"Pentylenetetrazole" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
| Descriptor ID |
D010433
|
| MeSH Number(s) |
D03.383.066.600
|
| Concept/Terms |
Pentylenetetrazole- Pentylenetetrazole
- Pentylenetetrazol
- Pentetrazole
- Leptazole
- Pentamethylenetetrazole
Corasol- Corasol
- Corazole
- Korazole
- Corazol
- Korazol
|
Below are MeSH descriptors whose meaning is more general than "Pentylenetetrazole".
Below are MeSH descriptors whose meaning is more specific than "Pentylenetetrazole".
This graph shows the total number of publications written about "Pentylenetetrazole" by people in this website by year, and whether "Pentylenetetrazole" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pentylenetetrazole" by people in Profiles.
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Liu Z, Lindemeyer AK, Liang J, Wallner M, Shao XM, Shao Y, Tao Y, Olsen RW. Flavonoids isolated from Tibetan medicines, binding to GABAA receptor and the anticonvulsant activity. Phytomedicine. 2018 Nov 15; 50:1-7.
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Torres-Hern?ndez BA, Col?n LR, Rosa-Falero C, Torrado A, Miscalichi N, Ort?z JG, Gonz?lez-Sep?lveda L, P?rez-R?os N, Su?rez-P?rez E, Bradsher JN, Behra M. Reversal of pentylenetetrazole-altered swimming and neural activity-regulated gene expression in zebrafish larvae by valproic acid and valerian extract. Psychopharmacology (Berl). 2016 07; 233(13):2533-47.
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Torres-Hern?ndez BA, Del Valle-Mojica LM, Ort?z JG. Valerenic acid and Valeriana officinalis extracts delay onset of Pentylenetetrazole (PTZ)-Induced seizures in adult Danio rerio (Zebrafish). BMC Complement Altern Med. 2015 Jul 14; 15:228.
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Jain AS, Date AA, Pissurlenkar RR, Coutinho EC, Nagarsenker MS. Sulfobutyl ether(7) ?-cyclodextrin (SBE(7) ?-CD) carbamazepine complex: preparation, characterization, molecular modeling, and evaluation of in vivo anti-epileptic activity. AAPS PharmSciTech. 2011 Dec; 12(4):1163-75.
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Jackson PL, Scott KR, Southerland WM, Fang YY. Enaminones 8: CoMFA and CoMSIA studies on some anticonvulsant enaminones. Bioorg Med Chem. 2009 Jan 01; 17(1):133-40.