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Ranajeet Ghose

TitleAssociate Professor of Biophysical Chemistry
InstitutionCity College, CUNY
AddressCity College, CUNY, Marshak Science Building
Covenant Avenue at 138th Street
New York NY 10031
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Piserchio A, Dalby KN, Ghose R. Revealing eEF-2 kinase: recent structural insights into function. Trends Biochem Sci. 2024 Feb; 49(2):169-182. PMID: 38103971.
      Citations:    Fields:    Translation:Cells
    2. Lopez B, Jiang D, Smith KT, Osborne IS, Szuromi P, Ghose R, Norton M, Hurtley SM, Simonti C, Ray LB, Olingy C, Foley JF. In Science Journals. Science. 2023 Jun 30; 380(6652):1333-1335. PMID: 37384678.
      Citations:    Fields:    
    3. Piserchio A, Isiorho EA, Dalby KN, Ghose R. Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor. J Biol Chem. 2023 06; 299(6):104813. PMID: 37172726.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    4. Piserchio A, Long KJ, Browning LS, Bohanon AL, Isiorho EA, Dalby KN, Ghose R. ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by?calmodulin. Proc Natl Acad Sci U S A. 2023 04 25; 120(17):e2300902120. PMID: 37068230.
      Citations: 1     Fields:    Translation:AnimalsCells
    5. Hajredini F, Alphonse S, Ghose R. BY-kinases: Protein tyrosine kinases like no other. J Biol Chem. 2023 01; 299(1):102737. PMID: 36423682.
      Citations: 1     Fields:    Translation:Cells
    6. Piserchio A, Isiorho EA, Long K, Bohanon AL, Kumar EA, Will N, Jeruzalmi D, Dalby KN, Ghose R. Structural basis for the calmodulin-mediated activation of eukaryotic elongation factor 2 kinase. Sci Adv. 2022 Jul 08; 8(27):eabo2039. PMID: 35857468.
      Citations: 4     Fields:    
    7. Alphonse S, Djemil I, Piserchio A, Ghose R. Structural basis for the recognition of the bacterial tyrosine kinase Wzc by its cognate tyrosine phosphatase Wzb. Proc Natl Acad Sci U S A. 2022 06 28; 119(26):e2201800119. PMID: 35737836.
      Citations: 1     Fields:    Translation:Cells
    8. Hajredini F, Ghose R. A Conserved Structural Role for the Walker-A Lysine in P-Loop Containing Kinases. Front Mol Biosci. 2021; 8:747206. PMID: 34660698.
    9. Alphonse S, Banerjee A, Dantuluri S, Shuman S, Ghose R. NMR solution structures of Runella slithyformis RNA 2'-phosphotransferase Tpt1 provide insights into NAD+ binding and specificity. Nucleic Acids Res. 2021 09 27; 49(17):9607-9624. PMID: 33880546.
      Citations: 2     Fields:    Translation:Cells
    10. Hajredini F, Ghose R. An ATPase with a twist: A unique mechanism underlies the activity of the bacterial tyrosine kinase, Wzc. Sci Adv. 2021 Sep 24; 7(39):eabj5836. PMID: 34550748.
      Citations: 3     Fields:    
    11. Piserchio A, Long K, Lee K, Kumar EA, Abzalimov R, Dalby KN, Ghose R. Structural dynamics of the complex of calmodulin with a minimal functional construct of eukaryotic elongation factor 2 kinase and the role of Thr348 autophosphorylation. Protein Sci. 2021 06; 30(6):1221-1234. PMID: 33890716.
      Citations: 4     Fields:    Translation:HumansCells
    12. Hajredini F, Piserchio A, Ghose R. Long-range dynamic correlations regulate the catalytic activity of the bacterial tyrosine kinase Wzc. Sci Adv. 2020 12; 6(51). PMID: 33355134.
      Citations: 5     Fields:    Translation:Cells
    13. Stenzoski NE, Zou J, Piserchio A, Ghose R, Holehouse AS, Raleigh DP. The Cold-Unfolded State Is Expanded but Contains Long- and Medium-Range Contacts and Is Poorly Described by Homopolymer Models. Biochemistry. 2020 09 15; 59(36):3290-3299. PMID: 32786415.
      Citations: 6     Fields:    Translation:Cells
    14. Ghose R. Keep a lid on it: A troika in kinase allostery. J Biol Chem. 2020 06 19; 295(25):8492-8493. PMID: 32561554.
      Citations:    Fields:    Translation:AnimalsCells
    15. Lee K, Kumar EA, Dalby KN, Ghose R. The role of calcium in the interaction between calmodulin and a minimal functional construct of eukaryotic elongation factor 2 kinase. Protein Sci. 2019 12; 28(12):2089-2098. PMID: 31626716.
      Citations: 5     Fields:    
    16. Kaoud TS, Johnson WH, Ebelt ND, Piserchio A, Zamora-Olivares D, Van Ravenstein SX, Pridgen JR, Edupuganti R, Sammons R, Cano M, Warthaka M, Harger M, Tavares CDJ, Park J, Radwan MF, Ren P, Anslyn EV, Tsai KY, Ghose R, Dalby KN. Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo. Nat Commun. 2019 11 19; 10(1):5232. PMID: 31745079.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    17. Sammons RM, Ghose R, Tsai KY, Dalby KN. Targeting ERK beyond the boundaries of the kinase active site in melanoma. Mol Carcinog. 2019 09; 58(9):1551-1570. PMID: 31190430.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    18. Piserchio A, Will N, Giles DH, Hajredini F, Dalby KN, Ghose R. Solution Structure of the Carboxy-Terminal Tandem Repeat Domain of Eukaryotic Elongation Factor 2 Kinase and Its Role in Substrate Recognition. J Mol Biol. 2019 07 12; 431(15):2700-2717. PMID: 31108082.
      Citations: 4     Fields:    Translation:HumansCells
    19. Sammons RM, Perry NA, Li Y, Cho EJ, Piserchio A, Zamora-Olivares DP, Ghose R, Kaoud TS, Debevec G, Bartholomeusz C, Gurevich VV, Iverson TM, Giulianotti M, Houghten RA, Dalby KN. A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation. ACS Chem Biol. 2019 06 21; 14(6):1183-1194. PMID: 31058487.
      Citations: 10     Fields:    Translation:HumansCells
    20. Ghose R. Nature of the Pre-Chemistry Ensemble in Mitogen-Activated Protein Kinases. J Mol Biol. 2019 01 18; 431(2):145-157. PMID: 30562484.
      Citations: 9     Fields:    Translation:HumansCells
    21. Alphonse S, Ghose R. Methyl NMR spectroscopy: Measurement of dynamics in viral RNA-directed RNA polymerases. Methods. 2018 09 15; 148:100-114. PMID: 29857193.
      Citations: 3     Fields:    Translation:Cells
    22. Will N, Lee K, Hajredini F, Giles DH, Abzalimov RR, Clarkson M, Dalby KN, Ghose R. Structural Dynamics of the Activation of Elongation Factor 2 Kinase by Ca2+-Calmodulin. J Mol Biol. 2018 08 17; 430(17):2802-2821. PMID: 29800565.
      Citations: 10     Fields:    Translation:HumansCells
    23. Alphonse S, Itin B, Khayat R, Ghose R. Sequential Protein Expression and Capsid Assembly in Cell: Toward the Study of Multiprotein Viral Capsids Using Solid-State Nuclear Magnetic Resonance Techniques. Biochemistry. 2018 03 13; 57(10):1568-1571. PMID: 29465229.
      Citations:    Fields:    Translation:Cells
    24. Piserchio A, Warthaka M, Kaoud TS, Callaway K, Dalby KN, Ghose R. Local destabilization, rigid body, and fuzzy docking facilitate the phosphorylation of the transcription factor Ets-1 by the mitogen-activated protein kinase ERK2. Proc Natl Acad Sci U S A. 2017 08 01; 114(31):E6287-E6296. PMID: 28716922.
      Citations: 14     Fields:    Translation:HumansCells
    25. Reed B, Yakovleva L, Shuman S, Ghose R. Characterization of DNA Binding by the Isolated N-Terminal Domain of Vaccinia Virus DNA Topoisomerase IB. Biochemistry. 2017 07 05; 56(26):3307-3317. PMID: 28570045.
      Citations: 2     Fields:    Translation:Cells
    26. Alphonse S, Ghose R. Cystoviral RNA-directed RNA polymerases: Regulation of RNA synthesis on multiple time and length scales. Virus Res. 2017 04 15; 234:135-152. PMID: 28104452.
      Citations: 3     Fields:    Translation:Cells
    27. Tavares CDJ, Giles DH, Stancu G, Chitjian CA, Ferguson SB, Wellmann RM, Kaoud TS, Ghose R, Dalby KN. Signal Integration at Elongation Factor 2 Kinase: THE ROLES OF CALCIUM, CALMODULIN, AND SER-500 PHOSPHORYLATION. J Biol Chem. 2017 02 03; 292(5):2032-2045. PMID: 27956550.
      Citations: 9     Fields:    Translation:HumansCells
    28. Will N, Piserchio A, Snyder I, Ferguson SB, Giles DH, Dalby KN, Ghose R. Structure of the C-Terminal Helical Repeat Domain of Eukaryotic Elongation Factor 2 Kinase. Biochemistry. 2016 09 27; 55(38):5377-86. PMID: 27571275.
      Citations: 4     Fields:    Translation:AnimalsCells
    29. Lee K, Alphonse S, Piserchio A, Tavares CD, Giles DH, Wellmann RM, Dalby KN, Ghose R. Structural Basis for the Recognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin. Structure. 2016 09 06; 24(9):1441-51. PMID: 27499441.
      Citations: 13     Fields:    Translation:HumansCells
    30. Alphonse S, Bhattacharya S, Wang H, Ghose R. Methyl Relaxation Measurements Reveal Patterns of Fast Dynamics in a Viral RNA-Directed RNA Polymerase. Biochemistry. 2015 Sep 29; 54(38):5828-38. PMID: 26333183.
      Citations: 2     Fields:    Translation:Cells
    31. Piserchio A, Ramakrishan V, Wang H, Kaoud TS, Arshava B, Dutta K, Dalby KN, Ghose R. Erratum: Structural and Dynamic Features of F-recruitment Site Driven Substrate Phosphorylation by ERK2. Sci Rep. 2015 Jul 31; 5:12369. PMID: 26230360.
      Citations:    Fields:    
    32. Piserchio A, Ramakrishan V, Wang H, Kaoud TS, Arshava B, Dutta K, Dalby KN, Ghose R. Structural and Dynamic Features of F-recruitment Site Driven Substrate Phosphorylation by ERK2. Sci Rep. 2015 Jun 08; 5:11127. PMID: 26054059.
      Citations: 13     Fields:    Translation:HumansCells
    33. Alphonse S, Arnold JJ, Bhattacharya S, Wang H, Kloss B, Cameron CE, Ghose R. Cystoviral polymerase complex protein P7 uses its acidic C-terminal tail to regulate the RNA-directed RNA polymerase P2. J Mol Biol. 2014 Jul 15; 426(14):2580-93. PMID: 24813120.
      Citations: 5     Fields:    Translation:Cells
    34. Ren Z, C Franklin M, Ghose R. Structure of the RNA-directed RNA polymerase from the cystovirus f12. Proteins. 2013 Aug; 81(8):1479-84. PMID: 23568335.
      Citations: 5     Fields:    Translation:Cells
    35. Temel DB, Dutta K, Alphonse S, Nourikyan J, Grangeasse C, Ghose R. Regulatory interactions between a bacterial tyrosine kinase and its cognate phosphatase. J Biol Chem. 2013 May 24; 288(21):15212-28. PMID: 23543749.
      Citations: 13     Fields:    Translation:Cells
    36. Ghose R. A measured approach: determining the PLC?1 docking site on Itk using a biochemical ruler. J Mol Biol. 2013 Feb 22; 425(4):679-82. PMID: 23266656.
      Citations: 1     Fields:    Translation:AnimalsCells
    37. Temel DB, Dutta K, Ghose R. Sequence-specific backbone ?H, ??C and ?5N assignments of the catalytic domain of the Escherichia coli protein tyrosine kinase, Wzc. Biomol NMR Assign. 2014 Apr; 8(1):37-41. PMID: 23225198.
      Citations: 2     Fields:    Translation:Cells
    38. Piserchio A, Francis DM, Koveal D, Dalby KN, Page R, Peti W, Ghose R. Docking interactions of hematopoietic tyrosine phosphatase with MAP kinases ERK2 and p38a. Biochemistry. 2012 Oct 16; 51(41):8047-9. PMID: 23030599.
      Citations: 14     Fields:    
    39. Piserchio A, Cowburn D, Ghose R. Expression and purification of Src-family kinases for solution NMR studies. Methods Mol Biol. 2012; 831:111-31. PMID: 22167671.
      Citations: 4     Fields:    Translation:Cells
    40. Piserchio A, Dalby KN, Ghose R. Assignment of backbone resonances in a eukaryotic protein kinase - ERK2 as a representative example. Methods Mol Biol. 2012; 831:359-68. PMID: 22167683.
      Citations: 6     Fields:    Translation:Cells
    41. Natarajan A, Dutta K, Temel DB, Nair PA, Shuman S, Ghose R. Solution structure and DNA-binding properties of the phosphoesterase domain of DNA ligase D. Nucleic Acids Res. 2012 Mar; 40(5):2076-88. PMID: 22084199.
      Citations: 6     Fields:    Translation:Cells
    42. Piserchio A, Warthaka M, Devkota AK, Kaoud TS, Lee S, Abramczyk O, Ren P, Dalby KN, Ghose R. Solution NMR insights into docking interactions involving inactive ERK2. Biochemistry. 2011 May 10; 50(18):3660-72. PMID: 21449613.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    43. Lee S, Warthaka M, Yan C, Kaoud TS, Piserchio A, Ghose R, Ren P, Dalby KN. A model of a MAPK?substrate complex in an active conformation: a computational and experimental approach. PLoS One. 2011 Apr 11; 6(4):e18594. PMID: 21494553.
      Citations: 14     Fields:    Translation:AnimalsCells
    44. Ren Z, Ghose R. Slow conformational dynamics in the cystoviral RNA-directed RNA polymerase P2: influence of substrate nucleotides and template RNA. Biochemistry. 2011 Mar 22; 50(11):1875-84. PMID: 21244027.
      Citations: 7     Fields:    Translation:Cells
    45. Dutta K, Natarajan A, Nair PA, Shuman S, Ghose R. Sequence-specific 1H, 13C and 15N assignments of the phosphoesterase (PE) domain of Pseudomonas aeruginosa DNA ligase D (LigD). Biomol NMR Assign. 2011 Oct; 5(2):151-5. PMID: 21213076.
      Citations: 2     Fields:    Translation:Cells
    46. Ferrage F, Reichel A, Battacharya S, Cowburn D, Ghose R. On the measurement of ?5N-{?H} nuclear Overhauser effects. 2. Effects of the saturation scheme and water signal suppression. J Magn Reson. 2010 Dec; 207(2):294-303. PMID: 20951618.
      Citations: 26     Fields:    
    47. Nicholas MP, Eryilmaz E, Ferrage F, Cowburn D, Ghose R. Nuclear spin relaxation in isotropic and anisotropic media. Prog Nucl Magn Reson Spectrosc. 2010 Aug; 57(2):111-58. PMID: 20633361.
      Citations: 16     Fields:    
    48. Ren Z, Wang H, Ghose R. Dynamics on multiple timescales in the RNA-directed RNA polymerase from the cystovirus phi6. Nucleic Acids Res. 2010 Aug; 38(15):5105-18. PMID: 20385578.
      Citations: 10     Fields:    Translation:Cells
    49. Piserchio A, Nair PA, Shuman S, Ghose R. Solution NMR studies of Chlorella virus DNA ligase-adenylate. J Mol Biol. 2010 Jan 15; 395(2):291-308. PMID: 19913033.
      Citations: 8     Fields:    Translation:AnimalsCells
    50. Ferrage F, Cowburn D, Ghose R. Accurate sampling of high-frequency motions in proteins by steady-state (15)N-{(1)H} nuclear Overhauser effect measurements in the presence of cross-correlated relaxation. J Am Chem Soc. 2009 May 06; 131(17):6048-9. PMID: 19358609.
      Citations: 38     Fields:    
    51. Piserchio A, Ghose R, Cowburn D. Optimized bacterial expression and purification of the c-Src catalytic domain for solution NMR studies. J Biomol NMR. 2009 Jun; 44(2):87-93. PMID: 19399371.
      Citations: 3     Fields:    Translation:AnimalsCells
    52. Piserchio A, Nair PA, Shuman S, Ghose R. Sequence-specific 1H N, 13C, and 15N backbone resonance assignments of the 34 kDa Paramecium bursaria Chlorella virus 1 (PBCV1) DNA ligase. Biomol NMR Assign. 2009 Jun; 3(1):77-80. PMID: 19636951.
      Citations: 1     Fields:    Translation:AnimalsCells
    53. Eryilmaz E, Benach J, Su M, Seetharaman J, Dutta K, Wei H, Gottlieb P, Hunt JF, Ghose R. Structure and dynamics of the P7 protein from the bacteriophage phi 12. J Mol Biol. 2008 Oct 03; 382(2):402-22. PMID: 18647606.
      Citations: 16     Fields:    Translation:Cells
    54. Ferrage F, Piserchio A, Cowburn D, Ghose R. On the measurement of 15N-{1H} nuclear Overhauser effects. J Magn Reson. 2008 Jun; 192(2):302-13. PMID: 18417394.
      Citations: 20     Fields:    Translation:Humans
    55. Del Rio A, Dutta K, Chavez J, Ubarretxena-Belandia I, Ghose R. Solution structure and dynamics of the N-terminal cytosolic domain of rhomboid intramembrane protease from Pseudomonas aeruginosa: insights into a functional role in intramembrane proteolysis. J Mol Biol. 2007 Jan 05; 365(1):109-22. PMID: 17059825.
      Citations: 5     Fields:    Translation:Cells
    56. Natarajan A, Ghose R, Hill JM. Structure and dynamics of ASC2, a pyrin domain-only protein that regulates inflammatory signaling. J Biol Chem. 2006 Oct 20; 281(42):31863-75. PMID: 16905547.
      Citations: 30     Fields:    Translation:HumansCells
    57. Ji H, Shekhtman A, Ghose R, McDonnell JM, Cowburn D. NMR determination that an extended BH3 motif of pro-apoptotic BID is specifically bound to BCL-XL. Magn Reson Chem. 2006 Jul; 44 Spec No:S101-7. PMID: 16826547.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    58. Pujato M, Navarro A, Versace R, Mancusso R, Ghose R, Tasayco ML. The pH-dependence of amide chemical shift of Asp/Glu reflects its pKa in intrinsically disordered proteins with only local interactions. Biochim Biophys Acta. 2006 Jul; 1764(7):1227-33. PMID: 16787768.
      Citations: 7     Fields:    Translation:Cells
    59. Del Rio A, Anand A, Ghose R. Detection of correlated dynamics on multiple timescales by measurement of the differential relaxation of zero- and double-quantum coherences involving sidechain methyl groups in proteins. J Magn Reson. 2006 May; 180(1):1-17. PMID: 16473030.
      Citations: 1     Fields:    Translation:Cells
    60. Pradhan P, Ghose R, Green ME. Voltage gating and anions, especially phosphate: a model system. Biochim Biophys Acta. 2005 Nov 30; 1717(2):97-103. PMID: 16289371.
      Citations: 3     Fields:    Translation:AnimalsCells
    61. Dutta K, Shi H, Cruz-Chu ER, Kami K, Ghose R. Dynamic influences on a high-affinity, high-specificity interaction involving the C-terminal SH3 domain of p67phox. Biochemistry. 2004 Jun 29; 43(25):8094-106. PMID: 15209505.
      Citations: 9     Fields:    Translation:Cells
    62. Majumdar A, Ghose R. Probing slow backbone dynamics in proteins using TROSY-based experiments to detect cross-correlated time-modulation of isotropic chemical shifts. J Biomol NMR. 2004 Mar; 28(3):213-27. PMID: 14752255.
      Citations: 12     Fields:    Translation:HumansCells
    63. Shekhtman A, Ghose R, Goger M, Cowburn D. NMR structure determination and investigation using a reduced proton (REDPRO) labeling strategy for proteins. FEBS Lett. 2002 Jul 31; 524(1-3):177-82. PMID: 12135763.
      Citations: 27     Fields:    Translation:Cells
    64. Morgan WD, Birks JL, Sivyer A, Ghose RR. An efficient technique for the simultaneous estimation of GFR and ERPF, involving a single injection and two blood samples. Int J Nucl Med Biol. 1977 Jan; 4(1):79-83. PMID: 405342.
      Citations: 11     Fields:    Translation:Humans
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