HIV Integrase

"HIV Integrase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Enzyme of the HUMAN IMMUNODEFICIENCY VIRUS that is required to integrate viral DNA into cellular DNA in the nucleus of a host cell. HIV integrase is a DNA nucleotidyltransferase encoded by the pol gene.

Descriptor ID	D019427
MeSH Number(s)	D08.811.739.500.667.500 D08.811.913.696.445.825.500 D12.776.964.775.375.545.500 D12.776.964.775.562.764.500 D12.776.964.970.600.850.375.545.500
Concept/Terms	HIV Integrase HIV Integrase Integrase, HIV p31 pol Gene Product, Human Immunodeficiency Virus p31 Integrase Protein, Human Immunodeficiency Virus p31 pol Gene Product, HIV HIV Integration Protein Integration Protein, HIV p31 Integrase Protein, HIV

Below are MeSH descriptors whose meaning is more general than "HIV Integrase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Recombinases [D08.811.739]
Integrases [D08.811.739.500]
Transposases [D08.811.739.500.667]
HIV Integrase [D08.811.739.500.667.500]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Nucleotidyltransferases [D08.811.913.696.445]
Transposases [D08.811.913.696.445.825]
HIV Integrase [D08.811.913.696.445.825.500]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Viral Proteins [D12.776.964]
Retroviridae Proteins [D12.776.964.775]
Gene Products, pol [D12.776.964.775.375]
pol Gene Products, Human Immunodeficiency Virus [D12.776.964.775.375.545]
HIV Integrase [D12.776.964.775.375.545.500]
Human Immunodeficiency Virus Proteins [D12.776.964.775.562]
pol Gene Products, Human Immunodeficiency Virus [D12.776.964.775.562.764]
HIV Integrase [D12.776.964.775.562.764.500]
Viral Structural Proteins [D12.776.964.970]
Nucleocapsid Proteins [D12.776.964.970.600]
Viral Core Proteins [D12.776.964.970.600.850]
Gene Products, pol [D12.776.964.970.600.850.375]
pol Gene Products, Human Immunodeficiency Virus [D12.776.964.970.600.850.375.545]
HIV Integrase [D12.776.964.970.600.850.375.545.500]

Below are MeSH descriptors whose meaning is related to "HIV Integrase".

Below are MeSH descriptors whose meaning is more specific than "HIV Integrase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "HIV Integrase" by people in this website by year, and whether "HIV Integrase" was a major or minor topic of these publications.

Bar chart showing 15 publications over 10 distinct years, with a maximum of 2 publications in 2005 and 2006 and 2009 and 2016 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	1	0	1
2005	1	1	2
2006	2	0	2
2007	1	0	1
2009	0	2	2
2011	1	0	1
2016	0	2	2
2017	2	0	2
2020	1	0	1
2022	0	1	1

Below are the most recent publications written about "HIV Integrase" by people in Profiles.

Sapp N, Burge N, Cox K, Prakash P, Balasubramaniam M, Thapa S, Christensen D, Li M, Linderberger J, Kvaratskhelia M, Pandhare J, Craigie R, Poirier MG, Dash C. HIV-1 Preintegration Complex Preferentially Integrates the Viral DNA into Nucleosomes Containing Trimethylated Histone 3-Lysine 36 Modification and Flanking Linker DNA. J Virol. 2022 09 28; 96(18):e0101122.

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Kapusta K, Sizochenko N, Anderson ML, Kolodziejczyk W, Voronkov EO, Saloni J, Leszczynski J, Hill GA. N-arylnaphthylamines as inhibitors of human immunodeficiency virus integrase - lens epithelium-derived growth factor interactions: theoretical studies. J Biomol Struct Dyn. 2021 Feb; 39(3):867-880.

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Matysiak J, Lesbats P, Mauro E, Lapaillerie D, Dupuy JW, Lopez AP, Benleulmi MS, Calmels C, Andreola ML, Ruff M, Llano M, Delelis O, Lavigne M, Parissi V. Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integration. Retrovirology. 2017 Jul 28; 14(1):39.

View in: PubMed
Balasubramaniam M, Davids B, Addai AB, Pandhare J, Dash C. Measurement of In Vitro Integration Activity of HIV-1 Preintegration Complexes. J Vis Exp. 2017 02 22; (120).

View in: PubMed
Lopez AP, Kugelman JR, Garcia-Rivera J, Urias E, Salinas SA, Fernandez-Zapico ME, Llano M. The Structure-Specific Recognition Protein 1 Associates with Lens Epithelium-Derived Growth Factor Proteins and Modulates HIV-1 Replication. J Mol Biol. 2016 Jul 17; 428(14):2814-31.

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Gutierrez DA, Valdes L, Serguera C, Llano M. Poly(ADP-ribose) polymerase-1 silences retroviruses independently of viral DNA integration or heterochromatin formation. J Gen Virol. 2016 07; 97(7):1686-1692.

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Astiazaran P, Bueno MT, Morales E, Kugelman JR, Garcia-Rivera JA, Llano M. HIV-1 integrase modulates the interaction of the HIV-1 cellular cofactor LEDGF/p75 with chromatin. Retrovirology. 2011 Apr 21; 8:27.

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Hu Z, Chen D, Dong L, Southerland WM. Prediction of the interaction of HIV-1 integrase and its dicaffeoylquinic acid inhibitor through molecular modeling approach. Ethn Dis. 2010; 20(1 Suppl 1):S1-45-9.

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Garcia-Rivera JA, Bueno MT, Morales E, Kugelman JR, Rodriguez DF, Llano M. Implication of serine residues 271, 273, and 275 in the human immunodeficiency virus type 1 cofactor activity of lens epithelium-derived growth factor/p75. J Virol. 2010 Jan; 84(2):740-52.

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Meehan AM, Saenz DT, Morrison JH, Garcia-Rivera JA, Peretz M, Llano M, Poeschla EM. LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors. PLoS Pathog. 2009 Jul; 5(7):e1000522.

View in: PubMed

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