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Francisco Muñoz
Title Mr.
Faculty Rank Instructor
Degree MPH
Institution University of Puerto Rico
Department Center for Clinical Research and Health Promotion
Clusters Cardiovascular and Related Diseases
Community Engagement
Obesity and Metabolic Syndromes
Address
Univ de Puerto rico
City San Juan
State PR
Postal Code 00936
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  Area of Expertise: Oral Systemic Disease.

For more information, please visit: http://sdrc.rcm.upr.edu/CCRHP/biosketch/francisco .

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1. Picón-Pagès P, Bonet J, García-García J, Garcia-Buendia J, Gutierrez D, Valle J, Gómez-Casuso CES, Sidelkivska V, Alvarez A, Perálvarez-Marín A, Suades A, Fernàndez-Busquets X, Andreu D, Vicente R, Oliva B, Muñoz FJ. Human Albumin Impairs Amyloid ß-peptide Fibrillation Through its C-terminus: From docking Modeling to Protection Against Neurotoxicity in Alzheimer''s disease. Comput Struct Biotechnol J. 2019; 17:963-971.
2. Picón-Pagès P, Garcia-Buendia J, Muñoz FJ. Functions and dysfunctions of nitric oxide in brain. Biochim Biophys Acta Mol Basis Dis. 2019 08 01; 1865(8):1949-1967.
3. Valls-Comamala V, Guivernau B, Bonet J, Puig M, Perálvarez-Marín A, Palomer E, Fernàndez-Busquets X, Altafaj X, Tajes M, Puig-Pijoan A, Vicente R, Oliva B, Muñoz FJ. The antigen-binding fragment of human gamma immunoglobulin prevents amyloid ß-peptide folding into ß-sheet to form oligomers. Oncotarget. 2017 Jun 20; 8(25):41154-41165.
4. Vilanova B, Fernández D, Casasnovas R, Pomar AM, Alvarez-Idaboy JR, Hernández-Haro N, Grand A, Adrover M, Donoso J, Frau J, Muñoz F, Ortega-Castro J. Formation mechanism of glyoxal-DNA adduct, a DNA cross-link precursor. Int J Biol Macromol. 2017 May; 98:664-675.
5. Pérez CM, Muñoz F, Andriankaja OM, Ritchie CS, Martínez S, Vergara J, Vivaldi J, López L, Campos M, Joshipura KJ. Cross-sectional associations of impaired glucose metabolism measures with bleeding on probing and periodontitis. J Clin Periodontol. 2017 02; 44(2):142-149.
6. Garcia-Garcia J, Valls-Comamala V, Guney E, Andreu D, Muñoz FJ, Fernandez-Fuentes N, Oliva B. iFrag: A Protein-Protein Interface Prediction Server Based on Sequence Fragments. J Mol Biol. 2017 02 03; 429(3):382-389.
7. Frau J, Muñoz F, Glossman-Mitnik D. A Molecular Electron Density Theory Study of the Chemical Reactivity of Cis- and Trans-Resveratrol. Molecules. 2016 Dec 01; 21(12).
8. Guivernau B, Bonet J, Valls-Comamala V, Bosch-Morató M, Godoy JA, Inestrosa NC, Perálvarez-Marín A, Fernández-Busquets X, Andreu D, Oliva B, Muñoz FJ. Amyloid-ß Peptide Nitrotyrosination Stabilizes Oligomers and Enhances NMDAR-Mediated Toxicity. J Neurosci. 2016 11 16; 36(46):11693-11703.
9. Ramos-Fernández E, Tajes M, Ill-Raga G, Vargas L, Busquets-García A, Bosch-Morató M, Guivernau B, Valls-Comamala V, Gomis M, Grau C, Fandos C, Rosen MD, Rabinowitz MH, Inestrosa N, Maldonado R, Altafaj X, Ozaita A, Alvarez A, Vicente R, Valverde MA, Muñoz FJ. Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2a kinase in cortical neurons. Oncotarget. 2016 09 13; 7(37):58876-58892.
10. Bosch-Morató M, Iriondo C, Guivernau B, Valls-Comamala V, Vidal N, Olivé M, Querfurth H, Muñoz FJ. Increased amyloid ß-peptide uptake in skeletal muscle is induced by hyposialylation and may account for apoptosis in GNE myopathy. Oncotarget. 2016 Mar 22; 7(12):13354-71.
11. Garfein RS, Collins K, Muñoz F, Moser K, Cerecer-Callu P, Raab F, Rios P, Flick A, Zúñiga ML, Cuevas-Mota J, Liang K, Rangel G, Burgos JL, Rodwell TC, Patrick K. Feasibility of tuberculosis treatment monitoring by video directly observed therapy: a binational pilot study. Int J Tuberc Lung Dis. 2015 Sep; 19(9):1057-64.
12. Mariño L, Pauwels K, Casasnovas R, Sanchis P, Vilanova B, Muñoz F, Donoso J, Adrover M. Ortho-methylated 3-hydroxypyridines hinder hen egg-white lysozyme fibrillogenesis. Sci Rep. 2015 Jul 14; 5:12052.
13. Solís-Calero C, Ortega-Castro J, Frau J, Muñoz F. Nonenzymatic Reactions above Phospholipid Surfaces of Biological Membranes: Reactivity of Phospholipids and Their Oxidation Derivatives. Oxid Med Cell Longev. 2015; 2015:319505.
14. Solís-Calero C, Ortega-Castro J, Hernández-Laguna A, Frau J, Muñoz F. A DFT study of the carboxymethyl-phosphatidylethanolamine formation from glyoxal and phosphatidylethanolamine surface. Comparison with the formation of N(e)-(carboxymethyl)lysine from glyoxal and L-lysine. Phys Chem Chem Phys. 2015 Mar 28; 17(12):8210-22.
15. Ill-Raga G, Tajes M, Busquets-García A, Ramos-Fernández E, Vargas LM, Bosch-Morató M, Guivernau B, Valls-Comamala V, Eraso-Pichot A, Guix FX, Fandos C, Rosen MD, Rabinowitz MH, Maldonado R, Alvarez AR, Ozaita A, Muñoz FJ. Physiological Control of Nitric Oxide in Neuronal BACE1 Translation by Heme-Regulated eIF2a Kinase HRI Induces Synaptogenesis. Antioxid Redox Signal. 2015 May 20; 22(15):1295-307.
16. Pacheco CR, Morales CN, Ramírez AE, Muñoz FJ, Gallegos SS, Caviedes PA, Aguayo LG, Opazo CM. Extracellular a-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane. J Neurochem. 2015 Mar; 132(6):731-41.
17. Vicario-Orri E, Opazo CM, Muñoz FJ. The pathophysiology of axonal transport in Alzheimer''s disease. J Alzheimers Dis. 2015; 43(4):1097-113.
18. Ill-Raga G, Palomer E, Ramos-Fernández E, Guix FX, Bosch-Morató M, Guivernau B, Tajes M, Valls-Comamala V, Jiménez-Conde J, Ois A, Pérez-Asensio F, Reyes-Navarro M, Caballo C, Gil-Gómez G, Lopez-Vilchez I, Galan AM, Alameda F, Escolar G, Opazo C, Planas AM, Roquer J, Valverde MA, Muñoz FJ. Fibrinogen nitrotyrosination after ischemic stroke impairs thrombolysis and promotes neuronal death. Biochim Biophys Acta. 2015 Mar; 1852(3):421-8.
19. Castro PA, Ramirez A, Sepúlveda FJ, Peters C, Fierro H, Waldron J, Luza S, Fuentealba J, Muñoz FJ, De Ferrari GV, Bush AI, Aguayo LG, Opazo CM. Copper-uptake is critical for the down regulation of synapsin and dynamin induced by neocuproine: modulation of synaptic activity in hippocampal neurons. Front Aging Neurosci. 2014; 6:319.
20. Adrover M, Mariño L, Sanchis P, Pauwels K, Kraan Y, Lebrun P, Vilanova B, Muñoz F, Broersen K, Donoso J. Mechanistic insights in glycation-induced protein aggregation. Biomacromolecules. 2014 Sep 08; 15(9):3449-62.
21. Tajes M, Ramos-Fernández E, Weng-Jiang X, Bosch-Morató M, Guivernau B, Eraso-Pichot A, Salvador B, Fernàndez-Busquets X, Roquer J, Muñoz FJ. The blood-brain barrier: structure, function and therapeutic approaches to cross it. Mol Membr Biol. 2014 Aug; 31(5):152-67.
22. Bellot A, Guivernau B, Tajes M, Bosch-Morató M, Valls-Comamala V, Muñoz FJ. The structure and function of actin cytoskeleton in mature glutamatergic dendritic spines. Brain Res. 2014 Jul 21; 1573:1-16.
23. Solís-Calero C, Ortega-Castro J, Hernández-Laguna A, Muñoz F. DFT study of the mechanism of the reaction of aminoguanidine with methylglyoxal. J Mol Model. 2014 Apr; 20(4):2202.
24. Muñoz FJ, Godoy JA, Cerpa W, Poblete IM, Huidobro-Toro JP, Inestrosa NC. Wnt-5a increases NO and modulates NMDA receptor in rat hippocampal neurons. Biochem Biophys Res Commun. 2014 Feb 07; 444(2):189-94.
25. Ramos-Fernández E, Tajes M, Palomer E, Ill-Raga G, Bosch-Morató M, Guivernau B, Román-Dégano I, Eraso-Pichot A, Alcolea D, Fortea J, Nuñez L, Paez A, Alameda F, Fernández-Busquets X, Lleó A, Elosúa R, Boada M, Valverde MA, Muñoz FJ. Posttranslational nitro-glycative modifications of albumin in Alzheimer''s disease: implications in cytotoxicity and amyloid-ß peptide aggregation. J Alzheimers Dis. 2014; 40(3):643-57.
26. Tajes M, Eraso-Pichot A, Rubio-Moscardó F, Guivernau B, Ramos-Fernández E, Bosch-Morató M, Guix FX, Clarimón J, Miscione GP, Boada M, Gil-Gómez G, Suzuki T, Molina H, Villà-Freixa J, Vicente R, Muñoz FJ. Methylglyoxal produced by amyloid-ß peptide-induced nitrotyrosination of triosephosphate isomerase triggers neuronal death in Alzheimer''s disease. J Alzheimers Dis. 2014; 41(1):273-88.
27. Rubio-Moscardo F, Setó-Salvia N, Pera M, Bosch-Morató M, Plata C, Belbin O, Gené G, Dols-Icardo O, Ingelsson M, Helisalmi S, Soininen H, Hiltunen M, Giedraitis V, Lannfelt L, Frank A, Bullido MJ, Combarros O, Sánchez-Juan P, Boada M, Tárraga L, Pastor P, Pérez-Tur J, Baquero M, Molinuevo JL, Sánchez-Valle R, Fuentes-Prior P, Fortea J, Blesa R, Muñoz FJ, Lleó A, Valverde MA, Clarimón J. Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer''s disease patients alter calcium homeostasis. PLoS One. 2013; 8(9):e74203.
28. Casasnovas R, Ortega-Castro J, Donoso J, Frau J, Muñoz F. Theoretical calculations of stability constants and pKa values of metal complexes in solution: application to pyridoxamine-copper(II) complexes and their biological implications in AGE inhibition. Phys Chem Chem Phys. 2013 Oct 14; 15(38):16303-13.
29. Tajes M, Ill-Raga G, Palomer E, Ramos-Fernández E, Guix FX, Bosch-Morató M, Guivernau B, Jiménez-Conde J, Ois A, Pérez-Asensio F, Reyes-Navarro M, Caballo C, Galán AM, Alameda F, Escolar G, Opazo C, Planas A, Roquer J, Valverde MA, Muñoz FJ. Nitro-oxidative stress after neuronal ischemia induces protein nitrotyrosination and cell death. Oxid Med Cell Longev. 2013; 2013:826143.
30. Casasnovas R, Frau J, Ortega-Castro J, Donoso J, Muñoz F. C-H activation in pyridoxal-5''-phosphate and pyridoxamine-5''-phosphate Schiff bases: effect of metal chelation. A computational study. J Phys Chem B. 2013 Feb 28; 117(8):2339-47.
31. Caldés C, Vilanova B, Adrover M, Donoso J, Muñoz F. The hydrophobic substituent in aminophospholipids affects the formation kinetics of their Schiff bases. Bioorg Med Chem Lett. 2013 Apr 01; 23(7):2202-6.
32. Tajes M, Guivernau B, Ramos-Fernández E, Bosch-Morató M, Palomer E, Guix FX, Muñoz FJ. The pathophysiology of triose phosphate isomerase dysfunction in Alzheimer''s disease. Histol Histopathol. 2013 01; 28(1):43-51.
33. Casasnovas R, Adrover M, Ortega-Castro J, Frau J, Donoso J, Muñoz F. C-H activation in pyridoxal-5''-phosphate Schiff bases: the role of the imine nitrogen. A combined experimental and computational study. J Phys Chem B. 2012 Sep 06; 116(35):10665-75.
34. Guix FX, Wahle T, Vennekens K, Snellinx A, Chávez-Gutiérrez L, Ill-Raga G, Ramos-Fernandez E, Guardia-Laguarta C, Lleó A, Arimon M, Berezovska O, Muñoz FJ, Dotti CG, De Strooper B. Modification of ?-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer''s disease. EMBO Mol Med. 2012 Jul; 4(7):660-73.
35. Ortega-Castro J, Frau J, Casasnovas R, Fernández D, Donoso J, Muñoz F. High- and low-spin Fe(III) complexes of various AGE inhibitors. J Phys Chem A. 2012 Mar 22; 116(11):2961-71.
36. Vilanova B, Gallardo JM, Caldés C, Adrover M, Ortega-Castro J, Muñoz F, Donoso J. Formation of Schiff bases of O-phosphorylethanolamine and O-phospho-D,L-serine with pyridoxal 5''-phosphate. experimental and theoretical studies. J Phys Chem A. 2012 Mar 01; 116(8):1897-905.
37. Aso E, Palomer E, Juvés S, Maldonado R, Muñoz FJ, Ferrer I. CB1 agonist ACEA protects neurons and reduces the cognitive impairment of AßPP/PS1 mice. J Alzheimers Dis. 2012; 30(2):439-59.
38. Caldés C, Vilanova B, Adrover M, Muñoz F, Donoso J. Phenol group in pyridoxamine acts as a stabilizing element for its carbinolamines and Schiff bases. Chem Biodivers. 2011 Jul; 8(7):1318-32.
39. Ill-Raga G, Palomer E, Wozniak MA, Ramos-Fernández E, Bosch-Morató M, Tajes M, Guix FX, Galán JJ, Clarimón J, Antúnez C, Real LM, Boada M, Itzhaki RF, Fandos C, Muñoz FJ. Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression. PLoS One. 2011; 6(6):e21456.
40. Caldés C, Vilanova B, Adrover M, Muñoz F, Donoso J. Understanding non-enzymatic aminophospholipid glycation and its inhibition. Polar head features affect the kinetics of Schiff base formation. Bioorg Med Chem. 2011 Aug 01; 19(15):4536-43.
41. Solís-Calero C, Ortega-Castro J, Muñoz F. Reactivity of a phospholipid monolayer model under periodic boundary conditions: a density functional theory study of the Schiff base formation between phosphatidylethanolamine and acetaldehyde. J Phys Chem B. 2010 Dec 09; 114(48):15879-85.
42. Ortega-Castro J, Adrover M, Frau J, Salvà A, Donoso J, Muñoz F. DFT studies on Schiff base formation of vitamin B6 analogues. Reaction between a pyridoxamine-analogue and carbonyl compounds. J Phys Chem A. 2010 Apr 08; 114(13):4634-40.
43. Ill-Raga G, Ramos-Fernández E, Guix FX, Tajes M, Bosch-Morató M, Palomer E, Godoy J, Belmar S, Cerpa W, Simpkins JW, Inestrosa And NC, Muñoz FJ. Amyloid-ß peptide fibrils induce nitro-oxidative stress in neuronal cells. J Alzheimers Dis. 2010; 22(2):641-52.
44. Guix FX, Ill-Raga G, Bravo R, Nakaya T, de Fabritiis G, Coma M, Miscione GP, Villà-Freixa J, Suzuki T, Fernàndez-Busquets X, Valverde MA, de Strooper B, Muñoz FJ. Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation. Brain. 2009 May; 132(Pt 5):1335-45.
45. Adrover M, Vilanova B, Muñoz F, Donoso J. Unexpected isomeric equilibrium in pyridoxamine Schiff bases. Bioorg Chem. 2009 Feb; 37(1):26-32.
46. Adrover M, Vilanova B, Frau J, Muñoz F, Donoso J. A comparative study of the chemical reactivity of pyridoxamine, Ac-Phe-Lys and Ac-Cys with various glycating carbonyl compounds. Amino Acids. 2009 Mar; 36(3):437-48.
47. Adrover M, Vilanova B, Frau J, Muñoz F, Donoso J. The pyridoxamine action on Amadori compounds: A reexamination of its scavenging capacity and chelating effect. Bioorg Med Chem. 2008 May 15; 16(10):5557-69.
48. Adrover M, Vilanova B, Muñoz F, Donoso J. Kinetic study of the reaction of glycolaldehyde with two glycation target models. Ann N Y Acad Sci. 2008 Apr; 1126:235-40.
49. Coma M, Guix FX, Ill-Raga G, Uribesalgo I, Alameda F, Valverde MA, Muñoz FJ. Oxidative stress triggers the amyloidogenic pathway in human vascular smooth muscle cells. Neurobiol Aging. 2008 Jul; 29(7):969-80.
50. Adrover M, Vilanova B, Muñoz F, Donoso J. Inhibition of glycosylation processes: the reaction between pyridoxamine and glucose. Chem Biodivers. 2005 Jul; 2(7):964-75.
51. Coma M, Guix FX, Uribesalgo I, Espuña G, Solé M, Andreu D, Muñoz FJ. Lack of oestrogen protection in amyloid-mediated endothelial damage due to protein nitrotyrosination. Brain. 2005 Jul; 128(Pt 7):1613-21.
52. Vilanova B, Adrover M, Muñoz F, Donoso J. Photo-induced processes in vitamin B6 compounds. Chem Biodivers. 2004 Jul; 1(7):1073-90.
53. Muñoz FJ, De la Fuente M. Lymphoid distribution in the migratory gull Larus ridibundus. Comp Biochem Physiol A Mol Integr Physiol. 2003 Nov; 136(3):749-56.
54. Clarimón J, Muñoz FJ, Boada M, Tàrraga L, Sunyer J, Bertranpetit J, Comas D. Possible increased risk for Alzheimer''s disease associated with neprilysin gene. J Neural Transm (Vienna). 2003 Jun; 110(6):651-7.
55. Fenollar-Ferrer C, Frau J, Donoso J, Muñoz F. Role of beta-lactam carboxyl group on binding of penicillins and cephalosporins to class C beta-lactamases. Proteins. 2003 May 15; 51(3):442-52.
56. Muñoz FJ, De la Fuente M. In vitro proliferation of blood, spleen and thymus leukocytes from the turtle Mauremys caspica. Comp Biochem Physiol C Toxicol Pharmacol. 2003 Mar; 134(3):303-9.
57. Muñoz FJ, Fuente M. Effect of migratory cycle and 17beta-estradiol on splenic leukocyte functions in female black-headed gulls. Pflugers Arch. 2003 Mar; 445(6):659-64.
58. Muñoz FJ, Opazo C, Gil-Gómez G, Tapia G, Fernández V, Valverde MA, Inestrosa NC. Vitamin E but not 17beta-estradiol protects against vascular toxicity induced by beta-amyloid wild type and the Dutch amyloid variant. J Neurosci. 2002 Apr 15; 22(8):3081-9.
59. Muñoz FJ, De la Fuente M. The effect of the seasonal cycle on the splenic leukocyte functions in the turtle Mauremys caspica. Physiol Biochem Zool. 2001 Sep-Oct; 74(5):660-7.
60. Muñoz FJ, De la Fuente M. The immune response of thymic cells from the turtle Mauremys caspica. J Comp Physiol B. 2001 Apr; 171(3):195-200.
61. Miranda S, Opazo C, Larrondo LF, Muñoz FJ, Ruiz F, Leighton F, Inestrosa NC. The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer''s disease. Prog Neurobiol. 2000 Dec; 62(6):633-48.
62. Valverde MA, Vázquez E, Muñoz FJ, Nobles M, Delaney SJ, Wainwright BJ, Colledge WH, Sheppard DN. Murine CFTR channel and its role in regulatory volume decrease of small intestine crypts. Cell Physiol Biochem. 2000; 10(5-6):321-8.
63. Alvarez A, Alarcón R, Opazo C, Campos EO, Muñoz FJ, Calderón FH, Dajas F, Gentry MK, Doctor BP, De Mello FG, Inestrosa NC. Stable complexes involving acetylcholinesterase and amyloid-beta peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer''s fibrils. J Neurosci. 1998 May 01; 18(9):3213-23.
64. Ruiz-Torres A, Gimeno A, Muñoz FJ. Estimation of the aging rates of populations through the prevalence of age-related diseases. Arch Gerontol Geriatr. 1994 Nov-Dec; 19(3):235-42.
65. Vilanova B, Muñoz F, Donoso J, Frau J, Garcia Blanco F. Alkaline hydrolysis of cefotaxime. A HPLC and 1H NMR study. J Pharm Sci. 1994 Mar; 83(3):322-7.

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