidemiological studies such as hepatic fibrosis, hepatocellular carcinoma, gastroesophageal reflux disease, esophageal cancer and anal cancer in African Americans among several other projects.

Please visit PubMed for the recent publications.

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  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

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2007METHYLATION PROFILING AND RISK OF COLORECTAL CANCER3R01CA102681-05S1
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2003Mechanisms of Growth Inhibition by Helicobacter Pylor3R03DK056664-02S1
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Publications icon

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1. Yoon JH, Ham IH, Kim O, Ashktorab H, Smoot DT, Nam SW, Lee JY, Hur H, Park WS. Gastrokine 1 protein is a potential theragnostic target for gastric cancer. Gastric Cancer. 2018 Apr 27.
2. Sahin D, Taflan SO, Yartas G, Ashktorab H, Smoot DT. Screening and Identification of Peptides Specifically Targeted to Gastric Cancer Cells from a Phage Display Peptide Library Asian Pac J Cancer Prev. 2018 Apr 25; 19(4):927-932.
3. Choi W, Kim J, Park J, Lee DH, Hwang D, Kim JH, Ashktorab H, Smoot DT, Kim SY, Choi C, Koh GY, Lim DS. YAP/TAZ initiates gastric tumorigenesis via upregulation of MYC. Cancer Res. 2018 Apr 18.
4. Ashktorab H, Soleimani A, Nichols A, Sodhi K, Laiyemo AO, Nunlee-Bland G, Nouraie SM, Brim H. Adiponectin, Leptin, IGF-1, and Tumor Necrosis Factor Alpha As Potential Serum Biomarkers for Non-Invasive Diagnosis of Colorectal Adenoma in African Americans. Front Endocrinol (Lausanne). 2018; 9:77.
5. Zhang L, Hu W, Cho CH, Chan FK, Yu J, Ross Fitzgerald J, Cheung CK, Xiao ZG, Shen J, Li LF, Li MX, Wu JC, Ling TK, Chan JY, Ko H, Tse G, Ng SC, Yu S, Wang MH, Gin T, Ashktorab H, Smoot DT, Wong SH, Chan MT, Wu WK. Reduced lysosomal clearance of autophagosomes promotes survival and colonization of Helicobacter pylori. J Pathol. 2018 Apr; 244(4):432-444.
6. Mimura K, Teh JL, Okayama H, Shiraishi K, Kua LF, Koh V, Smoot DT, Ashktorab H, Oike T, Suzuki Y, Fazreen Z, Asuncion BR, Shabbir A, Yong WP, So J, Soong R, Kono K. PD-L1 expression is mainly regulated by interferon gamma associated with JAK-STAT pathway in gastric cancer. Cancer Sci. 2018 Jan; 109(1):43-53.
7. Brim H, Yooseph S, Lee E, Sherif ZA, Abbas M, Laiyemo AO, Varma S, Torralba M, Dowd SE, Nelson KE, Pathmasiri W, Sumner S, de Vos W, Liang Q, Yu J, Zoetendal E, Ashktorab H. A Microbiomic Analysis in African Americans with Colonic Lesions Reveals Streptococcus sp.VT162 as a Marker of Neoplastic Transformation. Genes (Basel). 2017 11 09; 8(11).
8. Kang MH, Jeong GS, Smoot DT, Ashktorab H, Hwang CM, Kim BS, Kim HS, Park YY. Verteporfin inhibits gastric cancer cell growth by suppressing adhesion molecule FAT1. Oncotarget. 2017 Nov 17; 8(58):98887-98897.
9. Ashktorab H, Azimi H, Varma S, Tavakoli P, Nickerson ML, Brim H. Distinctive DNA mismatch repair and APC rare variants in African Americans with colorectal neoplasia. Oncotarget. 2017 Nov 21; 8(59):99966-99977.
10. Ashktorab H, Kupfer SS, Brim H, Carethers JM. Racial Disparity in Gastrointestinal Cancer Risk. Gastroenterology. 2017 10; 153(4):910-923.
11. Afsari A, Lee E, Shokrani B, Boortalary T, Sherif ZA, Nouraie M, Laiyemo AO, Alkhalloufi K, Brim H, Ashktorab H. Clinical and Pathological Risk Factors Associated with Liver Fibrosis and Steatosis in African-Americans with Chronic Hepatitis C. Dig Dis Sci. 2017 08; 62(8):2159-2165.
12. Qamra A, Xing M, Padmanabhan N, Kwok JJT, Zhang S, Xu C, Leong YS, Lee Lim AP, Tang Q, Ooi WF, Suling Lin J, Nandi T, Yao X, Ong X, Lee M, Tay ST, Keng ATL, Gondo Santoso E, Ng CCY, Ng A, Jusakul A, Smoot D, Ashktorab H, Rha SY, Yeoh KG, Peng Yong W, Chow PKH, Chan WH, Ong HS, Soo KC, Kim KM, Wong WK, Rozen SG, Teh BT, Kappei D, Lee J, Connolly J, Tan P. Epigenomic Promoter Alterations Amplify Gene Isoform and Immunogenic Diversity in Gastric Adenocarcinoma. Cancer Discov. 2017 06; 7(6):630-651.
13. Sanabria-Salas MC, Hernández-Suárez G, Umaña-Pérez A, Rawlik K, Tenesa A, Serrano-López ML, Sánchez de Gómez M, Rojas MP, Bravo LE, Albis R, Plata JL, Green H, Borgovan T, Li L, Majumdar S, Garai J, Lee E, Ashktorab H, Brim H, Li L, Margolin D, Fejerman L, Zabaleta J. IL1B-CGTC haplotype is associated with colorectal cancer in admixed individuals with increased African ancestry. Sci Rep. 2017 Feb 03; 7:41920.
14. Kim O, Yoon JH, Choi WS, Ashktorab H, Smoot DT, Nam SW, Lee JY, Park WS. Heterodimeric interaction between GKN2 and TFF1 entails synergistic antiproliferative and pro-apoptotic effects on gastric cancer cells. Gastric Cancer. 2017 Sep; 20(5):772-783.
15. Ashktorab H, Mokarram P, Azimi H, Olumi H, Varma S, Nickerson ML, Brim H. Targeted exome sequencing reveals distinct pathogenic variants in Iranians with colorectal cancer. Oncotarget. 2017 Jan 31; 8(5):7852-7866.
16. Rath S, Das L, Kokate SB, Ghosh N, Dixit P, Rout N, Singh SP, Chattopadhyay S, Ashktorab H, Smoot DT, Swamy MM, Kundu TK, Crowe SE, Bhattacharyya A. Inhibition of histone/lysine acetyltransferase activity kills CoCl2-treated and hypoxia-exposed gastric cancer cells and reduces their invasiveness. Int J Biochem Cell Biol. 2017 01; 82:28-40.
17. Liang Q, Chiu J, Chen Y, Huang Y, Higashimori A, Fang J, Brim H, Ashktorab H, Ng SC, Ng SSM, Zheng S, Chan FKL, Sung JJY, Yu J. Fecal Bacteria Act as Novel Biomarkers for Noninvasive Diagnosis of Colorectal Cancer. Clin Cancer Res. 2017 04 15; 23(8):2061-2070.
18. Brim H, Ashktorab H. Genomics of Colorectal Cancer in African Americans. Next Gener Seq Appl. 2016 Sep; 3(2).
19. Ashktorab H, Shakoori A, Zarnogi S, Sun X, Varma S, Lee E, Shokrani B, Laiyemo AO, Washington K, Brim H. Reduced Representation Bisulfite Sequencing Determination of Distinctive DNA Hypermethylated Genes in the Progression to Colon Cancer in African Americans. Gastroenterol Res Pract. 2016; 2016:2102674.
20. Ashktorab H, Etaati F, Rezaeean F, Nouraie M, Paydar M, Namin HH, Sanderson A, Begum R, Alkhalloufi K, Brim H, Laiyemo AO. Can optical diagnosis of small colon polyps be accurate? Comparing standard scope without narrow banding to high definition scope with narrow banding. World J Gastroenterol. 2016 Jul 28; 22(28):6539-46.
21. Ashktorab H, Hermann P, Nouraie M, Shokrani B, Lee E, Haidary T, Brim H, Stein U. Increased MACC1 levels in tissues and blood identify colon adenoma patients at high risk. J Transl Med. 2016 07 20; 14(1):215.
22. Ashktorab H, Vilmenay K, Brim H, Laiyemo AO, Kibreab A, Nouraie M. Colorectal Cancer in Young African Americans: Is It Time to Revisit Guidelines and Prevention? Dig Dis Sci. 2016 10; 61(10):3026-3030.
23. Ashktorab H, Ahuja S, Kannan L, Llor X, Ellis NA, Xicola RM, Laiyemo AO, Carethers JM, Brim H, Nouraie M. A meta-analysis of MSI frequency and race in colorectal cancer. Oncotarget. 2016 Apr 23; 7(23):34546-57.
24. Sherif ZA, Saeed A, Ghavimi S, Nouraie SM, Laiyemo AO, Brim H, Ashktorab H. Global Epidemiology of Nonalcoholic Fatty Liver Disease and Perspectives on US Minority Populations. Dig Dis Sci. 2016 May; 61(5):1214-25.
25. Shahnazi A, Sanderson AK, Laiyemo AO, Nouraie M, Haidary T, Brim H, Geramfard S, Afsari A, Ashktorab H. Diabetes Mellitus and Pancreatic Cysts in African Americans. Pancreas. 2016 Apr; 45(4):e14-5.
26. Ashktorab H, Azimi H, Nickerson ML, Bass S, Varma S, Brim H. Targeted Exome Sequencing Outcome Variations of Colorectal Tumors within and across Two Sequencing Platforms. Next Gener Seq Appl. 2016 Jun; 3(1).
27. Ashktorab H, Ogundipe T, Brim H, Shahnazi A, Laiyemo AO, Lee E, Shokrani B, Nouraie M. Lymph nodes' evaluation in relation to colorectal cancer staging among African Americans. BMC Cancer. 2015 Dec 16; 15:976.
28. Ashktorab H, Laiyemo AO, Lee E, Cruz-Correa M, Ghuman A, Nouraie M, Brim H. Prevalence and features of colorectal lesions among Hispanics: A hospital-based study. World J Gastroenterol. 2015 Dec 14; 21(46):13095-100.
29. Laiyemo AO, Thompson N, Williams CD, Idowu KA, Bull-Henry K, Sherif ZA, Lee EL, Brim H, Ashktorab H, Platz EA, Smoot DT. Race and colorectal cancer screening compliance among persons with a family history of cancer. World J Gastrointest Endosc. 2015 Dec 10; 7(18):1300-5.
30. Nayani R, Ashktorab H, Brim H, Laiyemo AO. Genetic Basis for Colorectal Cancer Disparities. Curr Colorectal Cancer Rep. 2015 Dec 01; 11(6):408-413.
31. Nouraie M, Kansal V, Belfonte C, Ghazvini M, Haidari T, Shahnazi A, Brim H, Soliman EZ, Ashktorab H. Atrial Fibrillation and Colonic Neoplasia in African Americans. PLoS One. 2015; 10(8):e0135609.
32. Laiyemo AO, Burnside C, Laiyemo MA, Kwagyan J, Williams CD, Idowu KA, Ashktorab H, Kibreab A, Scott VF, Sanderson AK. Beverage intake preference and bowel preparation laxative taste preference for colonoscopy. World J Gastrointest Pharmacol Ther. 2015 Aug 06; 6(3):84-8.
33. Ashktorab H, Panchal H, Shokrani B, Paydar M, Sanderson A, Lee EL, Begum R, Haidary T, Laiyemo AO, McDonald-Pinkett S, Brim H, Nouraie M. Association between Diverticular Disease and Pre-Neoplastic Colorectal Lesions in an Urban African-American Population. Digestion. 2015; 92(2):60-5.
34. Ashktorab H, Varma S, Brim H. Next-generation sequencing in African Americans with colorectal cancer. Proc Natl Acad Sci U S A. 2015 Jun 02; 112(22):E2852.
35. Kim O, Yoon JH, Choi WS, Ashktorab H, Smoot DT, Nam SW, Lee JY, Park WS. Gastrokine 1 inhibits gastrin-induced cell proliferation. Gastric Cancer. 2016 Apr; 19(2):381-91.
36. Ashktorab H, Brim H. DNA Methylation and Colorectal Cancer. Curr Colorectal Cancer Rep. 2014 Dec 01; 10(4):425-430.
37. Ashktorab H, Daremipouran M, Devaney J, Varma S, Rahi H, Lee E, Shokrani B, Schwartz R, Nickerson ML, Brim H. Identification of novel mutations by exome sequencing in African American colorectal cancer patients. Cancer. 2015 Jan 01; 121(1):34-42.
38. Yoon JH, Seo HS, Choi SS, Chae HS, Choi WS, Kim O, Ashktorab H, Smoot DT, Nam SW, Lee JY, Park WS. Gastrokine 1 inhibits the carcinogenic potentials of Helicobacter pylori CagA. Carcinogenesis. 2014 Nov; 35(11):2619-29.
39. Laiyemo AO, Williams CD, Burnside C, Moghadam S, Sanasi-Bhola KD, Kwagyan J, Brim H, Ashktorab H, Scott VF, Smoot DT. Factors associated with attendance to scheduled outpatient endoscopy. Postgrad Med J. 2014 Oct; 90(1068):571-5.
40. Hor YT, Voon DC, Koo JK, Wang H, Lau WM, Ashktorab H, Chan SL, Ito Y. A role for RUNX3 in inflammation-induced expression of IL23A in gastric epithelial cells. Cell Rep. 2014 Jul 10; 8(1):50-8.
41. Lee KS, Park JL, Lee K, Richardson LE, Johnson BH, Lee HS, Lee JS, Kim SB, Kwon OH, Song KS, Kim YS, Ashktorab H, Smoot DT, Jeon SH, Kim SY, Lee YS. nc886, a non-coding RNA of anti-proliferative role, is suppressed by CpG DNA methylation in human gastric cancer. Oncotarget. 2014 Jun 15; 5(11):3944-55.
42. Kim O, Yoon JH, Choi WS, Ashktorab H, Smoot DT, Nam SW, Lee JY, Park WS. GKN2 contributes to the homeostasis of gastric mucosa by inhibiting GKN1 activity. J Cell Physiol. 2014 Jun; 229(6):762-71.
43. Shim JH, Yoon JH, Choi SS, Ashktorab H, Smoot DT, Song KY, Nam SW, Lee JY, Park CH, Park WS. The effect of Helicobacter pylori CagA on the HER-2 copy number and expression in gastric cancer. Gene. 2014 Aug 10; 546(2):288-96.
44. Brim H, Zahaf M, Laiyemo AO, Nouraie M, Pérez-Pérez GI, Smoot DT, Lee E, Razjouyan H, Ashktorab H. Gastric Helicobacter pylori infection associates with an increased risk of colorectal polyps in African Americans. BMC Cancer. 2014 Apr 28; 14:296.
45. Ashktorab H, Paydar M, Yazdi S, Namin HH, Sanderson A, Begum R, Semati M, Etaati F, Lee E, Brim H, Zenebe A, Nunlee-Bland G, Laiyemo AO, Nouraie M. BMI and the risk of colorectal adenoma in African-Americans. Obesity (Silver Spring). 2014 May; 22(5):1387-91.
46. Brim H, Abu-Asab MS, Nouraie M, Salazar J, Deleo J, Razjouyan H, Mokarram P, Schaffer AA, Naghibhossaini F, Ashktorab H. An integrative CGH, MSI and candidate genes methylation analysis of colorectal tumors. PLoS One. 2014; 9(1):e82185.
47. Shin JY, Kim YI, Cho SJ, Lee MK, Kook MC, Lee JH, Lee SS, Ashktorab H, Smoot DT, Ryu KW, Kim YW, Choi IJ. MicroRNA 135a suppresses lymph node metastasis through down-regulation of ROCK1 in early gastric cancer. PLoS One. 2014; 9(1):e85205.
48. Ashktorab H, Daremipouran M, Goel A, Varma S, Leavitt R, Sun X, Brim H. DNA methylome profiling identifies novel methylated genes in African American patients with colorectal neoplasia. Epigenetics. 2014 Apr; 9(4):503-12.
49. Brim H, Yooseph S, Zoetendal EG, Lee E, Torralbo M, Laiyemo AO, Shokrani B, Nelson K, Ashktorab H. Microbiome analysis of stool samples from African Americans with colon polyps. PLoS One. 2013; 8(12):e81352.
50. Fatemi M, Paul TA, Brodeur GM, Shokrani B, Brim H, Ashktorab H. Epigenetic silencing of CHD5, a novel tumor-suppressor gene, occurs in early colorectal cancer stages. Cancer. 2014 Jan 15; 120(2):172-80.
51. Ashktorab H, Paydar M, Namin HH, Sanderson A, Begum R, Brim H, Panchal H, Lee E, Kibreab A, Nouraie M, Laiyemo AO. Prevalence of colorectal neoplasia among young African Americans and Hispanic Americans. Dig Dis Sci. 2014 Feb; 59(2):446-50.
52. Yoon JH, Cho ML, Choi YJ, Back JY, Park MK, Lee SW, Choi BJ, Ashktorab H, Smoot DT, Nam SW, Lee JY, Park WS. Gastrokine 1 regulates NF-?B signaling pathway and cytokine expression in gastric cancers. J Cell Biochem. 2013 Aug; 114(8):1800-9.
53. Yoon JH, Choi YJ, Choi WS, Ashktorab H, Smoot DT, Nam SW, Lee JY, Park WS. GKN1-miR-185-DNMT1 axis suppresses gastric carcinogenesis through regulation of epigenetic alteration and cell cycle. Clin Cancer Res. 2013 Sep 01; 19(17):4599-610.
54. Ashktorab H, Rahi H, Wansley D, Varma S, Shokrani B, Lee E, Daremipouran M, Laiyemo A, Goel A, Carethers JM, Brim H. Toward a comprehensive and systematic methylome signature in colorectal cancers. Epigenetics. 2013 Aug; 8(8):807-15.
55. Ashktorab H, Hassanzadeh Namin H, Taylor T, Williams C, Brim H, Mellman T, Shokrani B, Holt CL, Laiyemo AO, Nouraie M. Role of life events in the presence of colon polyps among African Americans. BMC Gastroenterol. 2013 Jun 12; 13:101.
56. Marimuthu A, Subbannayya Y, Sahasrabuddhe NA, Balakrishnan L, Syed N, Sekhar NR, Katte TV, Pinto SM, Srikanth SM, Kumar P, Pawar H, Kashyap MK, Maharudraiah J, Ashktorab H, Smoot DT, Ramaswamy G, Kumar RV, Cheng Y, Meltzer SJ, Roa JC, Chaerkady R, Prasad TS, Harsha HC, Chatterjee A, Pandey A. SILAC-based quantitative proteomic analysis of gastric cancer secretome. Proteomics Clin Appl. 2013 Jun; 7(5-6):355-66.
57. Errami Y, Brim H, Oumouna-Benachour K, Oumouna M, Naura AS, Kim H, Ju J, Davis CJ, Kim JG, Ashktorab H, Fallon K, Xu M, Zhang J, Del Valle L, Boulares AH. ICAD deficiency in human colon cancer and predisposition to colon tumorigenesis: linkage to apoptosis resistance and genomic instability. PLoS One. 2013; 8(2):e57871.
58. Laiyemo AO, Doubeni C, Brim H, Ashktorab H, Schoen RE, Gupta S, Charabaty A, Lanza E, Smoot DT, Platz E, Cross AJ. Short- and long-term risk of colorectal adenoma recurrence among whites and blacks. Gastrointest Endosc. 2013 Mar; 77(3):447-54.
59. Mitchell BD, Lee WJ, Tolea MI, Shields K, Ashktorab Z, Magder LS, Ryan KA, Pollin TI, McArdle PF, Shuldiner AR, Schäffer AA. Living the good life? Mortality and hospital utilization patterns in the Old Order Amish. PLoS One. 2012; 7(12):e51560.
60. Yang Y, Toy W, Choong LY, Hou P, Ashktorab H, Smoot DT, Yeoh KG, Lim YP. Discovery of SLC3A2 cell membrane protein as a potential gastric cancer biomarker: implications in molecular imaging. J Proteome Res. 2012 Dec 07; 11(12):5736-47.
61. Ashktorab H, Entezari O, Nouraie M, Dowlati E, Frederick W, Woods A, Lee E, Brim H, Smoot DT, Ghadyari F, Kamangar F, Razjouyan H. Helicobacter pylori protection against reflux esophagitis. Dig Dis Sci. 2012 Nov; 57(11):2924-8.
62. Ramachandran L, Manu KA, Shanmugam MK, Li F, Siveen KS, Vali S, Kapoor S, Abbasi T, Surana R, Smoot DT, Ashktorab H, Tan P, Ahn KS, Yap CW, Kumar AP, Sethi G. Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor ? activation pathway in gastric cancer. J Biol Chem. 2012 Nov 02; 287(45):38028-40.
63. Wang R, Löhr CV, Fischer K, Dashwood WM, Greenwood JA, Ho E, Williams DE, Ashktorab H, Dashwood MR, Dashwood RH. Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer. Int J Cancer. 2013 Mar 01; 132(5):1004-12.
64. Brim H, Lee E, Abu-Asab MS, Chaouchi M, Razjouyan H, Namin H, Goel A, Schäffer AA, Ashktorab H. Genomic aberrations in an African American colorectal cancer cohort reveals a MSI-specific profile and chromosome X amplification in male patients. PLoS One. 2012; 7(8):e40392.
65. Cheng Y, Jin Z, Agarwal R, Ma K, Yang J, Ibrahim S, Olaru AV, David S, Ashktorab H, Smoot DT, Duncan MD, Hutcheon DF, Abraham JM, Meltzer SJ, Mori Y. LARP7 is a potential tumor suppressor gene in gastric cancer. Lab Invest. 2012 Jul; 92(7):1013-9.
66. Ashktorab H, Green W, Finzi G, Sessa F, Nouraie M, Lee EL, Morgano A, Moschetta A, Cattaneo M, Mariani-Costantini R, Brim H, Biunno I. SEL1L, an UPR response protein, a potential marker of colonic cell transformation. Dig Dis Sci. 2012 Apr; 57(4):905-12.
67. Kwagyan J, Apprey V, Ashktorab H. Linkage disequilibrium and haplotype analysis of COX-2 and risk of colorectal adenoma development. Clin Transl Sci. 2012 Feb; 5(1):60-4.
68. Cai C, Ashktorab H, Pang X, Zhao Y, Sha W, Liu Y, Gu X. MicroRNA-211 expression promotes colorectal cancer cell growth in vitro and in vivo by targeting tumor suppressor CHD5. PLoS One. 2012; 7(1):e29750.
69. Ashktorab H, Nguza B, Fatemi M, Nouraie M, Smoot DT, Schäffer AA, Kupfer SS, Camargo CA, Brim H. Case-control study of vitamin D, dickkopf homolog 1 (DKK1) gene methylation, VDR gene polymorphism and the risk of colon adenoma in African Americans. PLoS One. 2011; 6(10):e25314.
70. Ashktorab H, Nouri Z, Nouraie M, Razjouyan H, Lee EE, Dowlati E, El-Seyed el-W, Laiyemo A, Brim H, Smoot DT. Esophageal carcinoma in African Americans: a five-decade experience. Dig Dis Sci. 2011 Dec; 56(12):3577-82.
71. Brim H, Kumar K, Nazarian J, Hathout Y, Jafarian A, Lee E, Green W, Smoot D, Park J, Nouraie M, Ashktorab H. SLC5A8 gene, a transporter of butyrate: a gut flora metabolite, is frequently methylated in African American colon adenomas. PLoS One. 2011; 6(6):e20216.
72. Tao J, Deng NT, Ramnarayanan K, Huang B, Oh HK, Leong SH, Lim SS, Tan IB, Ooi CH, Wu J, Lee M, Zhang S, Rha SY, Chung HC, Smoot DT, Ashktorab H, Kon OL, Cacheux V, Yap C, Palanisamy N, Tan P. CD44-SLC1A2 gene fusions in gastric cancer. Sci Transl Med. 2011 Apr 06; 3(77):77ra30.
73. Ahmadi L, Kamkari S, Mokarram P, Lankarani KB, Tabibi N, Ashktorab H, Vasei M. HER-2/neu and E-cadherin Expression and Microsatellite Instability in Gastric Dysplasia. Middle East J Dig Dis. 2011 Mar; 3(1):20-7.
74. Wang R, Dashwood WM, Nian H, Löhr CV, Fischer KA, Tsuchiya N, Nakagama H, Ashktorab H, Dashwood RH. NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Int J Cancer. 2011 Jun 01; 128(11):2581-90.
75. Yang Y, Yixuan Y, Lim SK, Kiat LS, Choong LY, Yee CL, Lee H, Huiyin L, Chen Y, Yunhao C, Chong PK, Kuan CP, Ashktorab H, Hassan A, Wang TT, Ting WT, Salto-Tellez M, Manuel ST, Yeoh KG, Guan YK, Lim YP, Pin LY. Cathepsin S mediates gastric cancer cell migration and invasion via a putative network of metastasis-associated proteins. J Proteome Res. 2010 Sep 03; 9(9):4767-78.
76. Chong PK, Lee H, Loh MC, Choong LY, Lin Q, So JB, Lim KH, Soo RA, Yong WP, Chan SP, Smoot DT, Ashktorab H, Yeoh KG, Lim YP. Upregulation of plasma C9 protein in gastric cancer patients. Proteomics. 2010 Sep; 10(18):3210-21.
77. Zhang L, Hou Y, Ashktorab H, Gao L, Xu Y, Wu K, Zhai J, Zhang L. The impact of C-MYC gene expression on gastric cancer cell. Mol Cell Biochem. 2010 Nov; 344(1-2):125-35.
78. Chong PK, Lee H, Zhou J, Liu SC, Loh MC, Wang TT, Chan SP, Smoot DT, Ashktorab H, So JB, Lim KH, Yeoh KG, Lim YP. ITIH3 is a potential biomarker for early detection of gastric cancer. J Proteome Res. 2010 Jul 02; 9(7):3671-9.
79. Nouraie M, Hosseinkhah F, Brim H, Zamanifekri B, Smoot DT, Ashktorab H. Clinicopathological features of colon polyps from African-Americans. Dig Dis Sci. 2010 May; 55(5):1442-9.
80. Naghibalhossaini F, Mokarram P, Khalili I, Vasei M, Hosseini SV, Ashktorab H, Rasti M, Abdollahi K. MTHFR C677T and A1298C variant genotypes and the risk of microsatellite instability among Iranian colorectal cancer patients. Cancer Genet Cytogenet. 2010 Mar; 197(2):142-51.
81. Ashktorab H, Schäffer AA, Daremipouran M, Smoot DT, Lee E, Brim H. Distinct genetic alterations in colorectal cancer. PLoS One. 2010 Jan 26; 5(1):e8879.
82. Smoot DT, Collins J, Dunlap S, Ali-Ibrahim A, Nouraie M, Lee EL, Ashktorab H. Outcome of colonoscopy in elderly African-American patients. Dig Dis Sci. 2009 Nov; 54(11):2484-7.
83. Mokarram P, Kumar K, Brim H, Naghibalhossaini F, Saberi-firoozi M, Nouraie M, Green R, Lee E, Smoot DT, Ashktorab H. Distinct high-profile methylated genes in colorectal cancer. PLoS One. 2009 Sep 11; 4(9):e7012.
84. Ashktorab H, Nouraie M, Hosseinkhah F, Lee E, Rotimi C, Smoot D. A 50-year review of colorectal cancer in African Americans: implications for prevention and treatment. Dig Dis Sci. 2009 Sep; 54(9):1985-90.
85. Kumar K, Brim H, Giardiello F, Smoot DT, Nouraie M, Lee EL, Ashktorab H. Distinct BRAF (V600E) and KRAS mutations in high microsatellite instability sporadic colorectal cancer in African Americans. Clin Cancer Res. 2009 Feb 15; 15(4):1155-61.
86. Ashktorab H, Belgrave K, Hosseinkhah F, Brim H, Nouraie M, Takkikto M, Hewitt S, Lee EL, Dashwood RH, Smoot D. Global histone H4 acetylation and HDAC2 expression in colon adenoma and carcinoma. Dig Dis Sci. 2009 Oct; 54(10):2109-17.
87. Ashktorab H, Dashwood RH, Dashwood MM, Zaidi SI, Hewitt SM, Green WR, Lee EL, Daremipouran M, Nouraie M, Malekzadeh R, Smoot DT. H. pylori-induced apoptosis in human gastric cancer cells mediated via the release of apoptosis-inducing factor from mitochondria. Helicobacter. 2008 Dec; 13(6):506-17.
88. Ashktorab H, Tsang S, Luke B, Sun Z, Adam-Campbell L, Kwagyan J, Poirier R, Akter S, Akhgar A, Smoot D, Munroe DJ, Ali IU. Protective effect of Cox-2 allelic variants on risk of colorectal adenoma development in African Americans. Anticancer Res. 2008 Sep-Oct; 28(5B):3119-23.
89. Brim H, Mokarram P, Naghibalhossaini F, Saberi-Firoozi M, Al-Mandhari M, Al-Mawaly K, Al-Mjeni R, Al-Sayegh A, Raeburn S, Lee E, Giardiello F, Smoot DT, Vilkin A, Boland CR, Goel A, Hafezi M, Nouraie M, Ashktorab H. Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study. Mol Cancer. 2008 Aug 21; 7:68.
90. Ashktorab H, Brim H, Al-Riyami M, Date A, Al-Mawaly K, Kashoub M, Al-Mjeni R, Smoot DT, Al-Moundhri M, Al-Hashemi S, Ganguly SS, Raeburn S. Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects. Dig Dis Sci. 2008 Oct; 53(10):2723-31.
91. Ashktorab H, Daremipouran M, Wilson M, Siddiqi S, Lee EL, Rakhshani N, Malekzadeh R, Johnson AC, Hewitt SM, Smoot DT. Transactivation of the EGFR by AP-1 is induced by Helicobacter pylori in gastric cancer. Am J Gastroenterol. 2007 Oct; 102(10):2135-46.
92. Ashktorab H, Begum R, Akhgar A, Smoot DT, Elbedawi M, Daremipouran M, Zhao A, Momen B, Giardiello FM. Folate status and risk of colorectal polyps in African Americans. Dig Dis Sci. 2007 Jun; 52(6):1462-70.
93. Siavoshi F, Malekzadeh R, Daneshmand M, Ashktorab H. Helicobacter pylori endemic and gastric disease. Dig Dis Sci. 2005 Nov; 50(11):2075-80.
94. Ashktorab H, Smoot DT, Farzanmehr H, Fidelia-Lambert M, Momen B, Hylind L, Iacosozio-Dononue C, Carethers JM, Goel A, Boland CR, Giardiello FM. Clinicopathological features and microsatellite instability (MSI) in colorectal cancers from African Americans. Int J Cancer. 2005 Oct 10; 116(6):914-9.
95. Ashktorab H, Dawkins FW, Mohamed R, Larbi D, Smoot DT. Apoptosis induced by aspirin and 5-fluorouracil in human colonic adenocarcinoma cells. Dig Dis Sci. 2005 Jun; 50(6):1025-32.
96. Siavoshi F, Malekzadeh R, Daneshmand M, Smoot DT, Ashktorab H. Association between Helicobacter pylori Infection in gastric cancer, ulcers and gastritis in Iranian patients. Helicobacter. 2004 Oct; 9(5):470.
97. Ashktorab H, Frank S, Khaled AR, Durum SK, Kifle B, Smoot DT. Bax translocation and mitochondrial fragmentation induced by Helicobacter pylori. Gut. 2004 Jun; 53(6):805-13.
98. Ashktorab H, Ahmed A, Littleton G, Wang XW, Allen CR, Tackey R, Walters C, Smoot DT. p53 and p14 increase sensitivity of gastric cells to H. pylori-induced apoptosis. Dig Dis Sci. 2003 Jul; 48(7):1284-91.
99. Ashktorab H, Smoot DT, Carethers JM, Rahmanian M, Kittles R, Vosganian G, Doura M, Nidhiry E, Naab T, Momen B, Shakhani S, Giardiello FM, Shakhani S. High incidence of microsatellite instability in colorectal cancer from African Americans. Clin Cancer Res. 2003 Mar; 9(3):1112-7.
100. Marlink KL, Bacon KD, Sheppard BC, Ashktorab H, Smoot DT, Cover TL, Deveney CW, Rutten MJ. Effects of Helicobacter pylori on intracellular Ca2+ signaling in normal human gastric mucous epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2003 Jul; 285(1):G163-76.
101. Ashktorab H, Neapolitano M, Bomma C, Allen C, Ahmed A, Dubois A, Naab T, Smoot DT. In vivo and in vitro activation of caspase-8 and -3 associated with Helicobacter pylori infection. Microbes Infect. 2002 Jun; 4(7):713-22.
102. Akhtar M, Cheng Y, Magno RM, Ashktorab H, Smoot DT, Meltzer SJ, Wilson KT. Promoter methylation regulates Helicobacter pylori-stimulated cyclooxygenase-2 expression in gastric epithelial cells. Cancer Res. 2001 Mar 15; 61(6):2399-403.
103. Smoot DT, Elliott TB, Verspaget HW, Jones D, Allen CR, Vernon KG, Bremner T, Kidd LC, Kim KS, Groupman JD, Ashktorab H. Influence of Helicobacter pylori on reactive oxygen-induced gastric epithelial cell injury. Carcinogenesis. 2000 Nov; 21(11):2091-5.
104. Ahmed A, Smoot D, Littleton G, Tackey R, Walters CS, Kashanchi F, Allen CR, Ashktorab H. Helicobacter pylori inhibits gastric cell cycle progression. Microbes Infect. 2000 Aug; 2(10):1159-69.
105. Smoot DT, Wynn Z, Elliott TB, Allen CR, Mekasha G, Naab T, Ashktorab H. Effects of Helicobacter pylori on proliferation of gastric epithelial cells in vitro. Am J Gastroenterol. 1999 Jun; 94(6):1508-11.
106. Smoot DT, Hinds T, Ashktorab H, Jagtap J, Kim KS, Scott VF. Effectiveness of ranitidine bismuth citrate, clarithromycin, and metronidazole therapy for treating Helicobacter pylori. Am J Gastroenterol. 1999 Apr; 94(4):955-8.
107. Ashktorab H, Cohen RJ. Facile isolation of genomic DNA from filamentous fungi. Biotechniques. 1992 Aug; 13(2):198-200.
108. Gazitt Y, He YJ, Erdos GW, Chang L, Ashktorab H, Cohen RJ. Development of a two color immunofluorescence stain and immunolocalization method for N-myc and c-myc oncoproteins with a newly generated mouse IgM anti N-myc antibody. J Immunol Methods. 1992 Apr 08; 148(1-2):159-69.
109. Jensen SL, Ashktorab H, Hughes JE, Welker DL. Gene amplification associated with the dominant cob-354 cobalt resistance trait in Dictyostelium discoideum. Mol Gen Genet. 1989 Dec; 220(1):25-32.
110. Ashktorab H, Srivastava A. Identification of nuclear proteins that specifically interact with adeno-associated virus type 2 inverted terminal repeat hairpin DNA. J Virol. 1989 Jul; 63(7):3034-9.
111. Ashktorab H, Welker DL. Establishment of the nuclear location of Dictyostelium discoideum plasmids. Gene. 1988 May 15; 65(1):41-9.

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