Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis.

Altomare DA, Menges CW, Xu J, Pei J, Zhang L, Tadevosyan A, Neumann-Domer E, Liu Z, Carbone M, Chudoba I, Klein-Szanto AJ, Testa JR. Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis. PLoS One. 2011 Apr 19; 6(4):e18828.

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subject areas

Alleles
Animals
Asbestos
Chromosomes, Mammalian
Cyclin-Dependent Kinase Inhibitor p16
Gene Silencing
Genetic Loci
Humans
Mesothelioma
Mice
Precancerous Conditions
Tumor Suppressor Protein p14ARF

authors with profiles

Michele Carbone, MD, PhD.

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