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Marcus Tius
Faculty Rank
Institution University of Hawaii
City Honolulu
State HI
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1. Lopez-Tapia F, Brotherton-Pleiss C, Yue P, Murakami H, Costa Araujo AC, Reis Dos Santos B, Ichinotsubo E, Rabkin A, Shah R, Lantz M, Chen S, Tius MA, Turkson J. Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors. ACS Med Chem Lett. 2018 Mar 08; 9(3):250-255.
2. Ho TC, Shimada N, Tius MA, Nikas SP, Zhang W, Makriyannis A. C1''-Azacycloalkyl Hexahydrocannabinols. J Org Chem. 2017 08 04; 82(15):7839-7849.
3. Zhou Z, Dixon DD, Jolit A, Tius MA. The Evolution of the Total Synthesis of Rocaglamide. Chemistry. 2016 Oct 24; 22(44):15929-15936.
4. Asari AH, Lam YH, Tius MA, Houk KN. Origins of the Stereoselectivity in a Thiourea-Primary Amine-Catalyzed Nazarov Cyclization. J Am Chem Soc. 2015 Oct 14; 137(40):13191-9.
5. Zhou Z, Walleser PM, Tius MA. Isotetronic acids from an oxidative cyclization. Chem Commun (Camb). 2015 Jul 11; 51(54):10858-60.
6. Yue P, Lopez-Tapia F, Paladino D, Li Y, Chen CH, Namanja AT, Hilliard T, Chen Y, Tius MA, Turkson J. Hydroxamic Acid and Benzoic Acid-Based STAT3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes In Vitro and In Vivo. Cancer Res. 2016 Feb 01; 76(3):652-63.
7. Miller CM, Benneche T, Tius MA. First total synthesis of the marine natural products clavulolactones II and III. Org Biomol Chem. 2015 Apr 07; 13(13):4051-8.
8. Kitamura K, Shimada N, Stewart C, Atesin AC, Atesin TA, Tius MA. Enantioselective palladium(0)-catalyzed Nazarov-type cyclization. Angew Chem Int Ed Engl. 2015 May 18; 54(21):6288-91.
9. Zhou Z, Tius MA. Synthesis of each enantiomer of rocaglamide by means of a palladium(0)-catalyzed Nazarov-type cyclization. Angew Chem Int Ed Engl. 2015 May 11; 54(20):6037-40.
10. Ogawa G, Tius MA, Zhou H, Nikas SP, Halikhedkar A, Mallipeddi S, Makriyannis A. 3''-functionalized adamantyl cannabinoid receptor probes. J Med Chem. 2015 Apr 09; 58(7):3104-16.
11. Pratt LM, Dixon DD, Tius MA. Mixed aggregates of 1-methoxyallenyllithium with lithium chloride. ChemistryOpen. 2014 Dec; 3(6):250-5.
12. Jolit A, Walleser PM, Yap GP, Tius MA. Catalytic enantioselective Nazarov cyclization: construction of vicinal all-carbon-atom quaternary stereocenters. Angew Chem Int Ed Engl. 2014 Jun 10; 53(24):6180-3.
13. Tius MA. Allene ether Nazarov cyclization. Chem Soc Rev. 2014 May 07; 43(9):2979-3002.
14. Jolit A, Vazquez-Rodriguez S, Yap GP, Tius MA. Diastereospecific nazarov cyclization of fully substituted dienones: generation of vicinal all-carbon-atom quaternary stereocenters. Angew Chem Int Ed Engl. 2013 Oct 11; 52(42):11102-5.
15. Dixon DD, Tius MA, Thakur GA, Zhou H, Bowman AL, Shukla VG, Peng Y, Makriyannis A. C3-heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor. Bioorg Med Chem Lett. 2012 Aug 15; 22(16):5322-5.
16. Shimada N, Stewart C, Bow WF, Jolit A, Wong K, Zhou Z, Tius MA. Neutral Nazarov-type cyclization catalyzed by palladium(0). Angew Chem Int Ed Engl. 2012 Jun 04; 51(23):5727-9.
17. Shimada N, Stewart C, Tius MA. Asymmetric Nazarov Cyclizations. Tetrahedron. 2011 Aug 19; 67(33):5851-5870.
18. Dixon DD, Sethumadhavan D, Benneche T, Banaag AR, Tius MA, Thakur GA, Bowman A, Wood JT, Makriyannis A. Heteroadamantyl cannabinoids. J Med Chem. 2010 Aug 12; 53(15):5656-66.
19. Basak AK, Shimada N, Bow WF, Vicic DA, Tius MA. An organocatalytic asymmetric Nazarov cyclization. J Am Chem Soc. 2010 Jun 23; 132(24):8266-7.
20. Shimada N, Ashburn BO, Basak AK, Bow WF, Vicic DA, Tius MA. Organocatalytic asymmetric aza-Nazarov cyclization of an azirine. Chem Commun (Camb). 2010 Jun 07; 46(21):3774-5.
21. Bow WF, Basak AK, Jolit A, Vicic DA, Tius MA. Enamine-iminium ion Nazarov cyclization of alpha-ketoenones. Org Lett. 2010 Feb 05; 12(3):440-3.
22. Dixon DD, Tius MA, Pratt LM. Gas phase and solution structures of 1-methoxyallenyllithium. J Org Chem. 2009 Aug 21; 74(16):5881-6.
23. Banaag AR, Tius MA. Traceless chiral auxiliaries for the allene ether Nazarov cyclization. J Org Chem. 2008 Nov 07; 73(21):8133-41.
24. Basak AK, Tius MA. Interrupting the Nazarov cyclization with indoles. Org Lett. 2008 Sep 18; 10(18):4073-6.
25. Binder CM, Dixon DD, Almaraz E, Tius MA, Singaram B. A Simple Procedure for C-C Bond Cleavage of Aromatic and Aliphatic Epoxides with Aqueous Sodium Periodate Under Ambient Conditions. Tetrahedron Lett. 2008 Apr 21; 49(17):2764-2767.
26. Berger GO, Tius MA. Total synthesis of (+/-)-terpestacin and (+/-)-11-epi-terpestacin. J Org Chem. 2007 Aug 17; 72(17):6473-80.
27. Dhoro F, Kristensen TE, Stockmann V, Yap GP, Tius MA. Asymmetric amine-intercepted Nazarov cyclization. J Am Chem Soc. 2007 Jun 13; 129(23):7256-7.
28. Banaag AR, Tius MA. Design of chiral auxiliaries for the allene ether nazarov cyclization. J Am Chem Soc. 2007 May 02; 129(17):5328-9.
29. Wan L, Tius MA. Synthesis of (+)-madindoline A and (+)-madindoline B. Org Lett. 2007 Feb 15; 9(4):647-50.
30. Le Goanvic D, Tius MA. Oxaza adamantyl cannabinoids. A new class of cannabinoid receptor probes. J Org Chem. 2006 Sep 29; 71(20):7800-4.
31. delos Santos DB, Banaag AR, Tius MA. An improved chiral auxiliary for the allene ether version of the Nazarov cyclization. Org Lett. 2006 Jun 08; 8(12):2579-82.
32. Berger GO, Tius MA. Terpestacin core structure. control of stereochemistry. Org Lett. 2005 Oct 27; 7(22):5011-3.
33. Dhoro F, Tius MA. Interrupted Nazarov cyclization on silica gel. J Am Chem Soc. 2005 Sep 14; 127(36):12472-3.
34. Batson WA, Sethumadhavan D, Tius MA. Alpha-hydroxy cyclopentenones from alpha-diketones. Org Lett. 2005 Jun 23; 7(13):2771-4.
35. Bee C, Leclerc E, Tius MA. The palladium(II)-catalyzed Nazarov reaction. Org Lett. 2003 Dec 25; 5(26):4927-30.
36. Forest J, Bee C, Cordaro F, Tius MA. Isomerization-cyclization approach to the synthesis of 2-hydroxy-5-alkylidene-cyclopent-2-enones. Org Lett. 2003 Oct 30; 5(22):4069-72.
37. Bee C, Tius MA. Convergent cyclopentannelation process. Org Lett. 2003 May 15; 5(10):1681-4.
38. Leclerc E, Tius MA. The first example of Nazarov reactions of vinyl cumulenyl ketones. Org Lett. 2003 Apr 17; 5(8):1171-4.
39. Tius MA. Cationic cyclopentannelation of allene ethers. Acc Chem Res. 2003 Apr; 36(4):284-90.
40. Chu C, Ramamurthy A, Makriyannis A, Tius MA. Synthesis of covalent probes for the radiolabeling of the cannabinoid receptor. J Org Chem. 2003 Jan 10; 68(1):55-61.
41. Thakur GA, Palmer SL, Harrington PE, Stergiades IA, Tius MA, Makriyannis A. Enantiomeric resolution of a novel chiral cannabinoid receptor ligand. J Biochem Biophys Methods. 2002 Dec 31; 54(1-3):415-22.
42. Nakazaki A, Sharma U, Tius MA. Synthesis of the hydroazulene portion of guanacastepene A from the cyclopentannelation reaction. Org Lett. 2002 Oct 03; 4(20):3363-6.
43. Harrington PE, Murai T, Chu C, Tius MA. Asymmetric cyclopentannelation: camphor-derived auxiliary. J Am Chem Soc. 2002 Aug 28; 124(34):10091-100.
44. Li LH, Tius MA. Stereospecific synthesis of cryptophycin 1. Org Lett. 2002 May 16; 4(10):1637-40.
45. Schultz-Fademrecht C, Tius MA, Grimme S, Wibbeling B, Hoppe D. Synthesis of enantioenriched 5-alkylidene-2-cyclopentenones from chiral allenyl carbamates: generation of a chiral lithium allenolate and allylic activation for a conrotatory 4pi-electrocyclization. Angew Chem Int Ed Engl. 2002 May 03; 41(9):1532-5.
46. Harrington PE, Tius MA. Synthesis and absolute stereochemistry of roseophilin. J Am Chem Soc. 2001 Sep 05; 123(35):8509-14.
47. Jang WB, Hu H, Lieberman MM, Morgan JA, Stergiades IA, Clark DS, Tius MA. Parallel synthesis and biocatalytic amplification of a cross-conjugated cyclopentenone library. J Comb Chem. 2001 Jul-Aug; 3(4):346-53.
48. Harrington PE, Stergiades IA, Erickson J, Makriyannis A, Tius MA. Synthesis of functionalized cannabinoids. J Org Chem. 2000 Oct 06; 65(20):6576-82.
49. Harrington PE, Tius MA. Asymmetric cyclopentannelation. Chiral auxiliary on the allene. Org Lett. 2000 Aug 10; 2(16):2447-50.
50. Harrington PE, Tius MA. A formal total synthesis of roseophilin: cyclopentannelation approach to the macrocyclic core. Org Lett. 1999 Aug 26; 1(4):649-51.
51. Liang J, Hoard DW, Khau VV, Martinelli MJ, Moher ED, Moore RE, Tius MA. Synthesis of Unit A of Cryptophycin via a [2,3]-Wittig Rearrangement. J Org Chem. 1999 Mar 05; 64(5):1459-1463.
52. Drake DJ, Jensen RS, Busch-Petersen J, Kawakami JK, Concepcion Fernandez-Garcia M, Fan P, Makriyannis A, Tius MA. Classical/nonclassical hybrid cannabinoids: southern aliphatic chain-functionalized C-6beta methyl, ethyl, and propyl analogues. J Med Chem. 1998 Sep 10; 41(19):3596-608.
53. Tius MA, Hu H, Kawakami JK, Busch-Petersen J. Synthesis of 15-Deoxy-12-hydroxy-10-(trifluoromethyl)-Delta(7)-PGA(1) Methyl Ester. J Org Chem. 1998 Aug 21; 63(17):5971-5976.
54. Biswas DK, Mhashilkar AM, Ewaniuk DS, Pezza JA, Oh LM, Kannangara GS, Tius MA, Pardee AB. Inhibition of HIV-1 replication by combination of a novel inhibitor of TNF-alpha with AZT. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Aug 15; 18(5):426-34.
55. Busch-Petersen J, Hill WA, Fan P, Khanolkar A, Xie XQ, Tius MA, Makriyannis A. Unsaturated side chain beta-11-hydroxyhexahydrocannabinol analogs. J Med Chem. 1996 Sep 13; 39(19):3790-6.
56. Komori A, Okabe S, Suganuma M, Kerr MA, Busch-Petersen J, Oh LM, Zhuo J, Kannangara GS, Zou X, Tius MA, Fujiki H. Anti-tumor promoting activity of canventol and its synthetic analogs through inhibition of protein isoprenylation. Jpn J Cancer Res. 1996 Sep; 87(9):875-81.
57. Biswas DK, Tius MA, Zhuo J, Pardee AB. Canventol inhibits HIV-1 replication by Tat-induced Tar-independent mechanism. J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 01; 12(2):120-7.
58. Tius MA, Hill WA, Zou XL, Busch-Petersen J, Kawakami JK, Fernandez-Garcia MC, Drake DJ, Abadji V, Makriyannis A. Classical/non-classical cannabinoid hybrids; stereochemical requirements for the southern hydroxyalkyl chain. Life Sci. 1995; 56(23-24):2007-12.
59. Komori A, Suganuma M, Okabe S, Zou X, Tius MA, Fujiki H. Canventol inhibits tumor promotion in CD-1 mouse skin through inhibition of tumor necrosis factor alpha release and of protein isoprenylation. Cancer Res. 1993 Aug 01; 53(15):3462-4.
60. Tius MA, Patterson GM, Astrab DP. Synthesis and in vitro activity of some methylenomycin analogs. J Antibiot (Tokyo). 1985 Aug; 38(8):1061-7.

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