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Academic Article
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Protein phosphatase 2A regulates interleukin-2 receptor complex formation and JAK3/STAT5 activation.
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Academic Article
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JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response.
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Academic Article
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Signal transducer and activator of transcription 5b (Stat5b) serine 193 is a novel cytokine-induced phospho-regulatory site that is constitutively activated in primary hematopoietic malignancies.
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Academic Article
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Analysis of Janus tyrosine kinase phosphorylation and activation.
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Academic Article
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Forskolin-inducible cAMP pathway negatively regulates T-cell proliferation by uncoupling the interleukin-2 receptor complex.
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Academic Article
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Interleukin-2 Receptor ? Thr-450 Phosphorylation Is a Positive Regulator for Receptor Complex Stability and Activation of Signaling Molecules.
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Academic Article
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Activation of receptor-associated tyrosine kinase JAK2 by prolactin.
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Academic Article
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Green barley mitigates cytotoxicity in human lymphocytes undergoing aggressive oxidative stress, via activation of both the Lyn/PI3K/Akt and MAPK/ERK pathways.
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Academic Article
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Prolactin stimulates serine/tyrosine phosphorylation and formation of heterocomplexes of multiple Stat5 isoforms in Nb2 lymphocytes.
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Academic Article
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Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase.
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Academic Article
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Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser725 of Stat5a and Ser730 of Stat5b in prolactin-sensitive cells.
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Academic Article
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Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells.
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Academic Article
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Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts.
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Academic Article
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Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin.
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Academic Article
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Molecular actions of sirolimus: sirolimus and mTor.
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Academic Article
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Interleukin 4 regulates phosphorylation of serine 756 in the transactivation domain of Stat6. Roles for multiple phosphorylation sites and Stat6 function.
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Academic Article
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Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukemia virus type 1-transformed human T cells.
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Academic Article
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Involvement of the ubiquitin-proteasome pathway in the degradation of nontyrosine kinase-type cytokine receptors of IL-9, IL-2, and erythropoietin.
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Academic Article
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Role of serine phosphorylation of Stat5a in prolactin-stimulated beta-casein gene expression.
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Academic Article
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Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.
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Academic Article
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Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit.
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Academic Article
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Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha.
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Academic Article
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The Mannich base NC1153 promotes long-term allograft survival and spares the recipient from multiple toxicities.
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Academic Article
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Involvement of JAK-family tyrosine kinases in hematopoietin receptor signal transduction.
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Academic Article
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JAK2 activation and cell proliferation induced by antibody-mediated prolactin receptor dimerization.
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Academic Article
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Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.
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Academic Article
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Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain.
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Academic Article
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A preferential role for STAT5, not constitutively active STAT3, in promoting survival of a human lymphoid tumor.
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Academic Article
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The PHB1/2 phosphocomplex is required for mitochondrial homeostasis and survival of human T cells.
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Academic Article
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Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity.
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Academic Article
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Prolactin recruits STAT1, STAT3 and STAT5 independent of conserved receptor tyrosines TYR402, TYR479, TYR515 and TYR580.
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Academic Article
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STAT5 regulation of BCL10 parallels constitutive NFkappaB activation in lymphoid tumor cells.
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Concept
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Phosphorylation
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Academic Article
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Phosphorylation of CrkL S114 induced by common gamma chain cytokines and T-cell receptor signal transduction.
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Academic Article
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Identification of a Potent Cytotoxic Pyrazole with Anti-Breast Cancer Activity That Alters Multiple Pathways.
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Academic Article
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Phosphorylation of Tyrosine 841 Plays a Significant Role in JAK3 Activation.
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Academic Article
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JAK1 Pseudokinase V666G Mutant Dominantly Impairs JAK3 Phosphorylation and IL-2 Signaling.
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Academic Article
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JAK3 Y841 Autophosphorylation Is Critical for STAT5B Activation, Kinase Domain Stability and Dimer Formation.
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