Differential inhibition of cytochromes P450 3A4 and 3A5 by the newly synthesized coumarin derivatives 7-coumarin propargyl ether and 7-(4-trifluoromethyl)coumarin propargyl ether.

Sridar C, Kent UM, Noon K, McCall A, Alworth B, Foroozesh M, Hollenberg PF. Differential inhibition of cytochromes P450 3A4 and 3A5 by the newly synthesized coumarin derivatives 7-coumarin propargyl ether and 7-(4-trifluoromethyl)coumarin propargyl ether. Drug Metab Dispos. 2008 Nov; 36(11):2234-43.

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subject areas

Alkynes
Coumarins
Cytochrome P-450 CYP3A
Enzyme Activation
Enzyme Inhibitors
Ethers
Humans
Imidazoles
Microsomes, Liver

authors with profiles

Maryam Foroozesh

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