PROFILES - Connect with RTRN Researchers

Qing Li
Title Professor, Director of Proteomics Core
Faculty Rank Full
Degree PhD
Institution University of Hawaii
Department Molecular Biosciences and Bioengineering
Clusters Genes and Environmental Health/Toxicology
Informatics
Address
1955 East-West Road
Agric Science Building Room 218
City Honolulu
State HI
Postal Code 96822
Telephone 8089562011
Fax 8089563542
Email
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Narrative icon

  I received Ph.D. in Agricultural and Environmental Chemistry from the University of California at Davis in 1990 and then post-doctoral training in UC-Berkeley. I joined the University of Hawaii at Manoa in 1995 as an assistant professor, was tenured and promoted to an associate professor in 1999 and to a full professor in 2002. I served as Director of pesticide residue chemistry laboratory (USDA-IR4 lab) in the Department of Molecular Biosciences and Bioengineering, UH-Manoa between 1995 and 2013. Since 2011, I have served as Director of UH Proteomics Core Facility.
My research is centered on agrochemicals and foods for human and environment health. Proteomics is used as a tool for the studies. My research has resulted in over 280 peer-reviewed scientific publications and 42 technical reports. I have mentored 15 MS students, 18 PhD students, 27 post-doctoral fellows and 20 researchers. I have hosted 30 visiting professors and scholars for research.
Current research
1. Palm peroxidases and glycoproteomics. We isolate, clone, engineer and express palm peroxidases for “green” synthesis of conductive polymers, biosensing and remediation. We use mass spectrometry to study plant glycoprotein heterogeneity, glycoforms and structure and activity relationship.
2. Pharmaceuticals. We isolate and characterize natural products and synthesize GSK3 inhibitors for Alzheimer’s disease and mechanisms of action.
3. Agrochemicals: biomonitoring, biotransformation, environmental fate and food safety. We study pesticides and pollutants in foods and the environment. We develop new immunoassays and other analytical methods. We study gas chromatography separation. We isolate novel bacteria, Archaea and fungi for bioremediation of agrochemicals and biosynthesis of high value products. We also study biocontamination of biofuels and blended fuels.

Websites
http://www.ctahr.hawaii.edu/mbbe/faculty/li.html
http://manoa.hawaii.edu/jabsom/proteomics

Publications icon

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1. Fu B, Baker MR, Li QX. Effect of N-Linked Glycosylation of Recombinant Windmill Palm Tree Peroxidase on Its Activity and Stability. J Agric Food Chem. 2018 May 02; 66(17):4414-4421.
2. Doello S, Liang Z, Cho IK, Kim JB, Li QX. Cytotoxic Effects of 24-Methylenecyloartanyl Ferulate on A549 Nonsmall Cell Lung Cancer Cells through MYBBP1A Up-Regulation and AKT and Aurora B Kinase Inhibition. J Agric Food Chem. 2018 Apr 11; 66(14):3726-3733.
3. Liang Z, Li QX. p-Cation Interactions in Molecular Recognition: Perspectives on Pharmaceuticals and Pesticides. J Agric Food Chem. 2018 Apr 04; 66(13):3315-3323.
4. Liang Z, Li QX. Discovery of Selective, Substrate-Competitive, and Passive Membrane Permeable Glycogen Synthase Kinase-3ß Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling of New C-Glycosylflavones. ACS Chem Neurosci. 2018 Feb 13.
5. Zhang L, Zhou L, Li QX, Liang H, Qin H, Masutani S, Yoza B. Toxicity of lanthanum oxide nanoparticles to the fungus Moniliella wahieum Y12T isolated from biodiesel. Chemosphere. 2018 May; 199:495-501.
6. Ye C, Long Y, Ji G, Li QQ, Wu X. APAtrap: identification and quantification of alternative polyadenylation sites from RNA-seq data. Bioinformatics. 2018 Jan 18.
7. Li QQ, Hsu I, Sanford T, Railkar R, Balaji N, Sourbier C, Vocke C, Balaji KC, Agarwal PK. Protein kinase D inhibitor CRT0066101 suppresses bladder cancer growth in vitro and xenografts via blockade of the cell cycle at G2/M. Cell Mol Life Sci. 2018 Mar; 75(5):939-963.
8. Chen C, Yan X, Yoza BA, Zhou T, Li Y, Zhan Y, Wang Q, Li QX. Efficiencies and mechanisms of ZSM5 zeolites loaded with cerium, iron, or manganese oxides for catalytic ozonation of nitrobenzene in water. Sci Total Environ. 2018 Jan 15; 612:1424-1432.
9. Pan D, Li QX, Lin Z, Chen Z, Tang W, Pan C, Tan H, Zeng D. Interactions between salicylic acid and antioxidant enzymes tilting the balance of H2O2 from photorespiration in non-target crops under halosulfuron-methyl stress. Pestic Biochem Physiol. 2017 Nov; 143:214-223.
10. Wang J, Boesch R, Li QX. A case study of air quality - Pesticides and odorous phytochemicals on Kauai, Hawaii, USA. Chemosphere. 2017 Dec; 189:143-152.
11. Su AL, Lan XW, Huang MB, Nong W, Li QQ, Leng J. Microsatellite analysis of genetic diversity in the Tupaia belangeri yaoshanensis. Biomed Rep. 2017 Oct; 7(4):349-352.
12. Wen B, Baker MR, Zhao H, Cui Z, Li QX. Expression and Characterization of Windmill Palm Tree (Trachycarpus fortunei) Peroxidase by Pichia pastoris. J Agric Food Chem. 2017 Jun 14; 65(23):4676-4682.
13. Chu S, Baker MR, Leong G, Letcher RJ, Gee SJ, Hammock BD, Li QX. Exploring adduct formation between human serum albumin and eleven organophosphate ester flame retardants and plasticizers using MALDI-TOF/TOF and LC-Q/TOF. Chemosphere. 2017 Aug; 180:169-177.
14. Li QQ, Hao JJ, Zhang Z, Krane LS, Hammerich KH, Sanford T, Trepel JB, Neckers L, Agarwal PK. Proteomic analysis of proteome and histone post-translational modifications in heat shock protein 90 inhibition-mediated bladder cancer therapeutics. Sci Rep. 2017 03 15; 7(1):201.
15. Wu L, Cho IK, Li Y, Zhang G, Li QX. Evaluation of sources of irreproducibility of retention indices under programmed temperature gas chromatography conditions. J Chromatogr A. 2017 Apr 28; 1495:57-63.
16. Wu L, Duan X, Liu C, Zhang G, Li QX. Phenomenon of dual- and single-retention behaviors of solutes and its validation by computational simulation in linear programmed temperature gas chromatography. J Sep Sci. 2016 Jul; 39(14):2785-95.
17. Liang Z, Zhang B, Su WW, Williams PG, Li QX. C-Glycosylflavones Alleviate Tau Phosphorylation and Amyloid Neurotoxicity through GSK3ß Inhibition. ACS Chem Neurosci. 2016 07 20; 7(7):912-23.
18. Baker MR, Tabb DL, Ching T, Zimmerman LJ, Sakharov IY, Li QX. Site-Specific N-Glycosylation Characterization of Windmill Palm Tree Peroxidase Using Novel Tools for Analysis of Plant Glycopeptide Mass Spectrometry Data. J Proteome Res. 2016 06 03; 15(6):2026-38.
19. Hennessee CT, Li QX. Effects of Polycyclic Aromatic Hydrocarbon Mixtures on Degradation, Gene Expression, and Metabolite Production in Four Mycobacterium Species. Appl Environ Microbiol. 2016 06 01; 82(11):3357-3369.
20. Li QQ, Hao JJ, Zhang Z, Hsu I, Liu Y, Tao Z, Lewi K, Metwalli AR, Agarwal PK. Histone deacetylase inhibitor-induced cell death in bladder cancer is associated with chromatin modification and modifying protein expression: A proteomic approach. Int J Oncol. 2016 Jun; 48(6):2591-607.
21. An F, Chen T, Stéphanie DM, Li K, Li QX, Carvalho LJ, Tomlins K, Li J, Gu B, Chen S. Domestication Syndrome Is Investigated by Proteomic Analysis between Cultivated Cassava (Manihot esculenta Crantz) and Its Wild Relatives. PLoS One. 2016; 11(3):e0152154.
22. He YU, Li QQ, Guo SC. Taurine Attenuates Dimethylbenz[a]anthracene-induced Breast Tumorigenesis in Rats: A Plasma Metabolomic Study. Anticancer Res. 2016 Feb; 36(2):533-43.
23. Fan Y, Feng Q, Lai K, Huang W, Zhang C, Li QX. Toxic effects of indoxacarb enantiomers on the embryonic development and induction of apoptosis in zebrafish larvae (Danio rerio). Environ Toxicol. 2017 Jan; 32(1):7-16.
24. Zhu Y, Huang B, Li QX, Wang J. Organochlorine pesticides in follicular fluid of women undergoing assisted reproductive technologies from central China. Environ Pollut. 2015 Dec; 207:266-72.
25. Kim J, Kagawa A, Kurasaki K, Ataie N, Cho IK, Li QX, Ng HL. Large-scale identification of membrane proteins with properties favorable for crystallization. Protein Sci. 2015 Nov; 24(11):1756-63.
26. Chu S, Wang J, Leong G, Woodward LA, Letcher RJ, Li QX. Perfluoroalkyl sulfonates and carboxylic acids in liver, muscle and adipose tissues of black-footed albatross (Phoebastria nigripes) from Midway Island, North Pacific Ocean. Chemosphere. 2015 Nov; 138:60-6.
27. Jia RZ, Zhang RJ, Wei Q, Chen WF, Cho IK, Chen WX, Li QX. Identification and Classification of Rhizobia by Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight Mass Spectrometry. J Proteomics Bioinform. 2015; 8:98-107.
28. Cho IK, Jeong M, You AS, Park KH, Li QX. Pulmonary Proteome and Protein Networks in Response to the Herbicide Paraquat in Rats. J Proteomics Bioinform. 2015 May; 8(5):67-79.
29. Wang J, Caccamise SA, Woodward LA, Li QX. Polychlorinated Biphenyls in the Plasma and Preen Oil of Black-Footed Albatross (Diomedea nigripes) Chicks and Adults on Midway Atoll, North Pacific Ocean. PLoS One. 2015; 10(4):e0123041.
30. Ji G, Li L, Li QQ, Wu X, Fu J, Chen G, Wu X. PASPA: a web server for mRNA poly(A) site predictions in plants and algae. Bioinformatics. 2015 May 15; 31(10):1671-3.
31. Zhao H, Ye X, Li QQ. Characterization of plant polyadenylation complexes by using tandem affinity purification. Methods Mol Biol. 2015; 1255:69-78.
32. Zhao H, Li QQ. In vitro analysis of cleavage and polyadenylation in Arabidopsis. Methods Mol Biol. 2015; 1255:79-89.
33. Baker MR, Zhao H, Sakharov IY, Li QX. Amino acid sequence of anionic peroxidase from the windmill palm tree Trachycarpus fortunei. J Agric Food Chem. 2014 Dec 10; 62(49):11941-8.
34. Ye L, Hua A, Dai B, Lu T, Zhang Z, Ye M, Weintraub M, Li QQ. Perfusion of a cerebral protective solution enhances neuroprotection in a rabbit model of occlusion-reperfusion: prolonged cerebral dormancy time. In Vivo. 2014 Sep-Oct; 28(5):727-32.
35. Kwak Y, Park GS, Lee SE, Li QX, Shin JH. Genome sequence of Mycobacterium aromaticivorans JS19b1(T), a novel isolate from Hawaiian soil. J Biotechnol. 2014 Sep 30; 186:137-8.
36. Weintraub MD, Li QQ, Agarwal PK. Advances in intravesical therapy for the treatment of non-muscle invasive bladder cancer (Review). Mol Clin Oncol. 2014 Sep; 2(5):656-660.
37. Wu J, Li QQ, Zhou H, Lu Y, Li JM, Ma Y, Wang L, Fu T, Gong X, Weintraub M, Wu S, Ding H. Selective tumor cell killing by triptolide in p53 wild-type and p53 mutant ovarian carcinomas. Med Oncol. 2014 Jul; 31(7):14.
38. Pettersson A, Graff RE, Ursin G, Santos Silva ID, McCormack V, Baglietto L, Vachon C, Bakker MF, Giles GG, Chia KS, Czene K, Eriksson L, Hall P, Hartman M, Warren RM, Hislop G, Chiarelli AM, Hopper JL, Krishnan K, Li J, Li Q, Pagano I, Rosner BA, Wong CS, Scott C, Stone J, Maskarinec G, Boyd NF, van Gils CH, Tamimi RM. Mammographic density phenotypes and risk of breast cancer: a meta-analysis. J Natl Cancer Inst. 2014 May 10; 106(5).
39. An F, Fan J, Li J, Li QX, Li K, Zhu W, Wen F, Carvalho LJ, Chen S. Comparison of leaf proteomes of cassava (Manihot esculenta Crantz) cultivar NZ199 diploid and autotetraploid genotypes. PLoS One. 2014; 9(4):e85991.
40. Zeng W, Chen X, Ma Y, Huang Z, Qin Y, Wu F, Wu L, Liang X, Qin Y, Zhou J, Lu D, Kuang X, Li QQ, Luo Z. A novel approach for enriching cancer stem cells from the human SW-13 adrenocortical carcinoma cell line. Anticancer Res. 2014 Jan; 34(1):117-23.
41. Ching TH, Yoza BA, Li QX. Quartet analysis of putative horizontal gene transfer in Crenarchaeota. J Mol Evol. 2014 Feb; 78(2):163-70.
42. Negi VS, Bingham JP, Li QX, Borthakur D. A carbon-nitrogen lyase from Leucaena leucocephala catalyzes the first step of mimosine degradation. Plant Physiol. 2014 Feb; 164(2):922-34.
43. Ma L, Guo C, Li QQ. Role of alternative polyadenylation in epigenetic silencing and antisilencing. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):9-10.
44. Cho IK, Chang CL, Li QX. Diet-induced over-expression of flightless-I protein and its relation to flightlessness in Mediterranean fruit fly, Ceratitis capitata. PLoS One. 2013; 8(12):e81099.
45. Baker MR, Li QX. Guanidination of tryptic peptides without desalting for matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry analysis. Anal Chem. 2013 Sep 17; 85(18):8873-80.
46. Wang J, Qu W, Bittenbender HC, Li QX. Kavalactone content and chemotype of kava beverages prepared from roots and rhizomes of Isa and Mahakea varieties and extraction efficiency of kavalactones using different solvents. J Food Sci Technol. 2015 Feb; 52(2):1164-9.
47. Wu L, Chen M, Chen Y, Li QX. Determination and evaluation of gas holdup time with the quadratic equation model and comparison with nonlinear models for isothermal gas chromatography. J Chromatogr A. 2013 Jul 05; 1297:196-203.
48. Xu C, Ou J, Cui Y, Wang L, Lv C, Liu K, Wang B, Xu T, Li QX, Liu S. Development of a monoclonal antibody-based enzyme-linked immunosorbent assay for tetrabromobisphenol A. Monoclon Antib Immunodiagn Immunother. 2013 Apr; 32(2):113-8.
49. Ge J, Woodward LA, Li QX, Wang J. Composition, distribution and risk assessment of organochlorine pesticides in soils from the Midway Atoll, North Pacific Ocean. Sci Total Environ. 2013 May 01; 452-453:421-6.
50. Gao S, Seo JS, Wang J, Keum YS, Li J, Li QX. Multiple degradation pathways of phenanthrene by Stenotrophomonas maltophilia C6. Int Biodeterior Biodegradation. 2013 Apr 01; 79:98-104.
51. Negi VS, Bingham JP, Li QX, Borthakur D. midD-encoded 'rhizomimosinase' from Rhizobium sp. strain TAL1145 is a C-N lyase that catabolizes L-mimosine into 3-hydroxy-4-pyridone, pyruvate and ammonia. Amino Acids. 2013 Jun; 44(6):1537-47.
52. Seo JS, Keum YS, Li QX. Metabolomic and proteomic insights into carbaryl catabolism by Burkholderia sp. C3 and degradation of ten N-methylcarbamates. Biodegradation. 2013 Nov; 24(6):795-811.
53. Wang J, Wang Z, Liu J, Li H, Li QX, Li J, Xu T. Nanocolloidal gold-based immuno-dip strip assay for rapid detection of Sudan red I in food samples. Food Chem. 2013 Feb 15; 136(3-4):1478-83.
54. Xu T, Xu QG, Li H, Wang J, Li QX, Shelver WL, Li J. Strip-based immunoassay for the simultaneous detection of the neonicotinoid insecticides imidacloprid and thiamethoxam in agricultural products. Talanta. 2012 Nov 15; 101:85-90.
55. Wu L, Chen M, Chen Y, Li QX. A new accurate quadratic equation model for isothermal gas chromatography and its comparison with the linear model. J Chromatogr A. 2012 Oct 19; 1260:224-31.
56. Ge J, Liu F, Holmes EH, Ostrander GK, Li QX. Aqueous normal phase liquid chromatography coupled with tandem time-of-flight quadrupole mass spectrometry for determination of zanamivir in human serum. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Oct 01; 906:58-62.
57. Wu L, Chen Y, Caccamise SA, Li QX. Difference equation model for isothermal gas chromatography expresses retention behavior of homologues of n-alkanes excluding the influence of holdup time. J Chromatogr A. 2012 Oct 19; 1260:215-23.
58. Xu T, Wang J, Liu SZ, Lü C, Shelver WL, Li QX, Li J. A highly sensitive and selective immunoassay for the detection of tetrabromobisphenol A in soil and sediment. Anal Chim Acta. 2012 Nov 02; 751:119-27.
59. Pan X, Zhu X, Li QQ. Case report of concurrent primary malignancies of the breast and nasopharynx. Oncol Lett. 2012 Aug; 4(2):285-288.
60. Wang D, Atkinson S, Hoover-Miller A, Shelver WL, Li QX. Organic halogenated contaminants in mother-fetus pairs of harbor seals (Phoca vitulina richardii) from Alaska, 2000-2002. J Hazard Mater. 2012 Jul 15; 223-224:72-8.
61. Pan X, Zhu X, Li QQ. Syphilis manifesting as a nasopharyngeal carcinoma with cervical lymphadenopathy: A case report. Exp Ther Med. 2012 Jun; 3(6):1023-1025.
62. Fan Z, Keum YS, Li QX, Shelver WL, Guo LH. Sensitive immunoassay detection of multiple environmental chemicals on protein microarrays using DNA/dye conjugate as a fluorescent label. J Environ Monit. 2012 May; 14(5):1345-52.
63. Wang J, Wei K, Li H, Li QX, Li J, Xu T. A sensitive and selective enzyme-linked immunosorbent assay for the analysis of Para red in foods. Analyst. 2012 May 07; 137(9):2136-42.
64. Seo JS, Keum YS, Li QX. Mycobacterium aromativorans JS19b1(T) Degrades Phenanthrene through C-1,2, C-3,4 and C-9,10 Dioxygenation Pathways. Int Biodeterior Biodegradation. 2012 May; 70:96-103.
65. Tong J, Trapido-Rosenthal H, Wang J, Wang Y, Li QX, Lu Y. Antiviral activities and putative identification of compounds in microbial extracts from the Hawaiian coastal waters. Mar Drugs. 2012 Mar; 10(3):521-38.
66. Chen P, Li J, Li QX, Wang Y, Li S, Ren T, Wang L. Simultaneous heterotrophic nitrification and aerobic denitrification by bacterium Rhodococcus sp. CPZ24. Bioresour Technol. 2012 Jul; 116:266-70.
67. Wang J, Chen WF, Li QX. Rapid identification and classification of Mycobacterium spp. using whole-cell protein barcodes with matrix assisted laser desorption ionization time of flight mass spectrometry in comparison with multigene phylogenetic analysis. Anal Chim Acta. 2012 Feb 24; 716:133-7.
68. Li L, Pan Z, Gao K, Zhang W, Luo Y, Yao Z, Liang X, Tang B, Li QQ. Impact of post-operative hormone replacement therapy on life quality and prognosis in patients with ovarian malignancy. Oncol Lett. 2012 Jan; 3(1):244-249.
69. Wang Q, Li D, Zhang W, Tang B, Li QQ, Li L. Evaluation of proteomics-identified CCL18 and CXCL1 as circulating tumor markers for differential diagnosis between ovarian carcinomas and benign pelvic masses. Int J Biol Markers. 2011 Oct-Dec; 26(4):262-73.
70. Zhang W, Yang HC, Wang Q, Yang ZJ, Chen H, Wang SM, Pan ZM, Tang BJ, Li QQ, Li L. Clinical value of combined detection of serum matrix metalloproteinase-9, heparanase, and cathepsin for determining ovarian cancer invasion and metastasis. Anticancer Res. 2011 Oct; 31(10):3423-8.
71. Cui Y, Nan T, Tan G, Li QX, Wang B, Liu S. Production of monoclonal antibody to herbicide fenoxaprop-ethyl. Hybridoma (Larchmt). 2011 Oct; 30(5):463-7.
72. Zhao H, Zheng J, Li QQ. A novel plant in vitro assay system for pre-mRNA cleavage during 3'-end formation. Plant Physiol. 2011 Nov; 157(3):1546-54.
73. Wang J, Li H, Shelver WL, Wang Z, Li QX, Li J, Xu T. Development of a monoclonal antibody-based, congener-specific and solvent-tolerable direct enzyme-linked immunosorbent assay for the detection of 2,2',4,4'-tetrabromodiphenyl ether in environmental samples. Anal Bioanal Chem. 2011 Oct; 401(7):2249-58.
74. Zhao H, Nan T, Tan G, Gao W, Cao Z, Sun S, Li Z, Li QX, Wang B. Development of two highly sensitive immunoassays for detection of copper ions and a suite of relevant immunochemicals. Anal Chim Acta. 2011 Sep 19; 702(1):102-8.
75. Wang J, Caccamise SA, Wu L, Woodward LA, Li QX. Spatial distribution of organochlorine contaminants in soil, sediment, and fish in Bikini and Enewetak Atolls of the Marshall Islands, Pacific Ocean. Chemosphere. 2011 Aug; 84(7):1002-8.
76. Tittabutr P, Cho IK, Li QX. Phn and Nag-like dioxygenases metabolize polycyclic aromatic hydrocarbons in Burkholderia sp. C3. Biodegradation. 2011 Nov; 22(6):1119-33.
77. Zhang H, Jin T, Zhang G, Chen L, Zou W, Li QQ. Polymorphisms in heat-shock protein 70 genes are associated with coal workers' pneumoconiosis in southwestern China. In Vivo. 2011 Mar-Apr; 25(2):251-7.
78. Wang J, Li QX. Chemical composition, characterization, and differentiation of honey botanical and geographical origins. Adv Food Nutr Res. 2011; 62:89-137.
79. Wang J, Hülck K, Hong SM, Atkinson S, Li QX. Accumulation and maternal transfer of polychlorinated biphenyls in Steller Sea Lions (Eumetopias jubatus) from Prince William Sound and the Bering Sea, Alaska. Environ Pollut. 2011 Jan; 159(1):71-77.
80. Wang J, Kim KH, Kim S, Kim YS, Li QX, Jun S. Simple quantitative analysis of Escherichia coli K-12 internalized in baby spinach using Fourier Transform Infrared spectroscopy. Int J Food Microbiol. 2010 Nov 15; 144(1):147-51.
81. Seo JS, Keum YS, Li QX. Comparative protein and metabolite profiling revealed a metabolic network in response to multiple environmental contaminants in Mycobacterium aromativorans JS19b1(T). J Agric Food Chem. 2011 Apr 13; 59(7):2876-82.
82. Mo L, Zhang J, Shi J, Xuan Q, Yang X, Qin M, Lee C, Klocker H, Li QQ, Mo Z. Human kallikrein 7 induces epithelial-mesenchymal transition-like changes in prostate carcinoma cells: a role in prostate cancer invasion and progression. Anticancer Res. 2010 Sep; 30(9):3413-20.
83. Wang D, Li QX. Application of mass spectrometry in the analysis of polybrominated diphenyl ethers. Mass Spectrom Rev. 2010 Sep-Oct; 29(5):737-75.
84. Zhao H, Xue C, Nan T, Tan G, Li Z, Li QX, Zhang Q, Wang B. Detection of copper ions using microcantilever immunosensors and enzyme-linked immunosorbent assay. Anal Chim Acta. 2010 Aug 31; 676(1-2):81-6.
85. Li QQ, Wang G, Huang F, Banda M, Reed E. Antineoplastic effect of beta-elemene on prostate cancer cells and other types of solid tumour cells. J Pharm Pharmacol. 2010 Aug; 62(8):1018-27.
86. Liang G, Tang A, Lin X, Li L, Zhang S, Huang Z, Tang H, Li QQ. Green tea catechins augment the antitumor activity of doxorubicin in an in vivo mouse model for chemoresistant liver cancer. Int J Oncol. 2010 Jul; 37(1):111-23.
87. Yang X, Xuan Q, Mo L, Huang F, Pang Y, He M, Lin W, Li QQ, Mo Z. Differential expression of genes in co-cultured versus separately cultured fibroblasts and epithelial cells from human benign hyperplastic prostate tissues. Int J Mol Med. 2010 Jul; 26(1):17-25.
88. Xu T, Wei KY, Wang J, Eremin SA, Liu SZ, Li QX, Li J. Development of an enzyme-linked immunosorbent assay specific to Sudan red I. Anal Biochem. 2010 Oct 01; 405(1):41-9.
89. Wang J, Kliks MM, Jun S, Li QX. Residues of polybrominated diphenyl ethers in honeys from different geographic regions. J Agric Food Chem. 2010 Mar 24; 58(6):3495-501.
90. Wang J, Kliks MM, Jun S, Jackson M, Li QX. Rapid analysis of glucose, fructose, sucrose, and maltose in honeys from different geographic regions using fourier transform infrared spectroscopy and multivariate analysis. J Food Sci. 2010 Mar; 75(2):C208-14.
91. Xu T, Wei KY, Wang J, Ma HX, Li J, Xu YJ, Li QX. Quantitative analysis of the neonicotinoid insecticides imidacloprid and thiamethoxam in fruit juices by enzyme-linked immunosorbent assays. J AOAC Int. 2010 Jan-Feb; 93(1):12-8.
92. Wang J, Kliks MM, Qu W, Jun S, Shi G, Li QX. Rapid determination of the geographical origin of honey based on protein fingerprinting and barcoding using MALDI TOF MS. J Agric Food Chem. 2009 Nov 11; 57(21):10081-8.
93. Wang D, Shelver WL, Atkinson S, Mellish JA, Li QX. Tissue distribution of polychlorinated biphenyls and organochlorine pesticides and potential toxicity to Alaskan northern fur seals assessed using PCBs congener specific mode of action schemes. Arch Environ Contam Toxicol. 2010 Feb; 58(2):478-88.
94. Zhao H, Xing D, Li QQ. Unique features of plant cleavage and polyadenylation specificity factor revealed by proteomic studies. Plant Physiol. 2009 Nov; 151(3):1546-56.
95. Sheng W, Xia X, Wei K, Li J, Li QX, Xu T. Determination of marbofloxacin residues in beef and pork with an enzyme-linked immunosorbent assay. J Agric Food Chem. 2009 Jul 08; 57(13):5971-5.
96. Li QQ, Wang G, Zhang M, Cuff CF, Huang L, Reed E. beta-Elemene, a novel plant-derived antineoplastic agent, increases cisplatin chemosensitivity of lung tumor cells by triggering apoptosis. Oncol Rep. 2009 Jul; 22(1):161-70.
97. Wang J, Jun S, Bittenbender HC, Gautz L, Li QX. Fourier transform infrared spectroscopy for Kona coffee authentication. J Food Sci. 2009 Jun; 74(5):C385-91.
98. Ma H, Xu Y, Li QX, Xu T, Wang X, Li J. Application of enzyme-linked immunosorbent assay for quantification of the insecticides imidacloprid and thiamethoxam in honey samples. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2009 May; 26(5):713-8.
99. Bingham JP, Chun JB, Ruzicka MR, Li QX, Tan ZY, Kaulin YA, Englebretsen DR, Moczydlowski EG. Synthesis of an iberiotoxin derivative by chemical ligation: a method for improved yields of cysteine-rich scorpion toxin peptides. Peptides. 2009 Jun; 30(6):1049-57.
100. Lee SE, Li QX, Yu J. Diverse protein regulations on PHA formation in Ralstonia eutropha on short chain organic acids. Int J Biol Sci. 2009; 5(3):215-25.
101. Hennessee CT, Seo JS, Alvarez AM, Li QX. Polycyclic aromatic hydrocarbon-degrading species isolated from Hawaiian soils: Mycobacterium crocinum sp. nov., Mycobacterium pallens sp. nov., Mycobacterium rutilum sp. nov., Mycobacterium rufum sp. nov. and Mycobacterium aromaticivorans sp. nov. Int J Syst Evol Microbiol. 2009 Feb; 59(Pt 2):378-87.
102. Chang CL, Cho IK, Li QX. Insecticidal activity of basil oil, trans-anethole, estragole, and linalool to adult fruit flies of Ceratitis capitata, Bactrocera dorsalis, and Bactrocera cucurbitae. J Econ Entomol. 2009 Feb; 102(1):203-9.
103. Xu T, Jacobsen CM, Hara AH, Li J, Li QX. Efficacy of systemic insecticides on the gall wasp Quadrastichus erythrinae in wiliwili trees (Erythrina spp.). Pest Manag Sci. 2009 Feb; 65(2):163-9.
104. Seo JS, Keum YS, Li QX. Bacterial degradation of aromatic compounds. Int J Environ Res Public Health. 2009 01; 6(1):278-309.
105. He SP, Tan GY, Li G, Tan WM, Nan TG, Wang BM, Li ZH, Li QX. Development of a sensitive monoclonal antibody-based enzyme-linked immunosorbent assay for the antimalaria active ingredient artemisinin in the Chinese herb Artemisia annua L. Anal Bioanal Chem. 2009 Feb; 393(4):1297-303.
106. Xu T, Cho IK, Wang D, Rubio FM, Shelver WL, Gasc AM, Li J, Li QX. Suitability of a magnetic particle immunoassay for the analysis of PBDEs in Hawaiian euryhaline fish and crabs in comparison with gas chromatography/electron capture detection-ion trap mass spectrometry. Environ Pollut. 2009 Feb; 157(2):417-22.
107. Xing D, Zhao H, Li QQ. Arabidopsis CLP1-SIMILAR PROTEIN3, an ortholog of human polyadenylation factor CLP1, functions in gametophyte, embryo, and postembryonic development. Plant Physiol. 2008 Dec; 148(4):2059-69.
108. Deng A, Tan W, He S, Liu W, Nan T, Li Z, Wang B, Li QX. Monoclonal antibody-based enzyme linked immunosorbent assay for the analysis of jasmonates in plants. J Integr Plant Biol. 2008 Aug; 50(8):1046-52.
109. Keum YS, Seo JS, Li QX, Kim JH. Comparative metabolomic analysis of Sinorhizobium sp. C4 during the degradation of phenanthrene. Appl Microbiol Biotechnol. 2008 Oct; 80(5):863-72.
110. Awaya JD, Tittabutr P, Li QX, Borthakur D. Pyruvate carboxylase is involved in metabolism of mimosine by Rhizobium sp. strain TAL1145. Arch Microbiol. 2008 Oct; 190(4):409-15.
111. Hunt AG, Xu R, Addepalli B, Rao S, Forbes KP, Meeks LR, Xing D, Mo M, Zhao H, Bandyopadhyay A, Dampanaboina L, Marion A, Von Lanken C, Li QQ. Arabidopsis mRNA polyadenylation machinery: comprehensive analysis of protein-protein interactions and gene expression profiling. BMC Genomics. 2008 May 14; 9:220.
112. Shelver WL, Parrotta CD, Slawecki R, Li QX, Ikonomou MG, Barcelo D, Lacorte S, Rubio FM. Development of a magnetic particle immunoassay for polybrominated diphenyl ethers and application to environmental and food matrices. Chemosphere. 2008 Aug; 73(1 Suppl):S18-23.
113. Tittabutr P, Awaya JD, Li QX, Borthakur D. The cloned 1-aminocyclopropane-1-carboxylate (ACC) deaminase gene from Sinorhizobium sp. strain BL3 in Rhizobium sp. strain TAL1145 promotes nodulation and growth of Leucaena leucocephala. Syst Appl Microbiol. 2008 Jun; 31(2):141-50.
114. Xing D, Zhao H, Xu R, Li QQ. Arabidopsis PCFS4, a homologue of yeast polyadenylation factor Pcf11p, regulates FCA alternative processing and promotes flowering time. Plant J. 2008 Jun; 54(5):899-910.
115. Khurana HK, Cho IK, Shim JY, Li QX, Jun S. Application of multibounce attenuated total reflectance fourier transform infrared spectroscopy and chemometrics for determination of aspartame in soft drinks. J Agric Food Chem. 2008 Feb 13; 56(3):778-83.
116. Wang D, Atkinson S, Hoover-Miller A, Shelver WL, Li QX. Simultaneous use of gas chromatography/ion trap mass spectrometry - electron capture detection to improve the analysis of bromodiphenyl ethers in biological and environmental samples. Rapid Commun Mass Spectrom. 2008; 22(5):647-56.
117. Campbell S, Harada RM, Li QX. Chryseobacterium arothri sp. nov., isolated from the kidneys of a pufferfish. Int J Syst Evol Microbiol. 2008 Jan; 58(Pt 1):290-3.
118. Campbell S, Harada RM, Li QX. Ferrimonas senticii sp. nov., a novel gammaproteobacterium isolated from the mucus of a puffer fish caught in Kaneohe Bay, Hawai'i. Int J Syst Evol Microbiol. 2007 Nov; 57(Pt 11):2670-3.
119. Wang D, Miao X, Li QX. Analysis of organochlorine pesticides in coral (Porites evermanni) samples using accelerated solvent extraction and gas chromatography/ion trap mass spectrometry. Arch Environ Contam Toxicol. 2008 Feb; 54(2):211-8.
120. Moon JK, Keum YS, Hwang EC, Park BS, Chang HR, Li QX, Kim JH. Hapten syntheses and antibody generation for a new herbicide, metamifop. J Agric Food Chem. 2007 Jul 11; 55(14):5416-22.
121. Seo JS, Keum YS, Harada RM, Li QX. Isolation and characterization of bacteria capable of degrading polycyclic aromatic hydrocarbons (PAHs) and organophosphorus pesticides from PAH-contaminated soil in Hilo, Hawaii. J Agric Food Chem. 2007 Jul 11; 55(14):5383-9.
122. Lee SE, Seo JS, Keum YS, Lee KJ, Li QX. Fluoranthene metabolism and associated proteins in Mycobacterium sp. JS14. Proteomics. 2007 Jun; 7(12):2059-69.
123. Xu T, Shao XL, Li QX, Keum YS, Jing HY, Sheng W, Li J. Development of an enzyme-linked immunosorbent assay for the detection of pentachloronitrobenzene residues in environmental samples. J Agric Food Chem. 2007 May 16; 55(10):3764-70.
124. Xu T, Wang BM, Sheng W, Li QX, Shao XL, Li J. Application of an enzyme-linked immunosorbent assay for the detection of clenbuterol residues in swine urine and feeds. J Environ Sci Health B. 2007 Feb; 42(2):173-7.
125. Wang D, Atkinson S, Hoover-Miller A, Li QX. Polychlorinated naphthalenes and coplanar polychlorinated biphenyls in tissues of harbor seals (Phoca vitulina) from the northern Gulf of Alaska. Chemosphere. 2007 May; 67(10):2044-57.
126. Xiao Q, Li L, Xie Y, Tan N, Wang C, Xu J, Xia K, Gardner K, Li QQ. Transcription factor E2F-1 is upregulated in human gastric cancer tissues and its overexpression suppresses gastric tumor cell proliferation. Cell Oncol. 2007; 29(4):335-49.
127. Xu T, Jacobsen CM, Cho IK, Hara AH, Li QX. Application of an enzyme-linked immunosorbent assay for the analysis of imidacloprid in wiliwili tree, Erythrina sandwicensis O. Deg, for control of the wasp Quadrastichus erythrinae. J Agric Food Chem. 2006 Nov 01; 54(22):8444-9.
128. Zhao J, Li G, Wang BM, Liu W, Nan TG, Zhai ZX, Li ZH, Li QX. Development of a monoclonal antibody-based enzyme-linked immunosorbent assay for the analysis of glycyrrhizic acid. Anal Bioanal Chem. 2006 Nov; 386(6):1735-40.
129. Wang D, Atkinson S, Hoover-Miller A, Lee SE, Li QX. Organochlorines in harbor seal (Phoca vitulina) tissues from the northern Gulf of Alaska. Environ Pollut. 2007 Mar; 146(1):268-80.
130. Lee SE, Li QX, Yu J. Proteomic examination of Ralstonia eutropha in cellular responses to formic acid. Proteomics. 2006 Aug; 6(15):4259-68.
131. Gao H, Ling Y, Xu T, Zhu W, Jing H, Sheng W, Li QX, Li J. Development of an enzyme-linked immunosorbent assay for the pyrethroid insecticide cyhalothrin. J Agric Food Chem. 2006 Jul 26; 54(15):5284-91.
132. Zhao J, Yi GX, He SP, Wang BM, Yu CX, Li G, Zhai ZX, Li ZH, Li QX. Development of a monoclonal antibody-based enzyme-linked immunosorbent assay for the herbicide chlorimuron-ethyl. J Agric Food Chem. 2006 Jul 12; 54(14):4948-53.
133. Xu R, Zhao H, Dinkins RD, Cheng X, Carberry G, Li QQ. The 73 kD subunit of the cleavage and polyadenylation specificity factor (CPSF) complex affects reproductive development in Arabidopsis. Plant Mol Biol. 2006 Jul; 61(4-5):799-815.
134. Seo JS, Keum YS, Hu Y, Lee SE, Li QX. Phenanthrene degradation in Arthrobacter sp. P1-1: initial 1,2-, 3,4- and 9,10-dioxygenation, and meta- and ortho-cleavages of naphthalene-1,2-diol after its formation from naphthalene-1,2-dicarboxylic acid and hydroxyl naphthoic acids. Chemosphere. 2006 Dec; 65(11):2388-94.
135. Wang D, Xu X, Chu S, Li QX. Polychlorinated naphthalenes and other chlorinated tricyclic aromatic hydrocarbons emitted from combustion of polyvinylchloride. J Hazard Mater. 2006 Nov 16; 138(2):273-7.
136. Kim HJ, Shelver WL, Hwang EC, Xu T, Li QX. Automated flow fluorescent immunoassay for part per trillion detection of the neonicotinoid insecticide thiamethoxam. Anal Chim Acta. 2006 Jun 30; 571(1):66-73.
137. Harada RM, Campbell S, Li QX. Pseudoxanthomonas kalamensis sp. nov., a novel gammaproteobacterium isolated from Johnston Atoll, North Pacific Ocean. Int J Syst Evol Microbiol. 2006 May; 56(Pt 5):1103-7.
138. Zhao J, Li G, Yi GX, Wang BM, Deng AX, Nan TG, Li ZH, Li QX. Comparison between conventional indirect competitive enzyme-linked immunosorbent assay (icELISA) and simplified icELISA for small molecules. Anal Chim Acta. 2006 Jun 30; 571(1):79-85.
139. Seo JS, Keum YS, Hu Y, Lee SE, Li QX. Degradation of phenanthrene by Burkholderia sp. C3: initial 1,2- and 3,4-dioxygenation and meta- and ortho-cleavage of naphthalene-1,2-diol. Biodegradation. 2007 Feb; 18(1):123-31.
140. Keum YS, Seo JS, Hu Y, Li QX. Degradation pathways of phenanthrene by Sinorhizobium sp. C4. Appl Microbiol Biotechnol. 2006 Aug; 71(6):935-41.
141. Cho IK, Chang CL, Li QX. Nicotinamide in relation to dietary nicotinic acid and nine other vitamins and larval development of Ceratitis capitata (Diptera: Tephritidae). J Agric Food Chem. 2005 Sep 07; 53(18):7307-11.
142. Zhao J, Kim JE, Reed E, Li QQ. Molecular mechanism of antitumor activity of taxanes in lung cancer (Review). Int J Oncol. 2005 Jul; 27(1):247-56.
143. Campbell S, Chen L, Yu J, Li QX. Adsorption and analysis of the insecticides thiamethoxam and indoxacarb in hawaiian soils. J Agric Food Chem. 2005 Jun 29; 53(13):5373-6.
144. Loke JC, Stahlberg EA, Strenski DG, Haas BJ, Wood PC, Li QQ. Compilation of mRNA polyadenylation signals in Arabidopsis revealed a new signal element and potential secondary structures. Plant Physiol. 2005 Jul; 138(3):1457-68.
145. Shelver WL, Keum YS, Kim HJ, Rutherford D, Hakk HH, Bergman A, Li QX. Hapten syntheses and antibody generation for the development of a polybrominated flame retardant ELISA. J Agric Food Chem. 2005 May 18; 53(10):3840-7.
146. Shelver WL, Kim HJ, Li QX. Development of a monoclonal antibody-based enzyme-linked immuosorbent assay for the beta-adrenergic agonist zilpaterol. J Agric Food Chem. 2005 May 04; 53(9):3273-80.
147. Hu J, Liu S, Wang J, Luo X, Gao X, Xia X, Feng Y, Tao D, Wang G, Li X, Zhao J, Ding H, Reed E, Li QQ, Gong J. Overexpression of the N-terminal end of the p55gamma regulatory subunit of phosphatidylinositol 3-kinase blocks cell cycle progression in gastric carcinoma cells. Int J Oncol. 2005 May; 26(5):1321-7.
148. Keum YS, Li QX. Reductive debromination of polybrominated diphenyl ethers by zerovalent iron. Environ Sci Technol. 2005 Apr 01; 39(7):2280-6.
149. Wang D, Atkinson S, Hoover-Miller A, Li QX. Analysis of organochlorines in harbor seal (Phoca vitulina) tissue samples from Alaska using gas chromatography/ion trap mass spectrometry by an isotopic dilution technique. Rapid Commun Mass Spectrom. 2005; 19(13):1815-21.
150. Hou S, Saw JH, Lee KS, Freitas TA, Belisle C, Kawarabayasi Y, Donachie SP, Pikina A, Galperin MY, Koonin EV, Makarova KS, Omelchenko MV, Sorokin A, Wolf YI, Li QX, Keum YS, Campbell S, Denery J, Aizawa S, Shibata S, Malahoff A, Alam M. Genome sequence of the deep-sea gamma-proteobacterium Idiomarina loihiensis reveals amino acid fermentation as a source of carbon and energy. Proc Natl Acad Sci U S A. 2004 Dec 28; 101(52):18036-41.
151. Liu S, Li QX. Photolysis of spinosyns in seawater, stream water and various aqueous solutions. Chemosphere. 2004 Sep; 56(11):1121-7.
152. Keum YS, Li QX. Fungal laccase-catalyzed degradation of hydroxy polychlorinated biphenyls. Chemosphere. 2004 Jul; 56(1):23-30.
153. McQuate GT, Keum YS, Sylva CD, Li QX, Jang EB. Active ingredients in cade oil that synergize attractiveness of alpha-ionol to male Bactrocera latifrons (Diptera: Tephritidae). J Econ Entomol. 2004 Jun; 97(3):862-70.
154. Willcox MK, Woodward LA, Ylitalo GM, Buzitis J, Atkinson S, Li QX. Organochlorines in the free-ranging Hawaiian monk seal (Monachus schauinslandi) from French Frigate Shoals, North Pacific Ocean. Sci Total Environ. 2004 Apr 25; 322(1-3):81-93.
155. Shen M, Feng Y, Gao C, Tao D, Hu J, Reed E, Li QQ, Gong J. Detection of cyclin b1 expression in g(1)-phase cancer cell lines and cancer tissues by postsorting Western blot analysis. Cancer Res. 2004 Mar 01; 64(5):1607-10.
156. Pruss GJ, Lawrence CB, Bass T, Li QQ, Bowman LH, Vance V. The potyviral suppressor of RNA silencing confers enhanced resistance to multiple pathogens. Virology. 2004 Mar 01; 320(1):107-20.
157. Campbell S, David MD, Woodward LA, Li QX. Persistence of carbofuran in marine sand and water. Chemosphere. 2004 Feb; 54(8):1155-61.
158. Keum YS, Li QX. Reduction of nitroaromatic pesticides with zero-valent iron. Chemosphere. 2004 Jan; 54(3):255-63.
159. Xu R, Li QQ. A RING-H2 zinc-finger protein gene RIE1 is essential for seed development in Arabidopsis. Plant Mol Biol. 2003 Sep; 53(1-2):37-50.
160. Campbell S, Ogoshi R, Uehara G, Li QX. Trace analysis of explosives in soil: pressurized fluid extraction and gas and liquid chromatography-mass spectrometry. J Chromatogr Sci. 2003 Jul; 41(6):284-8.
161. Kim HJ, Liu S, Keum YS, Li QX. Development of an enzyme-linked immunosorbent assay for the insecticide thiamethoxam. J Agric Food Chem. 2003 Mar 26; 51(7):1823-30.
162. Zhu Y, Li QX. Movement of bromacil and hexazinone in soils of Hawaiian pineapple fields. Chemosphere. 2002 Nov; 49(6):669-74.
163. Keum YS, Kim JH, Kim YW, Kim K, Li QX. Photodegradation of diafenthiuron in water. Pest Manag Sci. 2002 May; 58(5):496-502.
164. Licudine JA, McQuate GT, Cunningham RT, Liquido NJ, Li QX. Efficacy and residues of phloxine B and uranine for the suppression of Mediterranean fruit fly in coffee fields. Pest Manag Sci. 2002 Jan; 58(1):38-44.
165. Campbell S, Paquin D, Awaya JD, Li QX. Remediation of benzo[a]pyrene and chrysene-contaminated soil with industrial hemp (Cannabis sativa). Int J Phytoremediation. 2002; 4(2):157-68.

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