Aberrant Phosphorylation of SMAD4 Thr277-Mediated USP9x-SMAD4 Interaction by Free Fatty Acids Promotes Breast Cancer Metastasis.

Wu Y, Yu X, Yi X, Wu K, Dwabe S, Atefi M, Elshimali Y, Kemp KT, Bhat K, Haro J, Sarkissyan M, Vadgama JV. Aberrant Phosphorylation of SMAD4 Thr277-Mediated USP9x-SMAD4 Interaction by Free Fatty Acids Promotes Breast Cancer Metastasis. Cancer Res. 2017 03 15; 77(6):1383-1394.

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subject areas

Animals
Apoptosis
Breast Neoplasms
Cell Movement
Cell Proliferation
Fatty Acids, Nonesterified
Female
Humans
Lung Neoplasms
Mice
Mice, Nude
Obesity
Phosphorylation
Signal Transduction
Smad4 Protein
Transforming Growth Factor beta
Tumor Cells, Cultured
Ubiquitin Thiolesterase
Ubiquitination

authors with profiles

Yong Wu, MD, PhD
Jaydutt V Vadgama, PhD

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