"P-Glycoproteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP-BINDING CASSETTE, SUB-FAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
| Descriptor ID |
D018435
|
| MeSH Number(s) |
D12.776.157.530.100.652 D12.776.157.530.450.074.500.500.875 D12.776.395.550.020.610 D12.776.543.550.192.610 D12.776.543.585.100.610 D12.776.543.585.450.074.500.500.875
|
| Concept/Terms |
ATP Binding Cassette Transporter, Sub-Family B- ATP Binding Cassette Transporter, Sub-Family B
- ATP Binding Cassette Transporter, Sub Family B
- Multidrug Resistance Proteins
- ATP-Binding Cassette, Sub-Family B Proteins
- ATP Binding Cassette, Sub Family B Proteins
- P-Glycoproteins
- P Glycoproteins
|
Below are MeSH descriptors whose meaning is more general than "P-Glycoproteins".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- Membrane Transport Proteins [D12.776.157.530]
- ATP-Binding Cassette Transporters [D12.776.157.530.100]
- ATP Binding Cassette Transporter, Sub-Family B [D12.776.157.530.100.652]
- Ion Pumps [D12.776.157.530.450]
- Anion Transport Proteins [D12.776.157.530.450.074]
- Organic Anion Transporters [D12.776.157.530.450.074.500]
- Organic Anion Transporters, ATP-Dependent [D12.776.157.530.450.074.500.500]
- ATP Binding Cassette Transporter, Sub-Family B [D12.776.157.530.450.074.500.500.875]
- Glycoproteins [D12.776.395]
- Membrane Glycoproteins [D12.776.395.550]
- ATP-Binding Cassette Transporters [D12.776.395.550.020]
- ATP Binding Cassette Transporter, Sub-Family B [D12.776.395.550.020.610]
- Membrane Proteins [D12.776.543]
- Membrane Glycoproteins [D12.776.543.550]
- ATP-Binding Cassette Transporters [D12.776.543.550.192]
- ATP Binding Cassette Transporter, Sub-Family B [D12.776.543.550.192.610]
- Membrane Transport Proteins [D12.776.543.585]
- ATP-Binding Cassette Transporters [D12.776.543.585.100]
- ATP Binding Cassette Transporter, Sub-Family B [D12.776.543.585.100.610]
- Ion Pumps [D12.776.543.585.450]
- Anion Transport Proteins [D12.776.543.585.450.074]
- Organic Anion Transporters [D12.776.543.585.450.074.500]
- Organic Anion Transporters, ATP-Dependent [D12.776.543.585.450.074.500.500]
- ATP Binding Cassette Transporter, Sub-Family B [D12.776.543.585.450.074.500.500.875]
Below are MeSH descriptors whose meaning is more specific than "P-Glycoproteins".
This graph shows the total number of publications written about "P-Glycoproteins" by people in this website by year, and whether "P-Glycoproteins" was a major or minor topic of these publications.
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Below are the most recent publications written about "P-Glycoproteins" by people in Profiles.