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Marianela Perez-Torres

Faculty RankAssistant Professor
InstitutionUniversity of Puerto Rico
DepartmentSchool of Pharmacy
AddressUPR-Medical Sciences Campus, School of Pharmacy
San Juan PR 936
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    Collapse Overview 
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    Dr. Marianela Pérez-Torres is Assistant Professor at the School of Pharmacy of the University of Puerto
    Rico Medical Sciences Campus.
    Dr. Pérez-Torres received her PhD in Biochemistry from the University of Puerto Rico, Medical Sciences
    Campus. Afterwards, she became a post-doctoral fellow at the Department of Cancer Biology, Vanderbilt
    University, in Nashville, TN.
    The focus of Dr. Pérez-Torres’ research is to understand the biological principles underlying tumor development and the study of in vitro cancer cell systems to determine the signaling pathways involved in cellular responses to novel cancer therapeutic treatments. Emphasis is given to study the role of neuregulins in
    the regulation of the epidermal growth factor receptor gene.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Claudio-Campos K, Hernández-Rivera J, Rivera-Gutierrez J, Ortiz-Rivera I, Carvajal-Vélez A, Pérez-Torres M, Pagán-Ortiz M, Ospina-Millán CA. Biological screening of select Puerto Rican plants for cytotoxic and antitumor activities. P R Health Sci J. 2015 Mar; 34(1):25-30. PMID: 25856874.
      Citations: 1     Fields:    Translation:HumansAnimals
    2. Wilken JA, Perez-Torres M, Nieves-Alicea R, Cora EM, Christensen TA, Baron AT, Maihle NJ. Shedding of soluble epidermal growth factor receptor (sEGFR) is mediated by a metalloprotease/fibronectin/integrin axis and inhibited by cetuximab. Biochemistry. 2013 Jul 02; 52(26):4531-40. PMID: 23731208.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    3. Miller TW, Pérez-Torres M, Narasanna A, Guix M, Stål O, Pérez-Tenorio G, Gonzalez-Angulo AM, Hennessy BT, Mills GB, Kennedy JP, Lindsley CW, Arteaga CL. Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer. Cancer Res. 2009 May 15; 69(10):4192-201. PMID: 19435893.
      Citations: 68     Fields:    Translation:HumansCells
    4. Perez-Torres M, Valle BL, Maihle NJ, Negron-Vega L, Nieves-Alicea R, Cora EM. Shedding of epidermal growth factor receptor is a regulated process that occurs with overexpression in malignant cells. Exp Cell Res. 2008 Oct 01; 314(16):2907-18. PMID: 18687326.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    5. Ritter CA, Perez-Torres M, Rinehart C, Guix M, Dugger T, Engelman JA, Arteaga CL. Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor network. Clin Cancer Res. 2007 Aug 15; 13(16):4909-19. PMID: 17699871.
      Citations: 203     Fields:    Translation:AnimalsCells
    6. Perez-Torres M, Guix M, Gonzalez A, Arteaga CL. Epidermal growth factor receptor (EGFR) antibody down-regulates mutant receptors and inhibits tumors expressing EGFR mutations. J Biol Chem. 2006 Dec 29; 281(52):40183-92. PMID: 17082181.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    7. Wang SE, Narasanna A, Perez-Torres M, Xiang B, Wu FY, Yang S, Carpenter G, Gazdar AF, Muthuswamy SK, Arteaga CL. HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer Cell. 2006 Jul; 10(1):25-38. PMID: 16843263.
      Citations: 172     Fields:    Translation:HumansAnimalsCells
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