An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome is associated with mutations in the gene encoding fibrillin, a major element of extracellular microfibrils of connective tissue.

Descriptor ID	D008382
MeSH Number(s)	C05.116.099.674 C14.240.400.725 C14.280.400.725 C16.131.077.550 C16.131.240.400.720 C16.320.540 C17.300.500
Concept/Terms	Marfan Syndrome Marfan Syndrome Syndrome, Marfan Marfan Syndrome, Type I Marfan's Syndrome Marfans Syndrome Syndrome, Marfan's

Below are MeSH descriptors whose meaning is more general than "Marfan Syndrome".

Below are MeSH descriptors whose meaning is related to "Marfan Syndrome".

Below are MeSH descriptors whose meaning is more specific than "Marfan Syndrome".