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Cornelis Vlaar
Title Director Department of Pharmaceutical Sciences
Faculty Rank Professor
Degree Ph.D.
Institution University of Puerto Rico
Department Pharmaceutical Sciences
Clusters Cancer
Address
UPR- Medical Sciences Campus
School of Pharmacy
PO Box 365067
City San Juan
State PR
Postal Code 00936-5067
Telephone (787)758-2525 exts.: 5412, 5432
Fax
Email
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  Academic Position
Dr. Cornelis Vlaar is Professor at the School of Pharmacy, University of Puerto Rico Medical Sciences Campus, where since 2012 he also serves as Chair of the Department of Pharmaceutical Sciences.

Education
Dr. Vlaar received his doctoral degree in Organic Chemistry from the Vrije Universiteit in Amsterdam, The Netherlands. He conducted post doctoral studies in Louisiana State University and The Scripss Research Institute.

Research Area
Biologically active molecules.

Description of research interests
Dr. Vlaar research targets organic molecules with biological activity which can be used as enzyme inhibitors as well as therapeutic agents.

Research Funding
Research activities are currently supported by the NIGMS MBRS-SCORE program; Previously, research was supported via INDUNIV, a local research consortium, and institutional funds from the NCRR-RCMI program at the University of Puerto Rico Medical Sciences Campus.

NIH Awarded Grants icon

  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

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1.
2018HEAD START CONNECTS: INDIVIDUALIZING AND CONNECTS FAMILIES TO FAMILY SUPPORT SERVICESHHSP233201500059I/HHSP233201500059I
2.
2018 EARLY CARE AND EDUCATION LEADERSHIP STUDY (EXCELS)HHSP233201500035I / HHSP23337038T
3.
2018WHAT WORKS CLEARINGHOUSE OF PROVEN AND PROMISING APPROACHES TO MOVE WELFARE RECIPIENTS TO WORKHHSP233201500035I_HHSP23337034T
4.
2018RACIAL AND ETHNIC DISPARITIES IN HUMAN SERVICES ANALYSIS EXECUTION PROJECTHHSP233201500064I_HHSP23337020T
5.
2018ASSESSING MODELS OF COORDINATED SERVICES FOR LOW-INCOME CHILDREN AND THEIR FAMILIESHHSP233201500035I/HHSP23337028T
6.
2018CHILD CARE INTERSTATE BACKGROUND CHECKS (CC-IBACS)HHSP233201500045I
7.
2018MOTHER AND INFANT HOME VISITING PROGRAM EVALUATION, LONG-TERM FOLLOW-UP 2 (MIHOPE-LT2)HHSP233201500059I/ HHSP23337010T
8.
2017EXPLORING THE RELATION BETWEEN POSITIVE BEHAVIOR SUPPORT AND LANGUAGE LEARNING OPPORTUNITIES IN PRESCHOOL CLASSROOMS.90YR0101-01
9.
2017ADDRESSING THE NEEDS OF INFANTS AND TODDLERS EXPOSED TO MALTREATMENT: EXAMINING THE IMPACT OF AN INTEGRATED EARLY HEAD START & CHILDREN AND YOUTH SERVICES PROGRAM90YR0102-01
10.
2017LEVERAGING HOME LANGUAGES TO PROMOTE EXECUTIVE FUNCTIONING90YR0103-01
11.
2017A STRENGTHS-BASED APPROACH TO EXAMINING SUPPORTS FOR SELF-REGULATION SKILLS OF LATINO CHILDREN RAISED IN POVERTY90YR0104-01
12.
2017OBSERVING SELF-REGULATION IN CONTEXT IN HEAD START CLASSROOMS AND DUAL LANGUAGE LEARNERS SCHOOL READINESS90YR0105-01
13.
2017IMPLEMENTATION AND ASSESSMENT OF COMPETENCIES FOR TEACHERS AND CAREGIVERS SERVING INFANTS AND TODDLERSHHSP233201500035I/HHSP23337021T
14.
2017ASSESSMENT AND MAPPING OF COMMUNITY CONNECTIONS IN HOME VISITING (AMC-HV)HHSP233201500034I/HHSP23337002T
15.
2017CHILD MALTREATMENT INCIDENCE DATA LINKAGES (CMI DATA LINKAGES)HHSP233201500035I/HHSP23337022T
16.
2017EVIDENCE BUILDING IN TANF: ADVANCING INNOVATIONS TO PROMOTE EMPLOYMENT AND ECONOMIC SECURITY FOR LOW-INCOME INDIVIDUALSHHSP233201500059I/HHSP23337006T
17.
2017HEAD START FAMILY AND CHILD EXPERIENCES SURVEY (FACES) 2019HHSP233201500035I/HHSP23337024T
18.
2016TWO-GENERATION APPROACHES TO IMPROVING FAMILY SELF-SUFFICIENCYHHSP233201500035I/HHSP23337003T
19.
2016BUILDING CAPACITY TO EVALUATE INTERVENTIONS FOR YOUTH/YOUNG ADULTS WITH CHILD WELFARE INVOLVEMENT AT-RISK OF HOMELESSNESS: PHASE IIHHSP233201500035I/HHSP23337013T
20.
2016PROFESSIONAL DEVELOPMENT TOOLS TO IMPROVE THE QUALITY OF INFANT AND TODDLER CAREHHSP233201500035I/HHSP23337007T
21.
2016ASSESSING THE EVIDENCE: HOME VISITING EVIDENCE OF EFFECTIVENESSGS-10F-0050L/HHSP233201500115G
22.
2016TRIBAL HOME VISITING EVALUATION INSTITUTEGS-10F-0204K/HHSP233201500114G
23.
2016FAMILY SELF-SUFFICIENCY DATA CENTER90PD0272-04
24.
2016EVALUATION OF GOAL-DIRECTED PSYCHOLOGICAL CAPITAL AND EMPLOYER COACHING IN HEALTH PROFESSION OPPORTUNITY DEVELOPMENT90HG1003-01
25.
2016CULTURE OF CONTINUOUS LEARNING PROJECT: A BREAKTHROUGH SERIES COLLABORATIVE FOR IMPROVING CHILD CARE AND HEAD START QUALITYHHSP233201500034I/HHSP23337001T
26.
2016DOMESTIC HUMAN TRAFFICKING AND THE CHILD WELFARE POPULATIONHHSP23320150039I/HHSP23337011T
27.
2016EVALUATION OF COACHING-FOCUSED INTERVENTIONS FOR HARD-TO-EMPLOY TANF CLIENTS AND OTHER LOW-INCOME POPULATIONSHHSP233201500035I/HHSP23337018T
28.
2016EVALUATION OF THE NATIONAL HUMAN TRAFFICKING HOTLINE PROGRAMHHSP233201500039I/ HHSP23337007T
29.
2016MULTI-SITE IMPLEMENTATION EVALUATION OF TRIBAL HOME VISITING (MUSE)HHSP233201500133I/HHSP23337004T
30.
2016VARIATIONS IN IMPLEMENTATION OF QUALITY INTERVENTIONS: EXAMINING THE QUALITY-CHILD OUTCOMES RELATIONSHIP IN CHILD CARE AND EARLY EDUCATION (VIQI)HHSP233201500059I/HHSP23337002T
31.
2016DESIGN OPTIONS FOR HOME VISITING EVALUATION (DOHVE) 2.0HHSP233201500133I/HHSP23337002T
32.
2016ADVANCING WELFARE AND FAMILY SELF-SUFFICIENCY RESEARCH PROJECT (FOLLOW-ON) HHSP233201500035I/HHSP23337017T
33.
2016HPOG UNIVERSITY PARTNERSHIPS 2.0 RESEARCH SUPPORTHHSP233201500071I/HHSP23337011T
34.
2015THE CHANGING LANDSCAPE OF PUBLICLY-FUNDED CENTER-BASED CHILD CARE: 1990 AND 2012.90YE0165-01
35.
2015SUBSIDY UTILIZATION AND IMPACT ON EARLY CARE AND EDUCATION OF LOW-INCOME CHILDREN WITH SPECIAL NEEDS90YE0166-01
36.
2015PROMOTING SOCIAL COMPETENCE IN ECE: PREDICTING THE DEVELOPMENT OF PROSOCIAL BEHAVIOR FROM EARLY EXPERIENCES IN CHILD CARE AND FAMILIES90YE0168-01
37.
2015THE IMPACT OF EARLY CARE AND EDUCATION IN CHILD NUTRITION, SEDENTARY BEHAVIOR AND OBESITY BY KINDERGARTEN90YE0170-01
38.
2015HOW PARENTAL PREFERENCES AND SUBSIDY RECEIPT SHAPE IMMIGRANT FAMILIES? CHILD CARE CHOICES90YE0171-01
39.
2015SUPPORTING LOW-INCOME FAMILIES: STATE VARIATIONS IN CHILD CARE SUBSIDIES AND TANF POLICIES AND CHILDREN'S DEVELOPMENTAL ECOLOGIES90YE0173-01
40.
2015MITIGATING SUSCEPTIBILITY WITH THE CHILD CARE DEVELOPMENT FUND: USING FOUR LARGE DATA SETS TO CLASSIFY RISK PROFILES AND RISK TRANSMISSION BY MODIFIABLE FACTORS90YE0175-01
41.
2015ARE HIGHER SUBSIDY PAYMENT RATES AND PROVIDER-FRIENDLY PAYMENT POLICIES ASSOCIATED WITH CHILD CARE QUALITY?90YE0177-01
42.
2015CHILD CARE FACTORS THAT INFLUENCE PARENTAL ENGAGEMENT: UNDERSTANDING LONGITUDINAL PATHWAYS TO CHILDREN?S SCHOOL READINESS90YE0178-01
43.
2015CONSTELLATIONS OF SUPPORT: TEACHER PROFESSIONAL DEVELOPMENT IN HEAD START AND CHILD OUTCOMES90YE0179-01
44.
2015SUHMRE: SAME-SEX RELATIONSHIPS: UPDATES TO HEALTHY MARRIAGE AND RELATIONSHIP EDUCATION PROGRAMMINGHHSP233201500064I/HHSP23337001T
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2014ASSESSING THE COST AND IMPLEMENTATION OF HIGH QUALITY EARLY CARE AND EDUCATION (ACIHQECE)HHSP23320095642WC-01
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2014INTERMEDIATE OUTCOMES OF CAREER PATHWAYS PROGRAMSHHSP233200956WC-01
47.
2014CHILD CARE AND DEVELOPMENT FUND (CCDF) POLICIES DATABASE PROJECTHHSP23320095654WC-01
48.
2014EVALUATION OF DOMESTIC HUMAN TRAFFICKING DEMONSTRATION PROJECTSHHSP23320095651WC-01
49.
2014HOMELESS FAMILIES RESEARCH BRIEFSHHSP23320095624WC-01
50.
2014RESPONDING TO INTIMATE VIOLENCE IN RELATIONSHIP PROGRAMS (RIVIR)HHSP23320095651WC-01
51.
2014UNDERSTANDING THE INTERSECTION BETWEEN TANF AND REFUGEE CASH ASSISTANCE SERVICESHHSP23320095624WC-01
52.
2014IMPROVING CHILDREN?S WELL-BEING: IDENTIFYING MECHANISMS AND TIMING OF FAMILY STRENGTHENING PROGRAMS FOR LOW-INCOME FAMILIES THROUGH DIFFERENTIAL EQUATION MODELING90PD0285-01
53.
2013MOTHER AND INFANT HOME VISITING PROGRAM EVALUATION (MIHOPE)HHSP23337003T-03
54.
2013STUDY OF EMPLOYMENT AND ADVANCEMENT OF RACIAL, ETHNIC AND LINGUISTIC MINORITIES90PH0021-02
55.
2013CHILD CARE AND EARLY EDUCATION POLICY AND RESEARCH ANALYSES (CCEEPRA)HHSP23320095631WC-01
56.
2013EARLY HEAD START-CHILD CARE PARTNERSHIPS STUDYHHSP23320095642WC-01
57.
2013EMPLOYMENT AND TRAINING EVIDENCE REVIEWHHSP23320095642WC-01
58.
2013MATERNAL, INFANT AND EARLY CHILDHOOD HOME VISITING EVALUATION (MIHOPE) IIHHSP23320095644WC-01
59.
2013JOB SEARCH ASSISTANCE EVALUATIONHHSP23320095624WC-01
60.
2013CHILD CARE ADMINISTRATIVE DATA ANALYSIS90YE0148-01
61.
2013HEAD START UNIVERSITY PARTNERSHIPS: DUAL GENERATION APPROACHES90YR0073-01
62.
2013HEAD START UNIVERSITY PARTNERSHIPS: DUAL GENERATION APPROACHES90YR0075-01
63.
2013HUMAN SERVICES RESEARCH PARTNERSHIPS: PUERTO RICO 90YR0072-01

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1. Maldonado MDM, Rosado-González G, Bloom J, Duconge J, Ruiz-Calderón JF, Hernández-O''Farrill E, Vlaar C, Rodríguez-Orengo JF, Dharmawardhane S. Pharmacokinetics of the Rac/Cdc42 Inhibitor MBQ-167 in Mice by Supercritical Fluid Chromatography-Tandem Mass Spectrometry. ACS Omega. 2019 Nov 05; 4(19):17981-17989.
2. Vlaar CP, Castillo-Pichardo L, Medina JI, Marrero-Serra CM, Vélez E, Ramos Z, Hernández E. Design, synthesis and biological evaluation of new carbazole derivatives as anti-cancer and anti-migratory agents. Bioorg Med Chem. 2018 02 15; 26(4):884-890.
3. Humphries-Bickley T, Castillo-Pichardo L, Hernandez-O''Farrill E, Borrero-Garcia LD, Forestier-Roman I, Gerena Y, Blanco M, Rivera-Robles MJ, Rodriguez-Medina JR, Cubano LA, Vlaar CP, Dharmawardhane S. Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer. Mol Cancer Ther. 2017 05; 16(5):805-818.
4. Veluthakal R, Tunduguru R, Arora DK, Sidarala V, Syeda K, Vlaar CP, Thurmond DC, Kowluru A. VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells. Diabetologia. 2015 Nov; 58(11):2573-81.
5. Sidarala V, Veluthakal R, Syeda K, Vlaar C, Newsholme P, Kowluru A. Phagocyte-like NADPH oxidase (Nox2) promotes activation of p38MAPK in pancreatic ß-cells under glucotoxic conditions: Evidence for a requisite role of Ras-related C3 botulinum toxin substrate 1 (Rac1). Biochem Pharmacol. 2015 Jun 15; 95(4):301-10.
6. Humphries-Bickley T, Castillo-Pichardo L, Corujo-Carro F, Duconge J, Hernandez-O''Farrill E, Vlaar C, Rodriguez-Orengo JF, Cubano L, Dharmawardhane S. Pharmacokinetics of Rac inhibitor EHop-016 in mice by ultra-performance liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Feb 15; 981-982:19-26.
7. Castillo-Pichardo L, Humphries-Bickley T, De La Parra C, Forestier-Roman I, Martinez-Ferrer M, Hernandez E, Vlaar C, Ferrer-Acosta Y, Washington AV, Cubano LA, Rodriguez-Orengo J, Dharmawardhane S. The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model. Transl Oncol. 2014 Oct; 7(5):546-55.
8. Martin H, Mali RS, Ma P, Chatterjee A, Ramdas B, Sims E, Munugalavadla V, Ghosh J, Mattingly RR, Visconte V, Tiu RV, Vlaar CP, Dharmawardhane S, Kapur R. Pak and Rac GTPases promote oncogenic KIT-induced neoplasms. J Clin Invest. 2013 Oct; 123(10):4449-63.
9. Dharmawardhane S, Hernandez E, Vlaar C. Development of EHop-016: a small molecule inhibitor of Rac. Enzymes. 2013; 33 Pt A:117-46.
10. Montalvo-Ortiz BL, Castillo-Pichardo L, Hernández E, Humphries-Bickley T, De la Mota-Peynado A, Cubano LA, Vlaar CP, Dharmawardhane S. Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase. J Biol Chem. 2012 Apr 13; 287(16):13228-38.
11. Hernández E, De La Mota-Peynado A, Dharmawardhane S, Vlaar CP. Novel inhibitors of Rac1 in metastatic breast cancer. P R Health Sci J. 2010 Dec; 29(4):348-56.
12. Vlaar CP, Hernández L. Symposium review: drug discovery, development and clinical research in academia. P R Health Sci J. 2009 Sep; 28(3):268-73.
13. Espinosa S, Solivan M, Vlaar CP. Synthesis and redox-enzyme modulation by amino-1,4-dihydro-benzo[d][1,2]dithiine derivatives. Tetrahedron Lett. 2009 Jun 24; 50(25):3023-3026.
14. Hernández E, Vélez JM, Vlaar CP. Synthesis of 1,4-dihydro-benzo[d][1,3]oxazin-2-ones from phthalides via an aminolysis-Hofmann rearrangement protocol. Tetrahedron Lett. 2007 Dec 17; 48(51):8972-8975.

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Pyrimidines
rac1 GTP-Binding Protein
Carbazoles
rac GTP-Binding Proteins
Aminoquinolines
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