Polymerase Chain Reaction

"Polymerase Chain Reaction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

Descriptor ID	D016133
MeSH Number(s)	E05.393.620.500
Concept/Terms	Polymerase Chain Reaction Polymerase Chain Reaction Polymerase Chain Reactions Reaction, Polymerase Chain Reactions, Polymerase Chain PCR Inverse PCR Inverse PCR PCR, Inverse Inverse Polymerase Chain Reaction Nested Polymerase Chain Reaction Nested Polymerase Chain Reaction Nested PCR PCR, Nested Anchored PCR Anchored PCR PCR, Anchored Anchored Polymerase Chain Reaction

Below are MeSH descriptors whose meaning is more general than "Polymerase Chain Reaction".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Nucleic Acid Amplification Techniques [E05.393.620]
Polymerase Chain Reaction [E05.393.620.500]

Below are MeSH descriptors whose meaning is related to "Polymerase Chain Reaction".

Below are MeSH descriptors whose meaning is more specific than "Polymerase Chain Reaction".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Polymerase Chain Reaction" by people in this website by year, and whether "Polymerase Chain Reaction" was a major or minor topic of these publications.

Bar chart showing 351 publications over 28 distinct years, with a maximum of 28 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	9	9
1995	0	8	8
1996	0	18	18
1997	0	7	7
1998	1	15	16
1999	1	10	11
2000	2	6	8
2001	1	7	8
2002	1	18	19
2003	2	13	15
2004	3	25	28
2005	1	13	14
2006	3	11	14
2007	1	11	12
2008	3	13	16
2009	2	14	16
2010	3	19	22
2011	3	16	19
2012	4	22	26
2013	1	9	10
2014	0	9	9
2015	1	6	7
2016	0	9	9
2017	1	10	11
2018	2	6	8
2019	1	5	6
2020	0	3	3
2022	0	2	2

Below are the most recent publications written about "Polymerase Chain Reaction" by people in Profiles.

Yoshida K, Chambers JK, Uchida K. Systemic Streptococcus agalactiae infection with meningo-ventriculitis in a Linnaeus's two-toed sloth (Choloepus didactylus). J Vet Med Sci. 2022 Oct 01; 84(10):1417-1421.

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Halliday T, Tan C, Juarez R, Colby S, Bai G. Financial Implications of COVID-19 Polymerase Chain Reaction Tests on Independent Laboratories. J Gen Intern Med. 2022 08; 37(10):2617-2619.

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Zhao D, Cardona C, Gottel N, Winton VJ, Thomas PM, Raba DA, Kelley ST, Henry C, Gilbert JA, Stephens B. Chemical composition of material extractives influences microbial growth and dynamics on wetted wood materials. Sci Rep. 2020 09 02; 10(1):14500.

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Arora K, Belcaid M, Lantz MJ, Taketa R, Nichols RA. Transcriptome Profile of Nicotinic Receptor-Linked Sensitization of Beta Amyloid Neurotoxicity. Sci Rep. 2020 03 30; 10(1):5696.

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Rohner E, Rahangdale L, Sanusi B, Knittel AK, Vaughan L, Chesko K, Faherty B, Tulenko SE, Schmitt JW, Romocki LS, Sivaraman V, Nelson JAE, Smith JS. Test Accuracy of Human Papillomavirus in Urine for Detection of Cervical Intraepithelial Neoplasia. J Clin Microbiol. 2020 02 24; 58(3).

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Yu M, Chambers JK, Tsuzuki M, Yamashita N, Ushigusa T, Haga T, Nakayama H, Uchida K. Pigmented viral plaque and basal cell tumor associated with canine papillomavirus infection in Pug dogs. J Vet Med Sci. 2019 Nov 29; 81(11):1643-1648.

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Buenaventura DF, Corseri A, Emerson MM. Identification of Genes With Enriched Expression in Early Developing Mouse Cone Photoreceptors. Invest Ophthalmol Vis Sci. 2019 07 01; 60(8):2787-2799.

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Mfuh KO, Achonduh-Atijegbe OA, Bekindaka ON, Esemu LF, Mbakop CD, Gandhi K, Leke RGF, Taylor DW, Nerurkar VR. A comparison of thick-film microscopy, rapid diagnostic test, and polymerase chain reaction for accurate diagnosis of Plasmodium falciparum malaria. Malar J. 2019 Mar 12; 18(1):73.

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Clark ST, Sinha U, Zhang Y, Wang PW, Donaldson SL, Coburn B, Waters VJ, Yau YCW, Tullis DE, Guttman DS, Hwang DM. Penicillin-binding protein 3 is a common adaptive target among Pseudomonas aeruginosa isolates from adult cystic fibrosis patients treated with ?-lactams. Int J Antimicrob Agents. 2019 May; 53(5):620-628.

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Vidal RM, Muhsen K, Tennant SM, Svennerholm AM, Sow SO, Sur D, Zaidi AKM, Faruque ASG, Saha D, Adegbola R, Hossain MJ, Alonso PL, Breiman RF, Bassat Q, Tamboura B, Sanogo D, Onwuchekwa U, Manna B, Ramamurthy T, Kanungo S, Ahmed S, Qureshi S, Quadri F, Hossain A, Das SK, Antonio M, Mandomando I, Nhampossa T, Ac?cio S, Omore R, Ochieng JB, Oundo JO, Mintz ED, O'Reilly CE, Berkeley LY, Livio S, Panchalingam S, Nasrin D, Farag TH, Wu Y, Sommerfelt H, Robins-Browne RM, Del Canto F, Hazen TH, Rasko DA, Kotloff KL, Nataro JP, Levine MM. Colonization factors among enterotoxigenic Escherichia coli isolates from children with moderate-to-severe diarrhea and from matched controls in the Global Enteric Multicenter Study (GEMS). PLoS Negl Trop Dis. 2019 01; 13(1):e0007037.

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