Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deoxycholate 19-Hydroxylation Is an In Vitro Marker of CYP3A7 Activity.

Chen YJ, Zhang J, Zhu PP, Tan XW, Lin QH, Wang WX, Yin SS, Gao LZ, Su MM, Liu CX, Xu L, Jia W, Sevrioukova IF, Lan K. Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deoxycholate 19-Hydroxylation Is an In Vitro Marker of CYP3A7 Activity. Drug Metab Dispos. 2019 06; 47(6):574-581.

View in: PubMed

subject areas

Cytochrome P-450 CYP3A
Deoxycholic Acid
Humans
Hydroxylation
Kinetics
Liver
Microsomes, Liver
Oxidation-Reduction

authors with profiles

Jia Wei, PhD

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