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Copeland, Robert L.
One or more keywords matched the following items that are connected to
Copeland, Robert L.
Item Type
Name
Academic Article
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.
Concept
Methyltransferases
Concept
Protein-Arginine N-Methyltransferases
Academic Article
Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.
Academic Article
Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L.
Academic Article
DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells.
Academic Article
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia.
Academic Article
Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss.
Academic Article
Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation.
Search Criteria
Methyltransferases