A GCH1 haplotype confers sex-specific susceptibility to pain crises and altered endothelial function in adults with sickle cell anemia.

Belfer I, Youngblood V, Darbari DS, Wang Z, Diaw L, Freeman L, Desai K, Dizon M, Allen D, Cunnington C, Channon KM, Milton J, Hartley SW, Nolan V, Kato GJ, Steinberg MH, Goldman D, Taylor JG. A GCH1 haplotype confers sex-specific susceptibility to pain crises and altered endothelial function in adults with sickle cell anemia. Am J Hematol. 2014 Feb; 89(2):187-93.

View in: PubMed

subject areas

Adult
Alleles
Anemia, Sickle Cell
Case-Control Studies
Endothelium
Female
Gene Expression Regulation
Gene Frequency
Genetic Association Studies
Genetic Markers
Genetic Predisposition to Disease
GTP Cyclohydrolase
Haplotypes
Humans
Male
Middle Aged
Odds Ratio
Pain
Phenotype
Plethysmography
Sex Factors
Vascular Diseases
Young Adult

authors with profiles

James Taylor

RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

For technical support please contact support