"Acetazolamide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
| Descriptor ID |
D000086
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| MeSH Number(s) |
D02.886.675.867.060 D03.383.129.708.867.060
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Acetazolamide".
Below are MeSH descriptors whose meaning is more specific than "Acetazolamide".
This graph shows the total number of publications written about "Acetazolamide" by people in this website by year, and whether "Acetazolamide" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Acetazolamide" by people in Profiles.
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Wambo TO, Chen LY, McHardy SF, Tsin AT. Molecular dynamics study of human carbonic anhydrase II in complex with Zn(2+) and acetazolamide on the basis of all-atom force field simulations. Biophys Chem. 2016 Jul-Aug; 214-215:54-60.
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Huang JL, Zhang YL, Xiao X, Zhang JH, Lian QL, Liu Y, Sun XJ. Bidirectional influences of acetazolamide on central nervous system oxygen toxicity of rats. Undersea Hyperb Med. 2010 Sep-Oct; 37(5):271-80.
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Xu J, Peng Z, Li R, Dou T, Xu W, Gu G, Liu Y, Kang Z, Tao H, Zhang JH, Ostrowski RP, Lu J, Sun X. Normoxic induction of cerebral HIF-1alpha by acetazolamide in rats: role of acidosis. Neurosci Lett. 2009 Feb 27; 451(3):274-8.
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Taylor BE, Harris MB, Coates EL, Gdovin MJ, Leiter JC. Central CO2 chemoreception in developing bullfrogs: anomalous response to acetazolamide. J Appl Physiol (1985). 2003 Mar; 94(3):1204-12.
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Jen JC, Yue Q, Karrim J, Nelson SF, Baloh RW. Spinocerebellar ataxia type 6 with positional vertigo and acetazolamide responsive episodic ataxia. J Neurol Neurosurg Psychiatry. 1998 Oct; 65(4):565-8.
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Yue Q, Jen JC, Thwe MM, Nelson SF, Baloh RW. De novo mutation in CACNA1A caused acetazolamide-responsive episodic ataxia. Am J Med Genet. 1998 May 26; 77(4):298-301.
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Zachariah SB, Jimenez L, Zachariah B, Prockop LD. Pseudotumour cerebri with focal neurological deficit. J Neurol Neurosurg Psychiatry. 1990 Apr; 53(4):360-1.
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Conder GA, Mayberry LF, Bristol JR, Castro GA, Lee BL, Kratzer DD, Folz SD, Rector DL. Effects of PGE1 or PGE2 and/or acetazolamide on expulsion of Nippostrongylus brasiliensis from rats. Prostaglandins. 1987 Dec; 34(6):817-27.
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Fermin CD, Igarashi M, Yoshihara T. Ultrastructural changes of statoconia after segmentation of the otolithic membrane. Hear Res. 1987; 28(1):23-34.