Glomerulosclerosis, Focal Segmental

"Glomerulosclerosis, Focal Segmental" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.

Descriptor ID	D005923
MeSH Number(s)	C12.777.419.570.363.660 C13.351.968.419.570.363.640
Concept/Terms	Glomerulosclerosis, Focal Segmental Glomerulosclerosis, Focal Segmental Segmental Glomerulosclerosis, Focal Glomerulosclerosis, Focal Focal Glomerulosclerosis Focal Segmental Glomerulosclerosis Glomerulonephritis, Focal Sclerosing Focal Sclerosing Glomerulonephritides Focal Sclerosing Glomerulonephritis Glomerulonephritides, Focal Sclerosing Sclerosing Glomerulonephritides, Focal Sclerosing Glomerulonephritis, Focal Hyalinosis, Segmental Glomerular Hyalinosis, Segmental Glomerular Glomerular Hyalinosis, Segmental Segmental Glomerular Hyalinosis Hyalinosis, Segmental Segmental Hyalinosis

Below are MeSH descriptors whose meaning is more general than "Glomerulosclerosis, Focal Segmental".

Diseases [C]
Male Urogenital Diseases [C12]
Urologic Diseases [C12.777]
Kidney Diseases [C12.777.419]
Nephritis [C12.777.419.570]
Glomerulonephritis [C12.777.419.570.363]
Glomerulosclerosis, Focal Segmental [C12.777.419.570.363.660]
Female Urogenital Diseases and Pregnancy Complications [C13]
Female Urogenital Diseases [C13.351]
Urologic Diseases [C13.351.968]
Kidney Diseases [C13.351.968.419]
Nephritis [C13.351.968.419.570]
Glomerulonephritis [C13.351.968.419.570.363]
Glomerulosclerosis, Focal Segmental [C13.351.968.419.570.363.640]

Below are MeSH descriptors whose meaning is related to "Glomerulosclerosis, Focal Segmental".

Below are MeSH descriptors whose meaning is more specific than "Glomerulosclerosis, Focal Segmental".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Glomerulosclerosis, Focal Segmental" by people in this website by year, and whether "Glomerulosclerosis, Focal Segmental" was a major or minor topic of these publications.

Bar chart showing 8 publications over 7 distinct years, with a maximum of 2 publications in 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2009	1	0	1
2015	1	0	1
2017	1	0	1
2021	0	1	1
2023	1	0	1
2024	1	1	2
2025	1	0	1

Below are the most recent publications written about "Glomerulosclerosis, Focal Segmental" by people in Profiles.

Nicholas SB, Kornowske LM, Jones CR, Daratha KB, Alicic RZ, Reynolds CL, Neumiller JJ, Bensink ME, Gong W, Norris KC, Tuttle KR. Population risk predictors of major adverse kidney events attributed to focal segmental glomerulosclerosis from the CURE-CKD registry. BMC Nephrol. 2025 Jul 19; 26(1):403.

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Kumar V, Kaur P, Ayasolla K, Jha A, Wiqas A, Vashistha H, Saleem MA, Popik W, Malhotra A, Gebeshuber CA, Skorecki K, Singhal PC. APOL1 Modulates Renin-Angiotensin System. Biomolecules. 2024 Dec 10; 14(12).

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Feng Y, Sun Z, Fu J, Zhong F, Zhang W, Wei C, Chen A, Liu BC, He JC, Lee K. Podocyte-derived soluble RARRES1 drives kidney disease progression through direct podocyte and proximal tubular injury. Kidney Int. 2024 07; 106(1):50-66.

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Reghuvaran AC, Lin Q, Basgen JM, Banu K, Shi H, Vashist A, Pell J, Perinchery S, He JC, Moledina D, Wilson FP, Menon MC. Comparative evaluation of glomerular morphometric techniques reveals differential technical artifacts between focal segmental glomerulosclerosis and normal glomeruli. Physiol Rep. 2023 07; 11(13):e15688.

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Banu K, Lin Q, Basgen JM, Planoutene M, Wei C, Reghuvaran AC, Tian X, Shi H, Garzon F, Garzia A, Chun N, Cumpelik A, Santeusanio AD, Zhang W, Das B, Salem F, Li L, Ishibe S, Cantley LG, Kaufman L, Lemley KV, Ni Z, He JC, Murphy B, Menon MC. AMPK mediates regulation of glomerular volume and podocyte survival. JCI Insight. 2021 10 08; 6(19).

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Zhou Y, Castonguay P, Sidhom EH, Clark AR, Dvela-Levitt M, Kim S, Sieber J, Wieder N, Jung JY, Andreeva S, Reichardt J, Dubois F, Hoffmann SC, Basgen JM, Montesinos MS, Weins A, Johnson AC, Lander ES, Garrett MR, Hopkins CR, Greka A. A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science. 2017 12 08; 358(6368):1332-1336.

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Schwartzman M, Reginensi A, Wong JS, Basgen JM, Meliambro K, Nicholas SB, D'Agati V, McNeill H, Campbell KN. Podocyte-Specific Deletion of Yes-Associated Protein Causes FSGS and Progressive Renal Failure. J Am Soc Nephrol. 2016 Jan; 27(1):216-26.

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Toblli JE, Ferrini MG, Cao G, Vernet D, Angerosa M, Gonzalez-Cadavid NF. Antifibrotic effects of pioglitazone on the kidney in a rat model of type 2 diabetes mellitus. Nephrol Dial Transplant. 2009 Aug; 24(8):2384-91.

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