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Emily Cope

TitleAssistant Professor
Faculty RankAssistant Professor
InstitutionNorthern Arizona University
DepartmentBiological Sciences
AddressPO Box 5640
Flagstaff AZ 86011
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    Collapse Research 
    Collapse research activities and funding
    R15AI147148     (COPE, EMILY K)Jul 1, 2019 - Jun 30, 2022
    NIH
    Determining the Role of the Upper and Lower Airway Microbiota as Drivers of Concomitant Inflammatory Responses in patients with Chronic Rhinosinusitis and Asthma
    Role: Principal Investigator
    R21AG074203     (COPE, EMILY K)Sep 1, 2021 - Apr 30, 2024
    NIH
    Development of in vivo quantitative stable isotope probing to quantify microbiome dynamics in Alzheimers Disease
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Conn KA, Borsom EM, Cope EK. Implications of microbe-derived ?-aminobutyric acid (GABA) in gut and brain barrier integrity and GABAergic signaling in Alzheimer's disease. Gut Microbes. 2024 Jan-Dec; 16(1):2371950. PMID: 39008552.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Benton LD, Lopez-Galvez N, Herman C, Caporaso JG, Cope EK, Rosales C, Gameros M, Lothrop N, Mart?nez FD, Wright AL, Carr TF, Beamer PI. Environmental and structural factors associated with bacterial diversity in household dust across the Arizona-Sonora border. Sci Rep. 2024 06 04; 14(1):12803. PMID: 38834753.
      Citations:    Fields:    Translation:HumansCells
    3. Weninger SN, Herman C, Meyer RK, Beauchemin ET, Kangath A, Lane AI, Martinez TM, Hasneen T, Jaramillo SA, Lindsey J, Vedantam G, Cai H, Cope EK, Caporaso JG, Duca FA. Oligofructose improves small intestinal lipid-sensing mechanisms via alterations to the small intestinal microbiota. Microbiome. 2023 08 02; 11(1):169. PMID: 37533066.
      Citations: 7     Fields:    Translation:Animals
    4. Borsom EM, Conn K, Keefe CR, Herman C, Orsini GM, Hirsch AH, Palma Avila M, Testo G, Jaramillo SA, Bolyen E, Lee K, Caporaso JG, Cope EK. Predicting Neurodegenerative Disease Using Prepathology Gut Microbiota Composition: a Longitudinal Study in Mice Modeling Alzheimer's Disease Pathologies. Microbiol Spectr. 2023 Mar 06; e0345822. PMID: 36877047.
      Citations: 13     Fields:    
    5. Kotas ME, Patel NN, Cope EK, Gurrola JG, Goldberg AN, Pletcher SD, Seibold MA, Moore CM, Gordon ED. IL-13-associated epithelial remodeling correlates with clinical severity in nasal polyposis. J Allergy Clin Immunol. 2023 05; 151(5):1277-1285. PMID: 36736797.
      Citations: 3     Fields:    Translation:Humans
    6. Lal D, Song L, Brar T, Cope EK, Keim P, Williams S, Chung Y, Murugan V, LaBaer J, Magee DM. Antibody responses to the host microbiome in chronic rhinosinusitis. Int Forum Allergy Rhinol. 2023 08; 13(8):1503-1510. PMID: 36504343.
      Citations: 3     Fields:    Translation:HumansCells
    7. Kotas ME, Moore CM, Gurrola JG, Pletcher SD, Goldberg AN, Alvarez R, Yamato S, Bratcher PE, Shaughnessy CA, Zeitlin PL, Zhang IH, Li Y, Montgomery MT, Lee K, Cope EK, Locksley RM, Seibold MA, Gordon ED. IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function. JCI Insight. 2022 07 08; 7(13). PMID: 35608904.
      Citations: 14     Fields:    Translation:Animals
    8. Psaltis AJ, Mackenzie BW, Cope EK, Ramakrishnan VR. Unraveling the role of the microbiome in chronic rhinosinusitis. J Allergy Clin Immunol. 2022 05; 149(5):1513-1521. PMID: 35300985.
      Citations: 10     Fields:    Translation:Humans
    9. Cai Y, Juszczak HM, Cope EK, Goldberg AN. The microbiome in obstructive sleep apnea. Sleep. 2021 08 13; 44(8). PMID: 33705556.
      Citations: 19     Fields:    Translation:Animals
    10. Dillon MR, Bolyen E, Adamov A, Belk A, Borsom E, Burcham Z, Debelius JW, Deel H, Emmons A, Estaki M, Herman C, Keefe CR, Morton JT, Oliveira RRM, Sanchez A, Simard A, V?zquez-Baeza Y, Ziemski M, Miwa HE, Kerere TA, Coote C, Bonneau R, Knight R, Oliveira G, Gopalasingam P, Kaehler BD, Cope EK, Metcalf JL, Robeson Ii MS, Bokulich NA, Caporaso JG. Experiences and lessons learned from two virtual, hands-on microbiome bioinformatics workshops. PLoS Comput Biol. 2021 06; 17(6):e1009056. PMID: 34166363.
      Citations: 2     Fields:    Translation:HumansCells
    11. Bycura D, Santos AC, Shiffer A, Kyman S, Winfree K, Sutliffe J, Pearson T, Sonderegger D, Cope E, Caporaso JG. Impact of Different Exercise Modalities on the Human Gut Microbiome. Sports (Basel). 2021 Jan 21; 9(2). PMID: 33494210.
      Citations:    
    12. Borsom EM, Lee K, Cope EK. Do the Bugs in Your Gut Eat Your Memories? Relationship between Gut Microbiota and Alzheimer's Disease. Brain Sci. 2020 Nov 03; 10(11). PMID: 33153085.
      Citations:    
    13. Lee K, Zhang I, Kyman S, Kask O, Cope EK. Co-infection of Malassezia sympodialis With Bacterial Pathobionts Pseudomonas aeruginosa or Staphylococcus aureus Leads to Distinct Sinonasal Inflammatory Responses in a Murine Acute Sinusitis Model. Front Cell Infect Microbiol. 2020; 10:472. PMID: 33014894.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    14. Bassiouni A, Paramasivan S, Shiffer A, Dillon MR, Cope EK, Cooksley C, Ramezanpour M, Moraitis S, Ali MJ, Bleier BS, Callejas C, Cornet ME, Douglas RG, Dutra D, Georgalas C, Harvey RJ, Hwang PH, Luong AU, Schlosser RJ, Tantilipikorn P, Tewfik MA, Vreugde S, Wormald PJ, Caporaso JG, Psaltis AJ. Microbiotyping the Sinonasal Microbiome. Front Cell Infect Microbiol. 2020; 10:137. PMID: 32322561.
      Citations: 12     Fields:    Translation:HumansCells
    15. Paramasivan S, Bassiouni A, Shiffer A, Dillon MR, Cope EK, Cooksley C, Ramezanpour M, Moraitis S, Ali MJ, Bleier B, Callejas C, Cornet ME, Douglas RG, Dutra D, Georgalas C, Harvey RJ, Hwang PH, Luong AU, Schlosser RJ, Tantilipikorn P, Tewfik MA, Vreugde S, Wormald PJ, Caporaso JG, Psaltis AJ. The international sinonasal microbiome study: A multicentre, multinational characterization of sinonasal bacterial ecology. Allergy. 2020 08; 75(8):2037-2049. PMID: 32167574.
      Citations: 27     Fields:    Translation:HumansCells
    16. Bolyen E, Rideout JR, Dillon MR, Bokulich NA, Abnet CC, Al-Ghalith GA, Alexander H, Alm EJ, Arumugam M, Asnicar F, Bai Y, Bisanz JE, Bittinger K, Brejnrod A, Brislawn CJ, Brown CT, Callahan BJ, Caraballo-Rodr?guez AM, Chase J, Cope EK, Da Silva R, Diener C, Dorrestein PC, Douglas GM, Durall DM, Duvallet C, Edwardson CF, Ernst M, Estaki M, Fouquier J, Gauglitz JM, Gibbons SM, Gibson DL, Gonzalez A, Gorlick K, Guo J, Hillmann B, Holmes S, Holste H, Huttenhower C, Huttley GA, Janssen S, Jarmusch AK, Jiang L, Kaehler BD, Kang KB, Keefe CR, Keim P, Kelley ST, Knights D, Koester I, Kosciolek T, Kreps J, Langille MGI, Lee J, Ley R, Liu YX, Loftfield E, Lozupone C, Maher M, Marotz C, Martin BD, McDonald D, McIver LJ, Melnik AV, Metcalf JL, Morgan SC, Morton JT, Naimey AT, Navas-Molina JA, Nothias LF, Orchanian SB, Pearson T, Peoples SL, Petras D, Preuss ML, Pruesse E, Rasmussen LB, Rivers A, Robeson MS, Rosenthal P, Segata N, Shaffer M, Shiffer A, Sinha R, Song SJ, Spear JR, Swafford AD, Thompson LR, Torres PJ, Trinh P, Tripathi A, Turnbaugh PJ, Ul-Hasan S, van der Hooft JJJ, Vargas F, V?zquez-Baeza Y, Vogtmann E, von Hippel M, Walters W, Wan Y, Wang M, Warren J, Weber KC, Williamson CHD, Willis AD, Xu ZZ, Zaneveld JR, Zhang Y, Zhu Q, Knight R, Caporaso JG. Author Correction: Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2. Nat Biotechnol. 2019 Sep; 37(9):1091. PMID: 31399723.
      Citations: 150     Fields:    
    17. Bolyen E, Rideout JR, Dillon MR, Bokulich NA, Abnet CC, Al-Ghalith GA, Alexander H, Alm EJ, Arumugam M, Asnicar F, Bai Y, Bisanz JE, Bittinger K, Brejnrod A, Brislawn CJ, Brown CT, Callahan BJ, Caraballo-Rodr?guez AM, Chase J, Cope EK, Da Silva R, Diener C, Dorrestein PC, Douglas GM, Durall DM, Duvallet C, Edwardson CF, Ernst M, Estaki M, Fouquier J, Gauglitz JM, Gibbons SM, Gibson DL, Gonzalez A, Gorlick K, Guo J, Hillmann B, Holmes S, Holste H, Huttenhower C, Huttley GA, Janssen S, Jarmusch AK, Jiang L, Kaehler BD, Kang KB, Keefe CR, Keim P, Kelley ST, Knights D, Koester I, Kosciolek T, Kreps J, Langille MGI, Lee J, Ley R, Liu YX, Loftfield E, Lozupone C, Maher M, Marotz C, Martin BD, McDonald D, McIver LJ, Melnik AV, Metcalf JL, Morgan SC, Morton JT, Naimey AT, Navas-Molina JA, Nothias LF, Orchanian SB, Pearson T, Peoples SL, Petras D, Preuss ML, Pruesse E, Rasmussen LB, Rivers A, Robeson MS, Rosenthal P, Segata N, Shaffer M, Shiffer A, Sinha R, Song SJ, Spear JR, Swafford AD, Thompson LR, Torres PJ, Trinh P, Tripathi A, Turnbaugh PJ, Ul-Hasan S, van der Hooft JJJ, Vargas F, V?zquez-Baeza Y, Vogtmann E, von Hippel M, Walters W, Wan Y, Wang M, Warren J, Weber KC, Williamson CHD, Willis AD, Xu ZZ, Zaneveld JR, Zhang Y, Zhu Q, Knight R, Caporaso JG. Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2. Nat Biotechnol. 2019 08; 37(8):852-857. PMID: 31341288.
      Citations: 6142     Fields:    Translation:Humans
    18. Stone NE, Nunnally AE, Jimenez V, Cope EK, Sahl JW, Sheridan K, Hornstra HM, Vinocur J, Settles EW, Headley KC, Williamson CHD, Rideout JR, Bolyen E, Caporaso JG, Terriquez J, Monroy FP, Busch JD, Keim P, Wagner DM. Domestic canines do not display evidence of gut microbial dysbiosis in the presence of Clostridioides (Clostridium) difficile, despite cellular susceptibility to its toxins. Anaerobe. 2019 Aug; 58:53-72. PMID: 30946985.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    19. Pletcher SD, Goldberg AN, Cope EK. Loss of Microbial Niche Specificity Between the Upper and Lower Airways in Patients With Cystic Fibrosis. Laryngoscope. 2019 03; 129(3):544-550. PMID: 30284279.
      Citations: 14     Fields:    Translation:HumansCells
    20. Lee K, Pletcher SD, Lynch SV, Goldberg AN, Cope EK. Heterogeneity of Microbiota Dysbiosis in Chronic Rhinosinusitis: Potential Clinical Implications and Microbial Community Mechanisms Contributing to Sinonasal Inflammation. Front Cell Infect Microbiol. 2018; 8:168. PMID: 29876323.
      Citations: 12     Fields:    Translation:HumansAnimals
    21. Cope EK. Host-Microbe Interactions in Airway Disease: toward Disease Mechanisms and Novel Therapeutic Strategies. mSystems. 2018 Mar-Apr; 3(2). PMID: 29556535.
      Citations: 1     Fields:    
    22. Zhang I, Pletcher SD, Goldberg AN, Barker BM, Cope EK. Fungal Microbiota in Chronic Airway Inflammatory Disease and Emerging Relationships with the Host Immune Response. Front Microbiol. 2017; 8:2477. PMID: 29312187.
      Citations:    
    23. Cope EK, Goldberg AN, Pletcher SD, Lynch SV. Compositionally and functionally distinct sinus microbiota in chronic rhinosinusitis patients have immunological and clinically divergent consequences. Microbiome. 2017 05 12; 5(1):53. PMID: 28494786.
      Citations: 70     Fields:    Translation:HumansCells
    24. Lal D, Keim P, Delisle J, Barker B, Rank MA, Chia N, Schupp JM, Gillece JD, Cope EK. Mapping and comparing bacterial microbiota in the sinonasal cavity of healthy, allergic rhinitis, and chronic rhinosinusitis subjects. Int Forum Allergy Rhinol. 2017 06; 7(6):561-569. PMID: 28481057.
      Citations: 48     Fields:    Translation:HumansCells
    25. Cope EK, Goldberg AN, Pletcher SD, Lynch SV. A chronic rhinosinusitis-derived isolate of Pseudomonas aeruginosa induces acute and pervasive effects on the murine upper airway microbiome and host immune response. Int Forum Allergy Rhinol. 2016 12; 6(12):1229-1237. PMID: 27598436.
      Citations: 7     Fields:    Translation:AnimalsCells
    26. Gelber JT, Cope EK, Goldberg AN, Pletcher SD. Evaluation of Malassezia and Common Fungal Pathogens in Subtypes of Chronic Rhinosinusitis. Int Forum Allergy Rhinol. 2016 09; 6(9):950-5. PMID: 27153455.
      Citations: 11     Fields:    Translation:HumansAnimals
    27. Fox DT, Schmidt EN, Tian H, Dhungana S, Valentine MC, Warrington NV, Phillips PD, Finney KB, Cope EK, Leid JG, Testa CA, Koppisch AT. Sub-inhibitory fosmidomycin exposures elicits oxidative stress in Salmonella enterica serovar Typhimurium LT2. PLoS One. 2014; 9(4):e95271. PMID: 24751777.
      Citations: 3     Fields:    Translation:HumansCells
    28. Shikani AH, Sidhaye VK, Basaraba RJ, Shikani HJ, Alqudah MA, Kirk N, Cope E, Leid JG. Mucosal expression of aquaporin 5 and epithelial barrier proteins in chronic rhinosinusitis with and without nasal polyps. Am J Otolaryngol. 2014 May-Jun; 35(3):377-83. PMID: 24612929.
      Citations: 10     Fields:    Translation:Humans
    29. Nagalingam NA, Cope EK, Lynch SV. Probiotic strategies for treatment of respiratory diseases. Trends Microbiol. 2013 Sep; 21(9):485-92. PMID: 23707554.
      Citations: 9     Fields:    Translation:HumansAnimals
    30. Shen JC, Cope E, Chen B, Leid JG, Cohen NA. Regulation of murine sinonasal cilia function by microbial secreted factors. Int Forum Allergy Rhinol. 2012 Mar-Apr; 2(2):104-10. PMID: 22253045.
      Citations: 9     Fields:    Translation:AnimalsCells
    31. Cope EK, Goldstein-Daruech N, Kofonow JM, Christensen L, McDermott B, Monroy F, Palmer JN, Chiu AG, Shirtliff ME, Cohen NA, Leid JG. Regulation of virulence gene expression resulting from Streptococcus pneumoniae and nontypeable Haemophilus influenzae interactions in chronic disease. PLoS One. 2011; 6(12):e28523. PMID: 22162775.
      Citations: 25     Fields:    Translation:HumansCells
    32. Leid JG, Ditto AJ, Knapp A, Shah PN, Wright BD, Blust R, Christensen L, Clemons CB, Wilber JP, Young GW, Kang AG, Panzner MJ, Cannon CL, Yun YH, Youngs WJ, Seckinger NM, Cope EK. In vitro antimicrobial studies of silver carbene complexes: activity of free and nanoparticle carbene formulations against clinical isolates of pathogenic bacteria. J Antimicrob Chemother. 2012 Jan; 67(1):138-48. PMID: 21972270.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    33. Goldstein-Daruech N, Cope EK, Zhao KQ, Vukovic K, Kofonow JM, Doghramji L, Gonz?lez B, Chiu AG, Kennedy DW, Palmer JN, Leid JG, Kreindler JL, Cohen NA. Tobacco smoke mediated induction of sinonasal microbial biofilms. PLoS One. 2011 Jan 06; 6(1):e15700. PMID: 21253587.
      Citations: 35     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    34. Leid JG, Kerr M, Selgado C, Johnson C, Moreno G, Smith A, Shirtliff ME, O'Toole GA, Cope EK. Flagellum-mediated biofilm defense mechanisms of Pseudomonas aeruginosa against host-derived lactoferrin. Infect Immun. 2009 Oct; 77(10):4559-66. PMID: 19651866.
      Citations: 10     Fields:    Translation:HumansCells
    35. Panzner MJ, Deeraksa A, Smith A, Wright BD, Hindi KM, Kascatan-Nebioglu A, Torres AG, Judy BM, Hovis CE, Hilliard JK, Mallett RJ, Cope E, Estes DM, Cannon CL, Leid JG, Youngs WJ. Synthesis and in vitro Efficacy Studies of Silver Carbene Complexes on Biosafety Level 3 Bacteria. Eur J Inorg Chem. 2009 May 01; 2009(13):1739-1745. PMID: 20160993.
      Citations:    
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