Tom Huxford to Humans
This is a "connection" page, showing publications Tom Huxford has written about Humans.
Connection Strength
0.382
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Zhu N, Rogers WE, Heidary DK, Huxford T. Structural and biochemical analyses of the nuclear I?B? protein in complex with the NF-?B p50 homodimer. Genes Dev. 2024 Jul 19; 38(11-12):528-535.
Score: 0.046
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Zhu N, Mealka M, Mitchel S, Milani C, Acu?a LM, Rogers E, Lahana AN, Huxford T. X-ray Crystallographic Study of Preferred Spacing by the NF-?B p50 Homodimer on ?B DNA. Biomolecules. 2023 08 26; 13(9).
Score: 0.043
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Ko MS, Biswas T, Mulero MC, Bobkov AA, Ghosh G, Huxford T. Structurally plastic NEMO and oligomerization prone IKK2 subunits define the behavior of human IKK2:NEMO complexes in solution. Biochim Biophys Acta Proteins Proteom. 2020 12; 1868(12):140526.
Score: 0.035
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King AN, Fleming JK, Knapik SS, Visentin B, Wojciak JM, Huxford T. High-affinity pan-specific monoclonal antibodies that target cysteinyl leukotrienes and show efficacy in an acute model of colitis. J Lipid Res. 2017 07; 58(7):1386-1398.
Score: 0.028
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Hauenstein AV, Rogers WE, Shaul JD, Huang DB, Ghosh G, Huxford T. Probing kinase activation and substrate specificity with an engineered monomeric IKK2. Biochemistry. 2014 Apr 01; 53(12):2064-73.
Score: 0.022
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Polley S, Huang DB, Hauenstein AV, Fusco AJ, Zhong X, Vu D, Schr?felbauer B, Kim Y, Hoffmann A, Verma IM, Ghosh G, Huxford T. A structural basis for I?B kinase 2 activation via oligomerization-dependent trans auto-phosphorylation. PLoS Biol. 2013; 11(6):e1001581.
Score: 0.021
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Huxford T, Hoffmann A, Ghosh G. Understanding the logic of I?B:NF-?B regulation in structural terms. Curr Top Microbiol Immunol. 2011; 349:1-24.
Score: 0.018
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Wojciak JM, Zhu N, Schuerenberg KT, Moreno K, Shestowsky WS, Hiraiwa M, Sabbadini R, Huxford T. The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen. Proc Natl Acad Sci U S A. 2009 Oct 20; 106(42):17717-22.
Score: 0.016
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Huxford T, Ghosh G. A structural guide to proteins of the NF-kappaB signaling module. Cold Spring Harb Perspect Biol. 2009 Sep; 1(3):a000075.
Score: 0.016
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Shaul JD, Farina A, Huxford T. The human IKKbeta subunit kinase domain displays CK2-like phosphorylation specificity. Biochem Biophys Res Commun. 2008 Sep 26; 374(3):592-7.
Score: 0.015
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Trinh DV, Zhu N, Farhang G, Kim BJ, Huxford T. The nuclear I kappaB protein I kappaB zeta specifically binds NF-kappaB p50 homodimers and forms a ternary complex on kappaB DNA. J Mol Biol. 2008 May 23; 379(1):122-35.
Score: 0.015
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Huxford T, Ghosh G. Inhibition of transcription factor NF-kappaB activation by kappaB-Ras. Methods Enzymol. 2006; 407:527-34.
Score: 0.013
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Mealka M, Sierra NA, Avellaneda Matteo D, Albekioni E, Khoury R, Mai T, Conley BM, Coleman NJ, Sabo KA, Komives EA, Bobkov AA, Cooksy AL, Silletti S, Schiffer JM, Huxford T, Sohl CD. Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms. Nat Commun. 2024 May 06; 15(1):3785.
Score: 0.011
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Neal CL, Kronert WA, Camillo JRT, Suggs JA, Huxford T, Bernstein SI. Aging-affiliated post-translational modifications of skeletal muscle myosin affect biochemical properties, myofibril structure, muscle function, and proteostasis. Aging Cell. 2024 06; 23(6):e14134.
Score: 0.011
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Holmberg R, Robinson M, Gilbert SF, Lujano-Olazaba O, Waters JA, Kogan E, Velasquez CLR, Stevenson D, Cruz LS, Alexander LJ, Lara J, Mu EM, Camillo JR, Bitler BG, Huxford T, House CD. TWEAK-Fn14-RelB Signaling Cascade Promotes Stem Cell-like Features that Contribute to Post-Chemotherapy Ovarian Cancer Relapse. Mol Cancer Res. 2023 02 01; 21(2):170-186.
Score: 0.010
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Ko MS, Cohen SN, Polley S, Mahata SK, Biswas T, Huxford T, Ghosh G. Regulatory subunit NEMO promotes polyubiquitin-dependent induction of NF-?B through a targetable second interaction with upstream activator IKK2. J Biol Chem. 2022 05; 298(5):101864.
Score: 0.010
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Napoleon JV, Singh S, Rana S, Bendjennat M, Kumar V, Kizhake S, Palermo NY, Ouellette MM, Huxford T, Natarajan A. Small molecule binding to inhibitor of nuclear factor kappa-B kinase subunit beta in an ATP non-competitive manner. Chem Commun (Camb). 2021 May 11; 57(38):4678-4681.
Score: 0.009
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Mulero MC, Wang VY, Huxford T, Ghosh G. Genome reading by the NF-?B transcription factors. Nucleic Acids Res. 2019 11 04; 47(19):9967-9989.
Score: 0.008
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Mulero MC, Huxford T, Ghosh G. NF-?B, I?B, and IKK: Integral Components of Immune System Signaling. Adv Exp Med Biol. 2019; 1172:207-226.
Score: 0.008
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Huxford T, Malek S, Ghosh G. Structure and mechanism in NF-kappa B/I kappa B signaling. Cold Spring Harb Symp Quant Biol. 1999; 64:533-40.
Score: 0.008
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Mulero MC, Shahabi S, Ko MS, Schiffer JM, Huang DB, Wang VY, Amaro RE, Huxford T, Ghosh G. Protein Cofactors Are Essential for High-Affinity DNA Binding by the Nuclear Factor ?B RelA Subunit. Biochemistry. 2018 05 22; 57(20):2943-2957.
Score: 0.007
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Bergqvist S, Croy CH, Kjaergaard M, Huxford T, Ghosh G, Komives EA. Thermodynamics reveal that helix four in the NLS of NF-kappaB p65 anchors IkappaBalpha, forming a very stable complex. J Mol Biol. 2006 Jul 07; 360(2):421-34.
Score: 0.003
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Croy CH, Bergqvist S, Huxford T, Ghosh G, Komives EA. Biophysical characterization of the free IkappaBalpha ankyrin repeat domain in solution. Protein Sci. 2004 Jul; 13(7):1767-77.
Score: 0.003
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Malek S, Chen Y, Huxford T, Ghosh G. IkappaBbeta, but not IkappaBalpha, functions as a classical cytoplasmic inhibitor of NF-kappaB dimers by masking both NF-kappaB nuclear localization sequences in resting cells. J Biol Chem. 2001 Nov 30; 276(48):45225-35.
Score: 0.002
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Phelps CB, Sengchanthalangsy LL, Huxford T, Ghosh G. Mechanism of I kappa B alpha binding to NF-kappa B dimers. J Biol Chem. 2000 Sep 22; 275(38):29840-6.
Score: 0.002