Research Interests: Genetics, Epigenetics and environmental factors in African American Colon Cancer
Dr. Hassan Brim earned his PhD from the Free University of Brussels in the field of "Molecular Biology, Genetic Engineering and Environmental Microbiology." He then moved to the Naval Medical Center in Bethesda where he worked on the degradation and transformation of carcinogenic products in radioactive environments. This work was implemented in a radio resistant bacterium equipped with particular DNA repair mechanisms. This work has led to high profile publications in Nature Biotechnology and cited in Science Magazine. From there, Dr. Brim moved to study DNA repair in colon cancer specimens. He analyzed microsatellite instability, DNA methylation and chromosomal instability in colon cancer cases. He is currently addressing environmental factors that trigger and/or promote colon cancer among which the gut flora is a major player of which the role is yet to be defined. Dr. Brim is currently an Assistant professor at the Department of Pathology and has more than 30 publications.