"Ouabain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE.
| Descriptor ID |
D010042
|
| MeSH Number(s) |
D04.210.500.155.580.130.750.600 D09.408.180.810.600
|
| Concept/Terms |
Ouabain- Ouabain
- G-Strophanthin
- G Strophanthin
- Acocantherin
- Acolongifloroside K
|
Below are MeSH descriptors whose meaning is more general than "Ouabain".
Below are MeSH descriptors whose meaning is more specific than "Ouabain".
This graph shows the total number of publications written about "Ouabain" by people in this website by year, and whether "Ouabain" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2011 | 1 | 0 | 1 |
| 2013 | 1 | 1 | 2 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ouabain" by people in Profiles.
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Wang ZJ, Sun L, Heinbockel T. Resibufogenin and cinobufagin activate central neurons through an ouabain-like action. PLoS One. 2014; 9(11):e113272.
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Abushik PA, Sibarov DA, Eaton MJ, Skatchkov SN, Antonov SM. Kainate-induced calcium overload of cortical neurons in vitro: Dependence on expression of AMPAR GluA2-subunit and down-regulation by subnanomolar ouabain. Cell Calcium. 2013 Aug; 54(2):95-104.
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Iniouchine MY, Sibarov DA, Vol'nova AB. Comparative analysis of changes in membrane currents in neurons and astrocytes in rat hippocampal slices after stimulation of glutamatergic transmission. Dokl Biol Sci. 2013 Mar; 449:65-7.
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Gan XT, Hunter JC, Huang C, Xue J, Rajapurohitam V, Javadov S, Karmazyn M. Ouabain increases iNOS-dependent nitric oxide generation which contributes to the hypertrophic effect of the glycoside: possible role of peroxynitrite formation. Mol Cell Biochem. 2012 Apr; 363(1-2):323-33.
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De Mello WC. Intracellular and extracellular renin have opposite effects on the regulation of heart cell volume. Implications for myocardial ischaemia. J Renin Angiotensin Aldosterone Syst. 2008 Jun; 9(2):112-8.
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Krivoi II, Drabkina TM, Kravtsova VV, Vasiliev AN, Eaton MJ, Skatchkov SN, Mandel F. On the functional interaction between nicotinic acetylcholine receptor and Na+,K+-ATPase. Pflugers Arch. 2006 Sep; 452(6):756-65.
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Vu H, Ianosi-Irimie M, Danchuk S, Rabon E, Nogawa T, Kamano Y, Pettit GR, Wiese T, Puschett JB. Resibufogenin corrects hypertension in a rat model of human preeclampsia. Exp Biol Med (Maywood). 2006 Feb; 231(2):215-20.
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Krivoi II, Drabkina TM, Dobretsov MG, Vasil'ev AN, Kravtsova VV, Eaton MJ, Skachkov SN, Mandel F. [Functional interaction between nicotinic cholinergic receptors and Na, K-ATPase in the skeletal muscles]. Ross Fiziol Zh Im I M Sechenova. 2004 Jan; 90(1):59-72.
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Yudowski GA, Bar Shimon M, Tal DM, Gonz?lez-Lebrero RM, Rossi RC, Garrahan PJ, Beaug? LA, Karlish SJ. Evidence for tryptophan residues in the cation transport path of the Na(+),K(+)-ATPase. Biochemistry. 2003 Sep 02; 42(34):10212-22.
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Yudowski GA, Shimon MB, Gonz?lez-Lebrero RM, Rossi RC, Garrahan PJ, Karlish SJ, Beaug? L. Extracellularly applied Br-TITU inhibits the Na+/K+ pump by interacting with tryptophan at the entrance to the cation sites. Ann N Y Acad Sci. 2003 Apr; 986:287-9.