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YUSUF OMOSUN
Title DR.
Faculty Rank Assistant professor
Degree PHD
Institution Morehouse School of Medicine
Department Microbiology, Biochemistry and Immunology
Clusters Infectious and Immunological Diseases
Address
ROOM 320
HUGH GLOSTER BUILDING
720 WESTVIEW DRIVE
City ATLANTA
State GA
Postal Code 30310-1495
Telephone 4047521705
Fax 4047521179
Email
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  Research Focus
Chlamydia trachomatis (Ct) is a major cause of bacterial sexually transmitted disease (STD) in the United States. In 2010, a total of over 1 million chlamydial infections were reported to CDC. Complications caused by Chlamydia in women include pelvic inflammatory disease (PID), ectopic pregnancy and involuntary tubal factor infertility. Chlamydia infections also have a major economic impact in the US, with an estimated total cost of $701 million annually. Although chlamydiae are susceptible to antibiotics, the rampart asymptomatic infections often makes presentation of complications such as Tubal factor infertility (TFI) as the first indication of an infection, and resistant chlamydial strains may be emerging. My research focus involves elucidating the molecular mechanisms in the parthenogenesis of chlamydial infection.
I am currently involved in three projects which are all related

1. This project involves the use of IL-10 deficient dendritic cell system which has a distinct advantage for studies of therapeutic strategies and vaccine development to define a set of host immune molecules that regulate the induction of optimum protective immunity against Chlamydia and determine their mechanism of immunomodulation. Identify a set of host molecules such as the inflammasomes that are involved in the immune pathogenesis of Chlamydia disease, and determine their mechanism of action. This study may provide biomarkers for use in drug treatment and vaccine development against chlamydial disease.

2. This project involves studying the effect of caspase inhibition on infertility and the integrity of Dicer, a caspase-sensitive, fertility promoting ribonuclease III enzyme, and key micro-RNAs in the reproductive system of Ct infected mice. The results from this study will provide new insights into the molecular pathogenesis of TFI with significant implications for new strategies for diagnosis, treatment and prevention of chlamydial complications leading to TFI.

3. This project proposes to investigate the role of vitamin D in ameliorating the effect of Chlamydia infection, by studying host immune molecules in infected HELA cells, genital tract pathology, inflammatory responses, and rate of pregnancy and fertility of chlamydial infected VDR knockout mice. The knowledge garnered from this study might be useful for designing part of the prevention strategies against Chlamydia by showing the necessity of screening for vitamin D levels as part of the general Chlamydia screening and might be an index of protection against infection as well as sequelae.

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1. Omosun YO, Blackstock AJ, Williamson J, van Eijk AM, Ayisi J, Otieno J, Lal RB, Ter Kuile FO, Slutsker L, Shi YP. Association of maternal KIR gene content polymorphisms with reduction in perinatal transmission of HIV-1. PLoS One. 2018; 13(1):e0191733.
2. Igietseme JU, Omosun Y, Nagy T, Stuchlik O, Reed MS, He Q, Partin J, Joseph K, Ellerson D, George Z, Goldstein J, Eko FO, Bandea C, Pohl J, Black CM. Molecular Pathogenesis of Chlamydia Disease Complications: Epithelial-Mesenchymal Transition and Fibrosis. Infect Immun. 2018 01; 86(1).
3. McKeithen DN, Omosun YO, Ryans K, Mu J, Xie Z, Simoneaux T, Blas-Machado U, Eko FO, Black CM, Igietseme JU, He Q. The emerging role of ASC in dendritic cell metabolism during Chlamydia infection. PLoS One. 2017; 12(12):e0188643.
4. Pais R, Omosun Y, He Q, Blas-Machado U, Black C, Igietseme JU, Fujihashi K, Eko FO. Rectal administration of a chlamydial subunit vaccine protects against genital infection and upper reproductive tract pathology in mice. PLoS One. 2017; 12(6):e0178537.
5. Ryans K, Omosun Y, McKeithen DN, Simoneaux T, Mills CC, Bowen N, Eko FO, Black CM, Igietseme JU, He Q. The immunoregulatory role of alpha enolase in dendritic cell function during Chlamydia infection. BMC Immunol. 2017 May 19; 18(1):27.
6. George Z, Omosun Y, Azenabor AA, Partin J, Joseph K, Ellerson D, He Q, Eko F, Bandea C, Svoboda P, Pohl J, Black CM, Igietseme JU. The Roles of Unfolded Protein Response Pathways in Chlamydia Pathogenesis. J Infect Dis. 2017 Feb 01; 215(3):456-465.
7. Igietseme JU, Omosun Y, Stuchlik O, Reed MS, Partin J, He Q, Joseph K, Ellerson D, Bollweg B, George Z, Eko FO, Bandea C, Liu H, Yang G, Shieh WJ, Pohl J, Karem K, Black CM. Role of Epithelial-Mesenchyme Transition in Chlamydia Pathogenesis. PLoS One. 2015; 10(12):e0145198.
8. Gatei W, Gimnig JE, Hawley W, Ter Kuile F, Odero C, Iriemenam NC, Shah MP, Howard PP, Omosun YO, Terlouw DJ, Nahlen B, Slutsker L, Hamel MJ, Kariuki S, Walker E, Shi YP. Genetic diversity of Plasmodium falciparum parasite by microsatellite markers after scale-up of insecticide-treated bed nets in western Kenya. Malar J. 2015 Dec 09; 13 Suppl 1:495.
9. Omosun Y, McKeithen D, Ryans K, Kibakaya C, Blas-Machado U, Li D, Singh R, Inoue K, Xiong ZG, Eko F, Black C, Igietseme J, He Q. Interleukin-10 modulates antigen presentation by dendritic cells through regulation of NLRP3 inflammasome assembly during Chlamydia infection. Infect Immun. 2015 Dec; 83(12):4662-72.
10. Pan Q, Pais R, Ohandjo A, He C, He Q, Omosun Y, Igietseme JU, Eko FO. Comparative evaluation of the protective efficacy of two formulations of a recombinant Chlamydia abortus subunit candidate vaccine in a mouse model. Vaccine. 2015 Apr 08; 33(15):1865-72.
11. Shah M, Omosun Y, Lal A, Odero C, Gatei W, Otieno K, Gimnig JE, ter Kuile F, Hawley WA, Nahlen B, Kariuki S, Walker E, Slutsker L, Hamel M, Shi YP. Assessment of molecular markers for anti-malarial drug resistance after the introduction and scale-up of malaria control interventions in western Kenya. Malar J. 2015 Feb 14; 14:75.
12. Igietseme JU, Omosun Y, Partin J, Goldstein J, He Q, Joseph K, Ellerson D, Ansari U, Eko FO, Bandea C, Zhong G, Black CM. Prevention of Chlamydia-induced infertility by inhibition of local caspase activity. J Infect Dis. 2013 Apr; 207(7):1095-104.
13. Iriemenam NC, Shah M, Gatei W, van Eijk AM, Ayisi J, Kariuki S, Vanden Eng J, Owino SO, Lal AA, Omosun YO, Otieno K, Desai M, ter Kuile FO, Nahlen B, Moore J, Hamel MJ, Ouma P, Slutsker L, Shi YP. Temporal trends of sulphadoxine-pyrimethamine (SP) drug-resistance molecular markers in Plasmodium falciparum parasites from pregnant women in western Kenya. Malar J. 2012 Jul 04; 11:134.
14. Omosun YO, Blackstock AJ, Gatei W, Hightower A, van Eijk AM, Ayisi J, Otieno J, Lal RB, Steketee R, Nahlen B, ter Kuile FO, Slutsker L, Shi YP. Differential association of gene content polymorphisms of killer cell immunoglobulin-like receptors with placental malaria in HIV- and HIV+ mothers. PLoS One. 2012; 7(6):e38617.
15. Omosun YO, Adoro S, Anumudu CI, Odaibo A, Holder AA, Nwagwu M, Nwuba RI. Total immunoglobulin G and IgG1 subclass levels specific for the MSP-1(19) of Plasmodium falciparum are different in individuals with either processing-inhibitory, blocking or neutral antibodies. Afr Health Sci. 2010 Jun; 10(2):106-10.
16. Okafor CM, Anumudu CI, Omosun YO, Uthaipibull C, Ayede I, Awobode HO, Odaibo AB, Langhorne J, Holder AA, Nwuba RI, Troye-Blomberg M. Cellular responses to modified Plasmodium falciparum MSP119 antigens in individuals previously exposed to natural malaria infection. Malar J. 2009 Nov 23; 8:263.
17. Iriemenam NC, Okafor CM, Balogun HA, Ayede I, Omosun Y, Persson JO, Hagstedt M, Anumudu CI, Nwuba RI, Troye-Blomberg M, Berzins K. Cytokine profiles and antibody responses to Plasmodium falciparum malaria infection in individuals living in Ibadan, southwest Nigeria. Afr Health Sci. 2009 Jun; 9(2):66-74.
18. Omosun YO, Adoro S, Anumudu CI, Odaibo AB, Uthiapibull C, Holder AA, Nwagwu M, Nwuba RI. Antibody specificities of children living in a malaria endemic area to inhibitory and blocking epitopes on MSP-1 19 of Plasmodium falciparum. Acta Trop. 2009 Mar; 109(3):208-12.
19. Gruszynski AE, van Deursen FJ, Albareda MC, Best A, Chaudhary K, Cliffe LJ, del Rio L, Dunn JD, Ellis L, Evans KJ, Figueiredo JM, Malmquist NA, Omosun Y, Palenchar JB, Prickett S, Punkosdy GA, van Dooren G, Wang Q, Menon AK, Matthews KR, Bangs JD. Regulation of surface coat exchange by differentiating African trypanosomes. Mol Biochem Parasitol. 2006 Jun; 147(2):211-23.
20. Omosun YO, Anumudu CI, Adoro S, Odaibo AB, Sodeinde O, Holder AA, Nwagwu M, Nwuba RI. Variation in the relationship between anti-MSP-1(19) antibody response and age in children infected with Plasmodium falciparum during the dry and rainy seasons. Acta Trop. 2005 Sep; 95(3):233-47.
21. Nwuba RI, Sodeinde O, Anumudu CI, Omosun YO, Odaibo AB, Holder AA, Nwagwu M. The human immune response to Plasmodium falciparum includes both antibodies that inhibit merozoite surface protein 1 secondary processing and blocking antibodies. Infect Immun. 2002 Sep; 70(9):5328-31.
22. Nwuba RI, Anumudu CI, Omosun YO, Sodeinde O, Nwagwu M. Evaluation of a rapid immunochromatographic card test for Plasmodium falciparum in Ibadan, Nigeria. Afr J Med Med Sci. 2001 Mar-Jun; 30(1-2):123-4.

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