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Hassan Brim

TitleAssistant Professor
Faculty RankAssistant Professor
InstitutionHoward University
DepartmentPathology/ Cancer Center
Address2041 Georgia Avenue, NW
Suite 220, NW
Washington DC 20060
Phone2028064198
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    Collapse Overview 
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    Research Interests: Genetics, Epigenetics and environmental factors in African American Colon Cancer

    Dr. Hassan Brim earned his PhD from the Free University of Brussels in the field of "Molecular Biology, Genetic Engineering and Environmental Microbiology." He then moved to the Naval Medical Center in Bethesda where he worked on the degradation and transformation of carcinogenic products in radioactive environments. This work was implemented in a radio resistant bacterium equipped with particular DNA repair mechanisms. This work has led to high profile publications in Nature Biotechnology and cited in Science Magazine. From there, Dr. Brim moved to study DNA repair in colon cancer specimens. He analyzed microsatellite instability, DNA methylation and chromosomal instability in colon cancer cases. He is currently addressing environmental factors that trigger and/or promote colon cancer among which the gut flora is a major player of which the role is yet to be defined. Dr. Brim is currently an Assistant professor at the Department of Pathology and has more than 30 publications.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ashktorab H, Pizuomo A, González NAF, Villagrana EDC, Herrera-Solís ME, Cardenas G, Zavala-Alvarez D, Oskrochi G, Awoyemi E, Adeleye F, Dalivand MM, Laiyemo AO, Lee EE, Aduli F, Sherif ZA, Brim H. A Comprehensive Analysis of COVID-19 Impact in Latin America. Res Sq. 2021 Jan 08. PMID: 33442675.
      Citations:    
    2. Ashktorab Y, Brim A, Pizuorno A, Gayam V, Nikdel S, Brim H. COVID-19 Pediatric Patients: Gastrointestinal Symptoms, Presentations, and Disparities by Race/Ethnicity in a Large, Multicenter US Study. Gastroenterology. 2021 Jan 06. PMID: 33421514.
      Citations:    Fields:    
    3. Ashktorab H, Pizuorno A, Oskroch G, Fierro NA, Sherif ZA, Brim H. COVID-19 in Latin America: Symptoms, Morbidities, and Gastrointestinal Manifestations. Gastroenterology. 2021 02; 160(3):938-940. PMID: 33160964.
      Citations: 1     Fields:    
    4. Brim H, Mirabello L, Bass S, Ford DH, Carethers JM, Ashktorab H. Association of Human Papillomavirus Genotype 16 Lineages With Anal Cancer Histologies Among African Americans. Gastroenterology. 2021 Feb; 160(3):922-924. PMID: 33075347.
      Citations:    Fields:    
    5. Chawla K, Kibreab A, Scott V, Lee EL, Aduli F, Brim H, Ashktorab H, Howell CD, Laiyemo AO. Association of patients' perception of quality of healthcare received and colorectal cancer screening uptake: An analysis of two national surveys in the United States. Med Princ Pract. 2020 Oct 13. PMID: 33049736.
      Citations:    Fields:    
    6. Shokrani B, Brim H, Hydari T, Afsari A, Lee E, Nouraie M, Sherif Z, Ashktorab H. Analysis of ß-catenin association with obesity in African Americans with premalignant and malignant colorectal lesions. BMC Gastroenterol. 2020 Aug 18; 20(1):274. PMID: 32811441.
      Citations:    Fields:    
    7. Güllü N, Kobelt D, Brim H, Rahman S, Timm L, Smith J, Soleimani A, Di Marco S, Bisti S, Ashktorab H, Stein U. Saffron Crudes and Compounds Restrict MACC1-Dependent Cell Proliferation and Migration of Colorectal Cancer Cells. Cells. 2020 08 03; 9(8). PMID: 32756469.
      Citations:    Fields:    
    8. Ashktorab H, Brim H, Hassan S, Nouraie M, Gebreselassie A, Laiyemo AO, Kibreab A, Aduli F, Latella G, Brant SR, Sherif Z, Habtezion A. Inflammatory polyps occur more frequently in inflammatory bowel disease than other colitis patients. BMC Gastroenterol. 2020 Jun 05; 20(1):170. PMID: 32503428.
      Citations:    Fields:    
    9. Ashktorab H, Washington K, Zarnogi S, Shakoori A, Varma S, Lee E, Shokrani B, Laiyemo A, Brim H. Determination of distinctive hypomethylated genes in African American colorectal neoplastic lesions. Therap Adv Gastroenterol. 2020; 13:1756284820905482. PMID: 32547637.
      Citations:    
    10. Erfani M, Hosseini SV, Mokhtari M, Zamani M, Tahmasebi K, Alizadeh Naini M, Taghavi A, Carethers JM, Koi M, Brim H, Mokarram P, Ashktorab H. Altered ARID1A expression in colorectal cancer. BMC Cancer. 2020 Apr 25; 20(1):350. PMID: 32334542.
      Citations:    Fields:    Translation:HumansCells
    11. Laiyemo AO, Idowu KA, Burnside C, Williams CD, Jack M, Mekasha G, Ashktorab H, Brim H, Lee EL, Sanderson AK, Kibreab A, Kwagyan J. Comparison of patterns of laxative ingestion to improve bowel preparation for colonoscopy: a pilot randomized clinical trial. Endosc Int Open. 2020 May; 8(5):E617-E622. PMID: 32355879.
      Citations:    
    12. Sherif ZA, Nouraie M, Begum R, Afsari A, Shokrani B, Lee E, Laiyemo AO, Brim H, Ashktorab H. Factors influencing treatment outcome in hepatitis C virus minority patients at an inner-city hospital: A STROBE-complaint article. Medicine (Baltimore). 2020 Apr; 99(14):e19505. PMID: 32243366.
      Citations:    Fields:    Translation:Humans
    13. Abbas M, Mason T, Ibad A, Khraiwesh M, Apprey V, Kanaan Y, Wilson B, Dunston G, Ricks-Santi L, Brim H. Genetic Polymorphisms in IL-10 Promoter Are Associated With Smoking and Prostate Cancer Risk in African Americans. Anticancer Res. 2020 Jan; 40(1):27-34. PMID: 31892550.
      Citations:    Fields:    Translation:HumansCells
    14. Ashktorab H, Sherif Z, Tarjoman T, Azam S, Lee E, Shokrani B, Okereke I, Soleimani A, Carethers JM, Laiyemo AO, Aduli F, Nouraie M, Habtezion A, Brim H. Elevated Risk for Sessile Serrated Polyps in African Americans with Endometrial Polyps. Dig Dis Sci. 2020 09; 65(9):2686-2690. PMID: 31832971.
      Citations:    Fields:    Translation:Humans
    15. Laiyemo AO, Kwagyan J, Williams CD, Rogers J, Kibreab A, Jack MA, Lee EE, Brim H, Ashktorab H, Howell CD, Smoot DT, Platz EA. Using Patients' Social Network to Improve Compliance to Outpatient Screening Colonoscopy Appointments Among Blacks: A Randomized Clinical Trial. Am J Gastroenterol. 2019 10; 114(10):1671-1677. PMID: 31478919.
      Citations:    Fields:    Translation:HumansPHPublic Health
    16. Nouraie M, Ashktorab H, Atefi N, Azam S, Tarjoman T, Lee E, Shokrani B, Afsari A, Soleimani A, Laiyemo AO, Singh S, Brim H. Can the rate and location of sessile serrated polyps be part of colorectal Cancer disparity in African Americans? BMC Gastroenterol. 2019 May 24; 19(1):77. PMID: 31126232.
      Citations: 2     Fields:    Translation:Humans
    17. Ashktorab H, Soleimani A, Singh G, Amr A, Tabtabaei S, Latella G, Stein U, Akhondzadeh S, Solanki N, Gondré-Lewis MC, Habtezion A, Brim H. Saffron: The Golden Spice with Therapeutic Properties on Digestive Diseases. Nutrients. 2019 Apr 26; 11(5). PMID: 31027364.
      Citations: 6     Fields:    Translation:HumansAnimals
    18. Ashktorab H, Delker D, Kanth P, Goel A, Carethers JM, Brim H. Molecular Characterization of Sessile Serrated Adenoma/Polyps From a Large African American Cohort. Gastroenterology. 2019 08; 157(2):572-574. PMID: 31004568.
      Citations: 3     Fields:    Translation:Humans
    19. Ashktorab H, Azimi H, Varma S, Lee EL, Laiyemo AO, Nickerson ML, Brim H. Driver genes exome sequencing reveals distinct variants in African Americans with colorectal neoplasia. Oncotarget. 2019 Apr 05; 10(27):2607-2624. PMID: 31080553.
      Citations: 1     Fields:    
    20. Ashktorab H, Rahi H, Nouraie M, Shokrani B, Lee E, Haydari T, Laiyemo AO, Siegel P, Brim H. GPNMB methylation: a new marker of potentially carcinogenic colon lesions. BMC Cancer. 2018 Nov 06; 18(1):1068. PMID: 30400781.
      Citations: 1     Fields:    Translation:HumansCells
    21. Shahnazi A, Badurdeen D, Laiyemo AO, Nouraie M, Brim H, Wessly P, Geramfard S, Afsari A, Page N, Ashktorab H. Obesity and Pancreatic Cysts in African American Patients. Cureus. 2018 Aug 20; 10(8):e3160. PMID: 30357033.
      Citations:    
    22. Brim H, Shahnazi A, Nouraie M, Badurdeen D, Laiyemo AO, Haidary T, Afsari A, Ashktorab H. Gastrointestinal Lesions in African American Patients With Iron Deficiency Anemia. Clin Med Insights Gastroenterol. 2018; 11:1179552218778627. PMID: 29795991.
      Citations:    
    23. Ashktorab H, Soleimani A, Nichols A, Sodhi K, Laiyemo AO, Nunlee-Bland G, Nouraie SM, Brim H. Adiponectin, Leptin, IGF-1, and Tumor Necrosis Factor Alpha As Potential Serum Biomarkers for Non-Invasive Diagnosis of Colorectal Adenoma in African Americans. Front Endocrinol (Lausanne). 2018; 9:77. PMID: 29593647.
      Citations:    
    24. Brim H, Yooseph S, Lee E, Sherif ZA, Abbas M, Laiyemo AO, Varma S, Torralba M, Dowd SE, Nelson KE, Pathmasiri W, Sumner S, de Vos W, Liang Q, Yu J, Zoetendal E, Ashktorab H. A Microbiomic Analysis in African Americans with Colonic Lesions Reveals Streptococcus sp.VT162 as a Marker of Neoplastic Transformation. Genes (Basel). 2017 11 09; 8(11). PMID: 29120399.
      Citations: 3     Fields:    
    25. Ashktorab H, Azimi H, Varma S, Tavakoli P, Nickerson ML, Brim H. Distinctive DNA mismatch repair and APC rare variants in African Americans with colorectal neoplasia. Oncotarget. 2017 Nov 21; 8(59):99966-99977. PMID: 29245953.
      Citations:    Fields:    
    26. Ashktorab H, Kupfer SS, Brim H, Carethers JM. Racial Disparity in Gastrointestinal Cancer Risk. Gastroenterology. 2017 10; 153(4):910-923. PMID: 28807841.
      Citations: 54     Fields:    Translation:Humans
    27. Afsari A, Lee E, Shokrani B, Boortalary T, Sherif ZA, Nouraie M, Laiyemo AO, Alkhalloufi K, Brim H, Ashktorab H. Clinical and Pathological Risk Factors Associated with Liver Fibrosis and Steatosis in African-Americans with Chronic Hepatitis C. Dig Dis Sci. 2017 08; 62(8):2159-2165. PMID: 28612194.
      Citations:    Fields:    Translation:HumansCells
    28. Sanabria-Salas MC, Hernández-Suárez G, Umaña-Pérez A, Rawlik K, Tenesa A, Serrano-López ML, Sánchez de Gómez M, Rojas MP, Bravo LE, Albis R, Plata JL, Green H, Borgovan T, Li L, Majumdar S, Garai J, Lee E, Ashktorab H, Brim H, Li L, Margolin D, Fejerman L, Zabaleta J. IL1B-CGTC haplotype is associated with colorectal cancer in admixed individuals with increased African ancestry. Sci Rep. 2017 02 03; 7:41920. PMID: 28157220.
      Citations: 2     Fields:    Translation:HumansCells
    29. Ashktorab H, Mokarram P, Azimi H, Olumi H, Varma S, Nickerson ML, Brim H. Targeted exome sequencing reveals distinct pathogenic variants in Iranians with colorectal cancer. Oncotarget. 2017 Jan 31; 8(5):7852-7866. PMID: 28002797.
      Citations: 8     Fields:    Translation:Cells
    30. Liang Q, Chiu J, Chen Y, Huang Y, Higashimori A, Fang J, Brim H, Ashktorab H, Ng SC, Ng SSM, Zheng S, Chan FKL, Sung JJY, Yu J. Fecal Bacteria Act as Novel Biomarkers for Noninvasive Diagnosis of Colorectal Cancer. Clin Cancer Res. 2017 04 15; 23(8):2061-2070. PMID: 27697996.
      Citations: 67     Fields:    Translation:Humans
    31. Brim H, Ashktorab H. Genomics of Colorectal Cancer in African Americans. Next Gener Seq Appl. 2016 Sep; 3(2). PMID: 27917406.
      Citations:    
    32. Ashktorab H, Shakoori A, Zarnogi S, Sun X, Varma S, Lee E, Shokrani B, Laiyemo AO, Washington K, Brim H. Reduced Representation Bisulfite Sequencing Determination of Distinctive DNA Hypermethylated Genes in the Progression to Colon Cancer in African Americans. Gastroenterol Res Pract. 2016; 2016:2102674. PMID: 27688749.
      Citations:    
    33. Ashktorab H, Etaati F, Rezaeean F, Nouraie M, Paydar M, Namin HH, Sanderson A, Begum R, Alkhalloufi K, Brim H, Laiyemo AO. Can optical diagnosis of small colon polyps be accurate? Comparing standard scope without narrow banding to high definition scope with narrow banding. World J Gastroenterol. 2016 Jul 28; 22(28):6539-46. PMID: 27605888.
      Citations: 2     Fields:    Translation:Humans
    34. Ashktorab H, Hermann P, Nouraie M, Shokrani B, Lee E, Haidary T, Brim H, Stein U. Increased MACC1 levels in tissues and blood identify colon adenoma patients at high risk. J Transl Med. 2016 07 20; 14(1):215. PMID: 27439755.
      Citations: 4     Fields:    Translation:Humans
    35. Ashktorab H, Vilmenay K, Brim H, Laiyemo AO, Kibreab A, Nouraie M. Colorectal Cancer in Young African Americans: Is It Time to Revisit Guidelines and Prevention? Dig Dis Sci. 2016 10; 61(10):3026-3030. PMID: 27278956.
      Citations: 16     Fields:    Translation:Humans
    36. Abbas M, Berka N, Khraiwesh M, Ramadan A, Apprey V, Furbert-Harris P, Quinn T, Brim H, Dunston G. Genetic Polymorphisms of TLR4 and MICA are Associated with Severity of Trachoma Disease in Tanzania. Autoimmune Infect Dis. 2016 Jun; 2(3). PMID: 27559544.
      Citations:    
    37. Ashktorab H, Ahuja S, Kannan L, Llor X, Ellis NA, Xicola RM, Laiyemo AO, Carethers JM, Brim H, Nouraie M. A meta-analysis of MSI frequency and race in colorectal cancer. Oncotarget. 2016 Apr 23; 7(23):34546-57. PMID: 27120810.
      Citations: 21     Fields:    Translation:Humans
    38. Shahnazi A, Sanderson AK, Laiyemo AO, Nouraie M, Haidary T, Brim H, Geramfard S, Afsari A, Ashktorab H. Diabetes Mellitus and Pancreatic Cysts in African Americans. Pancreas. 2016 Apr; 45(4):e14-5. PMID: 26954497.
      Citations:    Fields:    Translation:Humans
    39. Sherif ZA, Saeed A, Ghavimi S, Nouraie SM, Laiyemo AO, Brim H, Ashktorab H. Global Epidemiology of Nonalcoholic Fatty Liver Disease and Perspectives on US Minority Populations. Dig Dis Sci. 2016 May; 61(5):1214-25. PMID: 27038448.
      Citations: 41     Fields:    Translation:Humans
    40. Ashktorab H, Azimi H, Nickerson ML, Bass S, Varma S, Brim H. Targeted Exome Sequencing Outcome Variations of Colorectal Tumors within and across Two Sequencing Platforms. Next Gener Seq Appl. 2016 Jun; 3(1). PMID: 27547838.
      Citations:    
    41. Ashktorab H, Ogundipe T, Brim H, Shahnazi A, Laiyemo AO, Lee E, Shokrani B, Nouraie M. Lymph nodes' evaluation in relation to colorectal cancer staging among African Americans. BMC Cancer. 2015 Dec 16; 15:976. PMID: 26673446.
      Citations: 2     Fields:    Translation:Humans
    42. Ashktorab H, Laiyemo AO, Lee E, Cruz-Correa M, Ghuman A, Nouraie M, Brim H. Prevalence and features of colorectal lesions among Hispanics: A hospital-based study. World J Gastroenterol. 2015 Dec 14; 21(46):13095-100. PMID: 26673447.
      Citations: 4     Fields:    Translation:Humans
    43. Laiyemo AO, Thompson N, Williams CD, Idowu KA, Bull-Henry K, Sherif ZA, Lee EL, Brim H, Ashktorab H, Platz EA, Smoot DT. Race and colorectal cancer screening compliance among persons with a family history of cancer. World J Gastrointest Endosc. 2015 Dec 10; 7(18):1300-5. PMID: 26672497.
      Citations:    
    44. Nayani R, Ashktorab H, Brim H, Laiyemo AO. Genetic Basis for Colorectal Cancer Disparities. Curr Colorectal Cancer Rep. 2015 Dec 01; 11(6):408-413. PMID: 26997937.
      Citations:    
    45. Nouraie M, Kansal V, Belfonte C, Ghazvini M, Haidari T, Shahnazi A, Brim H, Soliman EZ, Ashktorab H. Atrial Fibrillation and Colonic Neoplasia in African Americans. PLoS One. 2015; 10(8):e0135609. PMID: 26317627.
      Citations: 1     Fields:    Translation:Humans
    46. Ashktorab H, Panchal H, Shokrani B, Paydar M, Sanderson A, Lee EL, Begum R, Haidary T, Laiyemo AO, McDonald-Pinkett S, Brim H, Nouraie M. Association between Diverticular Disease and Pre-Neoplastic Colorectal Lesions in an Urban African-American Population. Digestion. 2015; 92(2):60-5. PMID: 26183208.
      Citations: 6     Fields:    Translation:HumansPHPublic Health
    47. Ashktorab H, Varma S, Brim H. Next-generation sequencing in African Americans with colorectal cancer. Proc Natl Acad Sci U S A. 2015 Jun 02; 112(22):E2852. PMID: 25941412.
      Citations: 5     Fields:    Translation:Humans
    48. Ashktorab H, Brim H. DNA Methylation and Colorectal Cancer. Curr Colorectal Cancer Rep. 2014 Dec 01; 10(4):425-430. PMID: 25580099.
      Citations:    
    49. Ashktorab H, Daremipouran M, Devaney J, Varma S, Rahi H, Lee E, Shokrani B, Schwartz R, Nickerson ML, Brim H. Identification of novel mutations by exome sequencing in African American colorectal cancer patients. Cancer. 2015 Jan 01; 121(1):34-42. PMID: 25250560.
      Citations: 18     Fields:    Translation:HumansCells
    50. Laiyemo AO, Williams CD, Burnside C, Moghadam S, Sanasi-Bhola KD, Kwagyan J, Brim H, Ashktorab H, Scott VF, Smoot DT. Factors associated with attendance to scheduled outpatient endoscopy. Postgrad Med J. 2014 Oct; 90(1068):571-5. PMID: 25180285.
      Citations: 4     Fields:    Translation:Humans
    51. Brim H, Zahaf M, Laiyemo AO, Nouraie M, Pérez-Pérez GI, Smoot DT, Lee E, Razjouyan H, Ashktorab H. Gastric Helicobacter pylori infection associates with an increased risk of colorectal polyps in African Americans. BMC Cancer. 2014 Apr 28; 14:296. PMID: 24774100.
      Citations: 11     Fields:    Translation:HumansCells
    52. Ashktorab H, Paydar M, Yazdi S, Namin HH, Sanderson A, Begum R, Semati M, Etaati F, Lee E, Brim H, Zenebe A, Nunlee-Bland G, Laiyemo AO, Nouraie M. BMI and the risk of colorectal adenoma in African-Americans. Obesity (Silver Spring). 2014 May; 22(5):1387-91. PMID: 24519988.
      Citations: 9     Fields:    Translation:Humans
    53. Brim H, Abu-Asab MS, Nouraie M, Salazar J, Deleo J, Razjouyan H, Mokarram P, Schaffer AA, Naghibhossaini F, Ashktorab H. An integrative CGH, MSI and candidate genes methylation analysis of colorectal tumors. PLoS One. 2014; 9(1):e82185. PMID: 24475022.
      Citations: 16     Fields:    Translation:HumansCells
    54. Ashktorab H, Daremipouran M, Goel A, Varma S, Leavitt R, Sun X, Brim H. DNA methylome profiling identifies novel methylated genes in African American patients with colorectal neoplasia. Epigenetics. 2014 Apr; 9(4):503-12. PMID: 24441198.
      Citations: 31     Fields:    Translation:HumansCells
    55. Brim H, Yooseph S, Zoetendal EG, Lee E, Torralbo M, Laiyemo AO, Shokrani B, Nelson K, Ashktorab H. Microbiome analysis of stool samples from African Americans with colon polyps. PLoS One. 2013; 8(12):e81352. PMID: 24376500.
      Citations: 22     Fields:    Translation:HumansCells
    56. Fatemi M, Paul TA, Brodeur GM, Shokrani B, Brim H, Ashktorab H. Epigenetic silencing of CHD5, a novel tumor-suppressor gene, occurs in early colorectal cancer stages. Cancer. 2014 Jan 15; 120(2):172-80. PMID: 24243398.
      Citations: 29     Fields:    Translation:HumansCells
    57. Ashktorab H, Paydar M, Namin HH, Sanderson A, Begum R, Brim H, Panchal H, Lee E, Kibreab A, Nouraie M, Laiyemo AO. Prevalence of colorectal neoplasia among young African Americans and Hispanic Americans. Dig Dis Sci. 2014 Feb; 59(2):446-50. PMID: 24193352.
      Citations: 12     Fields:    Translation:Humans
    58. Ashktorab H, Rahi H, Wansley D, Varma S, Shokrani B, Lee E, Daremipouran M, Laiyemo A, Goel A, Carethers JM, Brim H. Toward a comprehensive and systematic methylome signature in colorectal cancers. Epigenetics. 2013 Aug; 8(8):807-15. PMID: 23975090.
      Citations: 28     Fields:    Translation:HumansCells
    59. Ashktorab H, Hassanzadeh Namin H, Taylor T, Williams C, Brim H, Mellman T, Shokrani B, Holt CL, Laiyemo AO, Nouraie M. Role of life events in the presence of colon polyps among African Americans. BMC Gastroenterol. 2013 Jun 12; 13:101. PMID: 23758671.
      Citations: 2     Fields:    Translation:Humans
    60. Errami Y, Brim H, Oumouna-Benachour K, Oumouna M, Naura AS, Kim H, Ju J, Davis CJ, Kim JG, Ashktorab H, Fallon K, Xu M, Zhang J, Del Valle L, Boulares AH. ICAD deficiency in human colon cancer and predisposition to colon tumorigenesis: linkage to apoptosis resistance and genomic instability. PLoS One. 2013; 8(2):e57871. PMID: 23451280.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    61. Laiyemo AO, Doubeni C, Brim H, Ashktorab H, Schoen RE, Gupta S, Charabaty A, Lanza E, Smoot DT, Platz E, Cross AJ. Short- and long-term risk of colorectal adenoma recurrence among whites and blacks. Gastrointest Endosc. 2013 Mar; 77(3):447-54. PMID: 23337636.
      Citations: 14     Fields:    Translation:Humans
    62. Errami Y, Naura AS, Kim H, Ju J, Suzuki Y, El-Bahrawy AH, Ghonim MA, Hemeida RA, Mansy MS, Zhang J, Xu M, Smulson ME, Brim H, Boulares AH. Apoptotic DNA fragmentation may be a cooperative activity between caspase-activated deoxyribonuclease and the poly(ADP-ribose) polymerase-regulated DNAS1L3, an endoplasmic reticulum-localized endonuclease that translocates to the nucleus during apoptosis. J Biol Chem. 2013 Feb 01; 288(5):3460-8. PMID: 23229555.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    63. Ashktorab H, Entezari O, Nouraie M, Dowlati E, Frederick W, Woods A, Lee E, Brim H, Smoot DT, Ghadyari F, Kamangar F, Razjouyan H. Helicobacter pylori protection against reflux esophagitis. Dig Dis Sci. 2012 Nov; 57(11):2924-8. PMID: 23010740.
      Citations: 6     Fields:    Translation:HumansCells
    64. Brim H, Lee E, Abu-Asab MS, Chaouchi M, Razjouyan H, Namin H, Goel A, Schäffer AA, Ashktorab H. Genomic aberrations in an African American colorectal cancer cohort reveals a MSI-specific profile and chromosome X amplification in male patients. PLoS One. 2012; 7(8):e40392. PMID: 22879877.
      Citations: 21     Fields:    Translation:HumansCells
    65. Ashktorab H, Green W, Finzi G, Sessa F, Nouraie M, Lee EL, Morgano A, Moschetta A, Cattaneo M, Mariani-Costantini R, Brim H, Biunno I. SEL1L, an UPR response protein, a potential marker of colonic cell transformation. Dig Dis Sci. 2012 Apr; 57(4):905-12. PMID: 22350780.
      Citations: 14     Fields:    Translation:HumansCells
    66. Ashktorab H, Nguza B, Fatemi M, Nouraie M, Smoot DT, Schäffer AA, Kupfer SS, Camargo CA, Brim H. Case-control study of vitamin D, dickkopf homolog 1 (DKK1) gene methylation, VDR gene polymorphism and the risk of colon adenoma in African Americans. PLoS One. 2011; 6(10):e25314. PMID: 22022386.
      Citations: 12     Fields:    Translation:HumansCells
    67. Ashktorab H, Nouri Z, Nouraie M, Razjouyan H, Lee EE, Dowlati E, El-Seyed el-W, Laiyemo A, Brim H, Smoot DT. Esophageal carcinoma in African Americans: a five-decade experience. Dig Dis Sci. 2011 Dec; 56(12):3577-82. PMID: 21847566.
      Citations: 7     Fields:    Translation:Humans
    68. Brim H, Kumar K, Nazarian J, Hathout Y, Jafarian A, Lee E, Green W, Smoot D, Park J, Nouraie M, Ashktorab H. SLC5A8 gene, a transporter of butyrate: a gut flora metabolite, is frequently methylated in African American colon adenomas. PLoS One. 2011; 6(6):e20216. PMID: 21687703.
      Citations: 16     Fields:    Translation:HumansCells
    69. Nouraie M, Hosseinkhah F, Brim H, Zamanifekri B, Smoot DT, Ashktorab H. Clinicopathological features of colon polyps from African-Americans. Dig Dis Sci. 2010 May; 55(5):1442-9. PMID: 20225129.
      Citations: 21     Fields:    Translation:Humans
    70. Ashktorab H, Schäffer AA, Daremipouran M, Smoot DT, Lee E, Brim H. Distinct genetic alterations in colorectal cancer. PLoS One. 2010 Jan 26; 5(1):e8879. PMID: 20126641.
      Citations: 56     Fields:    Translation:HumansCells
    71. Mokarram P, Kumar K, Brim H, Naghibalhossaini F, Saberi-firoozi M, Nouraie M, Green R, Lee E, Smoot DT, Ashktorab H. Distinct high-profile methylated genes in colorectal cancer. PLoS One. 2009 Sep 11; 4(9):e7012. PMID: 19750230.
      Citations: 66     Fields:    Translation:HumansCells
    72. Kumar K, Brim H, Giardiello F, Smoot DT, Nouraie M, Lee EL, Ashktorab H. Distinct BRAF (V600E) and KRAS mutations in high microsatellite instability sporadic colorectal cancer in African Americans. Clin Cancer Res. 2009 Feb 15; 15(4):1155-61. PMID: 19190129.
      Citations: 41     Fields:    Translation:HumansCells
    73. Ashktorab H, Belgrave K, Hosseinkhah F, Brim H, Nouraie M, Takkikto M, Hewitt S, Lee EL, Dashwood RH, Smoot D. Global histone H4 acetylation and HDAC2 expression in colon adenoma and carcinoma. Dig Dis Sci. 2009 Oct; 54(10):2109-17. PMID: 19057998.
      Citations: 35     Fields:    Translation:HumansCells
    74. Brim H, Mokarram P, Naghibalhossaini F, Saberi-Firoozi M, Al-Mandhari M, Al-Mawaly K, Al-Mjeni R, Al-Sayegh A, Raeburn S, Lee E, Giardiello F, Smoot DT, Vilkin A, Boland CR, Goel A, Hafezi M, Nouraie M, Ashktorab H. Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study. Mol Cancer. 2008 Aug 21; 7:68. PMID: 18718023.
      Citations: 40     Fields:    Translation:Humans
    75. Ashktorab H, Brim H, Al-Riyami M, Date A, Al-Mawaly K, Kashoub M, Al-Mjeni R, Smoot DT, Al-Moundhri M, Al-Hashemi S, Ganguly SS, Raeburn S. Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects. Dig Dis Sci. 2008 Oct; 53(10):2723-31. PMID: 18299982.
      Citations: 14     Fields:    Translation:HumansCells
    76. Sultan AS, Brim H, Sherif ZA. Co-overexpression of Janus kinase 2 and signal transducer and activator of transcription 5a promotes differentiation of mammary cancer cells through reversal of epithelial-mesenchymal transition. Cancer Sci. 2008 Feb; 99(2):272-9. PMID: 18271926.
      Citations: 26     Fields:    Translation:HumansCells
    77. Brim H, Osborne JP, Kostandarithes HM, Fredrickson JK, Wackett LP, Daly MJ. Deinococcus radiodurans engineered for complete toluene degradation facilitates Cr(VI) reduction. Microbiology (Reading). 2006 Aug; 152(Pt 8):2469-2477. PMID: 16849809.
      Citations:    
    78. Qin J, Song L, Brim H, Daly MJ, Summers AO. Hg(II) sequestration and protection by the MerR metal-binding domain (MBD). Microbiology (Reading). 2006 Mar; 152(Pt 3):709-719. PMID: 16514151.
      Citations:    
    79. Ghosal D, Omelchenko MV, Gaidamakova EK, Matrosova VY, Vasilenko A, Venkateswaran A, Zhai M, Kostandarithes HM, Brim H, Makarova KS, Wackett LP, Fredrickson JK, Daly MJ. How radiation kills cells: survival of Deinococcus radiodurans and Shewanella oneidensis under oxidative stress. FEMS Microbiol Rev. 2005 Apr; 29(2):361-75. PMID: 15808748.
      Citations: 81     Fields:    Translation:Cells
    80. Brim H, Venkateswaran A, Kostandarithes HM, Fredrickson JK, Daly MJ. Engineering Deinococcus geothermalis for bioremediation of high-temperature radioactive waste environments. Appl Environ Microbiol. 2003 Aug; 69(8):4575-82. PMID: 12902245.
      Citations: 23     Fields:    Translation:CellsPHPublic Health
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