Tom Huxford to Humans
This is a "connection" page, showing publications Tom Huxford has written about Humans.
Connection Strength
0.330
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Zhu N, Mealka M, Mitchel S, Milani C, Acu?a LM, Rogers E, Lahana AN, Huxford T. X-ray Crystallographic Study of Preferred Spacing by the NF-?B p50 Homodimer on ?B DNA. Biomolecules. 2023 08 26; 13(9).
Score: 0.046
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Ko MS, Biswas T, Mulero MC, Bobkov AA, Ghosh G, Huxford T. Structurally plastic NEMO and oligomerization prone IKK2 subunits define the behavior of human IKK2:NEMO complexes in solution. Biochim Biophys Acta Proteins Proteom. 2020 12; 1868(12):140526.
Score: 0.037
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King AN, Fleming JK, Knapik SS, Visentin B, Wojciak JM, Huxford T. High-affinity pan-specific monoclonal antibodies that target cysteinyl leukotrienes and show efficacy in an acute model of colitis. J Lipid Res. 2017 07; 58(7):1386-1398.
Score: 0.029
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Hauenstein AV, Rogers WE, Shaul JD, Huang DB, Ghosh G, Huxford T. Probing kinase activation and substrate specificity with an engineered monomeric IKK2. Biochemistry. 2014 Apr 01; 53(12):2064-73.
Score: 0.024
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Polley S, Huang DB, Hauenstein AV, Fusco AJ, Zhong X, Vu D, Schr?felbauer B, Kim Y, Hoffmann A, Verma IM, Ghosh G, Huxford T. A structural basis for I?B kinase 2 activation via oligomerization-dependent trans auto-phosphorylation. PLoS Biol. 2013; 11(6):e1001581.
Score: 0.022
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Huxford T, Hoffmann A, Ghosh G. Understanding the logic of I?B:NF-?B regulation in structural terms. Curr Top Microbiol Immunol. 2011; 349:1-24.
Score: 0.019
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Wojciak JM, Zhu N, Schuerenberg KT, Moreno K, Shestowsky WS, Hiraiwa M, Sabbadini R, Huxford T. The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen. Proc Natl Acad Sci U S A. 2009 Oct 20; 106(42):17717-22.
Score: 0.017
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Huxford T, Ghosh G. A structural guide to proteins of the NF-kappaB signaling module. Cold Spring Harb Perspect Biol. 2009 Sep; 1(3):a000075.
Score: 0.017
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Shaul JD, Farina A, Huxford T. The human IKKbeta subunit kinase domain displays CK2-like phosphorylation specificity. Biochem Biophys Res Commun. 2008 Sep 26; 374(3):592-7.
Score: 0.016
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Trinh DV, Zhu N, Farhang G, Kim BJ, Huxford T. The nuclear I kappaB protein I kappaB zeta specifically binds NF-kappaB p50 homodimers and forms a ternary complex on kappaB DNA. J Mol Biol. 2008 May 23; 379(1):122-35.
Score: 0.016
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Huxford T, Ghosh G. Inhibition of transcription factor NF-kappaB activation by kappaB-Ras. Methods Enzymol. 2006; 407:527-34.
Score: 0.013
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Holmberg R, Robinson M, Gilbert SF, Lujano-Olazaba O, Waters JA, Kogan E, Velasquez CLR, Stevenson D, Cruz LS, Alexander LJ, Lara J, Mu EM, Camillo JR, Bitler BG, Huxford T, House CD. TWEAK-Fn14-RelB Signaling Cascade Promotes Stem Cell-like Features that Contribute to Post-Chemotherapy Ovarian Cancer Relapse. Mol Cancer Res. 2023 02 01; 21(2):170-186.
Score: 0.011
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Ko MS, Cohen SN, Polley S, Mahata SK, Biswas T, Huxford T, Ghosh G. Regulatory subunit NEMO promotes polyubiquitin-dependent induction of NF-?B through a targetable second interaction with upstream activator IKK2. J Biol Chem. 2022 05; 298(5):101864.
Score: 0.010
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Napoleon JV, Singh S, Rana S, Bendjennat M, Kumar V, Kizhake S, Palermo NY, Ouellette MM, Huxford T, Natarajan A. Small molecule binding to inhibitor of nuclear factor kappa-B kinase subunit beta in an ATP non-competitive manner. Chem Commun (Camb). 2021 May 11; 57(38):4678-4681.
Score: 0.010
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Mulero MC, Wang VY, Huxford T, Ghosh G. Genome reading by the NF-?B transcription factors. Nucleic Acids Res. 2019 11 04; 47(19):9967-9989.
Score: 0.009
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Huxford T, Malek S, Ghosh G. Structure and mechanism in NF-kappa B/I kappa B signaling. Cold Spring Harb Symp Quant Biol. 1999; 64:533-40.
Score: 0.008
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Mulero MC, Huxford T, Ghosh G. NF-?B, I?B, and IKK: Integral Components of Immune System Signaling. Adv Exp Med Biol. 2019; 1172:207-226.
Score: 0.008
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Mulero MC, Shahabi S, Ko MS, Schiffer JM, Huang DB, Wang VY, Amaro RE, Huxford T, Ghosh G. Protein Cofactors Are Essential for High-Affinity DNA Binding by the Nuclear Factor ?B RelA Subunit. Biochemistry. 2018 05 22; 57(20):2943-2957.
Score: 0.008
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Bergqvist S, Croy CH, Kjaergaard M, Huxford T, Ghosh G, Komives EA. Thermodynamics reveal that helix four in the NLS of NF-kappaB p65 anchors IkappaBalpha, forming a very stable complex. J Mol Biol. 2006 Jul 07; 360(2):421-34.
Score: 0.003
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Croy CH, Bergqvist S, Huxford T, Ghosh G, Komives EA. Biophysical characterization of the free IkappaBalpha ankyrin repeat domain in solution. Protein Sci. 2004 Jul; 13(7):1767-77.
Score: 0.003
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Phelps CB, Sengchanthalangsy LL, Huxford T, Ghosh G. Mechanism of I kappa B alpha binding to NF-kappa B dimers. J Biol Chem. 2000 Sep 22; 275(38):29840-6.
Score: 0.002