PROFILES - Connect with RTRN Researchers

Amos Sakwe
Title Assistant Professor
Faculty Rank
Degree PhD
Institution Meharry Medical College
Department Biochemistry and Cancer Biology
Clusters Cancer
Address
Meharry medical College
Department of Biochemistry and Cancer biology
1005 Dr. DB Todd Jr. Blvd
City Nashville
State TN
Postal Code 37208
Telephone (615) 327-6064
Fax
Email
QR Barcode

Narrative icon

 
Not Available

Online Resources icon

Publications icon

  Check NIH Public Access Policy Compliance

Loading
Please wait
1. Korolkova OY, Widatalla SE, Whalen DS, Nangami GN, Abimbola A, Williams SD, Beasley HK, Reisenbichler E, Washington MK, Ochieng J, Mayer IA, Lehmann BD, Sakwe AM. Reciprocal expression of Annexin A6 and RasGRF2 discriminates rapidly growing from invasive triple negative breast cancer subsets. PLoS One. 2020; 15(4):e0231711.
2. Widatalla SE, Korolkova OY, Whalen DS, Goodwin JS, Williams KP, Ochieng J, Sakwe AM. Lapatinib-induced annexin A6 upregulation as an adaptive response of triple-negative breast cancer cells to EGFR tyrosine kinase inhibitors. Carcinogenesis. 2019 08 22; 40(8):998-1009.
3. Whalen DS, Widatalla SE, Korolkova OY, Nangami GS, Beasley HK, Williams SD, Virgous C, Lehmann BD, Ochieng J, Sakwe AM. Implication of calcium activated RasGRF2 in Annexin A6-mediated breast tumor cell growth and motility. Oncotarget. 2019 Jan 04; 10(2):133-151.
4. Ochieng J, Nangami G, Sakwe A, Rana T, Ingram S, Goodwin JS, Moye C, Lammers P, Adunyah SE. Extracellular histones are the ligands for the uptake of exosomes and hydroxyapatite-nanoparticles by tumor cells via syndecan-4. FEBS Lett. 2018 10; 592(19):3274-3285.
5. Ochieng J, Nangami G, Sakwe A, Moye C, Alvarez J, Whalen D, Thomas P, Lammers P. Impact of Fetuin-A (AHSG) on Tumor Progression and Type 2 Diabetes. Int J Mol Sci. 2018 Jul 29; 19(8).
6. Burroughs AF, Eluhu S, Whalen D, Goodwin JS, Sakwe AM, Arinze IJ. PML-Nuclear Bodies Regulate the Stability of the Fusion Protein Dendra2-Nrf2 in the Nucleus. Cell Physiol Biochem. 2018; 47(2):800-816.
7. Williams AD, Korolkova OY, Sakwe AM, Geiger TM, James SD, Muldoon RL, Herline AJ, Goodwin JS, Izban MG, Washington MK, Smoot DT, Ballard BR, Gazouli M, M''Koma AE. Correction: Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease. PLoS One. 2017; 12(12):e0189551.
8. Williams AD, Korolkova OY, Sakwe AM, Geiger TM, James SD, Muldoon RL, Herline AJ, Goodwin JS, Izban MG, Washington MK, Smoot DT, Ballard BR, Gazouli M, M''Koma AE. Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease. PLoS One. 2017; 12(8):e0179710.
9. Wang L, Widatalla SE, Whalen DS, Ochieng J, Sakwe AM. Association of calcium sensing receptor polymorphisms at rs1801725 with circulating calcium in breast cancer patients. BMC Cancer. 2017 Aug 02; 17(1):511.
10. Nangami GN, Sakwe AM, Izban MG, Rana T, Lammers PE, Thomas P, Chen Z, Ochieng J. Fetuin-A (alpha 2HS glycoprotein) modulates growth, motility, invasion, and senescence in high-grade astrocytomas. Cancer Med. 2016 12; 5(12):3532-3543.
11. Nangami G, Koumangoye R, Shawn Goodwin J, Sakwe AM, Marshall D, Higginbotham J, Ochieng J. Fetuin-A associates with histones intracellularly and shuttles them to exosomes to promote focal adhesion assembly resulting in rapid adhesion and spreading in breast carcinoma cells. Exp Cell Res. 2014 Nov 01; 328(2):388-400.
12. Koumangoye RB, Nangami GN, Thompson PD, Agboto VK, Ochieng J, Sakwe AM. Reduced annexin A6 expression promotes the degradation of activated epidermal growth factor receptor and sensitizes invasive breast cancer cells to EGFR-targeted tyrosine kinase inhibitors. Mol Cancer. 2013 Dec 19; 12(1):167.
13. Thompson PD, Sakwe A, Koumangoye R, Yarbrough WG, Ochieng J, Marshall DR. Alpha-2 Heremans Schmid Glycoprotein (AHSG) modulates signaling pathways in head and neck squamous cell carcinoma cell line SQ20B. Exp Cell Res. 2014 Feb 15; 321(2):123-32.
14. Nangami GN, Watson K, Parker-Johnson K, Okereke KO, Sakwe A, Thompson P, Frimpong N, Ochieng J. Fetuin-A (a2HS-glycoprotein) is a serum chemo-attractant that also promotes invasion of tumor cells through Matrigel. Biochem Biophys Res Commun. 2013 Sep 06; 438(4):660-5.
15. Watson K, Koumangoye R, Thompson P, Sakwe AM, Patel T, Pratap S, Ochieng J. Fetuin-A triggers the secretion of a novel set of exosomes in detached tumor cells that mediate their adhesion and spreading. FEBS Lett. 2012 Sep 21; 586(19):3458-63.
16. Jagannathan M, Sakwe AM, Nguyen T, Frappier L. The MCM-associated protein MCM-BP is important for human nuclear morphology. J Cell Sci. 2012 Jan 01; 125(Pt 1):133-43.
17. Koumangoye RB, Sakwe AM, Goodwin JS, Patel T, Ochieng J. Detachment of breast tumor cells induces rapid secretion of exosomes which subsequently mediate cellular adhesion and spreading. PLoS One. 2011; 6(9):e24234.
18. Sakwe AM, Koumangoye R, Guillory B, Ochieng J. Annexin A6 contributes to the invasiveness of breast carcinoma cells by influencing the organization and localization of functional focal adhesions. Exp Cell Res. 2011 Apr 01; 317(6):823-37.
19. Sakwe AM, Koumangoye R, Goodwin SJ, Ochieng J. Fetuin-A ({alpha}2HS-glycoprotein) is a major serum adhesive protein that mediates growth signaling in breast tumor cells. J Biol Chem. 2010 Dec 31; 285(53):41827-35.
20. Guillory B, Sakwe AM, Saria M, Thompson P, Adhiambo C, Koumangoye R, Ballard B, Binhazim A, Cone C, Jahanen-Dechent W, Ochieng J. Lack of fetuin-A (alpha2-HS-glycoprotein) reduces mammary tumor incidence and prolongs tumor latency via the transforming growth factor-beta signaling pathway in a mouse model of breast cancer. Am J Pathol. 2010 Nov; 177(5):2635-44.
21. Ochieng J, Pratap S, Khatua AK, Sakwe AM. Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes. Exp Cell Res. 2009 Jul 01; 315(11):1875-88.
22. Aguda AH, Sakwe AM, Rask L, Robinson RC. Expression, crystallization and preliminary crystallographic data analysis of filamin A repeats 14-16. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Apr 01; 63(Pt 4):291-3.
23. Sakwe AM, Nguyen T, Athanasopoulos V, Shire K, Frappier L. Identification and characterization of a novel component of the human minichromosome maintenance complex. Mol Cell Biol. 2007 Apr; 27(8):3044-55.
24. Sakwe AM, Rask L, Gylfe E. Protein kinase C modulates agonist-sensitive release of Ca2+ from internal stores in HEK293 cells overexpressing the calcium sensing receptor. J Biol Chem. 2005 Feb 11; 280(6):4436-41.
25. Sakwe AM, Larsson M, Rask L. Involvement of protein kinase C-alpha and -epsilon in extracellular Ca(2+) signalling mediated by the calcium sensing receptor. Exp Cell Res. 2004 Jul 15; 297(2):560-73.
26. Larsson M, Hjälm G, Sakwe AM, Engström A, Höglund AS, Larsson E, Robinson RC, Sundberg C, Rask L. Selective interaction of megalin with postsynaptic density-95 (PSD-95)-like membrane-associated guanylate kinase (MAGUK) proteins. Biochem J. 2003 Jul 15; 373(Pt 2):381-91.
27. Sakwe AM, Engström A, Larsson M, Rask L. Biosynthesis and secretion of parathyroid hormone are sensitive to proteasome inhibitors in dispersed bovine parathyroid cells. J Biol Chem. 2002 May 17; 277(20):17687-95.
28. Sakwe AM, Evehe MS, Titanji VP. In vitro production and characterization of excretory/secretory products of Onchocerca volvulus. Parasite. 1997 Dec; 4(4):351-8.
29. Sakwe AM, Titanji VP. Evidence for increased hydroxylation of pyrrolidone amino acid residues in the cuticle of mature Onchocerca volvulus. Biochim Biophys Acta. 1997 May 24; 1360(3):196-202.
30. Titanji VP, Mbacham WF, Sakwe A. Identification of different radiolabelled antigens of the developmental stages of Onchocerca volvulus. Acta Trop. 1990 Jul; 47(5-6):307-21.

Research Resources icon

Publications Timeline

Top MeSH Keywords

Tree Map of Keyword Semantic Groups (Categories)

Left-click a node to move down the tree, right-click the graph to move back up the tree

Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile:
 
Keyword
Last Name
Institution
 
Keywords
Breast Neoplasms
Receptors, Calcium-Sensing
Calcium
alpha-2-HS-Glycoprotein
Exosomes
See all (258) keywords
See all (8) people See all (60) people Search for (7) people
Feedback

RTRN Collaboration and Professional Networking Feedback