Unfolded Protein Response

"Unfolded Protein Response" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.

Descriptor ID	D056811
MeSH Number(s)	G02.111.660.871.790.600.962 G02.111.691.600.850 G03.734.871.790.600.850 G05.308.670.600.850
Concept/Terms	Unfolded Protein Response Unfolded Protein Response Protein Response, Unfolded Protein Responses, Unfolded Response, Unfolded Protein Responses, Unfolded Protein Unfolded Protein Responses

Below are MeSH descriptors whose meaning is more general than "Unfolded Protein Response".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Peptide Biosynthesis [G02.111.660]
Protein Biosynthesis [G02.111.660.871]
Protein Modification, Translational [G02.111.660.871.790]
Protein Processing, Post-Translational [G02.111.660.871.790.600]
Unfolded Protein Response [G02.111.660.871.790.600.962]
Protein Modification, Translational [G02.111.691]
Protein Processing, Post-Translational [G02.111.691.600]
Unfolded Protein Response [G02.111.691.600.850]
Metabolism [G03]
Peptide Biosynthesis [G03.734]
Protein Biosynthesis [G03.734.871]
Protein Modification, Translational [G03.734.871.790]
Protein Processing, Post-Translational [G03.734.871.790.600]
Unfolded Protein Response [G03.734.871.790.600.850]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Protein Modification, Translational [G05.308.670]
Protein Processing, Post-Translational [G05.308.670.600]
Unfolded Protein Response [G05.308.670.600.850]

Below are MeSH descriptors whose meaning is related to "Unfolded Protein Response".

Below are MeSH descriptors whose meaning is more specific than "Unfolded Protein Response".

Unfolded Protein Response
Endoplasmic Reticulum-Associated Degradation

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Unfolded Protein Response" by people in this website by year, and whether "Unfolded Protein Response" was a major or minor topic of these publications.

Bar chart showing 14 publications over 10 distinct years, with a maximum of 2 publications in 2011 and 2018 and 2022 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2010	1	0	1
2011	2	0	2
2012	0	1	1
2017	1	0	1
2018	1	1	2
2019	0	1	1
2020	0	1	1
2022	0	2	2
2024	1	1	2
2025	0	1	1

Below are the most recent publications written about "Unfolded Protein Response" by people in Profiles.

Schloss JV. Is dolichol pathway dysfunction a significant factor in Alzheimer's disease? Inflammopharmacology. 2025 Aug; 33(8):4651-4658.

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Shukla M, Narayan M. Proteostasis and Its Role in Disease Development. Cell Biochem Biophys. 2025 Jun; 83(2):1725-1741.

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Zhu M, Fang Z, Wu Y, Dong F, Wang Y, Zheng F, Ma X, Ma S, He J, Liu X, Yao X, Fu C. A KDELR-mediated ER-retrieval system modulates mitochondrial functions via the unfolded protein response in?fission yeast. J Biol Chem. 2024 03; 300(3):105754.

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Qi Q, Niture S, Gadi S, Arthur E, Moore J, Levine KE, Kumar D. Per- and polyfluoroalkyl substances activate UPR pathway, induce steatosis and fibrosis in liver cells. Environ Toxicol. 2023 Jan; 38(1):225-242.

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Banerjee DK, Seijo Lebr?n A, Baksi K. Glycotherapy: A New Paradigm in Breast Cancer Research. Biomolecules. 2022 03 23; 12(4).

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Zhao N, Ren Y, Yamazaki Y, Qiao W, Li F, Felton LM, Mahmoudiandehkordi S, Kueider-Paisley A, Sonoustoun B, Arnold M, Shue F, Zheng J, Attrebi ON, Martens YA, Li Z, Bastea L, Meneses AD, Chen K, Thompson JW, St John-Williams L, Tachibana M, Aikawa T, Oue H, Job L, Yamazaki A, Liu CC, Storz P, Asmann YW, Ertekin-Taner N, Kanekiyo T, Kaddurah-Daouk R, Bu G. Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways. Neuron. 2020 06 03; 106(5):727-742.e6.

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Doycheva D, Xu N, Kaur H, Malaguit J, McBride DW, Tang J, Zhang JH. Adenoviral TMBIM6 vector attenuates ER-stress-induced apoptosis in a neonatal hypoxic-ischemic rat model. Dis Model Mech. 2019 11 22; 12(11).

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George Z, Omosun Y, Azenabor AA, Goldstein J, Partin J, Joseph K, Ellerson D, He Q, Eko F, McDonald MA, Reed M, Svoboda P, Stuchlik O, Pohl J, Lutter E, Bandea C, Black CM, Igietseme JU. The molecular mechanism of induction of unfolded protein response by Chlamydia. Biochem Biophys Res Commun. 2019 01 08; 508(2):421-429.

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Contreras L, Calderon RI, Varela-Ramirez A, Zhang HY, Quan Y, Das U, Dimmock JR, Skouta R, Aguilera RJ. Induction of apoptosis via proteasome inhibition in leukemia/lymphoma cells by two potent piperidones. Cell Oncol (Dordr). 2018 Dec; 41(6):623-636.

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George Z, Omosun Y, Azenabor AA, Partin J, Joseph K, Ellerson D, He Q, Eko F, Bandea C, Svoboda P, Pohl J, Black CM, Igietseme JU. The Roles of Unfolded Protein Response Pathways in Chlamydia Pathogenesis. J Infect Dis. 2017 02 01; 215(3):456-465.

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