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Idhaliz Flores

TitlePuerto Rico BIoBank Co-Leader
Faculty RankProfessor
InstitutionPonce Health Sciences University
DepartmentBasic Sciences/OBGYN
AddressP.O. Box 7010
Ponce PR 00722
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    I have worked in endometriosis research for over ten years, specifically looking at molecular biomarkers and genetic factors associated with this disease. I currently direct the Endometriosis Research Program (ERP) at PSM, funded through an R01 from NICHD (R01 HD050559) until 2011. The ERP helps mentor and train undergraduate, graduate and medical students in endometriosis-related research and has collaborative links with supporting specialists (Pathologists, Epidemiologists, Reproductive Endocrinologists, and Gynecologists). The ERP has established a unique biorepository of tissues, serum and nucleic acids, as well as demographic and clinical obtained from over 1000 patients with endometriosis and controls. Research at ERP has helped establish the prevalence of endometriosis in Puerto Rico, identify potential diagnostic markers and also identified a genetic region in chromosome 10 associated with disease. Recent studies identified SNPs that are strongly associated with endometriosis and/or infertility in our population. Ongoing interests include the validation of these genetic associations and evaluation of the role of admixture in the genetic predispositions to endometriosis. The ERP has also conducted studies on the impact of endometriosis on life, health and work productivity, and is currently studying the economic impact that this condition has on the health system. Ongoing collaborations include studies on the role of stress in the development/exacerbation of endometriosis-symptoms (ie, pain) in a rat model of disease (collaboration with Dr. Caroline Appleyard and Annelyn Torres; grant #1R15AT006373); studies of the epigenetics of endometriosis, specifically the role of histone modifications, a collaboration with Dr. Edward Seto at MCC (funded through an ARRA supplement to grant #1R01HD050559-S1); studies of the proteome of endometriosis (collaboration with Dr. Hugh Taylor, Yale, and Dr. Ignacio Pino, CDI Laboratories; pilot project to grant #1U54HD052668); and a project that involves development of a primate model of endometriosis at the Caribbean Primate Center (collaboration with Dr. Lynnette Ruiz, grant #1 454RR026139-01A1). I have served for the past four years as the Program Leader of the U56 PSM/MCC Cancer Center Partnership (grant #5U56CA126379). Under the recently funded U54 PSM-MCC Cancer Center Partnership I will continue to provide direct assistance to the PIs (Drs. Jaime Matta y José Torres-Ruiz) in overseeing the operation of the Cores that provide support to projects and programs of the U54. In particular, I have served as one of the co-leaders in charge of the development of a Tissue Procurement Core that for the first time accrues cancer tissues from patients in Puerto Rico. As such, I was part of the team that helped identify the initial barriers and difficulties in establishing a tissue bank where no such initiative was present were identified and surpassed. Throughout my professional career, I have established expertise in molecular genetics of endometriosis, epidemiology of endometriosis, tissue banking, grant administration, and training/mentoring of the next generation of scientists in reproduction, cancer and women’s health.

    Collapse Research 
    Collapse research activities and funding
    R01HD050559     (FLORES, IDHALIZ)Apr 24, 2006 - Mar 31, 2012
    SNP Analysis of Endometriosis Candidate Genes
    Role: Principal Investigator

    R41HD089803     (FLORES, IDHALIZ)Sep 1, 2016 - Aug 31, 2017
    Validation of immune-based biomarkers for endometriosis.
    Role: Principal Investigator

    R21HD098481     (FLORES, IDHALIZ)Jul 1, 2019 - Jun 30, 2021
    Enriched environments: a multi-level integrative medicine intervention for endometriosis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Handley KF, Mehta S, Martin AL, Biswas S, Maharaj K, Nagy MZ, Mine JA, Cortina C, Yu X, Sprenger K, Mandal G, Innamarato P, Powers JJ, Harro CM, Chaurio RA, Anadon CM, Shahzad MM, Flores I, Conejo-Garcia JR. Actionable spontaneous antibody responses antagonize malignant progression in ovarian carcinoma. Gynecol Oncol. 2023 06; 173:114-121. PMID: 37121178.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Nieves-V?zquez CI, Detr?s-Marqu?z AC, Torres-Rever?n A, Appleyard CB, Llorens-De Jes?s AP, Resto IN, L?pez-Rodr?guez V, Ramos-Echevarr?a PM, Castro EM, Flores I. Feasibility and acceptability of an adapted environmental enrichment intervention for endometriosis: A pilot study. Front Glob Womens Health. 2022; 3:1058559. PMID: 36683601.
    3. Castro-Figueroa EM, Acevedo KI, Pe?a-Vargas CI, Torres-Blasco N, Flores I, Col?n-Echevarria CB, Maldonado L, Rodr?guez Z, Aquino-Acevedo AN, Jim H, Lazaro MI, Armaiz-Pe?a GN. Depression, Anxiety, and Social Environmental Adversity as Potential Modulators of the Immune Tumor Microenvironment in Breast Cancer Patients. Med Sci (Basel). 2021 06 21; 9(2). PMID: 34205709.
      Citations: 1     Fields:    Translation:Humans
    4. Appleyard CB, Cruz ML, Velazquez-Cruz J, Rivera-Mendez RM, Jimenez-Garcia JG, Rivera LA, Del Mar Mendez-Casillas M, Flores I, Al-Nakkash L, Chompre G. Voluntary Wheel Running Reduces Vesicle Development in an Endometriosis Animal Model Through Modulation of Immune Parameters. Front Reprod Health. 2021; 3. PMID: 36284640.
    5. Seguinot-Tarafa I, Luna N, Suarez E, Appleyard CB, Flores I. Inhibition of Histone Methyltransferase EZH2 Suppresses Endometriotic Vesicle Development in a Rat Model of Endometriosis. Reprod Sci. 2020 09; 27(9):1812-1820. PMID: 32651901.
      Citations: 1     Fields:    Translation:Animals
    6. Rodriguez-Rabassa M, Hernandez R, Rodriguez Z, Colon-Echevarria CB, Maldonado L, Tollinchi N, Torres-Marrero E, Mulero A, Albors D, Perez-Morales J, Flores I, Dutil J, Jim H, Castro EM, Armaiz-Pena GN. Impact of a natural disaster on access to care and biopsychosocial outcomes among Hispanic/Latino cancer survivors. Sci Rep. 2020 06 25; 10(1):10376. PMID: 32587352.
      Citations: 8     Fields:    Translation:Humans
    7. Lopez A, Cruz ML, Chompre G, Hern?ndez S, Isidro RA, Flores I, Appleyard CB. Influence of Stress on the Vitamin D-Vitamin D Receptor System, Macrophages, and the Local Inflammatory Milieu in Endometriosis. Reprod Sci. 2020 12; 27(12):2175-2186. PMID: 32583376.
      Citations:    Fields:    Translation:AnimalsCells
    8. Appleyard CB, Flores I, Torres-Rever?n A. The Link Between Stress and Endometriosis: from Animal Models to the Clinical Scenario. Reprod Sci. 2020 09; 27(9):1675-1686. PMID: 32542543.
      Citations: 6     Fields:    Translation:HumansAnimals
    9. Smit AK, Collazo-Roman M, Vadaparampil ST, Valavanis S, Del Rio J, Soto B, Flores I, Dutil J, Kanetsky PA. MC1R variants and associations with pigmentation characteristics and genetic ancestry in a Hispanic, predominately Puerto Rican, population. Sci Rep. 2020 04 29; 10(1):7303. PMID: 32350296.
      Citations: 6     Fields:    Translation:Humans
    10. Col?n-Caraballo M, Garc?a M, Mendoza A, Flores I. Human Endometriosis Tissue Microarray Reveals Site-specific Expression of Estrogen Receptors, Progesterone Receptor, and Ki67. Appl Immunohistochem Mol Morphol. 2019 08; 27(7):491-500. PMID: 29629944.
      Citations: 14     Fields:    Translation:HumansCellsCTClinical Trials
    11. Fourquet J, Zavala DE, Missmer S, Bracero N, Romaguera J, Flores I. Disparities in healthcare services in women with endometriosis with public vs private health insurance. Am J Obstet Gynecol. 2019 12; 221(6):623.e1-623.e11. PMID: 31226295.
      Citations: 9     Fields:    Translation:Humans
    12. Torres-Rever?n A, Rivera-Lopez LL, Flores I, Appleyard CB. Antagonizing the corticotropin releasing hormone receptor 1 with antalarmin reduces the progression of endometriosis. PLoS One. 2018; 13(11):e0197698. PMID: 30427841.
      Citations: 4     Fields:    Translation:Animals
    13. Col?n-Caraballo M, Torres-Rever?n A, Soto-Vargas JL, Young SL, Lessey B, Mendoza A, Urrutia R, Flores I. Effects of histone methyltransferase inhibition in endometriosis. Biol Reprod. 2018 08 01; 99(2):293-307. PMID: 29408993.
      Citations: 10     Fields:    Translation:HumansCells
    14. O DF, Flores I, Waelkens E, D'Hooghe T. Noninvasive diagnosis of endometriosis: Review of current peripheral blood and endometrial biomarkers. Best Pract Res Clin Obstet Gynaecol. 2018 Jul; 50:72-83. PMID: 29778458.
      Citations: 14     Fields:    Translation:Humans
    15. Gonz?lez-Echevarr?a AM, Rosario E, Acevedo S, Flores I. Impact of coping strategies on quality of life of adolescents and young women with endometriosis. J Psychosom Obstet Gynaecol. 2019 06; 40(2):138-145. PMID: 29648907.
      Citations: 20     Fields:    Translation:Humans
    16. Ruiz A, Ruiz L, Col?n-Caraballo M, Torres-Collazo BJ, Monteiro JB, Bayona M, Fazleabas AT, Flores I. Pharmacological blockage of the CXCR4-CXCL12 axis in endometriosis leads to contrasting effects in proliferation, migration, and invasion. Biol Reprod. 2018 01 01; 98(1):4-14. PMID: 29161347.
      Citations: 11     Fields:    Translation:Humans
    17. Rockfield S, Flores I, Nanjundan M. Expression and function of nuclear receptor coactivator 4 isoforms in transformed endometriotic and malignant ovarian cells. Oncotarget. 2018 Jan 12; 9(4):5344-5367. PMID: 29435183.
      Citations: 16     Fields:    
    18. Torres-Rever?n A, Rivera LL, Flores I, Appleyard CB. Environmental Manipulations as an Effective Alternative Treatment to Reduce Endometriosis Progression. Reprod Sci. 2018 09; 25(9):1336-1348. PMID: 29137551.
      Citations: 5     Fields:    Translation:Animals
    19. Cuevas M, Cruz ML, Ramirez AE, Flores I, Thompson KJ, Bayona M, Vernon MW, Appleyard CB. Stress During Development of Experimental Endometriosis Influences Nerve Growth and Disease Progression. Reprod Sci. 2018 03; 25(3):347-357. PMID: 29108503.
      Citations: 5     Fields:    Translation:AnimalsCells
    20. Seijo E, Lima D, Iriabho E, Almeida J, Monico J, Echeverri M, Gutierrez S, Flores I, Lee JH, Fisher K, Grizzle WE, Sica GL, Butler C, Hicks C, Meade CD, Sodeke SO, Moroz K, Coppola D, Munoz-Antonia T. Construction and Validation of a Multi-Institutional Tissue Microarray of Invasive Ductal Carcinoma From Racially and Ethnically Diverse Populations. Cancer Control. 2016 Oct; 23(4):383-389. PMID: 27842327.
      Citations: 2     Fields:    Translation:Humans
    21. Torres-Rever?n A, Palermo K, Hern?ndez-L?pez A, Hern?ndez S, Cruz ML, Thompson KJ, Flores I, Appleyard CB. Endometriosis Is Associated With a Shift in MU Opioid and NMDA Receptor Expression in the Brain Periaqueductal Gray. Reprod Sci. 2016 09; 23(9):1158-67. PMID: 27089914.
      Citations: 6     Fields:    Translation:Animals
    22. Fourquet J, Sinaii N, Stratton P, Khayel F, Alvarez-Garriga C, Bayona M, Ballweg ML, Flores I. Characteristics of women with endometriosis from the USA and Puerto Rico. J Endometr Pelvic Pain Disord. 2015 Oct-Dec; 7(4):129-135. PMID: 27331050.
    23. Qui?ones M, Urrutia R, Torres-Rever?n A, Vincent K, Flores I. Anxiety, coping skills and hypothalamus-pituitary-adrenal (HPA) axis in patients with endometriosis. J Reprod Biol Health. 2015; 3. PMID: 26900480.
    24. Ruiz LA, B?ez-Vega PM, Ruiz A, Peterse DP, Monteiro JB, Bracero N, Beauchamp P, Fazleabas AT, Flores I. Dysregulation of Lysyl Oxidase Expression in Lesions and Endometrium of Women With Endometriosis. Reprod Sci. 2015 Dec; 22(12):1496-508. PMID: 25963914.
      Citations: 15     Fields:    Translation:HumansCells
    25. Col?n-Caraballo M, Monteiro JB, Flores I. H3K27me3 is an Epigenetic Mark of Relevance in Endometriosis. Reprod Sci. 2015 Sep; 22(9):1134-42. PMID: 25820690.
      Citations: 21     Fields:    Translation:HumansCells
    26. Appleyard CB, Cruz ML, Hern?ndez S, Thompson KJ, Bayona M, Flores I. Stress management affects outcomes in the pathophysiology of an endometriosis model. Reprod Sci. 2015 Apr; 22(4):431-41. PMID: 25015902.
      Citations: 15     Fields:    Translation:Animals
    27. Mora E, Robb JA, Stefanoff G, Mellado RH, Coppola D, Mu?oz-Antonia T, Flores I. Proceedings of the 1st Puerto Rico Biobanking Workshop. Rev Recent Clin Trials. 2014; 9(4):233-44. PMID: 25626063.
      Citations:    Fields:    Translation:Humans
    28. Wells KJ, Lima DS, Meade CD, Mu?oz-Antonia T, Scarinci I, McGuire A, Gwede CK, Pledger WJ, Partridge E, Lipscomb J, Matthews R, Matta J, Flores I, Weiner R, Turner T, Miele L, Wiese TE, Fouad M, Moreno CS, Lacey M, Christie DW, Price-Haywood EG, Quinn GP, Coppola D, Sodeke SO, Green BL, Lichtveld MY. Assessing needs and assets for building a regional network infrastructure to reduce cancer related health disparities. Eval Program Plann. 2014 Jun; 44:14-25. PMID: 24486917.
      Citations: 9     Fields:    Translation:Humans
    29. Matta JL, Flores I, Morales LM, Monteiro J, Alvarez-Garriga C, Bayona M. Women with endometriosis have a higher DNA repair capacity and diminished breast cancer risk. Mol Cancer Biol. 2013 Dec 20; 1(1). PMID: 25473592.
    30. Monteiro JB, Col?n-D?az M, Garc?a M, Gutierrez S, Col?n M, Seto E, Laboy J, Flores I. Endometriosis is characterized by a distinct pattern of histone 3 and histone 4 lysine modifications. Reprod Sci. 2014 Mar; 21(3):305-18. PMID: 23899551.
      Citations: 27     Fields:    Translation:HumansCells
    31. Cuevas M, Flores I, Thompson KJ, Ramos-Ortolaza DL, Torres-Reveron A, Appleyard CB. Stress exacerbates endometriosis manifestations and inflammatory parameters in an animal model. Reprod Sci. 2012 Aug; 19(8):851-62. PMID: 22527982.
      Citations: 29     Fields:    Translation:AnimalsCells
    32. Col?n-D?az M, B?ez-Vega P, Garc?a M, Ruiz A, Monteiro JB, Fourquet J, Bayona M, Alvarez-Garriga C, Achille A, Seto E, Flores I. HDAC1 and HDAC2 are differentially expressed in endometriosis. Reprod Sci. 2012 May; 19(5):483-92. PMID: 22344732.
      Citations: 31     Fields:    Translation:HumansCells
    33. Grechukhina O, Petracco R, Popkhadze S, Massasa E, Paranjape T, Chan E, Flores I, Weidhaas JB, Taylor HS. A polymorphism in a let-7 microRNA binding site of KRAS in women with endometriosis. EMBO Mol Med. 2012 Mar; 4(3):206-17. PMID: 22307873.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    34. Collazo MS, Porrata-Doria T, Flores I, Acevedo SF. Apolipoprotein E polymorphisms and spontaneous pregnancy loss in patients with endometriosis. Mol Hum Reprod. 2012 Jul; 18(7):372-7. PMID: 22266326.
      Citations: 8     Fields:    Translation:Humans
    35. Flores I, Mu?oz-Antonia T, Matta J, Garc?a M, Fenstermacher D, Gutierrez S, Seijo E, Torres-Ruiz J, Pledger WJ, Coppola D. The Establishment of the First Cancer Tissue Biobank at a Hispanic-Serving Institution: A National Cancer Institute-Funded Initiative between Moffitt Cancer Center in Florida and the Ponce School of Medicine and Health Sciences in Puerto Rico. Biopreserv Biobank. 2011 Dec; 9(4):363-71. PMID: 24836632.
      Citations: 2     Fields:    
    36. Ruiz LA, Dutil J, Ruiz A, Fourquet J, Abac S, Laboy J, Flores I. Single-nucleotide polymorphisms in the lysyl oxidase-like protein 4 and complement component 3 genes are associated with increased risk for endometriosis and endometriosis-associated infertility. Fertil Steril. 2011 Aug; 96(2):512-5. PMID: 21733505.
      Citations: 12     Fields:    Translation:Humans
    37. Fourquet J, B?ez L, Figueroa M, Iriarte RI, Flores I. Quantification of the impact of endometriosis symptoms on health-related quality of life and work productivity. Fertil Steril. 2011 Jul; 96(1):107-12. PMID: 21621771.
      Citations: 73     Fields:    Translation:Humans
    38. Ruiz A, Salvo VA, Ruiz LA, B?ez P, Garc?a M, Flores I. Basal and steroid hormone-regulated expression of CXCR4 in human endometrium and endometriosis. Reprod Sci. 2010 Oct; 17(10):894-903. PMID: 20720261.
      Citations: 15     Fields:    Translation:HumansCells
    39. Fourquet J, Gao X, Zavala D, Orengo JC, Abac S, Ruiz A, Laboy J, Flores I. Patients' report on how endometriosis affects health, work, and daily life. Fertil Steril. 2010 May 01; 93(7):2424-8. PMID: 19926084.
      Citations: 54     Fields:    Translation:Humans
    40. de Cavanagh EM, Flores I, Ferder M, Inserra F, Ferder L. Renin-angiotensin system inhibitors protect against age-related changes in rat liver mitochondrial DNA content and gene expression. Exp Gerontol. 2008 Oct; 43(10):919-28. PMID: 18765277.
      Citations: 8     Fields:    Translation:AnimalsCells
    41. Appleyard CB, Cruz ML, Rivera E, Hern?ndez GA, Flores I. Experimental endometriosis in the rat is correlated with colonic motor function alterations but not with bacterial load. Reprod Sci. 2007 Dec; 14(8):815-24. PMID: 18089600.
      Citations: 9     Fields:    Translation:AnimalsCells
    42. Flores I, Abreu S, Abac S, Fourquet J, Laboy J, R?os-Bedoya C. Self-reported prevalence of endometriosis and its symptoms among Puerto Rican women. Int J Gynaecol Obstet. 2008 Mar; 100(3):257-61. PMID: 17976623.
      Citations: 16     Fields:    Translation:Humans
    43. Flores I, Rivera E, Ruiz LA, Santiago OI, Vernon MW, Appleyard CB. Molecular profiling of experimental endometriosis identified gene expression patterns in common with human disease. Fertil Steril. 2007 May; 87(5):1180-99. PMID: 17478174.
      Citations: 32     Fields:    Translation:HumansAnimals
    44. Rivera E, Flores I, Rivera E, Appleyard CB. Molecular profiling of a rat model of colitis: validation of known inflammatory genes and identification of novel disease-associated targets. Inflamm Bowel Dis. 2006 Oct; 12(10):950-66. PMID: 17012966.
      Citations: 15     Fields:    Translation:Animals
    45. Flores I, Rivera E, Mousses S, Chen Y, Rozenblum E. Identification of molecular markers for endometriosis in blood lymphocytes by using deoxyribonucleic acid microarrays. Fertil Steril. 2006 Jun; 85(6):1676-83. PMID: 16759924.
      Citations: 4     Fields:    Translation:HumansCells
    46. Rojas-Cartagena C, Flores I, Appleyard CB. Role of tumor necrosis factor receptors in an animal model of acute colitis. Cytokine. 2005 Oct 21; 32(2):85-93. PMID: 16213154.
      Citations: 19     Fields:    Translation:Animals
    47. Rojas-Cartagena C, Appleyard CB, Santiago OI, Flores I. Experimental intestinal endometriosis is characterized by increased levels of soluble TNFRSF1B and downregulation of Tnfrsf1a and Tnfrsf1b gene expression. Biol Reprod. 2005 Dec; 73(6):1211-8. PMID: 16093357.
      Citations: 10     Fields:    Translation:AnimalsCells
    48. Flores I, Mora C, Rivera E, Donnelly R, Montealegre F. Cloning and molecular characterization of a cDNA from Blomia tropicalis homologous to dust mite group 3 allergens (trypsin-like proteases). Int Arch Allergy Immunol. 2003 Jan; 130(1):12-6. PMID: 12576730.
      Citations: 3     Fields:    Translation:AnimalsCells
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