Marcus Tius | Profiles RNS

Marcus Tius, PhD

Title
Faculty Rank	Professor
Institution	University of Hawaii
Department	Chemistry, University of Hawaii Cancer Center
Address	University of Hawaii Cancer Center 701 Ilalo St Honolulu HI 96813
vCard	Download vCard

Research

research activities and funding

R01CA045288 (TIUS, MARCUS ANTONIUS)Jul 1, 1987 - Dec 31, 1990 NIH LABELLED MARINE ANTITUMOR PROMOTERS Role: Principal Investigator

R01GM038598 (TIUS, MARCUS ANTONIUS)Jul 1, 1987 - Dec 31, 1990 NIH C-GLYCOSYL ANTHRAQUINONES Role: Principal Investigator

R01DA006731 (TIUS, MARCUS ANTONIUS)Sep 30, 1990 - Aug 31, 1994 NIH FUNCTIONALIZED CANNABINOIDS Role: Principal Investigator

R01GM057873 (TIUS, MARCUS ANTONIUS)Aug 1, 1998 - Jan 31, 2013 NIH Cyclopentannelation in Total Synthesis Role: Principal Investigator

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Chen Y, Zhai N, Zhu Y, Yue P, Verma N, Brotherton-Pleiss C, Fu W, Nakamura K, Chen W, Kawakami J, Murali R, Tius MA, Lopez-Tapia F, Turkson J. Azetidine ring, salicylic acid, and salicylic acid bioisosteres as determinants of the binding characteristics of novel potent compounds to Stat3. Bioorg Med Chem Lett. 2024 01 01; 97:129565. PMID: 38008341.

Citations: Fields:
Bio Biochemistry Che Chemistry
Dickinson CF, Yap GPA, Tius MA. Anion-accelerated asymmetric Nazarov cyclization: access to vicinal all-carbon quaternary stereocenters. Org Biomol Chem. 2023 Jun 21; 21(24):5014-5020. PMID: 37265330.

Citations: Fields:
Bio Biochemistry Che Chemistry
Zhu Y, Yue P, Dickinson CF, Yang JK, Datanagan K, Zhai N, Zhang Y, Miklossy G, Lopez-Tapia F, Tius MA, Turkson J. Natural product preferentially targets redox and metabolic adaptations and aberrantly active STAT3 to inhibit breast tumor growth in vivo. Cell Death Dis. 2022 12 06; 13(12):1022. PMID: 36473850.

Citations: 3 Fields:
Cel Cell Biology Int Internal Medicine
Translation:Humans Animals
Dickinson CF, Yang JK, Tius MA. Fluorine on fluorenes. Org Biomol Chem. 2022 Nov 16; 20(44):8615-8617. PMID: 36314529.

Citations: Fields:
Bio Biochemistry Che Chemistry
Dickinson CF, Yang JK, Yap GPA, Tius MA. Modular Synthesis of a Semibuckminsterfullerene. Org Lett. 2022 07 22; 24(28):5095-5098. PMID: 35819411.

Citations: 1 Fields:
Bio Biochemistry
Ho TC, Mullins JJ, Tius MA, Nikas SP, Tran NK, Tong F, Zvonok N, Makriyannis A. Corrigendum to "Oxa-adamantyl cannabinoids" [Bioorg. Med. Chem. Lett. 38 (2021) 127882]. Bioorg Med Chem Lett. 2022 Sep 15; 72:128836. PMID: 35803774.

Citations: Fields:
Bio Biochemistry Che Chemistry
Yue P, Zhu Y, Brotherton-Pleiss C, Fu W, Verma N, Chen J, Nakamura K, Chen W, Chen Y, Alonso-Valenteen F, Mikhael S, Medina-Kauwe L, Kershaw KM, Celeridad M, Pan S, Limpert AS, Sheffler DJ, Cosford NDP, Shiao SL, Tius MA, Lopez-Tapia F, Turkson J. Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo. Cancer Lett. 2022 05 28; 534:215613. PMID: 35276290.

Citations: Fields:
Neo Neoplasms
Translation:Humans Animals Cells
Dickinson CF, Yap GPA, Tius MA. Synthesis of Fluorenes and Dibenzo[g,p]chrysenes through an Oxidative Cascade. J Org Chem. 2022 01 21; 87(2):1559-1563. PMID: 35014253.

Citations: Fields:
Che Chemistry
Translation:Cells
Fu Y, Katsaros D, Biglia N, Wang Z, Pagano I, Tius M, Tiirikainen M, Rosser C, Yang H, Yu H. Vitamin D receptor upregulates lncRNA TOPORS-AS1 which inhibits the Wnt/?-catenin pathway and associates with favorable prognosis of ovarian cancer. Sci Rep. 2021 04 05; 11(1):7484. PMID: 33820921.

Citations: 11 Fields:
Sci Science
Translation:Humans Cells
Ho TC, Tius MA, Nikas SP, Tran NK, Tong F, Zhou H, Zvonok N, Makriyannis A. Oxa-adamantyl cannabinoids. Bioorg Med Chem Lett. 2021 04 15; 38:127882. PMID: 33636308.

Citations: 1 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Cells
Brotherton-Pleiss C, Yue P, Zhu Y, Nakamura K, Chen W, Fu W, Kubota C, Chen J, Alonso-Valenteen F, Mikhael S, Medina-Kauwe L, Tius MA, Lopez-Tapia F, Turkson J. Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors. J Med Chem. 2021 01 14; 64(1):695-710. PMID: 33352047.

Citations: 4 Fields:
Che Chemistry
Translation:Humans Cells
Liu C, Yap GPA, Rowland CA, Tius MA. (Z)-Trifluoromethyl-Trisubstituted Alkenes or Isoxazolines: Divergent Pathways from the Same Allene. Org Lett. 2020 09 18; 22(18):7208-7212. PMID: 32876462.

Citations: Fields:
Bio Biochemistry
Lopez-Tapia F, Brotherton-Pleiss C, Yue P, Murakami H, Costa Araujo AC, Reis Dos Santos B, Ichinotsubo E, Rabkin A, Shah R, Lantz M, Chen S, Tius MA, Turkson J. Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors. ACS Med Chem Lett. 2018 Mar 08; 9(3):250-255. PMID: 29541369.

Citations:
Ho TC, Shimada N, Tius MA, Nikas SP, Zhang W, Makriyannis A. C1'-Azacycloalkyl Hexahydrocannabinols. J Org Chem. 2017 08 04; 82(15):7839-7849. PMID: 28677397.

Citations: 2 Fields:
Che Chemistry
Translation:Humans Animals Cells
Zhou Z, Dixon DD, Jolit A, Tius MA. The Evolution of the Total Synthesis of Rocaglamide. Chemistry. 2016 Oct 24; 22(44):15929-15936. PMID: 27717051.

Citations: 5 Fields:
Che Chemistry
Translation:Cells
Asari AH, Lam YH, Tius MA, Houk KN. Origins of the Stereoselectivity in a Thiourea-Primary Amine-Catalyzed Nazarov Cyclization. J Am Chem Soc. 2015 Oct 14; 137(40):13191-9. PMID: 26426475.

Citations: 5 Fields:
Che Chemistry
Translation:Cells
Zhou Z, Walleser PM, Tius MA. Isotetronic acids from an oxidative cyclization. Chem Commun (Camb). 2015 Jul 11; 51(54):10858-60. PMID: 26050998.

Citations: 1 Fields:
Che Chemistry
Translation:Cells
Yue P, Lopez-Tapia F, Paladino D, Li Y, Chen CH, Namanja AT, Hilliard T, Chen Y, Tius MA, Turkson J. Hydroxamic Acid and Benzoic Acid-Based STAT3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes In Vitro and In Vivo. Cancer Res. 2016 Feb 01; 76(3):652-63. PMID: 26088127.

Citations: 35 Fields:
Neo Neoplasms
Translation:Humans Animals Cells
Miller CM, Benneche T, Tius MA. First total synthesis of the marine natural products clavulolactones II and III. Org Biomol Chem. 2015 Apr 07; 13(13):4051-8. PMID: 25733336.

Citations: Fields:
Bio Biochemistry Che Chemistry
Kitamura K, Shimada N, Stewart C, Atesin AC, Atesin TA, Tius MA. Enantioselective palladium(0)-catalyzed Nazarov-type cyclization. Angew Chem Int Ed Engl. 2015 May 18; 54(21):6288-91. PMID: 25833716.

Citations: 5 Fields:
Che Chemistry
Translation:Cells
Zhou Z, Tius MA. Synthesis of each enantiomer of rocaglamide by means of a palladium(0)-catalyzed Nazarov-type cyclization. Angew Chem Int Ed Engl. 2015 May 11; 54(20):6037-40. PMID: 25824525.

Citations: 7 Fields:
Che Chemistry
Translation:Cells
Ogawa G, Tius MA, Zhou H, Nikas SP, Halikhedkar A, Mallipeddi S, Makriyannis A. 3'-functionalized adamantyl cannabinoid receptor probes. J Med Chem. 2015 Apr 09; 58(7):3104-16. PMID: 25760146.

Citations: 10 Fields:
Che Chemistry
Translation:Humans Animals Cells
Pratt LM, Dixon DD, Tius MA. Mixed aggregates of 1-methoxyallenyllithium with lithium chloride. ChemistryOpen. 2014 Dec; 3(6):250-5. PMID: 25558443.

Citations: Fields:
Che Chemistry
Jolit A, Walleser PM, Yap GP, Tius MA. Catalytic enantioselective Nazarov cyclization: construction of vicinal all-carbon-atom quaternary stereocenters. Angew Chem Int Ed Engl. 2014 Jun 10; 53(24):6180-3. PMID: 24838340.

Citations: 16 Fields:
Che Chemistry
Translation:Cells
Tius MA. Allene ether Nazarov cyclization. Chem Soc Rev. 2014 May 07; 43(9):2979-3002. PMID: 24196585.

Citations: 15 Fields:
Che Chemistry
Translation:Cells
Jolit A, Vazquez-Rodriguez S, Yap GP, Tius MA. Diastereospecific nazarov cyclization of fully substituted dienones: generation of vicinal all-carbon-atom quaternary stereocenters. Angew Chem Int Ed Engl. 2013 Oct 11; 52(42):11102-5. PMID: 24002922.

Citations: 2 Fields:
Che Chemistry
Translation:Cells
Dixon DD, Tius MA, Thakur GA, Zhou H, Bowman AL, Shukla VG, Peng Y, Makriyannis A. C3-heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor. Bioorg Med Chem Lett. 2012 Aug 15; 22(16):5322-5. PMID: 22796181.

Citations: 9 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Cells
Shimada N, Stewart C, Bow WF, Jolit A, Wong K, Zhou Z, Tius MA. Neutral Nazarov-type cyclization catalyzed by palladium(0). Angew Chem Int Ed Engl. 2012 Jun 04; 51(23):5727-9. PMID: 22539448.

Citations: 8 Fields:
Che Chemistry
Translation:Cells
Shimada N, Stewart C, Tius MA. Asymmetric Nazarov Cyclizations. Tetrahedron. 2011 Aug 19; 67(33):5851-5870. PMID: 21857751.

Citations: 31 Fields:
Che Chemistry
Dixon DD, Sethumadhavan D, Benneche T, Banaag AR, Tius MA, Thakur GA, Bowman A, Wood JT, Makriyannis A. Heteroadamantyl cannabinoids. J Med Chem. 2010 Aug 12; 53(15):5656-66. PMID: 20593789.

Citations: 15 Fields:
Che Chemistry
Translation:Humans Animals Cells
Basak AK, Shimada N, Bow WF, Vicic DA, Tius MA. An organocatalytic asymmetric Nazarov cyclization. J Am Chem Soc. 2010 Jun 23; 132(24):8266-7. PMID: 20507121.

Citations: 23 Fields:
Che Chemistry
Translation:Cells
Shimada N, Ashburn BO, Basak AK, Bow WF, Vicic DA, Tius MA. Organocatalytic asymmetric aza-Nazarov cyclization of an azirine. Chem Commun (Camb). 2010 Jun 07; 46(21):3774-5. PMID: 20428578.

Citations: 8 Fields:
Che Chemistry
Translation:Cells
Bow WF, Basak AK, Jolit A, Vicic DA, Tius MA. Enamine-iminium ion Nazarov cyclization of alpha-ketoenones. Org Lett. 2010 Feb 05; 12(3):440-3. PMID: 20030316.

Citations: 18 Fields:
Bio Biochemistry
Translation:Cells
Dixon DD, Tius MA, Pratt LM. Gas phase and solution structures of 1-methoxyallenyllithium. J Org Chem. 2009 Aug 21; 74(16):5881-6. PMID: 20560562.

Citations: 1 Fields:
Che Chemistry
Translation:Cells
Banaag AR, Tius MA. Traceless chiral auxiliaries for the allene ether Nazarov cyclization. J Org Chem. 2008 Nov 07; 73(21):8133-41. PMID: 18808186.

Citations: 8 Fields:
Che Chemistry
Translation:Cells
Basak AK, Tius MA. Interrupting the Nazarov cyclization with indoles. Org Lett. 2008 Sep 18; 10(18):4073-6. PMID: 18720989.

Citations: 2 Fields:
Bio Biochemistry
Translation:Cells
Binder CM, Dixon DD, Almaraz E, Tius MA, Singaram B. A Simple Procedure for C-C Bond Cleavage of Aromatic and Aliphatic Epoxides with Aqueous Sodium Periodate Under Ambient Conditions. Tetrahedron Lett. 2008 Apr 21; 49(17):2764-2767. PMID: 19946457.

Citations: 5 Fields:
Che Chemistry
Berger GO, Tius MA. Total synthesis of (+/-)-terpestacin and (+/-)-11-epi-terpestacin. J Org Chem. 2007 Aug 17; 72(17):6473-80. PMID: 17630803.

Citations: 8 Fields:
Che Chemistry
Translation:Cells
Dhoro F, Kristensen TE, Stockmann V, Yap GP, Tius MA. Asymmetric amine-intercepted Nazarov cyclization. J Am Chem Soc. 2007 Jun 13; 129(23):7256-7. PMID: 17508753.

Citations: 19 Fields:
Che Chemistry
Translation:Cells
Banaag AR, Tius MA. Design of chiral auxiliaries for the allene ether nazarov cyclization. J Am Chem Soc. 2007 May 02; 129(17):5328-9. PMID: 17425314.

Citations: 6 Fields:
Che Chemistry
Translation:Cells
Wan L, Tius MA. Synthesis of (+)-madindoline A and (+)-madindoline B. Org Lett. 2007 Feb 15; 9(4):647-50. PMID: 17286372.

Citations: 6 Fields:
Bio Biochemistry
Translation:Cells
Le Goanvic D, Tius MA. Oxaza adamantyl cannabinoids. A new class of cannabinoid receptor probes. J Org Chem. 2006 Sep 29; 71(20):7800-4. PMID: 16995689.

Citations: 6 Fields:
Che Chemistry
Translation:Animals
delos Santos DB, Banaag AR, Tius MA. An improved chiral auxiliary for the allene ether version of the Nazarov cyclization. Org Lett. 2006 Jun 08; 8(12):2579-82. PMID: 16737318.

Citations: 5 Fields:
Bio Biochemistry
Translation:Cells
Berger GO, Tius MA. Terpestacin core structure. control of stereochemistry. Org Lett. 2005 Oct 27; 7(22):5011-3. PMID: 16235945.

Citations: 3 Fields:
Bio Biochemistry
Translation:Cells
Dhoro F, Tius MA. Interrupted Nazarov cyclization on silica gel. J Am Chem Soc. 2005 Sep 14; 127(36):12472-3. PMID: 16144378.

Citations: 12 Fields:
Che Chemistry
Translation:Cells
Batson WA, Sethumadhavan D, Tius MA. Alpha-hydroxy cyclopentenones from alpha-diketones. Org Lett. 2005 Jun 23; 7(13):2771-4. PMID: 15957943.

Citations: 7 Fields:
Bio Biochemistry
Translation:Cells
Bee C, Leclerc E, Tius MA. The palladium(II)-catalyzed Nazarov reaction. Org Lett. 2003 Dec 25; 5(26):4927-30. PMID: 14682731.

Citations: 8 Fields:
Bio Biochemistry
Translation:Cells
Forest J, Bee C, Cordaro F, Tius MA. Isomerization-cyclization approach to the synthesis of 2-hydroxy-5-alkylidene-cyclopent-2-enones. Org Lett. 2003 Oct 30; 5(22):4069-72. PMID: 14572251.

Citations: 3 Fields:
Bio Biochemistry
Translation:Cells
Bee C, Tius MA. Convergent cyclopentannelation process. Org Lett. 2003 May 15; 5(10):1681-4. PMID: 12735751.

Citations: 2 Fields:
Bio Biochemistry
Translation:Cells
Leclerc E, Tius MA. The first example of Nazarov reactions of vinyl cumulenyl ketones. Org Lett. 2003 Apr 17; 5(8):1171-4. PMID: 12688711.

Citations: 5 Fields:
Bio Biochemistry
Translation:Cells
Tius MA. Cationic cyclopentannelation of allene ethers. Acc Chem Res. 2003 Apr; 36(4):284-90. PMID: 12693926.

Citations: 16 Fields:
Che Chemistry
Translation:Cells
Chu C, Ramamurthy A, Makriyannis A, Tius MA. Synthesis of covalent probes for the radiolabeling of the cannabinoid receptor. J Org Chem. 2003 Jan 10; 68(1):55-61. PMID: 12515461.

Citations: 4 Fields:
Che Chemistry
Translation:Cells
Thakur GA, Palmer SL, Harrington PE, Stergiades IA, Tius MA, Makriyannis A. Enantiomeric resolution of a novel chiral cannabinoid receptor ligand. J Biochem Biophys Methods. 2002 Dec 31; 54(1-3):415-22. PMID: 12543516.

Citations: 4 Fields:
Bio Biochemistry Bio Biophysics
Translation:Humans Animals Cells
Nakazaki A, Sharma U, Tius MA. Synthesis of the hydroazulene portion of guanacastepene A from the cyclopentannelation reaction. Org Lett. 2002 Oct 03; 4(20):3363-6. PMID: 12323019.

Citations: 1 Fields:
Bio Biochemistry
Translation:Animals Cells
Harrington PE, Murai T, Chu C, Tius MA. Asymmetric cyclopentannelation: camphor-derived auxiliary. J Am Chem Soc. 2002 Aug 28; 124(34):10091-100. PMID: 12188673.

Citations: 9 Fields:
Che Chemistry
Translation:Cells
Li LH, Tius MA. Stereospecific synthesis of cryptophycin 1. Org Lett. 2002 May 16; 4(10):1637-40. PMID: 12000261.

Citations: 5 Fields:
Bio Biochemistry
Translation:Cells
Schultz-Fademrecht C, Tius MA, Grimme S, Wibbeling B, Hoppe D. Synthesis of enantioenriched 5-alkylidene-2-cyclopentenones from chiral allenyl carbamates: generation of a chiral lithium allenolate and allylic activation for a conrotatory 4pi-electrocyclization. Angew Chem Int Ed Engl. 2002 May 03; 41(9):1532-5. PMID: 19750656.

Citations: 1 Fields:
Che Chemistry
Liang J, Hoard DW, Khau VV, Martinelli MJ, Moher ED, Moore RE, Tius MA. Synthesis of Unit A of Cryptophycin via a [2,3]-Wittig Rearrangement. J Org Chem. 1999 Mar 05; 64(5):1459-1463. PMID: 11674204.

Citations: 2 Fields:
Che Chemistry
Tius MA, Hu H, Kawakami JK, Busch-Petersen J. Synthesis of 15-Deoxy-12-hydroxy-10-(trifluoromethyl)-Delta(7)-PGA(1) Methyl Ester. J Org Chem. 1998 Aug 21; 63(17):5971-5976. PMID: 11672201.

Citations: 2 Fields:
Che Chemistry

Year	Publications
1998	1
1999	1
2002	5
2003	6
2005	3
2006	2
2007	4
2008	3
2009	1
2010	4
2011	1
2012	2
2013	2
2014	2
2015	7
2016	1
2017	1
2018	1
2020	2
2021	2
2022	6
2023	2

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