"Caffeine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.
| Descriptor ID |
D002110
|
| MeSH Number(s) |
D03.132.960.175 D03.633.100.759.758.824.175
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Caffeine".
Below are MeSH descriptors whose meaning is more specific than "Caffeine".
This graph shows the total number of publications written about "Caffeine" by people in this website by year, and whether "Caffeine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2006 | 1 | 1 | 2 |
| 2007 | 1 | 1 | 2 |
| 2011 | 1 | 1 | 2 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 1 | 2 |
| 2015 | 0 | 2 | 2 |
| 2017 | 1 | 1 | 2 |
| 2018 | 2 | 0 | 2 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Caffeine" by people in Profiles.
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Dokunmu TM, Opara SC, Imaga NA, Awani OU, Enoma DO, Adelani BI. P53 Gene Expression and Nitric Oxide Levels after Artemisinin-Caffeine Treatment in Breast, Lungs and Liver of DMBA-Induced Tumorigenesis. Asian Pac J Cancer Prev. 2023 Feb 01; 24(2):451-458.
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Park SY, Freedman ND, Haiman CA, Le Marchand L, Wilkens LR, Setiawan VW. Prospective Study of Coffee Consumption and Cancer Incidence in Non-White Populations. Cancer Epidemiol Biomarkers Prev. 2018 08; 27(8):928-935.
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Crespo M, Le?n-Navarro DA, Mart?n M. Cerebellar oxidative stress and fine motor impairment in adolescent rats exposed to hyperthermia-induced seizures is prevented by maternal caffeine intake during gestation and lactation. Eur J Pharmacol. 2018 Mar 05; 822:186-198.
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Li X, Xu R, Wei X, Hu H, Zhao S, Liu YM. Direct Analysis of Biofluids by Mass Spectrometry with Microfluidic Voltage-Assisted Liquid Desorption Electrospray Ionization. Anal Chem. 2017 11 21; 89(22):12014-12022.
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Long Y, Sanchez-Espiridion B, Lin M, White L, Mishra L, Raju GS, Kopetz S, Eng C, Hildebrandt MAT, Chang DW, Ye Y, Liang D, Wu X. Global and targeted serum metabolic profiling of colorectal cancer progression. Cancer. 2017 Oct 15; 123(20):4066-4074.
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Acevedo J, Santana-Almansa A, Matos-Vergara N, Marrero-Cordero LR, Cabezas-Bou E, D?az-R?os M. Caffeine stimulates locomotor activity in the mammalian spinal cord via adenosine A1 receptor-dopamine D1 receptor interaction and PKA-dependent mechanisms. Neuropharmacology. 2016 Feb; 101:490-505.
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Martinez Gomez DA, Baca S, Walsh EJ. Lethal and sublethal effects of selected PPCPs on the freshwater rotifer, Plationus patulus. Environ Toxicol Chem. 2015 Apr; 34(4):913-22.
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Gonz?lez W, Altieri PI, Alvarado E, Banchs HL, Col?n E, Escobales N, Crespo M. Celiac trunk and branches dissection due to energy drink consumption and heavy resistance exercise: case report and review of literature. Bol Asoc Med P R. 2015 Jan-Mar; 107(1):38-40.
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Rivera-Oliver M, D?az-R?os M. Using caffeine and other adenosine receptor antagonists and agonists as therapeutic tools against neurodegenerative diseases: a review. Life Sci. 2014 Apr 17; 101(1-2):1-9.
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R?os JL, Betancourt J, Pag?n I, Fabi?n C, Cruz SY, Gonz?lez AM, Gonz?lez MJ, Rivera-Soto WT, Palacios C. Caffeinated-beverage consumption and its association with socio-demographic characteristics and self-perceived academic stress in first and second year students at the University of Puerto Rico Medical Sciences Campus (UPR-MSC). P R Health Sci J. 2013 Jun; 32(2):95-100.