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Ranajeet Ghose

TitleAssociate Professor of Biophysical Chemistry
InstitutionCity College, CUNY
AddressCity College, CUNY, Marshak Science Building
Covenant Avenue at 138th Street
New York NY 10031
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hajredini F, Piserchio A, Ghose R. Long-range dynamic correlations regulate the catalytic activity of the bacterial tyrosine kinase Wzc. Sci Adv. 2020 Dec; 6(51). PMID: 33355134.
      Citations:    Fields:    
    2. Stenzoski NE, Zou J, Piserchio A, Ghose R, Holehouse AS, Raleigh DP. The Cold-Unfolded State Is Expanded but Contains Long- and Medium-Range Contacts and Is Poorly Described by Homopolymer Models. Biochemistry. 2020 Sep 15; 59(36):3290-3299. PMID: 32786415.
      Citations:    Fields:    
    3. Ghose R. Keep a lid on it: A troika in kinase allostery. J Biol Chem. 2020 06 19; 295(25):8492-8493. PMID: 32561554.
      Citations:    Fields:    Translation:AnimalsCells
    4. Lee K, Kumar EA, Dalby KN, Ghose R. The role of calcium in the interaction between calmodulin and a minimal functional construct of eukaryotic elongation factor 2 kinase. Protein Sci. 2019 12; 28(12):2089-2098. PMID: 31626716.
      Citations: 1     Fields:    
    5. Kaoud TS, Johnson WH, Ebelt ND, Piserchio A, Zamora-Olivares D, Van Ravenstein SX, Pridgen JR, Edupuganti R, Sammons R, Cano M, Warthaka M, Harger M, Tavares CDJ, Park J, Radwan MF, Ren P, Anslyn EV, Tsai KY, Ghose R, Dalby KN. Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo. Nat Commun. 2019 11 19; 10(1):5232. PMID: 31745079.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    6. Sammons RM, Ghose R, Tsai KY, Dalby KN. Targeting ERK beyond the boundaries of the kinase active site in melanoma. Mol Carcinog. 2019 09; 58(9):1551-1570. PMID: 31190430.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    7. Piserchio A, Will N, Giles DH, Hajredini F, Dalby KN, Ghose R. Solution Structure of the Carboxy-Terminal Tandem Repeat Domain of Eukaryotic Elongation Factor 2 Kinase and Its Role in Substrate Recognition. J Mol Biol. 2019 07 12; 431(15):2700-2717. PMID: 31108082.
      Citations: 1     Fields:    Translation:HumansCells
    8. Sammons RM, Perry NA, Li Y, Cho EJ, Piserchio A, Zamora-Olivares DP, Ghose R, Kaoud TS, Debevec G, Bartholomeusz C, Gurevich VV, Iverson TM, Giulianotti M, Houghten RA, Dalby KN. A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation. ACS Chem Biol. 2019 06 21; 14(6):1183-1194. PMID: 31058487.
      Citations: 2     Fields:    Translation:HumansCells
    9. Ghose R. Nature of the Pre-Chemistry Ensemble in Mitogen-Activated Protein Kinases. J Mol Biol. 2019 01 18; 431(2):145-157. PMID: 30562484.
      Citations: 1     Fields:    Translation:HumansCells
    10. Alphonse S, Ghose R. Methyl NMR spectroscopy: Measurement of dynamics in viral RNA-directed RNA polymerases. Methods. 2018 09 15; 148:100-114. PMID: 29857193.
      Citations: 1     Fields:    Translation:Cells
    11. Will N, Lee K, Hajredini F, Giles DH, Abzalimov RR, Clarkson M, Dalby KN, Ghose R. Structural Dynamics of the Activation of Elongation Factor 2 Kinase by Ca2+-Calmodulin. J Mol Biol. 2018 08 17; 430(17):2802-2821. PMID: 29800565.
      Citations: 3     Fields:    Translation:HumansCells
    12. Alphonse S, Itin B, Khayat R, Ghose R. Sequential Protein Expression and Capsid Assembly in Cell: Toward the Study of Multiprotein Viral Capsids Using Solid-State Nuclear Magnetic Resonance Techniques. Biochemistry. 2018 03 13; 57(10):1568-1571. PMID: 29465229.
      Citations:    Fields:    Translation:Cells
    13. Piserchio A, Warthaka M, Kaoud TS, Callaway K, Dalby KN, Ghose R. Local destabilization, rigid body, and fuzzy docking facilitate the phosphorylation of the transcription factor Ets-1 by the mitogen-activated protein kinase ERK2. Proc Natl Acad Sci U S A. 2017 08 01; 114(31):E6287-E6296. PMID: 28716922.
      Citations: 7     Fields:    Translation:HumansCells
    14. Reed B, Yakovleva L, Shuman S, Ghose R. Characterization of DNA Binding by the Isolated N-Terminal Domain of Vaccinia Virus DNA Topoisomerase IB. Biochemistry. 2017 07 05; 56(26):3307-3317. PMID: 28570045.
      Citations: 1     Fields:    Translation:Cells
    15. Alphonse S, Ghose R. Cystoviral RNA-directed RNA polymerases: Regulation of RNA synthesis on multiple time and length scales. Virus Res. 2017 04 15; 234:135-152. PMID: 28104452.
      Citations: 3     Fields:    Translation:Cells
    16. Tavares CD, Giles DH, Stancu G, Chitjian CA, Ferguson SB, Wellmann RM, Kaoud TS, Ghose R, Dalby KN. Signal Integration at Elongation Factor 2 Kinase: THE ROLES OF CALCIUM, CALMODULIN, AND SER-500 PHOSPHORYLATION. J Biol Chem. 2017 02 03; 292(5):2032-2045. PMID: 27956550.
      Citations: 3     Fields:    Translation:HumansCells
    17. Will N, Piserchio A, Snyder I, Ferguson SB, Giles DH, Dalby KN, Ghose R. Structure of the C-Terminal Helical Repeat Domain of Eukaryotic Elongation Factor 2 Kinase. Biochemistry. 2016 09 27; 55(38):5377-86. PMID: 27571275.
      Citations: 2     Fields:    Translation:AnimalsCells
    18. Lee K, Alphonse S, Piserchio A, Tavares CD, Giles DH, Wellmann RM, Dalby KN, Ghose R. Structural Basis for the Recognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin. Structure. 2016 09 06; 24(9):1441-51. PMID: 27499441.
      Citations: 7     Fields:    Translation:HumansCells
    19. Alphonse S, Bhattacharya S, Wang H, Ghose R. Methyl Relaxation Measurements Reveal Patterns of Fast Dynamics in a Viral RNA-Directed RNA Polymerase. Biochemistry. 2015 Sep 29; 54(38):5828-38. PMID: 26333183.
      Citations: 2     Fields:    Translation:Cells
    20. Piserchio A, Ramakrishan V, Wang H, Kaoud TS, Arshava B, Dutta K, Dalby KN, Ghose R. Erratum: Structural and Dynamic Features of F-recruitment Site Driven Substrate Phosphorylation by ERK2. Sci Rep. 2015 Jul 31; 5:12369. PMID: 26230360.
      Citations:    Fields:    
    21. Piserchio A, Ramakrishan V, Wang H, Kaoud TS, Arshava B, Dutta K, Dalby KN, Ghose R. Structural and Dynamic Features of F-recruitment Site Driven Substrate Phosphorylation by ERK2. Sci Rep. 2015 Jun 08; 5:11127. PMID: 26054059.
      Citations: 7     Fields:    Translation:HumansCells
    22. Alphonse S, Arnold JJ, Bhattacharya S, Wang H, Kloss B, Cameron CE, Ghose R. Cystoviral polymerase complex protein P7 uses its acidic C-terminal tail to regulate the RNA-directed RNA polymerase P2. J Mol Biol. 2014 Jul 15; 426(14):2580-93. PMID: 24813120.
      Citations: 4     Fields:    Translation:Cells
    23. Ren Z, C Franklin M, Ghose R. Structure of the RNA-directed RNA polymerase from the cystovirus f12. Proteins. 2013 Aug; 81(8):1479-84. PMID: 23568335.
      Citations: 4     Fields:    Translation:Cells
    24. Temel DB, Dutta K, Alphonse S, Nourikyan J, Grangeasse C, Ghose R. Regulatory interactions between a bacterial tyrosine kinase and its cognate phosphatase. J Biol Chem. 2013 May 24; 288(21):15212-28. PMID: 23543749.
      Citations: 9     Fields:    Translation:Cells
    25. Ghose R. A measured approach: determining the PLC?1 docking site on Itk using a biochemical ruler. J Mol Biol. 2013 Feb 22; 425(4):679-82. PMID: 23266656.
      Citations: 1     Fields:    Translation:AnimalsCells
    26. Temel DB, Dutta K, Ghose R. Sequence-specific backbone ¹H, ¹³C and ¹5N assignments of the catalytic domain of the Escherichia coli protein tyrosine kinase, Wzc. Biomol NMR Assign. 2014 Apr; 8(1):37-41. PMID: 23225198.
      Citations: 1     Fields:    Translation:Cells
    27. Piserchio A, Francis DM, Koveal D, Dalby KN, Page R, Peti W, Ghose R. Docking interactions of hematopoietic tyrosine phosphatase with MAP kinases ERK2 and p38a. Biochemistry. 2012 Oct 16; 51(41):8047-9. PMID: 23030599.
      Citations: 11     Fields:    
    28. Piserchio A, Cowburn D, Ghose R. Expression and purification of Src-family kinases for solution NMR studies. Methods Mol Biol. 2012; 831:111-31. PMID: 22167671.
      Citations: 3     Fields:    Translation:Cells
    29. Piserchio A, Dalby KN, Ghose R. Assignment of backbone resonances in a eukaryotic protein kinase - ERK2 as a representative example. Methods Mol Biol. 2012; 831:359-68. PMID: 22167683.
      Citations: 6     Fields:    Translation:Cells
    30. Natarajan A, Dutta K, Temel DB, Nair PA, Shuman S, Ghose R. Solution structure and DNA-binding properties of the phosphoesterase domain of DNA ligase D. Nucleic Acids Res. 2012 Mar; 40(5):2076-88. PMID: 22084199.
      Citations: 4     Fields:    Translation:Cells
    31. Piserchio A, Warthaka M, Devkota AK, Kaoud TS, Lee S, Abramczyk O, Ren P, Dalby KN, Ghose R. Solution NMR insights into docking interactions involving inactive ERK2. Biochemistry. 2011 May 10; 50(18):3660-72. PMID: 21449613.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    32. Lee S, Warthaka M, Yan C, Kaoud TS, Piserchio A, Ghose R, Ren P, Dalby KN. A model of a MAPK•substrate complex in an active conformation: a computational and experimental approach. PLoS One. 2011 Apr 11; 6(4):e18594. PMID: 21494553.
      Citations: 13     Fields:    Translation:AnimalsCells
    33. Ren Z, Ghose R. Slow conformational dynamics in the cystoviral RNA-directed RNA polymerase P2: influence of substrate nucleotides and template RNA. Biochemistry. 2011 Mar 22; 50(11):1875-84. PMID: 21244027.
      Citations: 6     Fields:    Translation:Cells
    34. Dutta K, Natarajan A, Nair PA, Shuman S, Ghose R. Sequence-specific 1H, 13C and 15N assignments of the phosphoesterase (PE) domain of Pseudomonas aeruginosa DNA ligase D (LigD). Biomol NMR Assign. 2011 Oct; 5(2):151-5. PMID: 21213076.
      Citations: 2     Fields:    Translation:Cells
    35. Ferrage F, Reichel A, Battacharya S, Cowburn D, Ghose R. On the measurement of ¹5N-{¹H} nuclear Overhauser effects. 2. Effects of the saturation scheme and water signal suppression. J Magn Reson. 2010 Dec; 207(2):294-303. PMID: 20951618.
      Citations: 22     Fields:    
    36. Nicholas MP, Eryilmaz E, Ferrage F, Cowburn D, Ghose R. Nuclear spin relaxation in isotropic and anisotropic media. Prog Nucl Magn Reson Spectrosc. 2010 Aug; 57(2):111-58. PMID: 20633361.
      Citations: 7     Fields:    
    37. Ren Z, Wang H, Ghose R. Dynamics on multiple timescales in the RNA-directed RNA polymerase from the cystovirus phi6. Nucleic Acids Res. 2010 Aug; 38(15):5105-18. PMID: 20385578.
      Citations: 9     Fields:    Translation:Cells
    38. Piserchio A, Nair PA, Shuman S, Ghose R. Solution NMR studies of Chlorella virus DNA ligase-adenylate. J Mol Biol. 2010 Jan 15; 395(2):291-308. PMID: 19913033.
      Citations: 7     Fields:    Translation:AnimalsCells
    39. Ferrage F, Cowburn D, Ghose R. Accurate sampling of high-frequency motions in proteins by steady-state (15)N-{(1)H} nuclear Overhauser effect measurements in the presence of cross-correlated relaxation. J Am Chem Soc. 2009 May 06; 131(17):6048-9. PMID: 19358609.
      Citations: 31     Fields:    
    40. Piserchio A, Ghose R, Cowburn D. Optimized bacterial expression and purification of the c-Src catalytic domain for solution NMR studies. J Biomol NMR. 2009 Jun; 44(2):87-93. PMID: 19399371.
      Citations: 2     Fields:    Translation:AnimalsCells
    41. Piserchio A, Nair PA, Shuman S, Ghose R. Sequence-specific 1H N, 13C, and 15N backbone resonance assignments of the 34 kDa Paramecium bursaria Chlorella virus 1 (PBCV1) DNA ligase. Biomol NMR Assign. 2009 Jun; 3(1):77-80. PMID: 19636951.
      Citations: 1     Fields:    Translation:AnimalsCells
    42. Eryilmaz E, Benach J, Su M, Seetharaman J, Dutta K, Wei H, Gottlieb P, Hunt JF, Ghose R. Structure and dynamics of the P7 protein from the bacteriophage phi 12. J Mol Biol. 2008 Oct 03; 382(2):402-22. PMID: 18647606.
      Citations: 14     Fields:    Translation:Cells
    43. Ferrage F, Piserchio A, Cowburn D, Ghose R. On the measurement of 15N-{1H} nuclear Overhauser effects. J Magn Reson. 2008 Jun; 192(2):302-13. PMID: 18417394.
      Citations: 16     Fields:    Translation:Humans
    44. Del Rio A, Dutta K, Chavez J, Ubarretxena-Belandia I, Ghose R. Solution structure and dynamics of the N-terminal cytosolic domain of rhomboid intramembrane protease from Pseudomonas aeruginosa: insights into a functional role in intramembrane proteolysis. J Mol Biol. 2007 Jan 05; 365(1):109-22. PMID: 17059825.
      Citations: 5     Fields:    Translation:Cells
    45. Natarajan A, Ghose R, Hill JM. Structure and dynamics of ASC2, a pyrin domain-only protein that regulates inflammatory signaling. J Biol Chem. 2006 Oct 20; 281(42):31863-75. PMID: 16905547.
      Citations: 26     Fields:    Translation:HumansCells
    46. Ji H, Shekhtman A, Ghose R, McDonnell JM, Cowburn D. NMR determination that an extended BH3 motif of pro-apoptotic BID is specifically bound to BCL-XL. Magn Reson Chem. 2006 Jul; 44 Spec No:S101-7. PMID: 16826547.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    47. Pujato M, Navarro A, Versace R, Mancusso R, Ghose R, Tasayco ML. The pH-dependence of amide chemical shift of Asp/Glu reflects its pKa in intrinsically disordered proteins with only local interactions. Biochim Biophys Acta. 2006 Jul; 1764(7):1227-33. PMID: 16787768.
      Citations: 7     Fields:    Translation:Cells
    48. Del Rio A, Anand A, Ghose R. Detection of correlated dynamics on multiple timescales by measurement of the differential relaxation of zero- and double-quantum coherences involving sidechain methyl groups in proteins. J Magn Reson. 2006 May; 180(1):1-17. PMID: 16473030.
      Citations: 1     Fields:    Translation:Cells
    49. Pradhan P, Ghose R, Green ME. Voltage gating and anions, especially phosphate: a model system. Biochim Biophys Acta. 2005 Nov 30; 1717(2):97-103. PMID: 16289371.
      Citations: 3     Fields:    Translation:AnimalsCells
    50. Dutta K, Shi H, Cruz-Chu ER, Kami K, Ghose R. Dynamic influences on a high-affinity, high-specificity interaction involving the C-terminal SH3 domain of p67phox. Biochemistry. 2004 Jun 29; 43(25):8094-106. PMID: 15209505.
      Citations: 8     Fields:    Translation:Cells
    51. Majumdar A, Ghose R. Probing slow backbone dynamics in proteins using TROSY-based experiments to detect cross-correlated time-modulation of isotropic chemical shifts. J Biomol NMR. 2004 Mar; 28(3):213-27. PMID: 14752255.
      Citations: 11     Fields:    Translation:HumansCells
    52. Shekhtman A, Ghose R, Goger M, Cowburn D. NMR structure determination and investigation using a reduced proton (REDPRO) labeling strategy for proteins. FEBS Lett. 2002 Jul 31; 524(1-3):177-82. PMID: 12135763.
      Citations: 19     Fields:    Translation:Cells
    53. Morgan WD, Birks JL, Sivyer A, Ghose RR. An efficient technique for the simultaneous estimation of GFR and ERPF, involving a single injection and two blood samples. Int J Nucl Med Biol. 1977 Jan; 4(1):79-83. PMID: 405342.
      Citations: 12     Fields:    Translation:Humans
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