"Metallothionein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A low-molecular-weight (approx. 10 kD) protein occurring in the cytoplasm of kidney cortex and liver. It is rich in cysteinyl residues and contains no aromatic amino acids. Metallothionein shows high affinity for bivalent heavy metals.
| Descriptor ID |
D008668
|
| MeSH Number(s) |
D12.776.556.670
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Metallothionein".
Below are MeSH descriptors whose meaning is more specific than "Metallothionein".
This graph shows the total number of publications written about "Metallothionein" by people in this website by year, and whether "Metallothionein" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2001 | 1 | 1 | 2 |
| 2003 | 0 | 2 | 2 |
| 2004 | 2 | 0 | 2 |
| 2005 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
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Below are the most recent publications written about "Metallothionein" by people in Profiles.
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Kawahara B, Ramadoss S, Chaudhuri G, Janzen C, Sen S, Mascharak PK. Carbon monoxide sensitizes cisplatin-resistant ovarian cancer cell lines toward cisplatin via attenuation of levels of glutathione and nuclear metallothionein. J Inorg Biochem. 2019 02; 191:29-39.
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Velma V, Tchounwou PB. Hexavalent chromium-induced multiple biomarker responses in liver and kidney of goldfish, Carassius auratus. Environ Toxicol. 2011 Nov; 26(6):649-56.
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De Mello WC. Metallothionein reverses the harmful effects of angiotensin II on the diabetic heart. J Am Coll Cardiol. 2008 Aug 19; 52(8):667-9.
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Badisa VL, Latinwo LM, Odewumi CO, Ikediobi CO, Badisa RB, Ayuk-Takem LT, Nwoga J, West J. Mechanism of DNA damage by cadmium and interplay of antioxidant enzymes and agents. Environ Toxicol. 2007 Apr; 22(2):144-51.
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Achanta P, Thompson KJ, Fuss M, Martinez JL. Gene expression changes in the rodent hippocampus following whole brain irradiation. Neurosci Lett. 2007 May 17; 418(2):143-8.
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Kooncumchoo P, Sharma S, Porter J, Govitrapong P, Ebadi M. Coenzyme Q(10) provides neuroprotection in iron-induced apoptosis in dopaminergic neurons. J Mol Neurosci. 2006; 28(2):125-41.
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Mart?nez MM, Link JE, Hill GM. Dietary pharmacological or excess zinc and phytase effects on tissue mineral concentrations, metallothionein, and apparent mineral retention in the newly weaned pig. Biol Trace Elem Res. 2005; 105(1-3):97-115.
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Kuo HC, Moore JD, Krebs JE. Histone H2A and Spt10 cooperate to regulate induction and autoregulation of the CUP1 metallothionein. J Biol Chem. 2005 Jan 07; 280(1):104-11.
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Mart?nez MM, Hill GM, Link JE, Raney NE, Tempelman RJ, Ernst CW. Pharmacological zinc and phytase supplementation enhance metallothionein mRNA abundance and protein concentration in newly weaned pigs. J Nutr. 2004 Mar; 134(3):538-44.
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Tchounwou PB, Yedjou CG, Dorsey WC. Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2). Cell Mol Biol (Noisy-le-grand). 2003 Nov; 49(7):1071-9.