"Receptors, Interleukin-4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Receptors present on a wide variety of hematopoietic and non-hematopoietic cell types that are specific for INTERLEUKIN-4. They are involved in signaling a variety of immunological responses related to allergic INFLAMMATION including the differentiation of TH2 CELLS and the regulation of IMMUNOGLOBULIN E production. Two subtypes of receptors exist and are referred to as the TYPE I INTERLEUKIN-4 RECEPTOR and the TYPE II INTERLEUKIN-4 RECEPTOR. Each receptor subtype is defined by its unique subunit composition.
| Descriptor ID |
D019948
|
| MeSH Number(s) |
D12.776.543.750.705.852.420.360
|
| Concept/Terms |
Receptors, Interleukin-4- Receptors, Interleukin-4
- Receptors, Interleukin 4
- IL-4 Receptors
- IL 4 Receptors
- Receptors, IL-4
- Receptors, IL 4
- IL4 Receptors
- Receptors, IL4
- Interleukin 4 Receptor
- Receptor, Interleukin 4
- Interleukin-4 Receptors
- Interleukin 4 Receptors
- IL-4 Receptor
- IL 4 Receptor
- Receptor, IL-4
- IL4 Receptor
- Receptor, IL4
|
Below are MeSH descriptors whose meaning is more general than "Receptors, Interleukin-4".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Interleukin-4".
This graph shows the total number of publications written about "Receptors, Interleukin-4" by people in this website by year, and whether "Receptors, Interleukin-4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Receptors, Interleukin-4" by people in Profiles.
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Brestoff JR, Kim BS, Saenz SA, Stine RR, Monticelli LA, Sonnenberg GF, Thome JJ, Farber DL, Lutfy K, Seale P, Artis D. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature. 2015 Mar 12; 519(7542):242-6.
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Hung CY, Gonzalez A, W?thrich M, Klein BS, Cole GT. Vaccine immunity to coccidioidomycosis occurs by early activation of three signal pathways of T helper cell response (Th1, Th2, and Th17). Infect Immun. 2011 Nov; 79(11):4511-22.
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Rodriguez AR, Yu JJ, Murthy AK, Guentzel MN, Klose KE, Forsthuber TG, Chambers JP, Berton MT, Arulanandam BP. Mast cell/IL-4 control of Francisella tularensis replication and host cell death is associated with increased ATP production and phagosomal acidification. Mucosal Immunol. 2011 Mar; 4(2):217-26.
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Tam EK, Jourdan-LeSaux C, Stauder S, Bollt O, Reber B, Yamamoto F, Haymer D. Polymorphisms in the interleukin-4 receptor alpha chain: association with traits of allergy and asthma in an admixed population in Hawaii. Cell Mol Biol (Noisy-le-grand). 2003 Dec; 49(8):1345-9.
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Rahaman SO, Sharma P, Harbor PC, Aman MJ, Vogelbaum MA, Haque SJ. IL-13R(alpha)2, a decoy receptor for IL-13 acts as an inhibitor of IL-4-dependent signal transduction in glioblastoma cells. Cancer Res. 2002 Feb 15; 62(4):1103-9.
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Malabarba MG, Rui H, Deutsch HH, Chung J, Kalthoff FS, Farrar WL, Kirken RA. Interleukin-13 is a potent activator of JAK3 and STAT6 in cells expressing interleukin-2 receptor-gamma and interleukin-4 receptor-alpha. Biochem J. 1996 Nov 01; 319 ( Pt 3):865-72.
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Malabarba MG, Kirken RA, Rui H, Koettnitz K, Kawamura M, O'Shea JJ, Kalthoff FS, Farrar WL. Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha. J Biol Chem. 1995 Apr 21; 270(16):9630-7.