"RNA Precursors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
RNA transcripts of the DNA that are in some unfinished stage of post-transcriptional processing (RNA PROCESSING, POST-TRANSCRIPTIONAL) required for function. RNA precursors may undergo several steps of RNA SPLICING during which the phosphodiester bonds at exon-intron boundaries are cleaved and the introns are excised. Consequently a new bond is formed between the ends of the exons. Resulting mature RNAs can then be used; for example, mature mRNA (RNA, MESSENGER) is used as a template for protein production.
Descriptor ID |
D012322
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MeSH Number(s) |
D13.400.730 D13.444.735.640
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Concept/Terms |
RNA Precursor- RNA Precursor
- Precursor, RNA
- Precursor RNA
- RNA, Precursor
Primary RNA Transcript- Primary RNA Transcript
- RNA Transcript, Primary
- Transcript, Primary RNA
- Primary Transcript, RNA
- RNA Primary Transcript
- Transcript, RNA Primary
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Below are MeSH descriptors whose meaning is more general than "RNA Precursors".
Below are MeSH descriptors whose meaning is more specific than "RNA Precursors".
This graph shows the total number of publications written about "RNA Precursors" by people in this website by year, and whether "RNA Precursors" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 0 | 1 | 1 |
1999 | 1 | 0 | 1 |
2000 | 1 | 0 | 1 |
2002 | 0 | 1 | 1 |
2005 | 2 | 0 | 2 |
2006 | 0 | 2 | 2 |
2007 | 1 | 0 | 1 |
2008 | 1 | 1 | 2 |
2009 | 1 | 2 | 3 |
2011 | 1 | 0 | 1 |
2014 | 0 | 2 | 2 |
2015 | 1 | 0 | 1 |
2016 | 2 | 0 | 2 |
2017 | 1 | 0 | 1 |
2020 | 0 | 2 | 2 |
2021 | 0 | 1 | 1 |
2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "RNA Precursors" by people in Profiles.
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Zhang X, Zhan X, Bian T, Yang F, Li P, Lu Y, Xing Z, Fan R, Zhang QC, Shi Y. Structural insights into branch site proofreading by human spliceosome. Nat Struct Mol Biol. 2024 May; 31(5):835-845.
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Li D, Liu Y, Yi P, Zhu Z, Li W, Zhang QC, Li JB, Ou G. RNA editing restricts hyperactive ciliary kinases. Science. 2021 08 27; 373(6558):984-991.
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Chu H, Perea W, Greenbaum NL. Role of the central junction in folding topology of the protein-free human U2-U6 snRNA complex. RNA. 2020 07; 26(7):836-850.
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Yin Y, Lu JY, Zhang X, Shao W, Xu Y, Li P, Hong Y, Cui L, Shan G, Tian B, Zhang QC, Shen X. U1 snRNP regulates chromatin retention of noncoding RNAs. Nature. 2020 04; 580(7801):147-150.
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Na M, Valente ST, Ryan K. Optimizing In Vitro Pre-mRNA 3' Cleavage Efficiency: Reconstitution from Anion-Exchange Separated HeLa Cleavage Factors and from Adherent HeLa Cell Nuclear Extract. Methods Mol Biol. 2017; 1507:179-198.
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Khleborodova A, Pan X, Nagre NN, Ryan K. An investigation into the role of ATP in the mammalian pre-mRNA 3' cleavage reaction. Biochimie. 2016 Jun; 125:213-22.
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Perea W, Schroeder KT, Bryant AN, Greenbaum NL. Interaction between the Spliceosomal Pre-mRNA Branch Site and U2 snRNP Protein p14. Biochemistry. 2016 Feb 02; 55(4):629-32.
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Zhao H, Li QQ. In vitro analysis of cleavage and polyadenylation in Arabidopsis. Methods Mol Biol. 2015; 1255:79-89.
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Seyedali A, Berry MJ. Nonsense-mediated decay factors are involved in the regulation of selenoprotein mRNA levels during selenium deficiency. RNA. 2014 Aug; 20(8):1248-56.
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Shi L, Zhang Z, Yu AM, Wang W, Wei Z, Akhter E, Maurer K, Costa Reis P, Song L, Petri M, Sullivan KE. The SLE transcriptome exhibits evidence of chronic endotoxin exposure and has widespread dysregulation of non-coding and coding RNAs. PLoS One. 2014; 9(5):e93846.