"Glutaredoxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of thioltransferases that contain two active site CYSTEINE residues, which either form a disulfide (oxidized form) or a dithiol (reduced form). They function as an electron carrier in the GLUTHIONE-dependent synthesis of deoxyribonucleotides by RIBONUCLEOTIDE REDUCTASES and may play a role in the deglutathionylation of protein thiols. The oxidized forms of glutaredoxins are directly reduced by the GLUTATHIONE.
| Descriptor ID |
D054477
|
| MeSH Number(s) |
D08.811.682.667.084
|
| Concept/Terms |
Glutaredoxin 1- Glutaredoxin 1
- TTase-1
- TTase 1
- Thioltransferase-1
- Thioltransferase 1
|
Below are MeSH descriptors whose meaning is more general than "Glutaredoxins".
Below are MeSH descriptors whose meaning is more specific than "Glutaredoxins".
This graph shows the total number of publications written about "Glutaredoxins" by people in this website by year, and whether "Glutaredoxins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 1 | 2 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Glutaredoxins" by people in Profiles.
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Ye J, Nadar SV, Li J, Rosen BP. Structure of Escherichia coli Grx2 in complex with glutathione: a dual-function hybrid of glutaredoxin and glutathione S-transferase. Acta Crystallogr D Biol Crystallogr. 2014 Jul; 70(Pt 7):1907-13.
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Sundaram S, Rathinasabapathi B, Ma LQ, Rosen BP. An arsenate-activated glutaredoxin from the arsenic hyperaccumulator fern Pteris vittata L. regulates intracellular arsenite. J Biol Chem. 2008 Mar 07; 283(10):6095-101.
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Sheng J, Ye J, Rosen BP. Crystallization and preliminary X-ray crystallographic analysis of Escherichia coliglutaredoxin 2 in complex with glutathione and of a cysteine-less variant without glutathione. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Apr 01; 63(Pt 4):280-2.