"GABA Modulators" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.
| Descriptor ID |
D018757
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| MeSH Number(s) |
D27.505.519.625.240.500 D27.505.696.577.240.500
|
| Concept/Terms |
GABA Modulators- GABA Modulators
- Modulators, GABA
- GABAergic Modulators
- Modulators, GABAergic
- gamma-Aminobutyric Acid Modulators
- Acid Modulators, gamma-Aminobutyric
- Modulators, gamma-Aminobutyric Acid
- gamma Aminobutyric Acid Modulators
|
Below are MeSH descriptors whose meaning is more general than "GABA Modulators".
Below are MeSH descriptors whose meaning is more specific than "GABA Modulators".
This graph shows the total number of publications written about "GABA Modulators" by people in this website by year, and whether "GABA Modulators" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 1 | 0 | 1 |
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Below are the most recent publications written about "GABA Modulators" by people in Profiles.
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Wang ZJ, Sun L, Jackson PL, Scott KR, Heinbockel T. A substituted anilino enaminone acts as a novel positive allosteric modulator of GABA(A) receptors in the mouse brain. J Pharmacol Exp Ther. 2011 Mar; 336(3):916-24.