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Connection

Eunsook Lee to Manganese

This is a "connection" page, showing publications Eunsook Lee has written about Manganese.
Connection Strength

9.889
  1. Pajarillo E, Kim S, Digman A, Dutton M, Son DS, Aschner M, Lee E. The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction. J Biol Chem. 2023 07; 299(7):104879.
    View in: PubMed
    Score: 0.833
  2. Rizor A, Pajarillo E, Son DS, Aschner M, Lee E. Manganese phosphorylates Yin Yang 1 at serine residues to repress EAAT2 in human H4 astrocytes. Toxicol Lett. 2022 Feb 01; 355:41-46.
    View in: PubMed
    Score: 0.749
  3. Pajarillo E, Digman A, Nyarko-Danquah I, Son DS, Soliman KFA, Aschner M, Lee E. Astrocytic transcription factor REST upregulates glutamate transporter EAAT2, protecting dopaminergic neurons from manganese-induced excitotoxicity. J Biol Chem. 2021 12; 297(6):101372.
    View in: PubMed
    Score: 0.746
  4. Rizor A, Pajarillo E, Nyarko-Danquah I, Digman A, Mooneyham L, Son DS, Aschner M, Lee E. Manganese-induced reactive oxygen species activate I?B kinase to upregulate YY1 and impair glutamate transporter EAAT2 function in human astrocytes in vitro. Neurotoxicology. 2021 09; 86:94-103.
    View in: PubMed
    Score: 0.733
  5. Nyarko-Danquah I, Pajarillo E, Digman A, Soliman KFA, Aschner M, Lee E. Manganese Accumulation in the Brain via Various Transporters and Its Neurotoxicity Mechanisms. Molecules. 2020 Dec 12; 25(24).
    View in: PubMed
    Score: 0.702
  6. Pajarillo E, Rizor A, Son DS, Aschner M, Lee E. The transcription factor REST up-regulates tyrosine hydroxylase and antiapoptotic genes and protects dopaminergic neurons against manganese toxicity. J Biol Chem. 2020 03 06; 295(10):3040-3054.
    View in: PubMed
    Score: 0.661
  7. Kim J, Pajarillo E, Rizor A, Son DS, Lee J, Aschner M, Lee E. LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. PLoS One. 2019; 14(1):e0210248.
    View in: PubMed
    Score: 0.615
  8. Johnson J, Pajarillo E, Karki P, Kim J, Son DS, Aschner M, Lee E. Valproic acid attenuates manganese-induced reduction in expression of GLT-1 and GLAST with concomitant changes in murine dopaminergic neurotoxicity. Neurotoxicology. 2018 07; 67:112-120.
    View in: PubMed
    Score: 0.588
  9. Johnson J, Pajarillo EAB, Taka E, Reams R, Son DS, Aschner M, Lee E. Valproate and sodium butyrate attenuate manganese-decreased locomotor activity and astrocytic glutamate transporters expression in mice. Neurotoxicology. 2018 01; 64:230-239.
    View in: PubMed
    Score: 0.551
  10. Lee E, Karki P, Johnson J, Hong P, Aschner M. Manganese Control of Glutamate Transporters' Gene Expression. Adv Neurobiol. 2017; 16:1-12.
    View in: PubMed
    Score: 0.534
  11. Karki P, Smith K, Johnson J, Aschner M, Lee E. Role of transcription factor yin yang 1 in manganese-induced reduction of astrocytic glutamate transporters: Putative mechanism for manganese-induced neurotoxicity. Neurochem Int. 2015 Sep; 88:53-9.
    View in: PubMed
    Score: 0.453
  12. Karki P, Smith K, Johnson J, Aschner M, Lee EY. Genetic dys-regulation of astrocytic glutamate transporter EAAT2 and its implications in neurological disorders and manganese toxicity. Neurochem Res. 2015 Feb; 40(2):380-8.
    View in: PubMed
    Score: 0.451
  13. Lee E, Sidoryk-Wegrzynowicz M, Farina M, Rocha JB, Aschner M. Estrogen attenuates manganese-induced glutamate transporter impairment in rat primary astrocytes. Neurotox Res. 2013 Feb; 23(2):124-30.
    View in: PubMed
    Score: 0.394
  14. Nyarko-Danquah I, Pajarillo E, Kim S, Digman A, Multani HK, Ajayi I, Son DS, Aschner M, Lee E. Microglial Sp1 induced LRRK2 upregulation in response to manganese exposure, and 17?-estradiol afforded protection against this manganese toxicity. Neurotoxicology. 2024 Jul; 103:105-114.
    View in: PubMed
    Score: 0.224
  15. Pajarillo E, Demayo M, Digman A, Nyarko-Danquah I, Son DS, Aschner M, Lee E. Deletion of RE1-silencing transcription factor in striatal astrocytes exacerbates manganese-induced neurotoxicity in mice. Glia. 2022 10; 70(10):1886-1901.
    View in: PubMed
    Score: 0.194
  16. Tinkov AA, Martins AC, Avila DS, Gritsenko VA, Skalny AV, Santamaria A, Lee E, Bowman AB, Aschner M. Gut Microbiota as a Potential Player in Mn-Induced Neurotoxicity. Biomolecules. 2021 08 31; 11(9).
    View in: PubMed
    Score: 0.185
  17. Martins AC, Ruella Oliveira S, Barbosa F, Tinkov AA, V Skalny A, Santamar?a A, Lee E, Bowman AB, Aschner M. Evaluating the risk of manganese-induced neurotoxicity of parenteral nutrition: review of the current literature. Expert Opin Drug Metab Toxicol. 2021 May; 17(5):581-593.
    View in: PubMed
    Score: 0.178
  18. Martins AC, Gubert P, Villas Boas GR, Meirelles Paes M, Santamar?a A, Lee E, Tinkov AA, Bowman AB, Aschner M. Manganese-induced neurodegenerative diseases and possible therapeutic approaches. Expert Rev Neurother. 2020 11; 20(11):1109-1121.
    View in: PubMed
    Score: 0.172
  19. Ke T, Sidoryk-Wegrzynowicz M, Pajarillo E, Rizor A, Soares FAA, Lee E, Aschner M. Role of Astrocytes in Manganese Neurotoxicity Revisited. Neurochem Res. 2019 Nov; 44(11):2449-2459.
    View in: PubMed
    Score: 0.162
  20. Martins AC, Morcillo P, Ijomone OM, Venkataramani V, Harrison FE, Lee E, Bowman AB, Aschner M. New Insights on the Role of Manganese in Alzheimer's Disease and Parkinson's Disease. Int J Environ Res Public Health. 2019 09 22; 16(19).
    View in: PubMed
    Score: 0.161
  21. Karki P, Kim C, Smith K, Son DS, Aschner M, Lee E. Transcriptional Regulation of the Astrocytic Excitatory Amino Acid Transporter 1 (EAAT1) via NF-?B and Yin Yang 1 (YY1). J Biol Chem. 2015 Sep 25; 290(39):23725-37.
    View in: PubMed
    Score: 0.121
  22. Chen P, Chakraborty S, Mukhopadhyay S, Lee E, Paoliello MM, Bowman AB, Aschner M. Manganese homeostasis in the nervous system. J Neurochem. 2015 Aug; 134(4):601-10.
    View in: PubMed
    Score: 0.120
  23. Exil V, Ping L, Yu Y, Chakraborty S, Caito SW, Wells KS, Karki P, Lee E, Aschner M. Activation of MAPK and FoxO by manganese (Mn) in rat neonatal primary astrocyte cultures. PLoS One. 2014; 9(5):e94753.
    View in: PubMed
    Score: 0.111
  24. Karki P, Webb A, Smith K, Johnson J, Lee K, Son DS, Aschner M, Lee E. Yin Yang 1 is a repressor of glutamate transporter EAAT2, and it mediates manganese-induced decrease of EAAT2 expression in astrocytes. Mol Cell Biol. 2014 Apr; 34(7):1280-9.
    View in: PubMed
    Score: 0.109
  25. Lee E, Yin Z, Sidoryk-Wegrzynowicz M, Jiang H, Aschner M. 15-Deoxy-?12,14-prostaglandin J2 modulates manganese-induced activation of the NF-?B, Nrf2, and PI3K pathways in astrocytes. Free Radic Biol Med. 2012 Mar 15; 52(6):1067-74.
    View in: PubMed
    Score: 0.094
  26. Tinkov AA, Paoliello MMB, Mazilina AN, Skalny AV, Martins AC, Voskresenskaya ON, Aaseth J, Santamaria A, Notova SV, Tsatsakis A, Lee E, Bowman AB, Aschner M. Molecular Targets of Manganese-Induced Neurotoxicity: A Five-Year Update. Int J Mol Sci. 2021 Apr 28; 22(9).
    View in: PubMed
    Score: 0.045
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
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