"Mice, Inbred mdx" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A strain of mice arising from a spontaneous MUTATION (mdx) in inbred C57BL mice. This mutation is X chromosome-linked and produces viable homozygous animals that lack the muscle protein DYSTROPHIN, have high serum levels of muscle ENZYMES, and possess histological lesions similar to human MUSCULAR DYSTROPHY. The histological features, linkage, and map position of mdx make these mice a worthy animal model of DUCHENNE MUSCULAR DYSTROPHY.
| Descriptor ID |
D018101
|
| MeSH Number(s) |
B01.050.050.199.520.520.420.500 B01.050.150.900.649.313.992.635.505.500.400.420.500 B01.050.150.900.649.313.992.635.505.500.550.265
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| Concept/Terms |
Mice, Inbred mdx- Mice, Inbred mdx
- Inbred mdx Mice
- Mouse, Inbred mdx
- Inbred mdx Mouse
- Mice, mdx
- mdx Mice
- Mouse, mdx
- mdx Mouse
|
Below are MeSH descriptors whose meaning is more general than "Mice, Inbred mdx".
- Organisms [B]
- Eukaryota [B01]
- Animals [B01.050]
- Animal Population Groups [B01.050.050]
- Animals, Laboratory [B01.050.050.199]
- Animals, Inbred Strains [B01.050.050.199.520]
- Mice, Inbred Strains [B01.050.050.199.520.520]
- Mice, Inbred C57BL [B01.050.050.199.520.520.420]
- Mice, Inbred mdx [B01.050.050.199.520.520.420.500]
- Chordata [B01.050.150]
- Vertebrates [B01.050.150.900]
- Mammals [B01.050.150.900.649]
- Eutheria [B01.050.150.900.649.313]
- Rodentia [B01.050.150.900.649.313.992]
- Muridae [B01.050.150.900.649.313.992.635]
- Murinae [B01.050.150.900.649.313.992.635.505]
- Mice [B01.050.150.900.649.313.992.635.505.500]
- Mice, Inbred Strains [B01.050.150.900.649.313.992.635.505.500.400]
- Mice, Inbred C57BL [B01.050.150.900.649.313.992.635.505.500.400.420]
- Mice, Inbred mdx [B01.050.150.900.649.313.992.635.505.500.400.420.500]
- Mice, Mutant Strains [B01.050.150.900.649.313.992.635.505.500.550]
- Mice, Inbred mdx [B01.050.150.900.649.313.992.635.505.500.550.265]
Below are MeSH descriptors whose meaning is more specific than "Mice, Inbred mdx".
This graph shows the total number of publications written about "Mice, Inbred mdx" by people in this website by year, and whether "Mice, Inbred mdx" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Mice, Inbred mdx" by people in Profiles.
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Hughes MC, Ramos SV, Turnbull PC, Rebalka IA, Cao A, Monaco CMF, Varah NE, Edgett BA, Huber JS, Tadi P, Delfinis LJ, Schlattner U, Simpson JA, Hawke TJ, Perry CGR. Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H2 O2 emission during impaired oxidative phosphorylation. J Cachexia Sarcopenia Muscle. 2019 06; 10(3):643-661.
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Doe J, Kaindl AM, Jijiwa M, de la Vega M, Hu H, Griffiths GS, Fontelonga TM, Barraza P, Cruz V, Van Ry P, Ramos JW, Burkin DJ, Matter ML. PTRH2 gene mutation causes progressive congenital skeletal muscle pathology. Hum Mol Genet. 2017 04 15; 26(8):1458-1464.
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Heier CR, Guerron AD, Korotcov A, Lin S, Gordish-Dressman H, Fricke S, Sze RW, Hoffman EP, Wang P, Nagaraju K. Non-invasive MRI and spectroscopy of mdx mice reveal temporal changes in dystrophic muscle imaging and in energy deficits. PLoS One. 2014; 9(11):e112477.
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Tsao J, Vernet DA, Gelfand R, Kovanecz I, Nolazco G, Bruhn KW, Gonzalez-Cadavid NF. Myostatin genetic inactivation inhibits myogenesis by muscle-derived stem cells in vitro but not when implanted in the mdx mouse muscle. Stem Cell Res Ther. 2013 Jan 07; 4(1):4.
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Xiong Y, Zhou Y, Jarrett HW. Dystrophin glycoprotein complex-associated Gbetagamma subunits activate phosphatidylinositol-3-kinase/Akt signaling in skeletal muscle in a laminin-dependent manner. J Cell Physiol. 2009 May; 219(2):402-14.