"Buthionine Sulfoximine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)
| Descriptor ID |
D019328
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| MeSH Number(s) |
D02.886.030.676.620.125 D12.125.166.676.620.125
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Buthionine Sulfoximine".
Below are MeSH descriptors whose meaning is more specific than "Buthionine Sulfoximine".
This graph shows the total number of publications written about "Buthionine Sulfoximine" by people in this website by year, and whether "Buthionine Sulfoximine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2009 | 0 | 2 | 2 |
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Below are the most recent publications written about "Buthionine Sulfoximine" by people in Profiles.
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Su B, Wang X, Lee HG, Tabaton M, Perry G, Smith MA, Zhu X. Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells. Neurosci Lett. 2010 Jan 14; 468(3):267-71.
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Becker A, Soliman KF. The role of intracellular glutathione in inorganic mercury-induced toxicity in neuroblastoma cells. Neurochem Res. 2009 Sep; 34(9):1677-84.
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Chen J, Small-Howard A, Yin A, Berry MJ. The responses of Ht22 cells to oxidative stress induced by buthionine sulfoximine (BSO). BMC Neurosci. 2005 Feb 12; 6:10.
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Jones DP, Go YM, Anderson CL, Ziegler TR, Kinkade JM, Kirlin WG. Cysteine/cystine couple is a newly recognized node in the circuitry for biologic redox signaling and control. FASEB J. 2004 Aug; 18(11):1246-8.
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Bayorh MA, Ganafa AA, Socci RR, Eatman D, Silvestrov N, Abukhalaf IK. Effect of losartan on oxidative stress-induced hypertension in Sprague-Dawley rats. Am J Hypertens. 2003 May; 16(5 Pt 1):387-92.
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Ganafa AA, Socci RR, Eatman D, Silvestrova N, Abukhalaf IK, Bayorh MA. Acute inhibition of glutathione biosynthesis alters endothelial function and blood pressure in rats. Eur J Pharmacol. 2002 Nov 15; 454(2-3):217-23.
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Ganafa AA, Socci RR, Eatman D, Silvestrov N, Abukhalaf IK, Bayorh MA. Effect of palm oil on oxidative stress-induced hypertension in Sprague-Dawley rats. Am J Hypertens. 2002 Aug; 15(8):725-31.