"Sarin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An organophosphorus ester compound that produces potent and irreversible inhibition of cholinesterase. It is toxic to the nervous system and is a chemical warfare agent.
| Descriptor ID |
D012524
|
| MeSH Number(s) |
D02.705.429.750.500
|
| Concept/Terms |
Sarin- Sarin
- ortho-Isopropylmethyl Phosphonofluoridate
- Phosphonofluoridate, ortho-Isopropylmethyl
- ortho Isopropylmethyl Phosphonofluoridate
- o-Isopropylmethyl Phosphonofluoridate
- Phosphonofluoridate, o-Isopropylmethyl
- o Isopropylmethyl Phosphonofluoridate
|
Below are MeSH descriptors whose meaning is more general than "Sarin".
Below are MeSH descriptors whose meaning is more specific than "Sarin".
This graph shows the total number of publications written about "Sarin" by people in this website by year, and whether "Sarin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 2 | 0 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
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Below are the most recent publications written about "Sarin" by people in Profiles.
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Wang J, Gu J, Leszczynski J. Theoretical modeling study for the phosphonylation mechanisms of the catalytic triad of acetylcholinesterase by sarin. J Phys Chem B. 2008 Mar 20; 112(11):3485-94.
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Wang J, Gu J, Leszczynski J, Feliks M, Sokalski WA. Oxime-induced reactivation of sarin-inhibited AChE: a theoretical mechanisms study. J Phys Chem B. 2007 Mar 08; 111(9):2404-8.
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Majumdar D, Roszak S, Leszczynski J. Probing the acetylcholinesterase inhibition of sarin: a comparative interaction study of the inhibitor and acetylcholine with a model enzyme cavity. J Phys Chem B. 2006 Jul 13; 110(27):13597-607.
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Wang J, Gu J, Leszczynski J. Phosphonylation mechanisms of sarin and acetylcholinesterase: a model DFT study. J Phys Chem B. 2006 Apr 13; 110(14):7567-73.
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Wang J, Roszak S, Gu J, Leszczynski J. Comprehensive global energy minimum modeling of the sarin-serine adduct. J Phys Chem B. 2005 Jan 20; 109(2):1006-14.
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Henderson RF, Barr EB, Blackwell WB, Clark CR, Conn CA, Kalra R, March TH, Sopori ML, Tesfaigzi Y, M?nache MG, Mash DC. Response of rats to low levels of sarin. Toxicol Appl Pharmacol. 2002 Oct 15; 184(2):67-76.
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Henderson RF, Barr EB, Blackwell WB, Clark CR, Conn CA, Kalra R, March TH, Sopori ML, Tesfaigzi Y, M?nache MG, Mash DC, Dokladny K, Kozak W, Kozak A, Wachulec M, Rudolph K, Kluger MJ, Singh SP, Razani-Boroujerdi S, Langley RJ. Response of F344 rats to inhalation of subclinical levels of sarin: exploring potential causes of Gulf War illness. Toxicol Ind Health. 2001 Jun; 17(5-10):294-7.