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Olorunseun Ogunwobi
Title Dr.
Faculty Rank Associate Professor
Degree MD, PhD
Institution Hunter College, CUNY
Department Biological Sciences
Clusters Cancer
Address
695 Park Avenue
Room 932HN
City New York
State NY
Postal Code 10065
Telephone 212-396-6820
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2017 Carnegie Corporation of New York Carnegie African Diaspora Fellowship

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  The overall goal of our laboratory is to elucidate the mechanisms of metastasis in solid organ cancers. Ongoing studies include examination of the role of circulating tumor cell biology and epigenetics in the metastasis of solid organ cancers. Also, our laboratory is investigating the biological mechanisms underlying the racial disparities in specific solid organ cancers. The cancer models we are currently focused on are hepatocellular carcinoma, pancreatic cancer, colon cancer, and prostate cancer.

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1. Lee M, Zhu L, Wang MQ, Wei Z, Tan Y, Nguyen MT, Ogunwobi OO, Ma GX. Psychosocial Predictors of HBV Screening Behavior among Vietnamese Americans. Am J Health Behav. 2017 Sep 01; 41(5):561-570.
2. Luu HN, Lin HY, Sørensen KD, Ogunwobi OO, Kumar N, Chornokur G, Phelan C, Jones D, Kidd L, Batra J, Yamoah K, Berglund A, Rounbehler RJ, Yang M, Lee SH, Kang N, Kim SJ, Park JY, Di Pietro G. miRNAs associated with prostate cancer risk and progression. BMC Urol. 2017 Mar 20; 17(1):18.
3. Das DK, Ogunwobi OO. A novel microRNA-1207-3p/FNDC1/FN1/AR regulatory pathway in prostate cancer. RNA Dis. 2017; 4(1).
4. Das DK, Ali T, Krampis K, Ogunwobi OO. Fibronectin and androgen receptor expression data in prostate cancer obtained from a RNA-sequencing bioinformatics analysis. Data Brief. 2017 Apr; 11:131-135.
5. Das DK, Naidoo M, Ilboudo A, Park JY, Ali T, Krampis K, Robinson BD, Osborne JR, Ogunwobi OO. miR-1207-3p regulates the androgen receptor in prostate cancer via FNDC1/fibronectin. Exp Cell Res. 2016 Nov 01; 348(2):190-200.
6. Spratt DE, Chan T, Waldron L, Speers C, Feng FY, Ogunwobi OO, Osborne JR. Racial/Ethnic Disparities in Genomic Sequencing. JAMA Oncol. 2016 Aug 01; 2(8):1070-4.
7. Das DK, Osborne JR, Lin HY, Park JY, Ogunwobi OO. miR-1207-3p Is a Novel Prognostic Biomarker of Prostate Cancer. Transl Oncol. 2016 Jun; 9(3):236-41.
8. Ilboudo A, Chouhan J, McNeil BK, Osborne JR, Ogunwobi OO. PVT1 Exon 9: A Potential Biomarker of Aggressive Prostate Cancer? Int J Environ Res Public Health. 2015 Dec 22; 13(1):ijerph13010012.
9. Das DK, Durojaiye V, Ilboudo A, Naidoo MK, Ogunwobi O. A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis. J Vis Exp. 2015 Oct 24; (105):e52858.
10. Das DK, Naidoo MK, Ilboudo A, DuBois P, Durojaiye V, Liu C, Ogunwobi OO. Isolation and Propagation of Circulating Tumor Cells from a Mouse Cancer Model. J Vis Exp. 2015 Oct 09; (104).
11. George TJ, Ogunwobi OO, Sheng W, Fan ZH, Liu C. "Tissue is the issue": circulating tumor cells in pancreatic cancer. J Gastrointest Cancer. 2014 Dec; 45 Suppl 1:222-5.
12. Sheng W, Ogunwobi OO, Chen T, Zhang J, George TJ, Liu C, Fan ZH. Capture, release and culture of circulating tumor cells from pancreatic cancer patients using an enhanced mixing chip. Lab Chip. 2014 Jan 07; 14(1):89-98.
13. Beales ILP, Garcia-Morales C, Ogunwobi OO, Mutungi G. Adiponectin inhibits leptin-induced oncogenic signalling in oesophageal cancer cells by activation of PTP1B. Mol Cell Endocrinol. 2014 Jan 25; 382(1):150-158.
14. Ogunwobi OO, Puszyk W, Dong HJ, Liu C. Epigenetic upregulation of HGF and c-Met drives metastasis in hepatocellular carcinoma. PLoS One. 2013; 8(5):e63765.
15. Zhao X, Tian C, Puszyk WM, Ogunwobi OO, Cao M, Wang T, Cabrera R, Nelson DR, Liu C. OPA1 downregulation is involved in sorafenib-induced apoptosis in hepatocellular carcinoma. Lab Invest. 2013 Jan; 93(1):8-19.
16. Ogunwobi OO, Wang T, Zhang L, Liu C. Cyclooxygenase-2 and Akt mediate multiple growth-factor-induced epithelial-mesenchymal transition in human hepatocellular carcinoma. J Gastroenterol Hepatol. 2012 Mar; 27(3):566-78.
17. Ogunwobi OO, Liu C. Therapeutic and prognostic importance of epithelial-mesenchymal transition in liver cancers: insights from experimental models. Crit Rev Oncol Hematol. 2012 Sep; 83(3):319-28.
18. Zhao X, Ogunwobi OO, Liu C. Survivin inhibition is critical for Bcl-2 inhibitor-induced apoptosis in hepatocellular carcinoma cells. PLoS One. 2011; 6(8):e21980.
19. Ogunwobi OO, Liu C. Hepatocyte growth factor upregulation promotes carcinogenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via Akt and COX-2 pathways. Clin Exp Metastasis. 2011 Dec; 28(8):721-31.
20. Beales IL, Ogunwobi OO. Microsomal prostaglandin E synthase-1 inhibition blocks proliferation and enhances apoptosis in oesophageal adenocarcinoma cells without affecting endothelial prostacyclin production. Int J Cancer. 2010 May 01; 126(9):2247-55.
21. Sirica AE, Dumur CI, Campbell DJ, Almenara JA, Ogunwobi OO, Dewitt JL. Intrahepatic cholangiocarcinoma progression: prognostic factors and basic mechanisms. Clin Gastroenterol Hepatol. 2009 Nov; 7(11 Suppl):S68-78.
22. Beales IL, Ogunwobi OO. Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation. J Mol Endocrinol. 2009 Apr; 42(4):305-18.
23. Ogunwobi OO, Beales IL. Glycine-extended gastrin stimulates proliferation via JAK2- and Akt-dependent NF-kappaB activation in Barrett's oesophageal adenocarcinoma cells. Mol Cell Endocrinol. 2008 Dec 16; 296(1-2):94-102.
24. Ogunwobi OO, Beales IL. Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells. Am J Gastroenterol. 2008 Apr; 103(4):825-37.
25. Ogunwobi OO, Beales IL. Globular adiponectin, acting via adiponectin receptor-1, inhibits leptin-stimulated oesophageal adenocarcinoma cell proliferation. Mol Cell Endocrinol. 2008 Mar 26; 285(1-2):43-50.
26. Ogunwobi OO, Beales IL. Leptin stimulates the proliferation of human oesophageal adenocarcinoma cells via HB-EGF and Tgfalpha mediated transactivation of the epidermal growth factor receptor. Br J Biomed Sci. 2008; 65(3):121-7.
27. Beales IL, Ogunwobi O, Cameron E, El-Amin K, Mutungi G, Wilkinson M. Activation of Akt is increased in the dysplasia-carcinoma sequence in Barrett's oesophagus and contributes to increased proliferation and inhibition of apoptosis: a histopathological and functional study. BMC Cancer. 2007 Jun 08; 7:97.
28. Beales IL, Ogunwobi OO. Leptin synergistically enhances the anti-apoptotic and growth-promoting effects of acid in OE33 oesophageal adenocarcinoma cells in culture. Mol Cell Endocrinol. 2007 Aug 15; 274(1-2):60-8.
29. Ogunwobi OO, Beales IL. Cyclo-oxygenase-independent inhibition of apoptosis and stimulation of proliferation by leptin in human colon cancer cells. Dig Dis Sci. 2007 Aug; 52(8):1934-45.
30. Ogunwobi OO, Beales IL. The role of adiponectin in colitis. Gastroenterology. 2007 Mar; 132(3):1199-200; author reply 1200-1.
31. Beales IL, Ogunwobi O. Adipokines and gastrointestinal disease. Aliment Pharmacol Ther. 2006 Oct 01; 24(7):1127-8; author reply 1129-31.
32. Ogunwobi OO, Beales IL. The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt. Int J Colorectal Dis. 2007 Apr; 22(4):401-9.
33. Ogunwobi O, Mutungi G, Beales IL. Leptin stimulates proliferation and inhibits apoptosis in Barrett's esophageal adenocarcinoma cells by cyclooxygenase-2-dependent, prostaglandin-E2-mediated transactivation of the epidermal growth factor receptor and c-Jun NH2-terminal kinase activation. Endocrinology. 2006 Sep; 147(9):4505-16.
34. Ogunwobi OO, Beales IL. Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells. Regul Pept. 2006 May 15; 134(2-3):105-13.
35. Beales IL, Ogunwobi O. Glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of Akt and JNK pathways. Mol Cell Endocrinol. 2006 Mar 09; 247(1-2):140-9.
36. Ogunwobi OO, Beales IL. Glycine-extended gastrin stimulates proliferation and inhibits apoptosis in colon cancer cells via cyclo-oxygenase-independent pathways. Regul Pept. 2006 Mar 15; 134(1):1-8.

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Keywords
Esophageal Neoplasms
Adenocarcinoma
Apoptosis
Leptin
Carcinoma, Hepatocellular
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