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Alan F. Lau, PhD

Title
Faculty RankProfessor Emeritus
InstitutionUniversity of Hawaii
Department Pacific Biosciences Research Center
AddressUniversity of Hawaii at Manoa
1993 East West Road
Honolulu HI 96822
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Young LA, O'Connor LO, de Renty C, Veldman-Jones MH, Dorval T, Wilson Z, Jones DR, Lawson D, Odedra R, Maya-Mendoza A, Reimer C, Bartek J, Lau A, O'Connor MJ. Differential Activity of ATR and WEE1 Inhibitors in a Highly Sensitive Subpopulation of DLBCL Linked to Replication Stress. Cancer Res. 2019 07 15; 79(14):3762-3775. PMID: 31123088.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    2. Zhang J, Dulak AM, Hattersley MM, Willis BS, Nikkilä J, Wang A, Lau A, Reimer C, Zinda M, Fawell SE, Mills GB, Chen H. BRD4 facilitates replication stress-induced DNA damage response. Oncogene. 2018 07; 37(28):3763-3777. PMID: 29636547.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    3. Degorce SL, Barlaam B, Cadogan E, Dishington A, Ducray R, Glossop SC, Hassall LA, Lach F, Lau A, McGuire TM, Nowak T, Ouvry G, Pike KG, Thomason AG. Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase. J Med Chem. 2016 07 14; 59(13):6281-92. PMID: 27259031.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    4. Kopanic JL, Schlingmann B, Koval M, Lau AF, Sorgen PL, Su VF. Degradation of gap junction connexins is regulated by the interaction with Cx43-interacting protein of 75 kDa (CIP75). Biochem J. 2015 Mar 15; 466(3):571-85. PMID: 25583071.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    5. Gasser JA, Inuzuka H, Lau AW, Wei W, Beroukhim R, Toker A. SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer. Mol Cell. 2014 Nov 20; 56(4):595-607. PMID: 25458846.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    6. Dai X, Liu P, Lau AW, Liu Y, Inuzuka H. Acetylation-dependent regulation of essential iPS-inducing factors: a regulatory crossroad for pluripotency and tumorigenesis. Cancer Med. 2014 Oct; 3(5):1211-24. PMID: 25116380.
      Citations: 7     Fields:    Translation:HumansCells
    7. Su V, Hoang C, Geerts D, Lau AF. CIP75 (connexin43-interacting protein of 75 kDa) mediates the endoplasmic reticulum dislocation of connexin43. Biochem J. 2014 Feb 15; 458(1):57-67. PMID: 24256120.
      Citations: 7     Fields:    Translation:HumansCells
    8. Su V, Lau AF. Connexins: mechanisms regulating protein levels and intercellular communication. FEBS Lett. 2014 Apr 17; 588(8):1212-20. PMID: 24457202.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    9. Fukushima H, Ogura K, Wan L, Lu Y, Li V, Gao D, Liu P, Lau AW, Wu T, Kirschner MW, Inuzuka H, Wei W. SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. Cell Rep. 2013 Aug 29; 4(4):803-16. PMID: 23972993.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    10. Lau AW, Inuzuka H, Fukushima H, Wan L, Liu P, Gao D, Sun Y, Wei W. Regulation of APC(Cdh1) E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7. Cell Res. 2013 Jul; 23(7):947-61. PMID: 23670162.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    11. Cochrane K, Su V, Lau AF. The connexin43-interacting protein, CIP85, mediates the internalization of connexin43 from the plasma membrane. Cell Commun Adhes. 2013 Aug; 20(3-4):53-66. PMID: 23586710.
      Citations: 9     Fields:    Translation:HumansCells
    12. Lee B, Turley M, Meng D, Zhou Y, Garrido T, Lau A, Radler L. Effects of proactive population-based nephrologist oversight on progression of chronic kidney disease: a retrospective control analysis. BMC Health Serv Res. 2012 Aug 15; 12:252. PMID: 22894681.
      Citations: 9     Fields:    Translation:Humans
    13. Su V, Cochrane K, Lau AF. Degradation of connexins through the proteasomal, endolysosomal and phagolysosomal pathways. J Membr Biol. 2012 Jul; 245(7):389-400. PMID: 22772442.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    14. Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, Haigis MC, Pandolfi PP, Wei W. Acetylation-dependent regulation of Skp2 function. Cell. 2012 Jul 06; 150(1):179-93. PMID: 22770219.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    15. Lau AW, Fukushima H, Wei W. The Fbw7 and betaTRCP E3 ubiquitin ligases and their roles in tumorigenesis. Front Biosci (Landmark Ed). 2012 Jun 01; 17:2197-212. PMID: 22652772.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    16. Fukushima H, Matsumoto A, Inuzuka H, Zhai B, Lau AW, Wan L, Gao D, Shaik S, Yuan M, Gygi SP, Jimi E, Asara JM, Nakayama K, Nakayama KI, Wei W. SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction. Cell Rep. 2012 May 31; 1(5):434-43. PMID: 22708077.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    17. Su V, Lau AF. Ubiquitination, intracellular trafficking, and degradation of connexins. Arch Biochem Biophys. 2012 Aug 01; 524(1):16-22. PMID: 22239989.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    18. Dunn CA, Su V, Lau AF, Lampe PD. Activation of Akt, not connexin 43 protein ubiquitination, regulates gap junction stability. J Biol Chem. 2012 Jan 20; 287(4):2600-7. PMID: 22139843.
      Citations: 39     Fields:    Translation:AnimalsCells
    19. Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, DePinho RA, Wei W. SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature. 2011 Mar 03; 471(7336):104-9. PMID: 21368833.
      Citations: 284     Fields:    Translation:HumansAnimalsCells
    20. Kawakami JK, Martinez Y, Sasaki B, Harris M, Kurata WE, Lau AF. Investigation of a novel molecular descriptor for the lead optimization of 4-aminoquinazolines as vascular endothelial growth factor receptor-2 inhibitors: application for quantitative structure-activity relationship analysis in lead optimization. Bioorg Med Chem Lett. 2011 Mar 01; 21(5):1371-5. PMID: 21306896.
      Citations: 1     Fields:    Translation:Cells
    21. Su V, Nakagawa R, Koval M, Lau AF. Ubiquitin-independent proteasomal degradation of endoplasmic reticulum-localized connexin43 mediated by CIP75. J Biol Chem. 2010 Dec 24; 285(52):40979-90. PMID: 20940304.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    22. Lau AW, Pringle LM, Quick L, Riquelme DN, Ye Y, Oliveira AM, Chou MM. TRE17/ubiquitin-specific protease 6 (USP6) oncogene translocated in aneurysmal bone cyst blocks osteoblastic maturation via an autocrine mechanism involving bone morphogenetic protein dysregulation. J Biol Chem. 2010 Nov 19; 285(47):37111-20. PMID: 20864534.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    23. Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennett E, Tron AE, Gasser JA, Lau A, Gygi SP, Harper JW, DeCaprio JA, Toker A, Wei W. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol Cell. 2010 Sep 10; 39(5):797-808. PMID: 20832730.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    24. Kieken F, Spagnol G, Su V, Lau AF, Sorgen PL. NMR structure note: UBA domain of CIP75. J Biomol NMR. 2010 Mar; 46(3):245-50. PMID: 20127391.
      Citations: 7     Fields:    Translation:AnimalsCells
    25. Cochrane K, Berestecky JM, Kitamura C, Lau AF. Monoclonal antibodies against the connexin43-interacting protein CIP85. Hybridoma (Larchmt). 2009 Oct; 28(5):355-61. PMID: 19857117.
      Citations:    Fields:    Translation:HumansAnimalsCells
    26. Su V, Lau AF. Ubiquitin-like and ubiquitin-associated domain proteins: significance in proteasomal degradation. Cell Mol Life Sci. 2009 Sep; 66(17):2819-33. PMID: 19468686.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    27. Su V, Knutson A, Lau K, Kurata W, Berestecky J, Lau AF. Generation and characterization of mouse monoclonal antibodies against CIP75, an UbL-UBA domain-containing protein. Hybridoma (Larchmt). 2009 Apr; 28(2):79-84. PMID: 19249996.
      Citations: 2     Fields:    Translation:AnimalsCells
    28. Menear KA, Adcock C, Boulter R, Cockcroft XL, Copsey L, Cranston A, Dillon KJ, Drzewiecki J, Garman S, Gomez S, Javaid H, Kerrigan F, Knights C, Lau A, Loh VM, Matthews IT, Moore S, O'Connor MJ, Smith GC, Martin NM. 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1. J Med Chem. 2008 Oct 23; 51(20):6581-91. PMID: 18800822.
      Citations: 150     Fields:    Translation:HumansAnimalsCells
    29. Li X, Su V, Kurata WE, Jin C, Lau AF. A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43. J Biol Chem. 2008 Feb 29; 283(9):5748-59. PMID: 18079109.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    30. Park DJ, Wallick CJ, Martyn KD, Lau AF, Jin C, Warn-Cramer BJ. Akt phosphorylates Connexin43 on Ser373, a "mode-1" binding site for 14-3-3. Cell Commun Adhes. 2007 Sep-Oct; 14(5):211-26. PMID: 18163231.
      Citations: 44     Fields:    Translation:AnimalsCells
    31. Moreno AP, Lau AF. Gap junction channel gating modulated through protein phosphorylation. Prog Biophys Mol Biol. 2007 May-Jun; 94(1-2):107-19. PMID: 17507079.
      Citations: 36     Fields:    Translation:Cells
    32. Lin R, Martyn KD, Guyette CV, Lau AF, Warn-Cramer BJ. v-Src tyrosine phosphorylation of connexin43: regulation of gap junction communication and effects on cell transformation. Cell Commun Adhes. 2006 Jul-Aug; 13(4):199-216. PMID: 16916748.
      Citations: 11     Fields:    Translation:AnimalsCells
    33. Shen C, Ye Y, Robertson SE, Lau AW, Mak DO, Chou MM. Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6. J Biol Chem. 2005 Oct 28; 280(43):35967-73. PMID: 16127172.
      Citations: 22     Fields:    Translation:HumansCells
    34. Lau AF. c-Src: bridging the gap between phosphorylation- and acidification-induced gap junction channel closure. Sci STKE. 2005 Jul 05; 2005(291):pe33. PMID: 15998870.
      Citations: 12     Fields:    Translation:AnimalsCells
    35. Lan Z, Kurata WE, Martyn KD, Jin C, Lau AF. Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation. Biochemistry. 2005 Feb 22; 44(7):2385-96. PMID: 15709751.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    36. Lampe PD, Lau AF. The effects of connexin phosphorylation on gap junctional communication. Int J Biochem Cell Biol. 2004 Jul; 36(7):1171-86. PMID: 15109565.
      Citations: 214     Fields:    Translation:HumansCells
    37. Warn-Cramer BJ, Lau AF. Regulation of gap junctions by tyrosine protein kinases. Biochim Biophys Acta. 2004 Mar 23; 1662(1-2):81-95. PMID: 15033580.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    38. Jin C, Martyn KD, Kurata WE, Warn-Cramer BJ, Lau AF. Connexin43 PDZ2 binding domain mutants create functional gap junctions and exhibit altered phosphorylation. Cell Commun Adhes. 2004 Mar-Aug; 11(2-4):67-87. PMID: 16247852.
      Citations: 13     Fields:    Translation:AnimalsCells
    39. Warn-Cramer BJ, Lin R, Martyn K, Guyette CV, Lau AF. Maintaining connexin43 gap junctional communication in v-Src cells does not alter growth properties associated with the transformed phenotype. Cell Commun Adhes. 2003 Jul-Dec; 10(4-6):299-303. PMID: 14681032.
      Citations: 1     Fields:    Translation:AnimalsCells
    40. Cottrell GT, Lin R, Warn-Cramer BJ, Lau AF, Burt JM. Mechanism of v-Src- and mitogen-activated protein kinase-induced reduction of gap junction communication. . 2003 Feb; 284(2):C511-20. PMID: 12388103.
      Citations:    
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