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W. Malcolm Byrnes

TitleAssociate Professor
Faculty RankAssociate Professor
InstitutionHoward University
DepartmentBiochemistry and Molecular Biology
AddressHoward University College of Medicine
520 W Street, N.W.
Department of Biochemistry and Molecular Biology
Washington DC 20059
Phone2028069749
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    Collapse Biography 
    Collapse awards and honors
    1980American Chemical Society (ACS) Undergraduate Analytical Award, Xavier University of Louisiana
    1981M. Agatha Ryan Award, Xavier University of Louisiana
    1981summa cum laude (gpa 4.0) graduate, Honors in English, Xavier University of Louisiana
    1981The ACS Award, Xavier University of Louisiana
    1994Robert S. and Louise P. Allen Award, Louisiana State University, Baton Rouge
    1994University Travel Award, Louisiana State University, Baton Rouge
    1995 - 1996NIH Postdoctoral Fellowship (NRSA), Cornell University
    2003FFAE Travel Award, Howard University
    2004Faculty Merit Award, Howard University
    2005FFAE Travel Award, Howard University
    2006Faculty Merit Award, Howard University
    2014College of Pharmacy Professionalism Recognition Award, Howard University

    Collapse Overview 
    Collapse overview
    Research in my laboratory is concerned with the structure and function of bacterial and archaeal enzymes. Two NIH-funded research projects are currently ongoing: (1) characterization of fused chorismate-utilizing enzymes (e.g., certain anthranilate synthases and PABA synthases), and (2) characterization of streptomycin phosphotransferases, which confer resistance to the antibiotic streptomycin.

    I am also engaged in scholarly work in several broad areas: bioethics; ecological ethics, especially as it relates to climate change; the science-religion debate; and the scientific legacy of African American biologist Ernest Everett Just (1883-1941). I teach or team-teach courses in biochemistry to medical, graduate and pharmacy students.



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ashenafi M, Reddy PT, Parsons JF, Byrnes WM. The fused anthranilate synthase from Streptomyces venezuelae functions as a monomer. Mol Cell Biochem. 2015 Feb; 400(1-2):9-15. PMID: 25355158.
      Citations: 4     Fields:    Translation:Cells
    2. Byrnes WM, Newman SA. Ernest Everett Just: Egg and embryo as excitable systems. J Exp Zool B Mol Dev Evol. 2014 Jun; 322(4):191-201. PMID: 24665037.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Ashenafi M, Ammosova T, Nekhai S, Byrnes WM. Purification and characterization of aminoglycoside phosphotransferase APH(6)-Id, a streptomycin-inactivating enzyme. Mol Cell Biochem. 2014 Feb; 387(1-2):207-16. PMID: 24248535.
      Citations: 2     Fields:    Translation:Cells
    4. Debebe Z, Nekhai S, Ashenafi M, Lovejoy DB, Kalinowski DS, Gordeuk VR, Byrnes WM, Richardson DR, Karla PK. Development of a sensitive HPLC method to measure in vitro permeability of E- and Z-isomeric forms of thiosemicarbazones in Caco-2 monolayers. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Oct 01; 906:25-32. PMID: 22954966.
      Citations: 4     Fields:    Translation:HumansCells
    5. Byrnes WM. Ernest Everett Just, Johannes Holtfreter, and the origin of certain concepts in embryo morphogenesis. Mol Reprod Dev. 2009 Oct; 76(10):912-21. PMID: 19610071.
      Citations: 3     Fields:    Translation:Humans
    6. Byrnes WM. Introduction to Special Issue: Ernest Everett Just (1883-1941). Mol Reprod Dev. 2009 Aug 20; 76(10):10.1002/mrd.21098. PMID: 27627820.
      Citations:    Fields:    Translation:Animals
    7. Byrnes WM. The flawed scientific basis of the altered nuclear transfer-oocyte assisted reprogramming (ANT-OAR) proposal. Stem Cell Rev. 2007 Jan; 3(1):60-5. PMID: 17873382.
      Citations:    Fields:    Translation:HumansAnimalsCells
    8. Byrnes WM, Eckberg WR. Ernest Everett Just (1883-1941)--an early ecological developmental biologist. Dev Biol. 2006 Aug 01; 296(1):1-11. PMID: 16712833.
      Citations: 5     Fields:    Translation:Animals
    9. Ho DL, Byrnes WM, Ma WP, Shi Y, Callaway DJ, Bu Z. Structure-specific DNA-induced conformational changes in Taq polymerase revealed by small angle neutron scattering. J Biol Chem. 2004 Sep 10; 279(37):39146-54. PMID: 15247286.
      Citations: 13     Fields:    Translation:Cells
    10. Byrnes WM, Vilker VL. Extrinsic factors potassium chloride and glycerol induce thermostability in recombinant anthranilate synthase from Archaeoglobus fulgidus. Extremophiles. 2004 Dec; 8(6):455-62. PMID: 15235940.
      Citations: 2     Fields:    Translation:Cells
    11. Auzat I, Byrnes WM, Garel JR, Chang SH. Role of residue 161 in the allosteric transitions of two bacterial phosphofructokinases. Biochemistry. 1995 May 30; 34(21):7062-8. PMID: 7766616.
      Citations: 3     Fields:    Translation:Cells
    12. Zhu X, Byrnes M, Nelson JW, Chang SH. Role of glycine 212 in the allosteric behavior of phosphofructokinase from Bacillus stearothermophilus. Biochemistry. 1995 Feb 28; 34(8):2560-5. PMID: 7873536.
      Citations:    Fields:    Translation:Cells
    13. Byrnes WM, Hu W, Younathan ES, Chang SH. A chimeric bacterial phosphofructokinase exhibits cooperativity in the absence of heterotropic regulation. J Biol Chem. 1995 Feb 24; 270(8):3828-35. PMID: 7876126.
      Citations:    Fields:    Translation:Cells
    14. Byrnes M, Zhu X, Younathan ES, Chang SH. Kinetic characteristics of phosphofructokinase from Bacillus stearothermophilus: MgATP nonallosterically inhibits the enzyme. Biochemistry. 1994 Mar 22; 33(11):3424-31. PMID: 8136379.
      Citations: 3     Fields:    Translation:Cells
    15. Li J, Zhu X, Byrnes M, Nelson JW, Chang SH. Site-directed mutagenesis of rabbit muscle phosphofructokinase cDNA. Mutations at glutamine 200 affect the allosteric properties of the enzyme. J Biol Chem. 1993 Nov 25; 268(33):24599-606. PMID: 8227018.
      Citations: 1     Fields:    Translation:AnimalsCells
    16. Li J, Chen Z, Lu L, Byrnes M, Chang SH. Sequence diversity in the 5' untranslated region of rabbit muscle phosphofructokinase mRNA. Biochem Biophys Res Commun. 1990 Aug 16; 170(3):1056-60. PMID: 2143897.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
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