Methotrexate

"Methotrexate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

Descriptor ID	D008727
MeSH Number(s)	D03.633.100.733.631.192.500
Concept/Terms	Methotrexate Methotrexate Amethopterin Methotrexate, (D)-Isomer Methotrexate, (D)-Isomer Methotrexate, (DL)-Isomer Methotrexate, (DL)-Isomer Mexate Mexate Methotrexate Sodium Methotrexate Sodium Sodium, Methotrexate Methotrexate, Sodium Salt Methotrexate, Disodium Salt Methotrexate Hydrate Methotrexate Hydrate Hydrate, Methotrexate Methotrexate, Dicesium Salt Methotrexate, Dicesium Salt Dicesium Salt Methotrexate

Below are MeSH descriptors whose meaning is more general than "Methotrexate".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, Fused-Ring [D03.633]
Heterocyclic Compounds, 2-Ring [D03.633.100]
Pteridines [D03.633.100.733]
Pterins [D03.633.100.733.631]
Aminopterin [D03.633.100.733.631.192]
Methotrexate [D03.633.100.733.631.192.500]

Below are MeSH descriptors whose meaning is related to "Methotrexate".

Below are MeSH descriptors whose meaning is more specific than "Methotrexate".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Methotrexate" by people in this website by year, and whether "Methotrexate" was a major or minor topic of these publications.

Bar chart showing 22 publications over 15 distinct years, with a maximum of 3 publications in 2004 and 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1998	0	1	1
2000	0	1	1
2002	1	0	1
2004	2	1	3
2006	0	2	2
2007	0	3	3
2010	0	1	1
2012	0	1	1
2013	0	1	1
2014	1	1	2
2016	0	2	2
2019	1	0	1
2021	1	0	1
2023	0	1	1

Below are the most recent publications written about "Methotrexate" by people in Profiles.

Abhishek A, Peckham N, Pade C, Gibbons JM, Cureton L, Francis A, Barber V, Williams JAE, Appelbe D, Eldridge L, Julier P, Altmann DM, Bluett J, Brooks T, Coates LC, Rombach I, Semper A, Otter A, Valdes AM, Nguyen-Van-Tam JS, Williams HC, Boyton RJ, McKnight ?, Cook JA. Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial. Lancet Rheumatol. 2024 Feb; 6(2):e92-e104.

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Ghoneum M, El-Gerbed MSA. Human placental extract ameliorates methotrexate-induced hepatotoxicity in rats via regulating antioxidative and anti-inflammatory responses. Cancer Chemother Pharmacol. 2021 12; 88(6):961-971.

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Loyola AC, Zhang L, Shang R, Dutta P, Li J, Li WX. Identification of methotrexate as a heterochromatin-promoting drug. Sci Rep. 2019 08 12; 9(1):11673.

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Huber AM, Kim S, Reed AM, Carrasco R, Feldman BM, Hong SD, Kahn P, Rahimi H, Robinson AB, Vehe RK, Weiss JE, Spencer C. Childhood Arthritis and Rheumatology Research Alliance Consensus Clinical Treatment Plans for Juvenile Dermatomyositis with Persistent Skin Rash. J Rheumatol. 2017 01; 44(1):110-116.

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Varela-Rosario N, P?rez-Berenguer JL, Vil? LM. Efficacy of immunosuppressive treatment in a systemic lupus erythematosus patient presenting with inclusion body myositis. BMJ Case Rep. 2016 Apr 05; 2016.

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Goldman S, Smith L, Galardy P, Perkins SL, Frazer JK, Sanger W, Anderson JR, Gross TG, Weinstein H, Harrison L, Shiramizu B, Barth M, Cairo MS. Rituximab with chemotherapy in children and adolescents with central nervous system and/or bone marrow-positive Burkitt lymphoma/leukaemia: a Children's Oncology Group Report. Br J Haematol. 2014 Nov; 167(3):394-401.

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Deng DY, Yee K, Burkhalter W, Okimoto KC, Kon K, Kurahara DK. An intra-articular ganglion cyst in a patient with juvenile idiopathic arthritis. Pediatr Rheumatol Online J. 2014; 12:14.

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Barth MJ, Goldman S, Smith L, Perkins S, Shiramizu B, Gross TG, Harrison L, Sanger W, Geyer MB, Giulino-Roth L, Cairo MS. Rituximab pharmacokinetics in children and adolescents with de novo intermediate and advanced mature B-cell lymphoma/leukaemia: a Children's Oncology Group report. Br J Haematol. 2013 Sep; 162(5):678-83.

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Goldman S, Smith L, Anderson JR, Perkins S, Harrison L, Geyer MB, Gross TG, Weinstein H, Bergeron S, Shiramizu B, Sanger W, Barth M, Zhi J, Cairo MS. Rituximab and FAB/LMB 96 chemotherapy in children with Stage III/IV B-cell non-Hodgkin lymphoma: a Children's Oncology Group report. Leukemia. 2013 Apr; 27(5):1174-7.

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Peng XX, Tiwari AK, Wu HC, Chen ZS. Overexpression of P-glycoprotein induces acquired resistance to imatinib in chronic myelogenous leukemia cells. Chin J Cancer. 2012 Feb; 31(2):110-8.

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