Polypyrimidine Tract-Binding Protein
"Polypyrimidine Tract-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A RNA-binding protein that binds to polypyriminidine rich regions in the INTRONS of messenger RNAs. Polypyrimidine tract-binding protein may be involved in regulating the ALTERNATIVE SPLICING of mRNAs since its presence on an intronic RNA region that is upstream of an EXON inhibits the splicing of the exon into the final mRNA product.
| Descriptor ID |
D038941
|
| MeSH Number(s) |
D12.776.157.725.829.250 D12.776.664.962.829.250
|
| Concept/Terms |
Polypyrimidine Tract-Binding Protein- Polypyrimidine Tract-Binding Protein
- Polypyrimidine Tract Binding Protein
- Tract-Binding Protein, Polypyrimidine
- p57 Cytoplasmic RNA-Binding Protein
- p57 Cytoplasmic RNA Binding Protein
- PTB Splicing Factor
- Splicing Factor, PTB
- pPTB
- PTB Protein
|
Below are MeSH descriptors whose meaning is more general than "Polypyrimidine Tract-Binding Protein".
Below are MeSH descriptors whose meaning is more specific than "Polypyrimidine Tract-Binding Protein".
This graph shows the total number of publications written about "Polypyrimidine Tract-Binding Protein" by people in this website by year, and whether "Polypyrimidine Tract-Binding Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Polypyrimidine Tract-Binding Protein" by people in Profiles.
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La Porta J, Matus-Nicodemos R, Valent?n-Acevedo A, Covey LR. The RNA-Binding Protein, Polypyrimidine Tract-Binding Protein 1 (PTBP1) Is a Key Regulator of CD4 T Cell Activation. PLoS One. 2016; 11(8):e0158708.
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Matus-Nicodemos R, Vavassori S, Castro-Faix M, Valentin-Acevedo A, Singh K, Marcelli V, Covey LR. Polypyrimidine tract-binding protein is critical for the turnover and subcellular distribution of CD40 ligand mRNA in CD4+ T cells. J Immunol. 2011 Feb 15; 186(4):2164-71.
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Cosme RS, Yamamura Y, Tang Q. Roles of polypyrimidine tract binding proteins in major immediate-early gene expression and viral replication of human cytomegalovirus. J Virol. 2009 Apr; 83(7):2839-50.
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Xu M, McCarrey JR, Hecht NB. A cytoplasmic variant of the KH-type splicing regulatory protein serves as a decay-promoting factor for phosphoglycerate kinase 2 mRNA in murine male germ cells. Nucleic Acids Res. 2008 Dec; 36(22):7157-67.